The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Vasorelaxant effects of 10 traditional Korean Herbal Prescriptions on isolated rat aortic rings

전통 한의약 처방 10종에 대한 혈관이완 효능 연구

  • Eun-Jeong Park (Department of Korean Medicine and Healthcare, Kyung Hee Cyber University) ;
  • Bumjung Kim (Department of Korean Medicine and Healthcare, Kyung Hee Cyber University)
  • 박은정 (경희사이버대학교 한방건강관리학과) ;
  • 김범정 (경희사이버대학교 한방건강관리학과)
  • Received : 2023.10.10
  • Accepted : 2023.11.25
  • Published : 2023.11.30
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Abstract

Objectives : The objective of present study was to investigate the vasorelaxant effects of 10 traditional Korean Herbal Prescriptions (KHP) on isolated rat thoracic aorta precontracted with potassium chloride (KCl). Methods : An electric extractor was used to extract KHP in distilled water for 3h. Rat aorta rings were isolated and were precontracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. KHP extracts were added in increasing concentrations (10-1000 ㎍/㎖) to investigate vasorelaxant effects. The vasorelaxant responses induced by KHP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 KHP, Gamisoyo-san, Galgeun-tang, Gyeji-tang, Gwakhyangjeonggi-san, Daeyoung-jeon, and Socheongryong-tang showed significant vasorelaxant effect at high concentration. In contrast, Gyejibokryeong-hwan constricted more the aorta rings precontracted by KCl. And Gumiganghwal-tang, Guibi-tang, Saengmaek-san showed no significant effect. Also, rat aorta rings treated with Gyejibokryeong-hwan or Gyeji-tang after pre-relaxation by amlodipine did not cause any significant change. Conclusion : Thus, these results provide the experimental evidence as useful herbal prescriptions for the treatment of hypertension and suggest guidelines in conjunction with other western drugs, including amlodipine.

Keywords

Acknowledgement

이 연구는 한국한의학연구원(KIOM)의 '한약-약물 상호작용 평가(K16252)' 연구비지원에 의한 결과임.

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