• International Journal of Stem Cells
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• 제17권2호
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• pp.130-140
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• 2024

Cardiac organoids have emerged as invaluable tools for assessing the impact of diverse substances on heart function. This report introduces guidelines for general requirements for manufacturing cardiac organoids and conducting cardiac organoid-based assays, encompassing protocols, analytical methodologies, and ethical considerations. In the quest to employ recently developed three-dimensional cardiac organoid models as substitutes for animal testing, it becomes imperative to establish robust criteria for evaluating organoid quality and conducting toxicity assessments. This guideline addresses this need, catering to regulatory requirements, and describes common standards for organoid quality and toxicity assessment methodologies, commensurate with current technological capabilities. While acknowledging the dynamic nature of technological progress and the potential for future comparative studies, this guideline serves as a foundational framework. It offers a comprehensive approach to standardized cardiac organoid testing, ensuring scientific rigor, reproducibility, and ethical integrity in investigations of cardiotoxicity, particularly through the utilization of human pluripotent stem cell-derived cardiac organoids.

• 산업경영시스템학회지
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• 제39권1호
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• pp.116-122
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• 2016

Recently, the production cycle in manufacturing process has been getting shorter and different types of product have been produced in the same process line. In this case, the control chart using coefficient of variation would be applicable to the process. The theory that random variables are located in the three times distance of the deviation from mean value is applicable to the control chart that monitor the process in the manufacturing line, when the data of process are changed by the type of normal distribution. It is possible to apply to the control chart of coefficient of variation too. ${\bar{x}}$, s estimates that taken in the coefficient of variation have just used all of the data, but the upper control limit, center line and lower control limit have been settled by the effect of abnormal values, so this control chart could be in trouble of detection ability of the assignable value. The purpose of this study was to present the robust control chart than coefficient of variation control chart in the normal process. To perform this research, the location parameter, ${\bar{x_{\alpha}}}$, $s_{\alpha}$ were used. The robust control chart was named Tim-CV control chart. The result of simulation were summarized as follows; First, P values, the probability to get away from control limit, in Trim-CV control chart were larger than CV control chart in the normal process. Second, ARL values, average run length, in Trim-CV control chart were smaller than CV control chart in the normal process. Particularly, the difference of performance of two control charts was so sure when the change of the process was getting to bigger. Therefore, the Trim-CV control chart proposed in this paper would be more efficient tool than CV control chart in small quantity batch production.

• 산업공학
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• 제11권3호
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• pp.23-40
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• 1998

In this paper, a method to determine the optimal configuration of operating policies in an integrated-automated manufacturing system using the Taguchi method and computer simulation experiments is presented. An integrated-automated manufacturing system called direct-input-output manufacturing system(DIOMS) is described. We only consider the operational aspect of the DIOMS. Four operating policies including input sequencing control, dispatching rule for the storage/retrieval(S/R) machine, machine center-based part type selection rule, and storage assignment policy are treated as design factors. The number of machine centers, the number of part types, demand rate, processing time and the rate of each part type, vertical and horizontal speed of the S/R machine, and the size of a local buffer in the machine centers are considered as noise factors in generating various manufacturing system environment. For the performance characteristics, mean flow time and throughput are adopted. A robust design experiment with inner and outer orthogonal arrays are conducted by computer simulation, and an optimal configuration of operating policies is presented which consists of a combination of the level of each design factor. The validity of the optimal configurations is investigated by comparing their signal-to-noise ratios with those obtained with full factorial designs.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권1호
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• pp.25-30
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• 2001

Viral safety is a prerequisite for manufacturing clinical albumin and immunoglobulins from human plasma pools. This study was designed to evaluate the efficacy of cold ethanol fractionation and pasteurization (60$\^{C}$ heat treatment for 10h) for the removal/inactivation of human immunodeficiency virus type 1 (HIV-1) during the manufacturing of albumin and immunoglobulins. Samples from the relevant stages of the production process were spiked with HIV-1, and the amount of virus in each fraction was quantified by the 50% tissue culture infectious dose(TCID(sub)50). Both fraction IV fractionation and pasteurization steps during albumin processing were robust and effective in inactivating HIV-1, titers of which were reduced from an initial 8.5 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved were $\geq$ 4.5 and $\geq$ 6.5, respectively. In addition, fraction III fractionation and pasteurization during immunoglobulins processing were robust and effective in eliminating HIV-1. HIV-1 titers were reduced from an initial 7.3 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved in this case were $\geq$ 4.9 and $\geq$ 5.3, respectively. These results indicate that the process investigated for the production of albumin and immunoglobulins have sufficient HIV-1 reducing capacity to achieve a high margin of safety.

• 마이크로전자및패키징학회지
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• 제29권4호
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• pp.41-47
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• 2022

Ag sintering technologies have received great attention as it was applied to the inverter of Tesla's electric vehicle Model III. Ag sinter bonding technology has advantages in heat dissipation design as well as high-temperature stability due to the intrinsic properties of the material, so it is useful for practical use of SiC and GaN devices. This study was carried out to understand the sinter joining temperature effect on the robust Ag sintered joints in air without pressure within 10 min. Electroplated Ag finished Cu dies (3 mm × 3 mm × 2 mm) and substrates (10 mm × 10 mm × 2 mm) were introduced, respectively, and nano Ag paste was applied as a bonding material. The sinter joining process was performed without pressure in air with the bonding temperature as a variable of 175 ℃, 200 ℃, 225 ℃, and 250 ℃. As results, the bonding temperature of 175 ℃ caused 13.21 MPa of die shear strength, and when the bonding temperature was raised to 200 ℃, the bonding strength increased by 157% to 33.99 MPa. When the bonding temperature was increased to 225 ℃, the bonding strength of 46.54 MPa increased by about 37% compared to that of 200 ℃, and even at a bonding temperature of 250 ℃, the bonding strength exceeded 50 MPa. The bonding strength of Ag sinter joints was directly influenced by changes in the necking thickness and interfacial connection ratio. In addition, developments in the morphologies of the joint interface and porous structure have a significant effect on displacement. This study is systematically discussed on the relationship between processing temperatures and bonding strength of Ag sinter joints.

