• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5993-5999
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• 2015

Background: Molecular testing for human papillomavirus (HPV) is the most objective and reproducible of all cervical cancer screening tests and also less demanding in terms of training and quality assurance. However, there is an impending need for cost effective molecular HPV testing methods with sampling ease, easy storage measures and minimum turn around times suitable for a low resource setting. Objective : Our aim was to evaluate the feasibility of using a fast transfer analysis (FTA) mini elute cartridge for cervical sampling to identify high risk HPV by real time PCR and to compare molecular HPV testing and Pap cytology testing to predict histologically confirmed cervical precancer (CIN 2+ lesions) in a cervical cancer prevention program. Materials and Methods: This was conducted as a pilot study (n=200) on women sampled using FTA mini elute cartridges, genotyped by two different real time PCR assays, detecting 13 high risk HPV (HR HPV) species, including HPV16 along with its physical DNA status. Results obtained from each of the tests were compared and analysed using suitable statistical tests. Results: With FTA mini elute cartridge samples HR HPV positivity was seen in 48/200 (24%). Of these, presence of HPV 16 DNA was observed in 28/48 (58.3%) women. High risk HPV was positive in 20% (37/185) of women with benign cytology and 73.3% (11/15) of women with abnormal cytology findings. A very significant correlation (${\chi}^2=22.090$ ; p=0.000) was observed between cytology and HR HPV findings showing an increasing trend of HR HPV prevalence in 50% (1/2) of LSIL, 75% (3/4) of HSIL and 100% (3/3) of SCC. Of the CIN 2+ lesions identified by histopathology, 88.9% (8/9) had HR HPV. A significant association (${\chi}^2=11.223$ ; p=0.001) of HR HPV and histopathologically confirmed CIN 2+ lesions was found. Sensitivity of the two tests were comparable but specificity of Pap testing was better (90.7% vs 70.4%) to predict histopathologically diagnosed cervical precancers. Conclusions: The current study explored the feasibility of using a FTA mini elute cartridge for cervical sampling for the first time in India as a part of a community based cervical cancer prevention program. We suggest that FTA based sampling is suitable and feasible for real time based HPV testing. Molecular HR HPV testing can be more sensitive and useful to identify high risk women requiring Pap testing which is more specific to detect histologically confirmed cervical precancer.

• 한국신뢰성학회지:신뢰성응용연구
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• 제15권3호
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• pp.207-215
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• 2015

Safety' can be used in a variety of ways and may also have different meanings when used in theoretical field and routinely used. In this paper, the 'safety' means that human injury, fire or physical accident condition does not occur while used by the end-user. The meaning of safety may be different by era and culture. Even in contemporary era, the meaning can be used differently by country, region and culture. As the rights of consumers are increasingly reinforced, we can expect the acceptable risk or safety level can rise higher. In this paper, the R-map of Japan and the European risk assessment guidelines (RAPEX) were reviewed considering domestic incidents database status and its applicability. Because it is difficult to make a model based on a R-map, a revised model was developed mainly based on European Assessment Model with a combination of the important characteristics of Japan model R-map. Also utilizing this revised model, the availability as a new risk assessment model was confirmed by comparing the test results for the same scenarios to the other risk assessment model (RAPEX/RAG).

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3879-3887
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• 2012

Background: Development of effective educational strategies should accompany increases in public awareness and the availability of genetic testing for breast cancer (BC). These educational strategies should be designed to fulfill the knowledge gap while considering factors that influence women's interest in order to facilitate decision making. Objective: To determine the possible correlates of Saudi women's interest in BC genes testing including socio-demographics, the level of awareness towards BC genes, the family history of BC and the perceived personal risk among adult Saudi women in Al Hassa, Saudi Arabia. Subjects and methods: This cross-sectional study was carried out during the second BC community-based campaign in Al Hassa, Saudi Arabia. All Saudi women aged ${\geq}18$ years (n=781) attending the educational components of the campaign were invited to a personal interview. Data collection included gathering information about sociodemographics, family history of BC, the perceived personal risk for BC, awareness and attitude towards BC genes and the women's interest in BC genes testing. Results: Of the included women (n=599), 19.5% perceived higher risk for BC development, significantly more among < 40 years of age, and with positive family history of BC before 50 years of age. The participants demonstrated a poor level of awareness regarding the inheritance, risk, and availability of BC genetic testing. The median summated knowledge score was 1.0 (out of 7 points) with a knowledge deficit of 87.8%. The level of knowledge showed significant decline with age (> 40 years). Of the included women 54.7% expressed an interest in BC genetic testing for assessing their BC risk. Multivariate regression model showed that being middle aged (Odds Ratio 'OR'=1.88, confidence intervals 'C.I'=1.14-3.11), with higher knowledge level (OR=1.67, C.I=1.08-2.57) and perceiving higher risk for BC (OR=2.11, C.I=1.61-2.76) were the significant positive correlates for Saudi women interest in BC genetic testing. Conclusion: Saudi women express high interest in genetic testing for BC risk despite their poor awareness. This great interest may reflect the presence of inappropriate information regarding BC genetic testing and its role in risk analysis.

