• 대한수의학회지
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• 제44권4호
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• pp.515-522
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• 2004

The vasorelaxant effect of serotonin reuptake inhibitor fluoxetine was investigated in rat isolated thoracic aorta. Fluoxetine induced a concentration-dependent relaxation in aorta precontracted with phenylephrine (PE) and KCl. These relaxations were suppressed by removal of the endothelium (-E) or pretreatment of nitric oxide synthase inhibitors, N(G)-nitro-L-arginine (L-NNA) and N(omega)-nitro-Larginine methyl ester (L-NAME), guanylate cyclase inhibitors, methylene blue (MB) and 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one (ODQ), and $Ca^{2+}$ channel blockers, nifedipine and verapamil, in PE-precontracted +E rings. However, fluoxetine-induced relaxations were not suppressed by pretreatment of $K^{+}$ channel blockers, tetrabutylammonium and glibenclamide, in PE-precontracted endothelium intact (+E) rings. The fluoxetine-induced relaxations were not suppressed by removal of the endothelium or pretreatment of LNNA and MB in KCl-precontracted +E rings. Also, fluoxetine inhibited PE-induced sustained contraction in +E rings. These inhibitory effects of fluoxetine on contractions could be reversed by removal of the endothelium or pretreatment of L-NNA, L-NAME, MB, ODQ, nifedipine and verapamil, but not by pretreatment of etrabutylammonium and glibenclamide. These findings suggest that the vasorelaxant effect of fluoxetine is modulated by intracellular $Ca^{2+}$ with an involvement of endothelial NO-cGMP pathway and also may be related to the inhibition of $Ca^{2+}$ entry through voltage-gated channel.

• Steel and Composite Structures
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• 제13권6호
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• pp.587-606
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• 2012

Concrete-filled-steel-tubular (CFST) columns have been well proven to improve effectively the strength, stiffness and ductility of concrete members. However, the central part of concrete in CFST columns is not fully utilised under uni-axial compression, bending and torsion. It has small contribution to both flexural and torsion strength, while it can be replaced effectively by steel with smaller area to give similar load-carrying capacity. Also, the confining pressure in CFST columns builds up slowly because the initial elastic dilation of concrete is small before micro-crackings of concrete are developed. From these observations, it is convinced that the central concrete can be effectively replaced by another hollow steel tube with smaller area to form double-skinned concrete-filled-steel-tubular (CFDST) columns. In this study, a series of uni-axial compression tests were carried out on CFDST and CFST columns with and without external steel rings. From the test results, it was observed that on average that the stiffness and elastic strength of CFDST columns are about 25.8% and 33.4% respectively larger than CFST columns with similar equivalent area. The averaged axial load-carrying capacity of CFDST columns is 7.8% higher than CFST columns. Lastly, a theoretical model that takes into account the confining effects of steel tube and external rings for predicting the uni-axial load-carrying capacity of CFDST columns is developed.

• Kyungpook Mathematical Journal
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• 제61권1호
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• pp.33-48
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• 2021

Most of the research on weakly prime and weakly 2-absorbing modules is for modules over commutative rings. Only scatterd results about these notions with regard to non-commutative rings are available. The motivation of this paper is to show that many results for the commutative case also hold in the non-commutative case. Let R be a non-commutative ring with identity. We define the notions of a weakly prime and a weakly 2-absorbing submodules of R and show that in the case that R commutative, the definition of a weakly 2-absorbing submodule coincides with the original definition of A. Darani and F. Soheilnia. We give an example to show that in general these two notions are different. The notion of a weakly m-system is introduced and the weakly prime radical is characterized interms of weakly m-systems. Many properties of weakly prime submodules and weakly 2-absorbing submodules are proved which are similar to the results for commutative rings. Amongst these results we show that for a proper submodule Ni of an Ri-module Mi, for i = 1, 2, if N1 × N2 is a weakly 2-absorbing submodule of M1 × M2, then Ni is a weakly 2-absorbing submodule of Mi for i = 1, 2

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2173-2187
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• 2022