• 한국항행학회논문지
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• 제27권5호
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• pp.594-609
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• 2023

이 연구는 블록체인 기반 5G세라믹 안테나 제조(B-5GAM) 아키텍처를 활용하여 5G세라믹 안테나 제조 공정의 복잡성을 해결하기 위한 새로운 접근 방식을 소개한다. 이 아키텍처는 블록체인 기술과 스마트 컨트랙트를 원활하게 통합하여 5G세라믹 안테나 제조 영역에서 투명성, 보안성, 효율성을 향상시켰다. 블록체인을 적용하여 보안 조치, 프로세스 효율성 및 전반적인 신뢰성을 향상시킴으로써 생산 프로세스를 최적화할 뿐만 아니라 향후 통신 기술 발전을 위한 견고한 기반을 구축하는 효과는 분명하다. 5G 안테나를 제조하고 블록체인 및 스마트컨트랙트를 적용하기 위한 알고리즘 제시를 통해 B-5GAM 아키텍처를 검증하고 실제 제조 환경에서의 적용 가능성을 확인하였다. 이 연구 결과는 5G세라믹 안테나 제조 분야에서 블록체인과 스마트 컨트랙트의 활용 가능성을 입증하여 제조 효율성과 신뢰성을 향상시킬 수 있음을 확인하였다.

• 대한기계학회논문집A
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• 제36권10호
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• pp.1109-1114
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• 2012

제품 생산 시 발생하는 제작 공차, 항복강도와 탄성계수 등 재료 물성치의 불확실성, 온도와 습도 같이 시스템에 작용하는 환경인자 등은 시스템의 성능에 영향을 미친다. 강건 최적설계는 이러한 인자들이 시스템에 미치는 영향을 최소화하면서 성능을 개선하는 설계기법으로 최근 많은 연구가 이루어지고 있다. 하지만 기존의 강건 최적설계 기법은 여러 인자들의 분포를 고려해야 하기 때문에 막대한 계산비용이 드는 문제가 있다. 본 논문에서는 이러한 문제점을 개선하기 위하여 곱분해 기법을 이용한 강건 최적설계를 제안한다. 제안된 기법을 이용하여 설계영역을 크리깅 메타모델로 근사하고 곱분해 기법을 적용하여 평균과 분산을 효율적이고 정확하게 계산하여 강건 최적설계를 수행한다. 제안된 방법을 수학예제와 공학예제에 적용하여 유용성을 검증한다.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2006년도 춘계학술대회 논문집
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• pp.395-398
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• 2006

Forging is applied for many industrial fields. Also, it is applied to hose nipple. Stress and metal analysis is finding method of forging possibility and we predict this possibility by finite element forging analysis. But there are also many manufacturing procedure after forging, and metal texture is varied by additional heat treatment or coating. So this research is focused on the measuring and analysis of plastic residual stress distribution at overall manufacturing procedure. From raw material to final product we measured real residual stress at each manufacturing procedure by X ray diffract meter, and simulated another procedure except forging by nonlinear finite element analysis. Also we showed how Zn-Ni coating is more contributable to metal strength than Zn coating. By this research we make final conclusion that process analysis must be observed from raw material to final manufacturing state for robust design.

• The Journal of Asian Finance, Economics and Business
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• 제9권1호
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• pp.133-142
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• 2022

This study examines the relationship between debt maturity structure and bankruptcy risk. There are various studies of leverage's effect on bankruptcy risk. Debt maturity, however, has not received the attention it deserves, especially in emerging markets with a high degree of information asymmetry. Using Vietnamese listed company data and various estimations, we find that leverage is positively associated with the likelihood of default. Importantly, short-term leverage shows a significantly positive effect on bankruptcy risk, while long-term leverage does not show significant results. The findings highlight that rollover risk firms are exposed to when using short-term debt increases bankruptcy risk. Meanwhile, firms do not cope with this risk in case of long-term debt adoption. High information asymmetry in emerging markets may be the main reason for the difference. The result is robust for subsamples of firms in different financial conditions, in concentrated and competitive industries, as well as for manufacturing and non-manufacturing companies. We also find that firms in a better financial situation and concentrated industries experience a higher short-term leverage effect than their counterparts. We, however, do not find a significant difference in the impact between manufacturing and non-manufacturing companies. This paper is among the first to examine the relation between debt maturity and bankruptcy risk in Vietnam.

• 대한기계학회논문집A
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• 제21권1호
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• pp.112-123
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• 1997

The optimization techniques have been applied to versatile engineering problems for reducing manufacturing cost and for automatic design. The deterministic approaches or op5imization neglect the effects on uncertainties of design variables. The uncertainties include variation or perturbation such as tolerance band. The optimum may be useless when the constraints considering worst cases of design variables can not be satisfied, which results from constraint variation. The variation of design variables can also give rise to drastic change of performances. The two issues are related to constraint feasibility and insensitive performance. Robust design suggested in the present study is developed to gain an optimum insensitive to variation on design variables within feasible region. The multiobjective function is composed to the mean and the standard deviation of original objective function, while the constraints are supplemented by adding penalty term to original constraints. This method has a advantage that the second derivatives of the constraints are not required. A mathematical problem and several standard problems for structural optimization are solved to check out the usefulness of the suggested method.