• 대한의생명과학회지
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• 제15권4호
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• pp.327-333
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• 2009

Heterotrimeric GTP binding proteins, G-proteins, mediate signal transduction generated by neurotransmitters and hormones. Among G-proteins, Go proteins are the most abundant in brain and classified as a member of Gi family. Ras-like protein in all tissues (Rit), one of the small GTPases, is a member of a Ras superfamily and identified as an important regulator of neuronal differentiation and cell transformation. Recently, we have reported that Rit functioned as a candidate downstream effector for alpha subunit of Go proteins ($Go{\alpha}$) and regulated neurite outgrowth triggered by $Go{\alpha}$ activation. In this study, we showed that the GTPase domain of $Go{\alpha}$ contributed to the direct interaction with Rit. We also demonstrated that $Go{\alpha}$ could lead to an increase of Rit activity suggesting that Rit play a role as a downstream effector of $Go{\alpha}$.

• 한국인터넷방송통신학회논문지
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• 제24권2호
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• pp.65-70
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• 2024

근래에 와서 유틸리티들을 무선으로 원격제어 하는 스마트 팩토리 무선 이동 통신 기술에 대한 연구가 활발히 진행되고 있다. Wi-SUN(Wireless Smart Utility Network) 얼라이언스에서는 EEE802.15.4g/e에 기반한 새로운 무선통신 표준화 규격으로 스마트팩토리와 같은 플랫폼 구축에 적합한 Wi-SUN 프로토콜 구조를 제시하였다. IEEE802.15.4e의 RIT(Receiver Initiated Transmission) 모드 MAC(Media Access Control)의 throughput 및 지연시간 측면의 성능을 분석하고 효율적 운용을 위한 고려 사항을 살펴본다. RIT 모드는 체크 인터벌이 길어질수록 지연시간과 throughput이 떨어짐을 볼 수 있다. 트래픽 부하가 커질수록 RIT 체크 인터벌을 짧게 운용하면 지연시간도 짧아지면서 throughput을 높일수 있음을 보였다. RIT 모드는 전력소모가 작은 장점을 가지고 있으면서 지연시간이나 throughput 측면에서 IEEE802.15.4와 CSL 모드 사이의 중립적 특징을 가지는 것을 볼 수 있었다.

• Nuclear Medicine and Molecular Imaging
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• 제43권6호
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• pp.572-576
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• 2009

목적: 분화 갑상선암으로 갑상선전절제술 이후 고용량 방사성요오드치료(HD-RIT)를 시행하는 환자에서 Helicobacter (H) pylori 감염에 대한 유병률을 알아보고 HDRIT가 H. pylori 제균에 영향을 미치는 지를 알아보고자 하였다. 대상 및 방법: 2008년 6월부터 2009년 2월까지 분화 갑상선암으로 갑상선전절제술과 중앙과 주변 림프절제 거술 후 최초 HD-RIT를 시행한 환자 199명(남:녀=33:166, 나이 $46.7{\pm}12.3$세)과 건강검진을 목적으로 요소호기검사(UBT)를 시행한 건강한 156명(남:녀=57:99, 나이 $48.7{\pm}14.3$세)을 대상으로 하였다. HD-RIT를 받기 위하여 입원한 환자에서 H. pylori 감염 유무를 확인하기 위하여 방사성요오드 투여 1시간 전에 UBT를 시행하였다. HDRIT 시행전 UBT에서 양성을 보인 환자에서는 HD-RIT 시행 후 4주 경과시에 추적 UBT를 시행하였다. HD-RIT 시행전과 추적 UBT 측정치의 변화는 paired Student's t test를 이용하여 p값이 0.05 미만인 경우를 통계적으로 유의 하다고 판정하였다. 결과: 건강한 대조군 156명에서 시행된 UBT에서 115명(73.7%)에서는 양성이었고, 41명(26.8%)은 음성이었다. 분화 갑상선암으로 갑상선절제술을 시행받은 대상환자 199명 중에서 103명(51.8%)이 치료전 UBT에서 양성이었고, 96명 (48.2%)이 음성으로 대조군에 비하여 H. pylori 유병율이 낮았다. 양성을 보인 103명 중 80명에 대해서 HD-RIT 후 추적 UBT를 시행하였고 76명(95.0%)에서는 여전히 양성을 보였고, 4명(5.0%)만이 음성으로 변하였다. 지속적으로 추적 UBT에서 양성을 보인 76명 중 26명 (34.2%)에서는 HD-RIT 후에 측정값이 증가하였으며 증가정도는 $66{\pm}66.1\;dpm$ 이었다. 반면에 49명(64.5%)에서는 HD-RIT 후에 측정값이 감소하였으며 감소정도는 $153.3{\pm}157.1\;dpm$ 이었고, 1명(1.3%)은 방사성 요오드 치료전후 같은 값을 보였다. 결론: 갑상선암 환자에서 H. pylori 유병률은 건강한 성인에 비하여 높지 않으며, HD-RIT가 H. pylori의 제균에 의미있는 효과는 없으나 H. pylori 감염의 정도나 분포에 영향을 줄 수 있을 것으로 생각된다.

