• 대한공간정보학회지
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• 제14권4호통권38호
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• pp.71-77
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• 2006

통계학습이론에 기반하고 있는 Support Vector Machine(SVM)은 구조적 위험 최소화원리를 바탕으로 하는 학습 알고리즘이다. 일반적으로SVM은 비선형 경계를 결정하고 자료를 분류하기 위해서 커널(kernel)을 사용한다. 그러나 기존의 커널들은 두 벡터간의 내적이나 거리차를 이용하여 유사도를 측정하기 때문에 하이퍼스펙트럴 영상분류에 효과적으로 적용될 수 없다. 본 논문에서는 이를 해결하기 위해서 분광유사도커널(Spectral similarity kernel)을 제안한다. 분광유사도 커널은 두 벡터의 거리차와 각 차이를 모두 계산하는 지역적 커널로 하이퍼스펙트럴 영상의 분광특성을 효과적으로 고려할 수 있다. 이를 검증하기 위해서 Hyperion 영상에 polynomial kernel, RBF kernel을 사용한 SVM 분류기와 분광유사도 커널을 사용한 SVM 분류기를 적용하여 토지피복분류를 시행하였다. 분류결과를 통해서 분광유사도 커널을 사용한 SVM 분류기가 정량적, 공간적으로 가장 우수한 결과를 보임을 확인하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.267-268
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• 2002

Microbeam is a new avenue of radiation research especially in radiation biology and radiation protection. Selective irradiation of an ionizing particle to a targeted cell organelle may disclose such mechanisms as signal transaction among cell organelles and cell-to-cell communication in the processes toward an endpoint observed. Bystander effect, existence of which is clearly evidenced by application of the particle microbeam to biological experiments, suggests potential underestimation in the conventional risk estimation at low particle fluence rates, such as environment of space radiations in ISS (International Space Station). To promote these studies we started the construction of our microbeam facility (named as SPICE) to our HVEE Tandem accelerator (3.4 MeV proton and 5.1 MeV $^4$He$\^$2+/). For our primary goal, "irradiation of single particle to cell organelle within a position resolution of 2 micrometer in a reasonable irradiation time", special features are considered. Usage of a triplet Q magnet for focussing the beam to submicron of size is an outstanding feature compared to facilities of other institutes. Followings are other features: precise position control of cell dish holder, design of the cell dish, data acquisition of microscopic image of a cell organelle (cell nucleus) and data processing, a reliable particle detection, soft and hard wares to integrate all these related data, to control and irradiate exactly determined number of particles to a targeted spot.

• Archives of Plastic Surgery
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• 제38권1호
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• pp.35-42
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• 2011

Purpose: Blow-out fractures can be reduced using various methods. The orbital reconstruction technique using a balloon under endoscopic control has advantages over other methods. However, this method has some problems too, such as postoperative follow-up, management of the balloon catheter, and reduction of the posterior orbital floor. Thus, we developed a simple, effective method for orbital floor reduction that involves molding and shaping the antral balloon catheter. Methods: A 0, 30, or $70^{\circ}$, 4-mm endoscope was placed though a two-point, 5-mm maxillary antrostomy. The balloon catheter is placed directly at the orbital apex to reconstruct the anterior shelf (spherical shape), while it is turned in a U-shape towards the anterior maxilla for the posterior shelf (elliptical shape). Orbital floor defects, compound or comminuted fractures are reconstructed with alloplastic materials through an open lid incision under the endoscopic control. Results: This technique was applied to ten patients with orbital floor fractures: five anterior shelf and five posterior shelf fracture, respectively. Four of the patients had zygomatico-orbital fractures, while the rest had isolated orbital floor fractures. Two patients were given porous polyethylene implants Synpor$^{(R)}$) and three underwent reconstruction with a resorbable mesh plate. No complication associated with this technique was identified. Conclusion: The freestyle placement and selection of a urinary balloon catheter under endoscopic control and the preoperative estimation of the volume enhanced the stabilization of the orbital contour. This method improves the adaptation of the orbital floor without the risk of injuring the surrounding orbital contents, dissecting blindly, or using sharp traction. One drawback of this method is the patient's discomfort from the catheter during treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3923-3926
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• 2015

