• Molecules and Cells
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• 제37권11호
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• pp.767-776
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• 2014

Alzheimer's disease (AD) is clinically characterized with progressive memory loss and cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to neurodegeneration and memory dysfunction. Mounting evidence suggests that aggregation of amyloid-${\alpha}$ ($A{\alpha}$) and hyperphosphorylated tau leads to synaptic deficits and neurodegeneration, thereby to memory loss. Among the established genetic risk factors for AD, the ${\varepsilon}4$ allele of apolipoprotein E (APOE) is the strongest genetic risk factor. We and others previously demonstrated that apoE regulates $A{\alpha}$ aggregation and clearance in an isoform-dependent manner. While the effect of apoE on $A{\alpha}$ may explain how apoE isoforms differentially affect AD pathogenesis, there are also other underexplored pathogenic mechanisms. They include differential effects of apoE on cerebral energy metabolism, neuroinflammation, neurovascular function, neurogenesis, and synaptic plasticity. ApoE is a major carrier of cholesterols that are required for neuronal activity and injury repair in the brain. Although there are a few conflicting findings and the underlying mechanism is still unclear, several lines of studies demonstrated that apoE4 leads to synaptic deficits and impairment in long-term potentiation, memory and cognition. In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.

• Journal of Korean Biological Nursing Science
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• 제19권4호
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• pp.276-283
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• 2017

Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.

• 한국산업정보학회논문지
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• 제25권4호
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• pp.101-115
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• 2020

기업은 수익 극대화 및 새로운 고객유치와 기존고객 이탈방지를 위해 강력한 브랜드 공감을 형성하는 것은 매우 중요하다. 본 연구에서는 브랜드 정체성에 대한 인지, 브랜드 성과, 브랜드 감정으로 이어지는 브랜드 인식요인들과 브랜드 애착과의 관계를 살펴보고, 브랜드 애착이 브랜드 공감을 형성하는데 어떠한 역할을 하는지 검증하였다. 결과적으로, 브랜드 인식요인 중 브랜드 감정이 브랜드 애착에 영향을 미치고 브랜드 공감을 형성하는 핵심요인임을 확인하였다. 또한 소비자들의 진정한 브랜드 공감이 형성되기까지 브랜드 정체성에 대한 인지가 정립되면, 브랜드에 대한 차별적 성과를 통하여 브랜드에 대한 진정한 가치를 경험하게 되고 소비자들의 감성적 반응을 높인다. 이는 브랜드에 대한 애착을 통해 브랜드와 소비자와의 깊은 결속으로 이어지며, 브랜드와 상호작용하고 높은 브랜드 공감적 행동을 보여 주는 것으로 나타났다.

• 한국멀티미디어학회논문지
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• 제24권10호
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• pp.1449-1460
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• 2021

The visual design elements of packaging play an vital role in attracting consumers' attention, forming their sense of pleasure and sensory expectations, as well as having an important impact on the actual product experience. This study aims to explore whether the colors and textures in the packaging design elements of canned beer will affect consumers' senses, judgments and taste perception of canned beer. Participants in Survey I (N=193) evaluated their expectations for beer freshness, softness, bitterness and alcohol content by observing the packaging of canned beer, then recorded whether they could get the expected experience when tasting beer, and evaluated their preference and purchase intention. In the Survey II, 4 kind of colors and 2 types of texture shapes were applied, and all participants were provided with the same beer for multivariate cross contract analysis to evaluate the specific impact of color and texture of packaging design elements on consumers' taste and the interaction between sensory judgment and taste perception.The results showed that both colors and textures had a significant affect on the sensory expectation (pre-tasting score) of canned beer, but their effects on the sensory score after tasting (actual perception)were inobvious. The analysis of the influence of the interaction between color, texture and shape on taste perception shows that when the expected packaging appearance perception is similar to the actual drinking perception (i.e., straight line and B/G or arc line and Y/R), it is more likely to obtain consumers' favor and higher purchase intention evaluation than the inconsistent canned beer packaging (i.e., straight line and Y/R and arc line and B/G). This paper discusses the influence of these results on the packaging design of canned beer and the possibility of improving the brand efficiency by meeting the visual elements of packaging design expected by consumers.