A 3D thermo-elasto-hydrodynamic model is developed to analyze the sealing performance of a notched mechanical seal applied in the reactor coolant pump. In the model, the generalized Reynolds equation, the energy equation coupled with notch heat balance equation, the heat conduction equations, and the deformation equations of the sealing rings are iteratively solved by the finite element method. The film pressure and temperature distribution are obtained, and the deformation of the sealing rings is revealed to study the mechanism of the notched mechanical seals. A parameterized study is conducted to analyze the sealing performance under different operating conditions. As a comparison, the sealing performance of non-notched seals is also studied. The results show that the hydrostatic effect is dominant in the load-carrying capacity of the fluid film due to the radial mechanical and thermal deformations. The notch can cool the fluid film and influence the thermal deformation of seal rings. The sealing performance is sensitive to the pressure difference, ambient temperature, and rotational speed. It is suggested to set the notches on the softer sealing rings to acquire the greater hydrodynamic effect. Compared with the non-notched, the notched end face holds a better lubrication performance, especially under lower rotational speed.

• 천문학회보
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• 제46권1호
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• pp.51.2-51.2
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• 2021

Nuclear rings are sites of intense star formation at the center of barred spiral galaxies. A straightforward but unanswered question is what controls star formation rate (SFR) in nuclear rings. To understand how the ring SFR is related to mass inflow rate, gas content, and background gravitational field, we run a series of semi-global hydrodynamic simulations of nuclear rings, adopting the TIGRESS framework to handle radiative heating and cooling as well as star formation and supernova feedback. We find: 1) when the mass inflow rate is constant, star formation proceeds in a remarkably steady fashion, without showing any burst-quench behavior suggested in the literature; 2) the steady state SFR has a simple linear relationship with the inflow rate rather than the ring gas mass; 3) the midplane pressure balances the weight of the overlying gas and the SFR surface density is linearly correlated with the midplane pressure, consistent with the self-regulated star formation theory. We suggest that the ring SFR is controlled by the mass inflow rate in the first place, while the gas mass adjusts to the resulting feedback in the course of achieving the vertical dynamical equilibrium.

• 대한본초학회지
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• 제38권6호
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• pp.53-60
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• 2023

Objectives : The objective of present study was to investigate the vasorelaxant effects of 10 traditional Korean Herbal Prescriptions (KHP) on isolated rat thoracic aorta precontracted with potassium chloride (KCl). Methods : An electric extractor was used to extract KHP in distilled water for 3h. Rat aorta rings were isolated and were precontracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. KHP extracts were added in increasing concentrations (10-1000 ㎍/㎖) to investigate vasorelaxant effects. The vasorelaxant responses induced by KHP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 KHP, Gamisoyo-san, Galgeun-tang, Gyeji-tang, Gwakhyangjeonggi-san, Daeyoung-jeon, and Socheongryong-tang showed significant vasorelaxant effect at high concentration. In contrast, Gyejibokryeong-hwan constricted more the aorta rings precontracted by KCl. And Gumiganghwal-tang, Guibi-tang, Saengmaek-san showed no significant effect. Also, rat aorta rings treated with Gyejibokryeong-hwan or Gyeji-tang after pre-relaxation by amlodipine did not cause any significant change. Conclusion : Thus, these results provide the experimental evidence as useful herbal prescriptions for the treatment of hypertension and suggest guidelines in conjunction with other western drugs, including amlodipine.

• 한국추진공학회지
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• 제1권1호
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• pp.104-110
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• 1997

고강도 알루미늄 합금 링롤재의 급냉, 링 팽창(expansion) 및 링 압축(compression) 응력제거처리 후 잔류응력을 예측하기 위하여 2차원 축대칭 열해석 및 탄소성 해석을 수행하였다. 급냉 및 응력제거처리 후 2단 과시효 처리(T73)된 링롤재에 대하여 3단계 절단법(Three step sectioning method)을 적용하여 링롤재의 두께에 따른 잔류응력 분포를 측정하였으며, 측정결과를 급냉 및 응력제거처리후 잔류응력 해석결과와 비교분석하였다. 링의 급냉후 원주 및 축방향의 잔류응력 해석값은 T73후 측정값과 비슷한 경향을 보였으며, 링의 내면과 외면에서 압축응력을 나타내었고 중심에서 인장응력을 나타내었다. 잔류응력은 링 팽창(T7351) 및 링 압축(T7352) 적용후 T73에 비해 현저히 감소하였으며, 축방향의 제거 효과가 원주방향보다 우수하게 나타났다. 또한 링 압축에 의한 제거효과가 링 팽창보다 크게 나타났다. 링롤재의 응력제거처리는 제거 효과 및 실용성 측면에서 링 압축 공정이 유리하며, 치수제어 및 장비용량 측면에서 링 팽창 공정이 유리하다는 결론을 얻었다.