• 한국인터넷방송통신학회논문지
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• 제23권4호
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• pp.23-28
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• 2023

무선 스마트 유틸리티 네트워크 통신시스템에서는 비동기 저전력 MAC이 IEEE 802.15.4e에 의해 표준화되어 사용되고 있다. RIT(Receiver Initiated Transmission)라고 불리는 비동기 방식 MAC은 체크인터벌(RIT period)에 따라 지연시간과 전력소모가 크게 영향을 받는 특성이 있다. 체크인터벌 마다 수면에서 깨어나 자신이 수신할 데이터가 있는지 확인함으로써, 수신단 전력 소모는 획기적으로 줄일 수 있지만 송신단에서는 과도한 웨이크업 시퀀스(wakeup sequence)로 전력소모가 발생하는 단점을 가진다. 체크 인터벌을 짧게하여 과도한 웨이크업 시퀀스를 줄이면 너무 빈번한 웨이크업으로 수신단 전력 소모가 많아지게 된다. RIT 비동기식 MAC 기법에서 트래픽 부하와 체크인터벌의 운용에 따른 전력소모 성능을 분석하여 Wi-SUN 구축시 적용코자 한다.

• 생약학회지
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• 제40권4호
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• pp.280-285
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• 2009

Korean folk medicine 'JoRitDae' has been used mainly to cure vomiting and cancer. With regard to the botanical origin of 'JoRitDae', it has been considered to designate the rhizome of Sasa species (Gramineae), but there was no pharmacognostical confirmation on it. To clarify the botanical origin of 'JoRitDae', the anatomical characteristics of the rhizome of Sasa species growing wild in Korea and Japan, Sasa borealis, S, kurilensis, S. quelpaertensis, S. charatacea and S. senanensis were studied. As a result, it was found the morphological criteria for the five Sasa species that could discriminate them by the number of cell layers in cortex, the ratio of thickness of cortex to rhizome radius, the number of cell layers in the vascular bundle sheath, the total number of vascular bundle and thickness of vascular bundle sheath. According to these criteria, it was clarified that the commercial folk medicine 'JoRitDae' was the rhizome of Sasa borealis.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.637-643
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• 2018

Radioimmunotherapy (RIT) is a therapy that takes advantage of the "cross-fire" effect of emitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb) (including those fragments) or peptides. While RIT has been successfully employed for the treatment of lymphoma, mostly with radiolabeled antibodies against CD20 [$^{90}yttrium$ ($^{90}Y$)-ibritumomab tiuxetan; $Zevalin^{(R)}$ and $^{131}iodine$ ($^{131}I)-tositumomab$; $Bexxar^{(R)}$], its use in solid tumors is more challenging, so far. Immuno-PET, a tool for tracking and quantification of mAbs with PET in vivo, is an exciting novel option to improve diagnostic imaging and guide mAb-based therapy. RIT in solid tumors including head and neck cancer may be an alternative treatment with advances in various biological, chemical, and treatment procedures, and it may help to reduce unnecessary exposure and enhance the therapeutic efficacy. Also, immuno-PET based on RIT might play an important role in cancer staging, in patients or targets selection of targeted therapeutics and in monitoring the response of targeted therapeutics as precision medicine. In this review, fundamentals of RIT/immune-PET and current knowledge of the preclinical/clinical trials in RIT for solid tumor including head and neck cancer are reviewed.