• 디지털융복합연구
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• 제17권6호
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• pp.439-446
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• 2019

이 연구의 목적은 뇌졸중 후 발생가능한 정서적, 사회인지 문제의 중재를 위해 작업 치료에 기초한 인지자극순환프로그램(CSCP ; Cognitive Stimulation Circulative Program)의 효과를 확인하는 것이다. 이 연구에는 12명의 뇌졸중 환자가 참여하였고 CSCP는 인지과정을 촉진시키는 방법으로 조직화되었으며 총 16회기의 순환 프로그램으로 실시되었다. 프로그램의 효과를 알아보기 위하여 우울증 척도와 관계 변화 척도, 삶의 질 평가 도구를 사용하였다. 연구결과 피험자의 우울증 척도와 역할의 물리적 및 사회적 인지 기능 능력을 평가하기 위해 사용된 관계 변화 척도는 통계적으로 유의미한 변화가 있었다(p<.05). 또한, 삶의 질 영역 중에서 신체적 역할, 사회적 기능의 항목에서 의미있는 향상이 있었다. CSCP가 뇌졸중 환자의 우울을 감소시키고 사회인지 기능을 향상시켜 삶의 질을 향상시키는 효율적인 중재 프로그램으로 사용 가능함을 입증하였다.

• Journal of Preventive Medicine and Public Health
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• 제52권5호
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• pp.333-343
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• 2019

Objectives: This study aimed to evaluate the association between dental implants and cognitive function in community-dwelling older adults. Methods: Data were collected from the baseline survey (2016-2017) of the Korean Frailty and Aging Cohort Study. The study sample comprised 1115 community-dwelling people aged 70 years to 84 years who had 0-19 natural teeth. Dental implants and natural teeth were identified by panoramic radiography, while the cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The association between dental implants and cognitive function was analyzed by multiple linear regression. Sensitivity analysis was performed to test for potential bias. Results: The mean number of natural teeth in the study population was 9.50 (standard deviation [SD], 6.42), and the mean MMSE-KC score was 24.93 (SD, 3.55). In the simple univariate analysis, tooth replacement, age, sex, smoking status, alcohol consumption, body mass index, osteoporosis, number of natural teeth, periodontitis, chewing discomfort, tooth-brushing frequency, education level, monthly household income, participation in economic activity, living alone, and marital status had a significant impact on the association. After adjusting for confounders, the association between dental implants and cognitive function remained significant (B, 0.85; standard error, 0.40; p<0.05). Age, body mass index, periodontitis, tooth-brushing frequency, and education level were also significantly associated with cognitive function. The results of the sensitivity analyses were consistent with those of the primary analysis. Conclusions: Dental implants were associated with cognitive function in older adults living in the community. Dental implants as tooth replacements may play a role in preserving cognitive function.

• International Journal of Computer Science & Network Security
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• 제21권3호
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• pp.287-294
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• 2021

Modern small farms are important link components in the structure of the world agro-industrial complex. It ensures the food and nutritional sustainability of the country exclusively at the local regional level. The purpose of the research is to examine the role of farming in ensuring nutritional security and food stability based on the analysis of the Food Sustainability Index (FSI). Research methods: modeling, abstraction, analogy, analysis, synthesis, formalization, logical abstraction, theoretical cognition, systematization and classification, abstract-logical, etc. Results. Having analyzed the Food Sustainability Index for 2018, it has been established that there is a lack of a clear relationship between the pace of economic development and the level of food and nutritional sustainability. In addition, this study has identified the countries with the largest number of small farms, as well as the number of farms within the region. The correlation between the size of the farm and the area of agricultural land that it cultivates has been determined. The problems faced by small farms in the process of their activity have been analyzed. The programs implemented in the field of agro-industrial complex development by international profile institutions have been systematized. Particularly, the regional structure of agricultural development programs under the guidance of IFAD is defined, as well as the areas to which they are directed. Specific measures taken by governments to stimulate the development of small farms have been outlined. Reasonable conclusions have been formed based on the study. The direction of future research is seen in the assessment of the export potential of small farms in terms of range, volume of export deliveries and geographical direction of movement of their products.

