• 비파괴검사학회지
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• 제18권5호
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• pp.389-397
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• 1998

Windows 95 환경하에서 PSI/ISI 데이터의 효율적 관리를 위한 종합지원시스템의 구축과 다원적평가와 분석이 가능하고, 비파괴검사에 의한 원전기기의 건전성 평가시 규제측면에서 기술적인 지원을 할 수 있는 고리 원전 PSI/ISI 데이터 베이스 구축과 프로그램을 개발하였다. 이 프로그램을 활용하면 현재까지 수행된 고리 원전 PSI/ISI의 수행현황과 지금까지 발견된 결함에 대한 조사분석이 가능하며, 향후 국내 PSI/ISI 결과의 자료분석이 가능한 전문가 시스템(expert system) 개발에 한단계 접근하게 되었다. 그리고, PSI/ISI에서 발견된 결함에 대한 조사분석 결과를 근거로 결함의 종류, 형태, 처리방법 등에 대한 자세한 분석을 통하여 국내 원전 PSI/ISI 결과의 확률론적 신뢰도 평가 또는 확률론적 안전성평가를 위한 결함검출확률곡선의 작성과 위험도에 근거한 가동중검사제도의 도입에 필요한 기초 자료를 제공하였다. 더 나아가 지금까지의 자료분석을 바탕으로 보다 경제적이며 신뢰성이 높은 PSI/ISI의 수행으로 원전 압력경계기기의 건전성과 신뢰성 확보 및 수명예측을 위한 기초자료를 제공하였다.

• Journal of Genetic Medicine
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• 제16권2호
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• pp.85-89
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• 2019

Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive urea cycle disorder. HHH is caused by a deficiency of the mitochondrial ornithine transporter protein, which is encoded by the solute carrier family 25, member 15 (SLC25A15) gene. Recently, government supported Korean newborn screening has been expanded to include a tandem mass spectrometry (MS/MS) measurement of ornithine level. We report a case of a neonate with HHH syndrome showing a normal MS/MS measurement of ornithine level. A female newborn was admitted to neonatal intensive unit due to familial history of HHH syndrome. Her parents were consanguineous Parkistani couple. The subject's older sister was diagnosed with HHH syndrome at age of 30 months based on altered mental status and liver dysfunction. Even though the subject displayed normal ammonia and ornithine levels based on MS/MS analysis, a molecular test confirmed the diagnosis of HHH syndrome. At 1 month of age, amino acid analysis of blood and urine showed high levels of ornithine and homocitrulline. After 11 months of follow up, she showed normal growth and development, whereas affected sister showed progressive cognitive impairment despite no further hyperammonemia after protein restriction and standard therapy. Our report is in agreement with a previous Canadian study, which showed that neonatal samples from HHH syndrome patients demonstrate normal ornithine levels despite having known mutations. Considering the delayed rise of ornithine in affected patients, genetic testing, and repetitive metabolic testing is needed to prevent patient loss in high risk patients.

• 한국정보통신학회논문지
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• 제21권6호
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• pp.1218-1224
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• 2017

액화천연가스운반선(LNGC) 건조 시 증가하는 리스크로 인해 시스템 통합 및 안전 운용에 다양한 시나리오의 사전 시뮬레이션이 필요하다. 특히, LNGC에서 전력관리시스템은 중요한 장비이고, 전력 제어 시스템과의 오류없는 통합이 이루어져야 기대하는 성능 및 안전성이 보장된다. 본 논문에서는 LNGC에서 발생하는 오류를 개선하기 위해 Software-In-the-Loop(SIL) 기반의 PMS 테스트용 전력 발생원과 소모원에 대한 시뮬레이션 모델을 구현하였다. PMS 제어 및 검증을 위해 MATLAB/Simulink를 활용하여 수치적 물리 시뮬레이션 모델링을 수행하였고, 시뮬레이션 모델을 검증하기 위하여 시운전 시나리오를 대상으로 부하 분배 테스트를 하였다. PMS SIL 시뮬레이션은 고부가가치 선박 및 해양플랜트의 시운전, 설치, 유지보수 시장 진출에 크게 기여할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2063-2068
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• 2012