• 한국환경보건학회지
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• 제50권2호
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• pp.138-145
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• 2024

Background: Appropriateness issues have emerged regarding the non-application of hazardous substance safety standards for items classified as 'other textile products'. Objectives: Testing for formaldehyde (HCHO) and risk assessment were conducted on 'other textiles products' to provide reference data for promoting product safety policies. Methods: Testing was conducted on five items (102 products) classified as 'other textile products' according to relevant standards (textile products safety standards), and the risk of each product was assessed using the evaluation methodologies of the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) and European Chemical Agency (ECHA). Results: Out of the 102 products tested, HCHO was detected above the quantification limit in five. Based on these results, the screening risk assessment indicated that three products exceeded the criteria. Upon reassessing the emission and transfer rates of products exceeding the criteria, it was confirmed that there were no instances of exceeding the criteria. Conclusions: Risk assessment results can be used as supporting data for non-application of hazardous substance standards. However, it is deemed necessary to transition towards a management approach based on risks in order to addressing emerging trends such as convergence/new products.

• 산업경영시스템학회지
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• 제4권5호
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• pp.11-14
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• 1981

This study intends to decide the economic sample size based on the cost of sampling Inspection for destructive testing. The marginal percent defective is used as the lot tolerance percent defective (LTPD), and the Newton's iterative method is adopted to calculate the optimum sample size(n), given by the consumer's risk($\beta$ - risk) and the acceptance number(c).

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2020년도 제62차 하계학술대회논문집 28권2호
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• pp.489-492
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• 2020

현재 청강 게임 졸업작품 프로젝트에서 QA팀의 테스트 활동은 명세를 기반으로 진행된다. 하지만 대학의 게임 개발 프로젝트 특성상 체계적인 문서와 같은 테스트 베이시스를 확보하기 어렵다. 이렇게 부족한 명세를 기반으로한 테스트는 테스트할 게임의 전체를 커버하기 어렵다. 따라서 이를 보완하기 위해 리스크 기반의 탐색적 테스팅 접근법을 활용하여 조금 더 효율적인 테스트 전략 및 프로세스를 제시하고자 한다.

• 응용통계연구
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• 제23권2호
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• pp.219-234
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• 2010

시가총액에 따른 인덱스(INDEX) 투자를 했을 경우에, VaR(Value at Risk)을 종합주가지수(KOSPI)로부터 얻은 수익율의 극단 손실값들로부터 추정한다. 이를 위해, 극단값 이론 중 BM(Block Maxima) 모형을 적용하며, 극단 손실값들의 비독립적 발생을 고려하기 위하여, extremal index 역시 추정한다. 모형의 타당성을 알아보기 위해, 실패율방법을 이용한 사후검정 (back-testing) 을 실시한다. 사후검정을 통해, BM 모형을 적용한 VaR의 추정이 적절함을 알 수 있었다. 또한, 일반적으로 많이 사용되는 GARCH 모형을 이용한 VaR의 추정과 비교한다. 이를 통해, 오차가 t-분포를 따른다고 가정하는 경우, GARCH 모형을 이용한 VaR의 추정이 BM 모형을 이용한 경우와 사후 검정결과에 차이가 없음을 확인하였다. 그러나, GARCH 모형을 통한 VaR 추정은 추정시점근방의 극단 손실값들에 민감하게 반응하지만, BM 모형은 그렇지 않았다. 따라서, 현 시점으로부터 단기간동안의 손실위험은 GARCH 모형을 이용한 VaR의 추정값을 사용하는 것이 적절하며, 장기간동안의 손실위험은 BM 모형으로부터 얻은 VaR의 추정값을 사용하는 것이 적절하다.

• 정보관리연구
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• 제37권1호
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• pp.131-148
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• 2006

디지털 아카이빙 실행을 위한 위험관리의 필요성을 인식하고, 위험을 줄이기 위한 방안을 강구하고자 해외의 위험관리 사례를 조사한다. 사례로 선정된 기관은 OCLC와 코넬대학 도서관이다. 양 기관은 실질적인 실험을 바탕으로 위험관리를 수행해 타 기관에 좋은 모범이 되고 있다. 사례를 바탕으로 국내에서 위험관리의 실행을 위한 방안으로 위험관리 요소 규명, 파일 포맷과 마이그레이션 프로그램 등의 실험 테스트, 위험관리 수행 전담기구 설립을 제안한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10539-10542
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• 2015

A method to predict the risk of lung cancer is proposed, based on two feature selection algorithms: Fisher and ReliefF, and BP Neural Networks. An appropriate quantity of risk factors was chosen for lung cancer risk prediction. The process featured two steps, firstly choosing the risk factors by combining two feature selection algorithms, then providing the predictive value by neural network. Based on the method framework, an algorithm LCRP (lung cancer risk prediction) is presented, to reduce the amount of risk factors collected in practical applications. The proposed method is suitable for health monitoring and self-testing. Experiments showed it can actually provide satisfactory accuracy under low dimensions of risk factors.

• Nuclear Engineering and Technology
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• 제34권4호
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• pp.331-343
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• 2002

We performed an importance analysis of In-Service Testing (157) components for Ulchin Unit 3 using the integrated evaluation method for categorizing component safety significance developed in this study. The developed method is basically aimed at having a PSA expert perform an importance analysis using PSA and its related information. The importance analysis using the developed method is initiated by ranking the component importance using quantitative PSA information. The importance analysis of the IST components not modeled in the PSA is performed through the engineering judgment, based on the expertise of PSA, and the quantitative and qualitative information for the 157 components. The PSA scope for importance analysis includes not only Level 1 and 2 internal PSA but also Level 1 external and shutdown/low power operation PSA. The importance analysis results of valves show that 167 (26.55%) of the 629 IST valves are HSSCs and 462 (73.45%) are LSSCs. Those of pumps also show that 28 (70%)of the 40157 pumps are HSSCs and 12 (30%) are LSSCs.