Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지

Obsessive-Compulsive Disorder and Glutamatergic Dysfunction

강박장애와 글루타메이트 기능 이상

  • Hwang, Syung-Shick (Department of Psychiatry, Hallym University College of Medicine) ;
  • Kim, Chan-Hyung (Department of Psychiatry, Yonsei University College of Medicine)
  • 황성식 (한림대학교 의과대학 정신과학교실) ;
  • 김찬형 (연세대학교 의과대학 정신과학교실)
  • Received : 2007.04.11
  • Accepted : 2007.04.12
  • Published : 2007.04.30
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Abstract

The definite causes of obsessive-compulsive disorder (OCD) are still unknown. OCD has been suggested to be related to many neurotransmitters in brain, such as serotonin, dopamine and glutamate. It has been shown that serotonergic neurons play a crucial role in the pathophysiology of OCD. Recently, it is known that neurotransmitters other than serotonin also play a role in the pathophysiology of OCD, and a series of studies have provided a few evidence that glutamate may be involved in some OCD patients. The purpose of this article was to review the literatures on glutamatergic dysfunction in OCD. We suggest that glutamatergic dysfunction may be implicated in the pathophysiology of OCD.

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