• 한국화재소방학회논문지
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• 제32권2호
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• pp.118-129
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• 2018

본 연구는 산업재해예방기관인 안전보건공단(KOSHA)에서 실시한 소화약제 중독 질식 재해사례분석을 통해 소화 약제를 포함한 화학물질의 안전한 취급방안을 제안하기 위함이다. 산업재해통계에 따르면 2011~2016년 산업현장에서 발생한 화학물질 중독 질식재해는 해마다 증가 및 다 변화 양상을 보여주고 있다. 일반 사고성재해와 달리 화학물질 재해는 재해강도가 크고 화학물질 위험성 정보 확인이 어려운 특징이 있다. 화학물질 재해의 예방을 위해서는 화학물질 취급 전 위험성을 평가하는 것이 무엇보다 중요하다. 본 논문은 유해위험성인지와 위험성평가가 어려운 화학물질의 안전한 사용을 위해 안전보건공단에서 개발한 화학물질 필수정보 확인 프로세스(CHEM-i)와 화학물질위험성평가기법(CHARM)의 활용방안을 제시하고자 한다.

• 품질경영학회지
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• 제46권2호
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• pp.327-338
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• 2018

Purpose: A risk evaluation procedure is proposed for common failure causes in FMEA(Failure Mode and Effects Analysis). The conventional FMEA does not provide a proper means to compare common failure causes with other failure causes. This research aims to develop a risk evaluation procedure in FMEA where common failure causes and other failure causes exist together. Methods: For each common failure cause, the effect of each combination of its resulting failures is recommended to be reevaluated considering their interactive worsening effect. And the probability that each combination of failures is incurred by the same common cause is also considered. Based on these two factors, the severity of each common cause is determined. Other procedures are similar to the conventional method. Results: The proposed procedure enables to compare and prioritize every failure cause. Thus, the common causes, each of which incurring two or more failures, and other causes, each of which is corresponding to one failure, can be fairly compared. Conclusion: A fair and proper way of comparing the common failure causes and other causes is provided. The procedure is somewhat complicated and requires more works to do. But it is worth to do.

• The Korean Journal of Pain
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• 제31권3호
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• pp.155-173
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• 2018

Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain. The preventive strategies include modification of the surgical technique, good pain control throughout the perioperative period, and preoperative psychological intervention focusing on the psychosocial and cognitive risk factors. Appropriate management of CPSP patients is also necessary to reduce their suffering. CPSP usually has a neuropathic pain component; therefore, the current recommendations are based on data on chronic neuropathic pain. Hence, voltage-dependent calcium channel antagonists, antidepressants, topical lidocaine and topical capsaicin are the main pharmacological treatments. Paracetamol, NSAIDs and weak opioids can be used according to symptom severity, but strong opioids should be used with great caution and are not recommended. Other drugs that may be helpful are ketamine, clonidine, and intravenous lidocaine infusion. For patients with failed pharmacological treatment, consideration should be given to pain interventions; examples include transcutaneous electrical nerve stimulation, botulinum toxin injections, pulsed radiofrequency, nerve blocks, nerve ablation, neuromodulation and surgical management. Physical therapy, cognitive behavioral therapy and lifestyle modifications are also useful for relieving the pain and distress experienced by CPSP patients.

• 한국콘텐츠학회논문지
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• 제20권10호
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• pp.326-337
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• 2020

본 연구의 목적은 도시 고령자와 농촌 고령자의 사회참여활동 유형이 인지기능 손상 정도(정상, 경증 인지기능저하, 중증 치매 의심)에 미치는 영향을 분석하는 것이다. 연구목적을 위해 6차(2016년)와 7차(2018년) 고령화 연구패널 조사 데이터 중 55세 이상 고령자 5,668명의 자료를 사용하여 다항 로지스틱 회귀분석을 하였다. 분석결과는 어떤 유형이든지 사회참여활동 하는 것이 인지기능 장애 위험을 줄여준다는 것은 도시와 농촌 둘 다 일관되게 유의하였으나, 도움이 되는 사회참여활동 유형이 도시와 농촌 간 차이가 있었다. 즉, 도시와 농촌에 사는지에 따라 정상군에서 인지기능저하 또는 치매 의심이 될 위험을 낮추는 데 도움이 되는 사회참여 활동 유형과 인지기능저하에서 치매 의심이 될 위험을 낮추는 데 유의한 유형이 달랐다. 따라서 인지기능 장애를 예방하고 치매 중증도를 완화하는 데 사회참여활동을 적극적으로 권장돼야 하며 적절한 지원이 필요하다는 것을 보여준다. 그리고 도시와 농촌의 차이를 고려한 정책과 개입이 요구됨을 함의한다.