Background: Lung cancer is a fatal malignancy with high mortality and short survival time. The aim of this study was to estimate survival rates of Iranian patients with lung cancer and its associate predictive factors. Materials and Methods: The study was conducted on 355 patients admitted to hospitals of West Azerbaijan in the year 2007. The patients were followed up by phone calls until the end of June 2014. The survival rate was estimated using the Kaplan-Meier method and log-rank test for comparison. The Cox's proportional hazard model was used to investigate the effect of various variables on patient survival time, including age, sex, Eastern Cooperative Oncology Group (ECOG) performance, smoking status, tumor type, tumor stage, treatment, metastasis, and blood hemoglobin concentration. Results: Of the 355 patients under study, 240 died and 115 were censored. The mean and median survival time of patients was 13 and 4.8 months, respectively. According to the results of Kaplan-Meier method, 1, 2, and 3 years survival rates were 39%, 18%, and 0.07%, respectively. Based on Cox regression analysis, the risk of death was associated with ECOG group V (1.83, 95% CI: 1 Conclusions: The survival time of the patients with lung cancer is very short. While early diagnosis may improve the life expectancy effective treatment is not available.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1539-1546
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• 2016

Specific patterns of the hereditary breast and ovarian cancer (HBOC) syndrome are related to mutations in the BRCA1 gene. One hundred unrelated breast cancer patients were interviewed to obtain clinical symptoms and signs, pedigree and familial history of HBOC syndrome related cancer. Subsequently, data were calculated using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk prediction model. Patients with high score of BOADICEA were offered genetic testing. Eleven patients with high score of BOADICEA, 2 patients with low score of BOADICEA, 2 patient's family members and 15 controls underwent BRCA1 genetic testing. Mutation screening using PCR-HRM was carried out in 22 exons (41 amplicons) of BRCA1 gene. Sanger sequencing was subjected in all samples with aberrant graph. This study identified 10 variants in the BRCA1 gene, consisting of 6 missense mutations (c.1480C>A, c.2612C>T, c.2566T>C, c.3113A>G, c.3548 A>G, c.4837 A>G), 3 synonymous mutations (c.2082 C>T, c.2311 T>C and c.4308T>C) and one intronic mutation (c.134+35 G>T). All variants tend to be polymorphisms and unclassified variants. However, no known pathogenic mutations were found.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7991-7995
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• 2015

Background: To identify the epidemiological characteristics of colorectal cancer mortality in China during the period of 1991-2011, and forecast the future five-year trend. Materials and Methods: Mortality data for colorectal cancer in China from 1991 to 2011 was used to describe epidemiological characteristics in terms of age group, gender, and rural/urban residence. Trend surface analysis was performed to analyze the geographical distribution of colorectal cancer. Four models including curve estimation, time series modeling, gray modeling and joinpoint regression were applied to forecast the trends for the future five years. Results: Since 1991 the colorectal cancer mortality rate increased yearly, and our results showed that the trend would continue to increase in the ensuing 5 years. The mortality rate in males was higher than that of females and the rate in urban areas was higher than in rural areas. The mortality rate was relatively low for individuals less than 60 years of age, but increased dramatically afterwards. People living in the northeastern China provinces or in eastern China had a higher mortality rate for colorectal cancer than those living in middle or western China provinces. Conclusions: The steadily increasing mortality of colorectal cancer in China will become a substantial public health burden in the foreseeable future. For this increasing trend to be controlled, further efforts should concentrate on educating the general public to increase prevention and early detection by screening. More effective prevention and management strategies are needed in higher mortality areas (Eastern parts of China) and high-risk populations (60+ years old).