Aim: Liquid-based cytology is the most often used method for cervical cancer screening, but it is relatively insensitive and frequently gives equivocal results. Used as a complementary procedure, the high-risk human papillomavirus (HPV) DNA test is highly sensitive but not very specific. The human telomerase RNA gene (TERC) is the most often amplified oncogene that is observed in cervical precancerous lesions. We assessed genomic amplification of TERC in liquid-based cytological specimens to explore the optimal strategy of using this for cervical cancer screening. Methods: Six hundred and seventy-one residual cytological specimens were obtained from outpatients aged 25 to 64 years. The specimens were evaluated by the Digene Hybrid Capture 2 (HC2) HPV DNA test and fluorescence in situ hybridization (FISH) with a chromosome probe to TERC (3q26). Colposcopic examination and histological evaluation were performed where indicated. Results: The TERC positive rate was higher in the CIN2+ (CIN2, CIN3 and SCC) group than in the normal and CIN 1 groups (90.0% vs. 10.4%, p < 0.01). In comparison with the HC2 HPV DNA test, the TERC amplification test had lower sensitivity but higher specificity (90.0% vs. 100.0%, 89.6% vs. 44.0%, respectively). TERC amplification test used in conjunction with the HC2 HPV DNA test showed a combination of 90.0% sensitivity and 92.2% specificity. Conclusion: The TERC amplification test can be used to diagnose cervical precancerous lesions. TERC and HPV DNA co-testing shows an optimal combination of sensitivity and specificity for cervical cancer screening.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.679-683
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• 2013

Background: Dysplasia and adenocarcinoma developing in Barrett's esophagus (BE) are not always endoscopically identifiable. Molecular markers are needed for early recognition of these focal lesions and to identify patients at increased risk of developing adenocarcinoma. The aim of the current study was to correlate increased telomerase activity (TA) with dysplasia and adenocarcinoma occurring in the setting of BE. Materials and Methods: Esophageal mucosal biopsies were obtained from patients (N=62) who had pathologically verified BE at esophagogastroduodenoscopy (EGD). Mucosal biopsies were also obtained from the gastric fundus as controls. Based on histopathology, patients were divided into three groups: 1) BE without dysplasia (n=24); 2) BE with dysplasia (both high grade and low grade, n=13); and 3) BE with adenocarcinoma (n=25). TA was measured by a PCR-based assay (TRAPeze$^{(R)}$ ELISA Telomerase Detection Kit). Statistical analyses were performed using one-way ANOVA and post-hoc Bonferroni testing. Results: TA was significantly higher in biopsies of BE with dyplasia and BE with adenocarcinoma than in BE without dysplasia. Subgroup analyses did not reveal any significant correlations between TA and patient age, length of BE, or presence of gastritis. Conclusions: Telomerase activity in esophageal mucosal biopsies of BE may constitute a useful biomarker for the early detection of esophageal dysplasia and adenocarcinoma.

• Journal of Community Nutrition
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• 제6권1호
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• pp.26-34
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• 2004

Hypertension is prevalent among older adults, and nutrition is important for hypertension management. However, there are few nutrition education materials developed for older adults. The purpose of this study was to develop a booklet for prevention and management of hypertension for older adults. Based on lesson plans, topics for the booklet included introduction to hypertension, hypertension prevention through weight management, nutritional management of hypertension, and lifestyle modifications. After several revisions of the draft were made, illustrations and icons appropriate to the text were designed by a graphic designer using Illustrator 9.0 and Photoshop 6.0. The booklet consisted of four chapters and 40 pages. The first chapter dealt with information on hypertension, risk factors, complications and dietary guidelines. These were mainly explained by illustrations and characters of older adults. The second chapter included assessment of obesity, reducing fat intake and behavioral change strategies. The third chapter focused on practical tips for reducing salt, eating more fiber and calcium, and sample menus. The fourth chapter presented information for quitting smoking and drinking, and stress management. Finally, games, meal planning and quizes, were presented as reinforcement. Based on pilot testing with 10 adults aged 50 and older, minor changes were made in wording, expressions and information. This booklet is characterized by using simple and specific messages, providing tips for dietary and lifestyle changes, and using illustrations and characters of older adults to increase understanding. The revised booklet is self-explanatory and can be used by older adults or in nutrition education for older adults.

• 제어로봇시스템학회논문지
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• 제14권3호
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• pp.301-306
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• 2008

Drivers are becoming more fatigued and uncomfortable with increase in traffic density, and this condition can lead to slower reaction time. Consequently, they may face the danger of traffic accidents due to their inability to cope with frequent gear shifting. To reduce this risk, some drivers prefer automatic transmission (AT) over manual transmission (MT). The AT offers more superior drivability and less shifting shock than the MT; therefore, the AT market share has been increasing. The AT is controlled by an electronic control unit (ECU), which provides better shifting performance. The transmission control unit (TCU) is a higher-value-added product, so the companies that have advanced technologies end to evade technology transfer. With more cars gradually using the ECU, the TCU is expected to be faster and more efficient for organic communication and arithmetic processing between the control systems than the l6-bit controller. In this paper, the model of an automatic transmission vehicle using MATLAB/Simulink is developed for the Hardware in-the-Loop (HIL) simulation with a 32-bit embedded system, and also the AT control logic for shifting is developed by using MATLAB/Simulink. The developed AT control logic, transformed automatically by real time workshop toolbox, is loaded to a 32-bit embedded system platform based on Freescale's MPC565. With both vehicle model and 32-bit embedded system platform, we make the HIL simulation system and HIL simulation of AT based on real time operating system (RTOS) is performed. According to the simulation results, the developed HIL simulator will be used for the performance test of embedded system for AT with low cost and effort.