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.95-101
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• 2016

Background and Objectives : The main purpose of this study is to clarify perceptual and acoustic analysis for the patients with hypothyroidism after thyroidectomy especially focused on the characteristics of speech articulation with special reference to the consonant production. Materials and Methods : The subjects of the research were 40 male and female adults (males : 5, females : 35). They were all received radioactive iodine treatment which after total thyroidectomy. Voice samples were collected during the three stages of after surgery, pre-radioisotope treatment (RIT), and post-RIT. The acoustic analysis was conducted by using Pratt (ver.5.2.21) after measuring voice onset time (VOT). The subjective evaluation of the voices used CAPE-V. Results : A significant decrease in overall severity was displayed in the CAPE-V following RIT. It may be conjectured that this is connected to the change in voice following RIT. The loudness of the sound displayed a significant decrease in the CAPE-V following RIT. It is conjectured that this is connected to the decrease in vocal intensity following RIT. No statistically significant results were revealed for the comparative analysis on the voice onset time (VOT) in all plosives during the three periods. Conclusion : Perceptually, the overall severity of the voice with hypothyroidism was changed significantly before and after RIT. Eventhough VOT were not significantly changed, it tended to decrease VOT in patients with hypothyroidism.

• 대기
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• 제33권4호
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• pp.343-354
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• 2023

Turbulence produced on roadways is one of the major factors determining the dilution rates at the initial stage of traffic emissions of air pollutants and, thus, the distribution of air pollutants near the roadways. Field experiments were conducted on Gyeongbu Highway, one of the busiest highways in Korea, for 4~7 days in winter, spring, and summer. Two three-dimensional ultrasonic anemometers were installed on both sides of the highway to estimate turbulence intensities (vertical wind fluctuation and kinetic turbulence energy) induced by the roadway. Roadway-induced turbulence consists of three components: structural road-induced turbulence (S-RIT), thermal road-induced turbulence (T-RIT), and vehicle-induced turbulence (VIT). The contribution of T-RIT to the total RIT was insignificant (less than 10%), and the majority of RIT was S-RIT (by the highway embankment) and VIT. In this study, we propose the empirical relationships of VIT as a function of traffic density and wind speed under free-flow traffic conditions. Although this empirical relationship appears to underestimate the VIT, it can be applied to the air quality models easily because the relationship is simple and only needs readily obtainable input variables (wind speed and traffic information).

• 대한조선학회지
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• 제22권2호
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• pp.49-65
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• 1985

The RIT(Research Institude of Technology) in KTMI(Korea Tacoma Marine Industries, Ltd) has played a vital role in maintaining the comapany's leader ship as a pioneer in the technical development of shipbuilding and new type of special vessel design. As a results, in February of 1981, the RIT could succeed in designing and constructing a small manned test hovercraft. In Arpril of 1983, the RIT started to design a 12M class, 55knots hovercraft with the highly skilled and experienced technology through the development of 4 kinds of SES(Surface Effect Ship), totally 10 vessels. In December of 1984, the diesel-powered 12M class hovercraft of proto type was developed with RIT'S own technical ability. The craft is the first hovercraft in domestic and the first diesel-powered hovercraft in Asia area. The paper describe the progress of development and general review of technology and concept of design about the hovercraft developed.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.28-31
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• 2004

This paper describe analysis active microstrip antenna with low noise amplifier at 900 MHz for mobile communication. The microstrip patch antenna is integrated with low noise amplifier on a permittivity 4.5 (Epoxy-FR4) and thickness of substrate 1.6 mm. Low noise amplifier is designed by using GaAs FETs. The analysis characteristics of antenna include return loss, input impedance, vswr, radiation pattarn, bandwidth and gain of antenna. Mesurement gain of antenna is shown 19.2435 dBi.