• Journal of Korean Neurosurgical Society
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• 제29권10호
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• pp.1333-1339
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• 2000

Objective : The goal of this study is to identify the significant radiologic abnormalities in patients complaining headache and to determine predictive factors for clinically significant radiological abnormalities. Method : The study population was 410 patients having underwent CT or MRI study among 1000 patients complaining headache in outpatient basis between 1996-1999. All of these patients answered self-administered questionaire about their headaches. We reviewed the patient's charts and the questionaires and examined the radiologic study results. Result : Of the 410 patients referred for CT or MRI study, male : female ratio was 1 : 1.97. Twenty-five patients(6.1%) revealed clinically significant organic lesions. Mean age was 46.1 in radiologic abnormal group and 48.4 in normal group. Short symptom duration(p<0.01), motor weakness(p<0.05), vomiting(p<0.05), cranial nerve palsy(p<0.05), and trauma history(p<0.05) were factors indicated higher incidence of radiologic abnormality. But, patients age, and severity of headache were not associated with clinically significant radiologic lesion. The ratio of radiologic abnormality was 0.8% in patients not having any risk factor. Conclusion : The results indicate that radiologic study should be done in headache patients having the risk factors such as short symptom duration, motor weakness, vomiting, cranial nerve palsy, trauma history. For patients without any such a risk factor, the radiologic study doesn't seem mandatory.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.269-278
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• 2014

Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated with increased vascular risk, through impairment of the endogenous antioxidative ability which may trigger oxygen-dependent tissue injury. Lamotrigine (LTG) a non-enzyme-inducing AED has scarce information regarding its effects on oxidative stress. The present study aimed to study the possible modulation of vascular risk factors of epileptogenesis by LTG, in a rat model of kindling seizure induced by pentylenetetrazole (PTZ). Four groups of male Wister rats were used; vehicle control group, PTZ group (alternate day PTZ, 30 mg/kg, i.p), LTG/PTZ group (LTG 20 mg/kg/day p.o and alternate day PTZ) and LTG group. The study period was 5 weeks. Lipoproteins and total homocysteine (tHcy), malondialdehyde (MDA) and reduced glutathione (GSH) were measured. Aortic endothelial function study and histopathological examination of the rats' brains, aortas and coronaries were conducted. Serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), tHcy, MDA, GSH levels were significantly higher in epileptic rats than normal controls rats. A decrease in HDL-cholesterol with high atherosclerotic index was also demonstrated. The administration of LTG improved the PTZ-kindled seizures. It produced a significant decrease in TC, TG and LDL-cholesterol, MDA, aortic GSH and increase in HDL-cholesterol with no significant effect on serum GSH and tHcy levels. LTG improved endothelium-dependent relaxation, decreased hippocampal neurodegenerative changes and atherosclerotic changes of aortas and coronaries. LTG decreased seizures severity, hippocampal damage and improved vascular risk markers in this rat model of kindling seizures.

• Journal of Korean Neurosurgical Society
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• 제43권3호
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• pp.143-148
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• 2008

Objective: Postoperative delirium (POD) is characterized by an acute change in cognitive function and can result in longer hospital stays, higher morbidity rates, and more frequent discharges to long-term care facilities. In this study, we investigated the incidence and risk factors of POD in 224 patients older than 70 years of age, who had undergone a neurosurgical operation in the last two years. Methods: Data related to preoperative factors (male gender, >70 years, previous dementia or delirium, alcohol abuse, serum levels of sodium, potassium and glucose, and co-morbidities), perioperative factors (type of surgery and anesthesia, and duration of surgery) and postoperative data (length of stay in recovery room, severity of pain and use of opioid analgesics) were retrospectively collected and statistically analyzed. Results: POD appeared in 48 patients (21.4%) by postoperative day 3. When we excluded 26 patients with previous dementia or delirium, 17 spontaneously recovered by postoperative day 14, while 5 patients recovered by postoperative 2 months with medication, among 22 patients with newly developed POD. The univariate risk factors for POD included previously dementic or delirious patients, abnormal preoperative serum glucose level, pre-existent diabetes, the use of local anesthesia for the operation, longer operation time (>3.2 hr) or recovery room stay (>90 mini, and severe pain (VAS>6.8) requiring opioid treatment (p<0.05). Backward regression analysis revealed that previously dementic patients with diabetes, the operation being performed under local anesthesia, and severe postoperative pain treated with opioids were independent risk factors for POD. Conclusion: Our study shows that control of blood glucose levels and management of pain during local anesthesia and in the immediate postoperative period can reduce unexpected POD and help preventing unexpected medicolegal problems and economic burdens.