• Journal of Preventive Medicine and Public Health
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• 제55권4호
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• pp.360-370
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• 2022

Objectives: This study evaluated the response in Daegu, Korea to the first wave of the coronavirus disease 2019 (COVID-19) pandemic according to a public health emergency response model. Methods: After an examination of the official data reported by the city of Daegu and the Korea Centers for Disease Control and Prevention, as well as a literature review and advisory meetings, we chose a response model. Daegu's responses were organized into 4 phases and evaluated by applying the response model. Results: In phase 1, efforts were made to block further transmission of the virus through preemptive testing of a religious group. In phase 2, efforts were concentrated on responding to mass infections in high-risk facilities. Phase 3 involved a transition from a high-intensity social distancing campaign to a citizen participation-based quarantine system. The evaluation using the response model revealed insufficient systematic preparation for a medical surge. In addition, an incorporated health-related management system and protection measures for responders were absent. Nevertheless, the city encouraged the participation of private hospitals and developed a severity classification system. Citizens also played active roles in the pandemic response by practicing social distancing. Conclusions: This study employed the response model to evaluate the early response in Daegu to the COVID-19 pandemic and revealed areas in need of improvement or maintenance. Based on the study results, creation of a systematic model is necessary to prepare for and respond to future public health emergencies like the COVID-19 pandemic.

• Journal of Radiation Protection and Research
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• 제47권2호
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• pp.93-98
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• 2022

Background: This study aims to derive the characteristics of each work type for industrial radiography based on empirical evidence through expert advice and a survey of radiation workers of various types of industrial radiography. Materials and Methods: According to a Korean report, work types of industrial radiography are classified into indoor tests, underground pipe tests, tests in a shielded room (radiographic testing [RT] room test), outdoor field tests, and outdoor large structure tests. For each work type, exposure geometry and radiation sources were mainly identified through the expert advice and workers' survey as reliable empirical evidence. Results and Discussion: The expert advice and survey results were consistent as the proportion of the work types were high in the order of RT room test, outdoor large structure test, underground pipe test, outdoor field test, and indoor test. The outdoor large structure test is the highest exposure risk work type in the industrial radiography. In most types of industrial radiography, radiation workers generally used ¹⁹²Ir as the main source. In the results of the survey, the portion of sources was high in the order of ¹⁹²Ir, X-ray generator, ⁶⁰Co, and ⁷⁵Se. As the exposure geometry, the antero-posterior geometry is dominant, and the rotational and isotropic geometry should be also considered with the work type. Conclusion: In this study, through expert advice and a survey, the external exposure characteristics for each work type of industrial radiography workers were derived. This information will be used in the reconstruction of organ dose for health effects assessment of Korean radiation workers.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.270-272
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• 2022

임상을 거친 약물이 시중에 유통되지 못하는 요인 중 하나는 안전성이다. 약물 부작용으로 인해 발생하는 안전성 문제의 주된 원인인 신경독성의 경우, 사전에 약물이나 화합물에 대한 위험 평가가 필요하다. 현재 약물의 안전성 검사를 위한 실험들은 동물 실험을 기반으로 하고 있으며, 이는 시간과 비용이 많이 든다는 단점을 갖는다. 따라서 위 문제를 해결하기 위해 in silico 실험을 통한 신경독성 예측모델을 제안하고자 한다. 본 연구에서는 의학 언어 시스템 (Unified Medical Language System)을 이용해 신경독성의 범주를 확대하고, 통합 데이터베이스를 기반으로 다양한 관련 화합물 데이터를 얻었다. 얻은 화합물들의 SMILES (Simplified Molecular Input Line Entry System)를 fingerprint로 변환시키고 이를 사용한 기계학습 기반의 모델을 만들었다. 모델은 최종적으로 신경독성의 유무를 예측한다. 해당 연구에서 제안된 실험은 in vivo 실험에 소요되는 시간 및 비용을 줄일 수 있다. 더 나아가 신약 개발 연구 기간을 단축하고 개발 중지 등의 부담을 줄일 수 있을 것으로 기대된다.