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6391-6396
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• 2015

Background: To analyze cervical cancer mortality trends in China from 1991-2013 and forecast the mortality distribution in future five years (2014-2018), and provide clues for prevention and treatment. Materials and Methods: Mortality data for cervical cancer in China from 1991 to 2013 were used to describe the epidemiological characteristics and distribution, including the trend of the standardized mortality rate, urban-rural differences, and age variation. Trend-surface analysis was used to analyze the geographical distribution of mortality. Curve estimation, time series, gray modeling, and joinpoint regression were performed to predict and forecast mortality trends. Results: In recent years, the mortality rate of cervical cancer has increased, and there is also a steady increase in the incidence from 2003 to 2013 in China. Mortality rates in rural areas are higher than in urban areas. The mortality dramatically increases in the 40+ yr age group, reaching a peak in the >85 yr age group. In addition, geographical analysis showed that the cervical cancer mortality increased from the southwest to west-central and from the southeast to northeast of the country. Conclusions: The incidence rate and the mortality rate are increasing from 1991 to 2013, and the predictions show this will continue in the future. Thus, implementation of prevention and management programs for cervical cancer are necessary in China, especially for rural areas, young women in urban areas, and high risk regions (the west-central).

• 한국컴퓨터정보학회논문지
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• 제17권5호
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• pp.49-57
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• 2012

본 논문에서는 P2P스트리밍에서 peer간 연결 정보를 이용하는 방법을 기반으로 topology 최적화를 연구한다. 제안하는 방법은 mesh-network에서 사용된 link와 사용되지 않은 link의 수로 peer의 업로드 용량을 추정하는 방법을 기반으로 한다. 연결된 link의 정보를 사용하는 기존 방법은 peer의 자원 관리 측면에서 메시지 과부하를 줄이는데 효과적이다. 하지만 업로드 대역폭이 고려되지 않는 topology를 구성할 우려가 있다. 또한 서버에 가까운 peer에서 네트워크 오류 발생시 네트워크 전송성능이 저하될 수 있다. 본 논문에서는 기존 방법의 단점을 보완하는 방법을 제안한다. 기존 방법과 제안하는 방법을 시뮬레이션 하고 결과를 비교 분석한다.

• Nuclear Engineering and Technology
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• 제47권2호
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• pp.204-211
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• 2015

Probabilistic safety assessment (PSA) has had a significant role in quantitative decision-making by finding design and operational vulnerabilities and evaluating cost-benefit in improving such weak points. In particular, it has been widely used as the core methodology for risk-informed applications (RIAs). Even though the nature of PSA seeks realistic results, there are still "conservative" aspects. One of the sources for the conservatism is the assumptions of safety analysis and the estimation of failure frequency. Surveillance, diagnosis, and prognosis (SDP), utilizing massive databases and information technology, is worth highlighting in terms of its capability for alleviating the conservatism in conventional PSA. This article provides enabling techniques to solidify a method to provide time- and condition-dependent risks by integrating a conventional PSA model with condition monitoring and prognostics techniques. We will discuss how to integrate the results with frequency of initiating events (IEs) and probability of basic events (BEs). Two illustrative examples will be introduced: (1) how the failure probability of a passive system can be evaluated under different plant conditions and (2) how the IE frequency for a steam generator tube rupture (SGTR) can be updated in terms of operating time. We expect that the proposed model can take a role of annunciator to show the variation of core damage frequency (CDF) depending on operational conditions.

• 암석학회지
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• 제25권4호
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• pp.325-334
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• 2016

한반도에서는 크고 작은 지진이 꾸준히 발생하고 있음을 역사문헌과 계기지진 관측 자료를 통해 알 수 있다. 본 연구에서는 역사지진과 계기지진 자료를 이용해 지리정보시스템(GIS)의 공간분석 결과, 북한의 평양지역이 지진으로부터 가장 위험한 지역으로 결정되었다. 평양은 북한의 수도로서 인구와 구조물의 밀집도가 높아 지진뿐만 아니라 재해로 인해 큰 위험에 처할 수 있다. 502년 평양에서 발생한 규모 6.7의 지진을 토대로 지진동 지도를 작성한 결과, 0.24 g보다 높은 지진동을 느낄 수 있는 지역이 평양지역의 약 51.1%를 차지한다. 또한 통계청 자료에 의하면 북한은 우리나라보다 재해로부터 열악한 환경에 처해 있음을 확인할 수 있었다. 이번 연구결과는 향후 북한을 포함한 우리나라의 포괄적인 지진재해예측 연구에 유용한 정보로 사용될 수 있다.