Browse > Article
http://dx.doi.org/10.4110/in.2010.10.4.109

Role of Th17 Cell and Autoimmunity in Chronic Obstructive Pulmonary Disease  

Hong, Seok Chan (Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology)
Lee, Seung-Hyo (Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology)
Publication Information
IMMUNE NETWORK / v.10, no.4, 2010 , pp. 109-114 More about this Journal
Abstract
The molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) are poorly defined. Accumulating evidences indicate that chronic inflammatory responses and adaptive immunity play important roles in the development and progression of the disease. Recently, it has been shown that IL-17 producing CD4 T cells, named Th17 cells, which have been implicated in the pathogenesis of several inflammatory and autoimmune diseases, are involved in airway inflammation and COPD. In addition, we and others suggest that autoimmunity may play a critical role in the pathogenesis of COPD. Here, we will review the current understanding of roles of Th17 cells and autoimmune responses in COPD.
Keywords
COPD; Inflammation; Th17 cells; Autoimmunity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight- White S, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Cogswell S, Storness-Bliss C, Corry DB, Kheradmand F: Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 13;567-569, 2007   DOI   ScienceOn
2 Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350;2645-2653, 2004   DOI   ScienceOn
3 Baraldo S, Turato G, Badin C, Bazzan E, Beghe B, Zuin R, Calabrese F, Casoni G, Maestrelli P, Papi A, Fabbri LM, Saetta M: Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 59;308-312, 2004   DOI   ScienceOn
4 Keatings VM, Collins PD, Scott DM, Barnes PJ: Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 153;530-534, 1996   DOI   ScienceOn
5 Keatings VM, Collins PD, Scott DM, Barnes PJ: Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 153;530-534, 1996   DOI   ScienceOn
6 Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A: Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 163; 2329-2335, 2003   DOI   ScienceOn
7 Voynow JA, Young LR, Wang Y, Horger T, Rose MC, Fischer BM: Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 276; L835-843, 1999
8 Barnes PJ: Alveolar macrophages as orchestrators of COPD. COPD 1;59-70, 2004   DOI   ScienceOn
9 Churg A, Wright JL: Proteases and emphysema. Curr Opin Pulm Med 11;153-159, 2005   DOI   ScienceOn
10 Russell RE, Thorley A, Culpitt SV, Dodd S, Donnelly LE, Demattos C, Fitzgerald M, Barnes PJ: Alveolar macrophage- mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol 283;L867-873, 2002   DOI
11 Finlay GA, Russell KJ, McMahon KJ, D'arcy EM, Masterson JB, FitzGerald MX, O'Connor CM: Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 52;502-506, 1997   DOI   ScienceOn
12 Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD: Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277;2002-2004, 1997   DOI   ScienceOn
13 Grumelli S, Corry DB, Song LZ, Song L, Green L, Huh J, Hacken J, Espada R, Bag R, Lewis DE, Kheradmand F: An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med 1;e8, 2004   DOI   ScienceOn
14 Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, Mason RJ: Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 280;L39-49, 2001   DOI
15 Aaron SD, Angel JB, Lunau M, Wright K, Fex C, Le Saux N, Dales RE: Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163;349-355, 2001   DOI   ScienceOn
16 Dentener MA, Creutzberg EC, Pennings HJ, Rijkers GT, Mercken E, Wouters EF: Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study. Respiration 76;275-282, 2008   DOI   ScienceOn
17 Rennard SI, Fogarty C, Kelsen S, Long W, Ramsdell J, Allison J, Mahler D, Saadeh C, Siler T, Snell P, Korenblat P, Smith W, Kaye M, Mandel M, Andrews C, Prabhu R, Donohue JF, Watt R, Lo KH, Schlenker-Herceg R, Barnathan ES, Murray J; COPD Investigators: The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 175;926-934, 2007   DOI   ScienceOn
18 Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, Turato G, Lokar-Oliani K, Papi A, Zuin R, Sfriso P, Balestro E, Dinarello CA, Saetta M: IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 178;894-901, 2008   DOI   ScienceOn
19 Sapey E, Ahmad A, Bayley D, Newbold P, Snell N, Rugman P, Stockley RA: Imbalances between interleukin-1 and tumor necrosis factor agonists and antagonists in stable COPD. J Clin Immunol 29;508-516, 2009   DOI   ScienceOn
20 Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA: Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 55;114-120, 2000   DOI   ScienceOn
21 Miossec P, Korn T, Kuchroo VK: Interleukin-17 and type 17 helper T cells. N Engl J Med 361;888-898, 2009   DOI   ScienceOn
22 Louten J, Boniface K, de Waal Malefyt R: Development and function of TH17 cells in health and disease. J Allergy Clin Immunol 123;1004-1011, 2009   DOI   ScienceOn