• 한국컴퓨터정보학회논문지
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• 제26권1호
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• pp.223-229
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• 2021

본 연구는 장애 발생이 경제·사회·문화적 배제에 어떠한 영향을 미치는가를 살펴보고, 이들 변수 간의 관계에 있어서 사회환경이 조절변수로서 역할을 하는지에 대해 경험적으로 검증해 봄으로써 신규 장애인을 위한 이론적 정책적 시사점을 도출하는데 연구 목적을 두고 있다. 이를 위해 이 연구에서는 장애인들을 표본추출하여 신규 장애인의 경제·사회·문화적 배제와 사회환경의 조절효과를 분석하였다. 분석결과는 다음과 같다. 첫째, 신규장애자의 장애 발생은 경제적 영역에서 배제효과가 있는 것으로 나타났으며, 둘째, 사회문화적 영역에서도 배제효과가 큰 것으로 나타났다. 셋째, 장애 발생에 따른 경제·사회문화적 배제효과에 있어서 사회적 지지의 조절효과가 큰 것으로 나타나, 사회적 지지는 장애 발생이 장애인의 사회적 배제에 미치는 부정적인 영향을 줄이는데 중요한 역할을 하는 것으로 나타났다. 이 연구에서는 이러한 분석결과를 토대로 장애인에 대한 사회적 지지를 제고시켜주기 위한 정책적 시사점을 제시하였다. 첫째, 장애인에 대한 인식개선 프로그램을 개발하여 어린 시기부터 실천되어야 할 것이다. 둘째, 장애인에 대한 인식 개선을 위해 민간부문을 통한 사회적 캠페인이 적극적으로 추진되어야 할 것이다. 셋째, 장애인들을 위한 공공정책이 물질적 지원뿐만 아니라 정서적 지원으로까지 더욱 확대·강화되어야 할 것이다.

• 동의생리병리학회지
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• 제35권5호
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• pp.139-150
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• 2021

This paper examines whether the conceptual metaphor theory, which has been recently treated as important research topic in the field of cognitive linguistics, can be a new method that can promote the modernization of basic Korean medicine (KM) theory. In addition, the significance and potential of this study are reviewed by looking at Chinese research cases that applied this theory to Traditional Chinese Medicine theories and terminologies. The results are summarized as follows. From the viewpoint of metaphoric cognition, KM is a medicine that attempts to understand the human body (microcosm) through nature (great universe) by metaphorically projecting human experiences of nature on the human body based on the thought of correspondence between nature and human (天人相應). The language system of KM is based on a metaphor that extends our experience of nature to the human body, and an abundance of metaphors can be seen throughout the language of KM. Understanding and interpreting KM theories and terminologies from a metaphorical point of view allow us to understand the nature of KM theoretical key terms more deeply than now. And this understanding can help define and describe KM theoretical key terms and promote the modernization of KM theory research. In addition, various image schema that plays an important role in the metaphorical expansion of physical experience can be used for modeling KM theory. Research of KM theories and terminologies from a metaphorical point of view can serve as a bridge between traditional KM theory and modernization research, opening a new path to the modernization of basic KM theory in difficult situations.

• 미래기술융합논문지
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• 제1권2호
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• pp.37-48
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• 2022

본 연구는 광고 모델의 속성이 OTT 이용자의 광고 인지, 구매 의도, 몰입과 중독에 미치는 영향에 대한 중국 소비자 대상의 실증적 연구로 진행되었다. 최근 중국의 화장품 시장이 성장하면서 광고 모델의 역할이 부각되고 있으며 과몰입에 따른 쇼핑 중독 현상이 사회문제화 되고 있다. 연구자들은 광고 모델의 어떠한 특성이 소비자를 구매, 몰입에 이르게 하며, 궁극적으로 중독으로 연결되는지 연구모형을 설정하여 검정하고자 하였다. 연구결과는 다음과 같다. 유명도, 매력도 등의 광고 모델 속성은 시청자의 광고 인지와 태도에 긍정적인 영향을 주며, 시청자의 인지된 유용성은 구매 의도와 몰입에 긍정적인 영향을 주는 것을 확인하였다. 또한 시청자의 구매 의도는 화장품에 대한 중독에 정의 영향을 주었다.