• Journal of electromagnetic engineering and science
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• 제17권3호
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• pp.153-158
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• 2017

This work reports on the effect of plasma area on the frequency characteristics of the monostatic radar cross section (RCS) of a square metallic plate. A dielectric barrier discharge (DBD) plasma actuator consisting of 10 rings is proposed. The actuator is fabricated in three different configurations such that only three inner rings, seven inner rings, and all rings can be biased. By applying an 18-kV bias at 1 kHz, the three types of DBD actuators generate plasma with a total area of 16.96, 36.74, and $53.69cm^2$, respectively, in a ring or circular form. The experimental results reveal that when the DBD actuator is placed in front of a $20mm{\times}20cm$ conducting plate, the monostatic RCS is reduced by as much as 18.5 dB in the range of 9.41-11.65 GHz. Furthermore, by generating the plasma and changing the area, the frequency of maximum reduction in the monostatic RCS of the plate can be controlled. The frequency is reduced by nearly 20% in the X band when all rings are biased. Finally, an electromagnetic model of the plasma is obtained by comparing the experimental and full-wave simulated results.

• 대한기계학회논문집B
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• 제27권8호
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• pp.1174-1181
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• 2003

The flow around a circular cylinder was controlled by attaching O-rings to reduce drag force acting on the cylinder. Four experimental models were tested in this study; one smooth cylinder of diameter D (D=60mm) and three cylinders fitted with O-rings of diameters d=0.0167 D, 0.05D and 0.067 D with pitches of PPD=2D, 1D, 0.5D and 0.25D. The drag force, mean velocity and turbulence Intensity profiles in the near wake behind the cylinders were measured for Reynolds numbers based on the cylinder diameter in the range of Re$_{D}$=7.8$\times$10$^3$~1.2$\times$10$^{5}$ . At Re$_{D}$=1.2$\times$10$^{5}$ , the cylinder fitted with O-rings of d=0.0167D in a pitch interval of 0.25D shows the maximum drag reduction of about 5.4%, compared that with the smooth cylinder. The drag reduction effect of O-rings of d=0.067D is not so high. For O-ring circulars, as the Reynolds number increases, the peak location of turbulence intensity shifts downstream and the peak magnitude is decreased. Flow field around the cylinders was visualized using a smoke-wire technique to see the flow structure qualitatively. The size of vortices and vortex formation region formed behind the O-ring cylinders are smaller, compared with the smooth cylinder.der.

• 대한약침학회지
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• 제19권4호
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• pp.329-335
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• 2016

Objectives: Safranal is a pharmacologically active component of saffron and is responsible for the unique aroma of saffron. The hypotensive effect of safranal has been shown in previous studies. This study evaluates the mechanism for the vasodilatory effects induced by safranal on isolated rat aortas. Methods: To study the vasodilatory effects of safranal (0.2, 0.4 and 0.8 mM), we contracted isolated rat thoracic aorta rings by using $10^{-6}-M$ phenylephrine (PE) or 80-mM KCl. Dimethyl sulfoxide (DMSO) was used as a control. The vasodilatory effect of safranal was also evaluated both on intact and denuded endothelium aortic rings. Furthermore, to study the role of nitric oxide and prostacyclin in the relaxation induced by safranal, we incubated the aortic rings by using L-NAME ($10^{-6}M$) or indomethacin ($10^{-5}M$), each for 20 minutes. Results: Safranal induced relaxation in endothelium-intact aortic rings precontracted by using PE or KCl in a concentration-dependent manner, with a maximum relaxation of more than 100%. The relaxant activity of safranal was not eliminated by incubating the aortic rings with L-NAME ($EC_{50}=0.29$ vs. $EC_{50}=0.43$) or with indomethacin ($EC_{50}=0.29$ vs. $EC_{50}=0.35$), where $EC_{50}$ is the half maximal effective concentration. Also, the vasodilatory activity of safranal was not modified by endothelial removal. Conclusion: This study indicated that relaxant activity of safranal is mediated predominantly through an endothelium-independent mechanism.