• Journal of Trauma and Injury
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• 제33권2호
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• pp.88-95
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• 2020

Purpose: The present study will identify risk factors for aspiration in severe trauma patients by comparing patients who showed a sign of aspiration lung disease on chest computed tomography (CT) and those who did not. Methods: We conducted a retrospective review of the Korean Trauma Data Bank between January 2014 and December 2019 in a single regional trauma center. The inclusion criteria were patients aged ≥18 years with chest CT, and who had an Injury Severity Score ≥16. Patients with Abbreviated Injury Scale (AIS)-chest score ≥1 and lack of medical records were excluded. General characteristics and patient status were analyzed. Results: 425 patients were included in the final analysis. There were 48 patients showing aspiration on CT (11.2%) and 377 patients showing no aspiration (88.7%). Aspiration group showed more endotracheal intubation in the ER (p=0.000) and a significantly higher proportion of severe Glasgow Coma Scale (GCS) (p=0.000) patients than the non-aspiration group. In AIS as well, the median AIS head score was higher in the aspiration group (p=0.046). Median oxygen saturation was significantly lower in the aspiration group (p=0.002). In a logistic regression analysis, relative to the GCS mild group, the moderate group showed an odds ratio (OR) for aspiration of 2.976 (CI, 1.024-8.647), and the severe group showed an OR of 5.073 (CI, 2.442-10.539). Conclusions: Poor mental state and head injury increase the risk of aspiration. To confirm for aspiration, it would be useful to perform chest CT for severe trauma patients with a head injury.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.71-79
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• 2014

Objectives : The aim of this study is to evaluate the safety of acupuncture therapy when applied to patients who are undergoing anticoagulants / antiplatelet medication therapy combined with herbal medicine using a retrospective, case-control study. Methods : 428 charts of patients were reviewed in this study. Odds ratio between case of bleeding-related adverse event and control was calculated as main analysis. Exposures were anticoagulants / antiplatelet medication, Hwalhyeolgeoeo herbal medicine and combination of both drugs. Additionally, odds ratios were calculated according to the severity of bleeding-related adverse events. Results : The results were as following: 1. Analysis of all bleeding-related adverse events showed there was no increased risk of combined therapy compared with other exposures and control group. 2. Analysis of only clinically significant adverse events showed there was no increased risk of combined therapy compared with other exposure and control group. 3. Hwalhyeolgeoeo herbal medicine group showed a tendency of increased risk of bleeding-related adverse events in all analysis but was not statistically significant. Conclusions : The results suggest that Hwalhyeolgeoeo herbal medicine-anticoagulant / antiplatelet medication combined therapy may not increase risk of bleeding-related adverse events in acupuncture therapy. By executing various modules of analysis, it was possible to acquire useful data for possible future studies. Further research is needed to confirm such results.

• 한국방재안전학회논문집
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• 제5권2호
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• pp.61-70
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• 2012

특정관리 대상 시설의 범위는 건축물 분야와 토목 시설물 분야로 구분되며 이들 시설 중 본 연구에서는 건축물 분야의 주거와 비주거시설에 대한 최근 5년간 발생한 화재발생을 중심으로 위험도 분석을 수행하였다. 주거시설 및 비 주거시설에서 발생한 화재사건은 전기적 원인에 의한 화재발생이 가장 많았으며 이로 인한 인명 피해 또한 매우 높은 것으로 분석되었다. 따라서 본 연구에서는 화재가 발생하게 된 원인적인 내용을 규명하고 이를 근거로 각 시설물 별 화재에 얼마나 위험한 수준인지를 위험도 평가지수 개발을 통해 분석하였다. 본 분석은 향후 이들 시설의 안전 관리를 위한 기준으로 활용될 수 있으며 이를 바탕으로 좀 더 전문적이고 집중적인 안전관리를 유도할 수 있을 것으로 판단된다.