23 Jones CE, Chan K: Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocytecolony- stimulating factor by human airway epithelial cells. Am J Respir Cell Mol Biol 26;748-753, 2002   DOI   ScienceOn
24 Kao CY, Huang F, Chen Y, Thai P, Wachi S, Kim C, Tam L, Wu R: Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J Immunol 175;6676-6685, 2005   DOI
25 Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R: Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 278;17036-17043, 2003   DOI   ScienceOn
26 Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6;1133-1141, 2005   DOI   ScienceOn
27 Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R: The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol 39;3570-3581, 2009   DOI   ScienceOn
28 Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, Walsh PT: Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett 121;13-21, 2008   DOI   ScienceOn
29 Barczyk A, Pierzchala W, Sozanska E: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 97;726-733, 2003   DOI   ScienceOn
30 Ikeuchi H, Kuroiwa T, Hiramatsu N, Kaneko Y, Hiromura K, Ueki K, Nojima Y: Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 52;1037-1046, 2005   DOI   ScienceOn
31 Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK: IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14;275-281, 2008   DOI   ScienceOn
32 Di Stefano A, Caramori G, Gnemmi I, Contoli M, Vicari C, Capelli A, Magno F, D'Anna SE, Zanini A, Brun P, Casolari P, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B: T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol 157;316-324, 2009   DOI   ScienceOn
33 Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D: Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med 207;1293- 1305, 2010   DOI   ScienceOn
34 Voelkel N, Taraseviciene-Stewart L: Emphysema: an autoimmune vascular disease? Proc Am Thorac Soc 2;23-25, 2005   DOI   ScienceOn
35 Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421;744-748, 2003   DOI   ScienceOn
36 Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ: Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198;1951-1957, 2003   DOI   ScienceOn
37 Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201;233-240, 2005   DOI   ScienceOn
38 Agusti A, MacNee W, Donaldson K, Cosio M: Hypothesis: does COPD have an autoimmune component? Thorax 58;832-834, 2003   DOI   ScienceOn
39 Shan M, Cheng HF, Song LZ, Roberts L, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Storness-Bliss C, Ramchandani M, Lee SH, Corry DB, Kheradmand F: Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Science Translational Medicine 1;4ra10, 2009   DOI   ScienceOn
40 Cottin V, Fabien N, Khouatra C, Moreira A, Cordier JF: Anti-elastin autoantibodies are not present in combined pulmonary fibrosis and emphysema. Eur Respir J 33;219-221, 2009   DOI   ScienceOn
41 Greene CM, Low TB, O'Neill SJ, McElvaney NG: Anti-proline- glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease. Am J Respir Crit Care Med 181;31-35, 2010   DOI   ScienceOn
42 Ind PW: COPD disease progression and airway inflammation: uncoupled by smoking cessation. Eur Respir J 26;764-766, 2005   DOI   ScienceOn
43 Hogg JC, Timens W: The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 4;435-459, 2009   DOI   ScienceOn
44 Mathers CD, Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3;e442, 2006   DOI
45 Fletcher C, Peto R: The natural history of chronic airflow obstruction. Br Med J 1;1645-1648, 1977   DOI
46 Taraseviciene-Stewart L, Voelkel NF: Molecular pathogenesis of emphysema. J Clin Invest 118;394-402, 2008   DOI   ScienceOn
47 Simmons MS, Connett JE, Nides MA, Lindgren PG, Kleerup EC, Murray RP, Bjornson WM, Tashkin DP: Smoking reduction and the rate of decline in FEV(1): results from the Lung Health Study. Eur Respir J 25;1011-1017, 2005   DOI   ScienceOn
48 Chung KF, Adcock IM: Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J 31;1334-1356, 2008   DOI   ScienceOn
49 Sharafkhaneh A, Hanania NA, Kim V: Pathogenesis of emphysema: from the bench to the bedside. Proc Am Thorac Soc 5; 475-477, 2008   DOI   ScienceOn
50 Tuder RM, Yoshida T, Arap W, Pasqualini R, Petrache I: State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc 3;503-510, 2006   DOI   ScienceOn
51 Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, Deka R, Borchers MT: Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. J Immunol 181;8036-8043, 2008   DOI
52 Motz GT, Eppert BL, Wesselkamper SC, Flury JL, Borchers MT: Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice. Am J Respir Crit Care Med 181;1223-1233, 2010   DOI   ScienceOn
53 Sullivan AK, Simonian PL, Falta MT, Mitchell JD, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP: Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med 172;590-596, 2005   DOI   ScienceOn