• 상하수도학회지
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• 제19권1호
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• pp.98-105
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• 2005

The effects of chlorination on the elimination of three estrogenic chemicals such as $17{\beta}$-estradiol (E2), nonylphenol (NP) and bis-phenol A (BPA) were investigated using yeast two-hybrid assay (YTA), estrogen receptor competition assay (ER-CA), and high-performance liquid chromatography/mass spectrometer (LC/MS). Results of YTA, ECA and the analysis of LC/MS indicated that the estrogenic activity of above mentioned three endocrine disruptors were significantly reduced as the result of chlorination. The decrease in estrogenic activity paralleled with decrease in estrogenic chemicals under the influence of free chlorine. One common characteristic of estrogenic chemicals is the presence of a phenolic ring. Considering that a phenolic ring is likely to undergo some sort of transformation in aqueous chlorination solution, the above mentioned results may be applied to the rest of the other estrogenic chemicals in natural waters.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 1996년도 The Korean Institute of Navigation 1996년도 한·중 국제학술 심포지움 및 추계학술발표회 논문집
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• pp.89-94
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• 1996

In this paper A methode for design of hybrid-ring couplers having sections of lenth λ/n is proposed. Assuming only one - axis symmitry and isolation of output arms general expressions for the scattering parameters are obtained. The new design method using λ/n sections for 3 dB couplers is derived, . The calculated frequency reponse of the new design has been compared with that of conventional ones, . A new design using λ/5 section and having an overall length 13λ/10 is found to be superior to the 7λ/6 design is expected to have a low insertion loss by virtue of its shorter length.

• 한국산업정보학회논문지
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• 제20권1호
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• pp.1-7
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• 2015

In this paper, a 12-bit high resolution, power and area efficiency hybrid digital pulse width modulator (DPWM) with process and temperature (PT) calibration has been proposed for digital controlled DC-DC converters. The hybrid structure of DPWM combines a 6-bit differential tapped delay line ring-mux digital-to-time converter (DTC) schema and a 6-bit counter-comparator DTC schema, resulting in a power and area saving solution. Furthermore, since the 6-bit differential delay line ring oscillator serves as the clock to the high 6-bit counter-comparator DTC, a high frequency clock is eliminated, and the power is significantly saved. In order to have a simple delay cell and flexible delay time controllability, a voltage controlled inverter is adopted to build the deferential delay cell, which allows fine-tuning of the delay time. The PT calibration circuit is composed of process and temperature monitors, two 2-bit flash ADCs and a lookup table. The monitor circuits sense the PT (Process and Temperature) variations, and the flash ADC converts the data into a digital code. The complete circuits design has been verified under different corners of CMOS 0.18um process technology node.

• 산업기술연구
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• 제26권A호
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• pp.95-99
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• 2006

In this paper, we proposed the new wavelength tunable filter for wide tunability of fiber ring laser. The proposed filter consists of the cascaded connection of Fiber Reflection Mach-Zehnder Interferometer and Sagnac filter or of hybrid filter and Fiber Reflection Mach-Zehnder Interferometer. The simulation shows that the continuous tunable range of 50nm can be obtained and that more stable single mode operation of ring laser can be expected due to narrow FWHM. of filter spectrum.

• 한국위성정보통신학회논문지
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• 제11권2호
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• pp.29-35
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• 2016

High-availability seamless redundancy (HSR) 은 두 개의 복제된 프레임을 각각의 경로로 전송하여 거의'0'시간에 고장을 복구하는 실시간 고장 허용 프로토콜이다. 그러므로 HSR은 스마트 그리드 통신과 같은 첨단 실시간 네트워크에 사용이 가능하다. 그러나 HSR 프로토콜은 고장 복구를 위해 생성되는 불필요한 트래픽이 목적지 노드가 포함되지 않은 하부 네트워크에도 지속적으로 순환하는 주요 단점이 있으며, 이는 네트워크의 트래픽 성능을 저하시키고, 네트워크의 활용 자원을 감소시키는 원인이 된다. 이러한 단점을 보완하기 위해, 효율적인 두 가지 알고리즘, Quick Removing (QR) 과 Port Locking (PL) 이 발표된 바 있다. 본 논문은 QR과 PL을 결합한 새로운 알고리즘, QRPL의 구현 가능성 및 그 성능을 수학적으로 해석 제시하고 시뮬레이션으로 확인하였다. 그 결과 다수의 하위 ring이 연결된 HSR 네트워크에서 유니캐스트 트래픽을 적용시, 표준 HSR, QR, 또는 PL 알고리즘을 개별로 사용하는 것보다, QRPL 알고리즘을 사용하는 경우 성능이 크게 향상됨을 확인하였다.

• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.4079-4083
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• 2012

The mechanism of the cycloaddition reaction between singlet state dichlorosilylene germylidene ($Cl_2Si=Ge:$) and acetone has been investigated with B3LYP/6-$31G^*$ and B3LYP/6-$31G^{**}$ method, from the potential energy profile, we predict that the reaction has one dominant reaction pathway. The presented rule of the reaction is that the two reactants firstly form a Si-heterocyclic four-membered ring germylene through the [2+2] cycloaddition reaction. Because of the 4p unoccupied orbital of Ge atom in the Si-heterocyclic four-membered ring germylene and the ${\pi}$ orbital of acetone forming a ${\pi}{\rightarrow}p$ donor-acceptor bond, the Si-heterocyclic four-membered ring germylene further combines with acetone to form an intermediate. Because the Ge atom in the intermediate hybridizes to an $sp^3$ hybrid orbital after the transition state, then, the intermediate isomerizes to spiro-heterocyclic ring compound involving Si and Ge (P4) via a transition state.

• 한국터널지하공간학회 논문집
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• 제14권1호
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• pp.55-77
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• 2012

현대식 Rock TBM공법은 TBM에 의한 굴착과 지반 타입에 따른 능동적인 지보가 어우러진 공법으로 세그먼트를 사용하지 않고 숏크리트, 링빔, 록볼트, 와이어매쉬 등의 지보재에 의해 터널을 지보한다. 현대식 Rock TBM에서 사용되는 링빔은 H-형강을 사용하여 NATM의 강지보재와 유사하나 원형으로 완전히 폐합되어 설치됨에 따라 강지보재보다 더 효과적이다. 따라서 현대식 Rock TBM에서 링빔은 터널의 안정성 향상에 기여하는 바가 크며, 본 연구에서 소개하는 가압형 링빔(pressurized ring beam)은 그 효과를 더욱 향상 시킬 수 있다. 가압형 링빔의 효과를 검증하기 위해 3차원 수치해석을 수행하였으며 그 결과 최소주응력 증가, 과대변위를 발생시키는 소성변형률의 감소, 링빔 설치 후 발생하는 변위인 상대변위감소 그리고 링빔 간격 증가 효과를 확인하였다.

• BMB Reports
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• 제35권6호
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• pp.629-636
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• 2002

Protein kinase CKII (CKII) is required for progression through the cell division cycle. We recently reported that the $\beta$ subunit of protein kinase CKII ($CKII{\beta}$) associates with CKBBP1 that contains the Ring-H2 finger motif in the yeast two-hybrid system. We demonstrate here that the Ring-H2 finger-disrupted mutant of CKBBP1 does not interact with purified $CKII{\beta}$ in vitro, which shows that the Ring-H2 finger motif is critical for direct interaction with $CKII{\beta}$. The CKII holoenzyme is efficiently co-precipitated with the wild-type CKBBP1, but not with the Ring-H2 finger-disrupted CKBBP1, from whole cell extracts when epitope-tagged CKBBP1 is transiently expressed in HeLa cells. Disruption of the Ring-H2 finger motif does not affect the cellular localization of CKBBP1 in HeLa cells. The increased expression of either the wild-type CKBBP1 or Ring-H2 finger-disrupted CKBBP1 does not modulate the protein or the activity levels of CKII in HeLa cells. However, the stable expression of Ring-H2 finger-disrupted CKBBP1 in HeLa cells suppresses cell proliferation and causes the accumulation of the G1/G0 peak of the cell cycle. The Ring-H2 finger motif is required for maximal CKBBP1 phosphorylation by CKII, suggesting that the stable binding of CKBBP1 to CKII is necessary for its efficient phosphorylation. Taken together, these results suggest that the complex formation of $CKII{\beta}$ with CKBBP1 and/or CKII-mediated CKBBP1 phosphorylation is important for the G1/S phase transition of the cell cycle.

• 대한의생명과학회지
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• 제13권1호
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• pp.1-10
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• 2007

Nebulin, a giant modular protein from muscle, is thought to act as molecular ruler in sarcomere assembly. In skeletal muscle, the C-terminal ${\sim}50 kDa$ region of nebulin extends into the Z-line lattice. The most recent studies implicated highlighting its extensive isoform diversity and exciting reports revealed its expression in cardiac and non-muscle tissues containing brain. Also these novel findings are indicating that nebulin is actually a multifunctional filament system, perhaps playing roles in signal transduction, contractile regulation, and myofibril force generation, as well as other not yet defined functions. However the binding protein of nebulin and function in brain is still unknown. A novel binding partner of nebulin C-terminal region was identified by screening a human brain cDNA library using yeast two-hybrid system. Nebulin C-terminus binding protein 51 (NCBP51) was contained a RING-finger domain and identified a new isoform of RING finger protein 125 (RNF125). The interaction was confirmed using the GST pull-down assay. NCBP51 belongs to a family of the RING finger proteins and its function remains to be identified in brain. The role of nebulin and NCBP51 will be studied by loss-of-function using siRNA technique in brain.

• 한국항공우주학회지
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• 제40권9호
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• pp.745-751
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• 2012

하이브리드 로켓은 축 방향의 산화제 유동과 고체 연료의 기화로 인한 벽면 분출 유동사이의 상호 간섭에 의해 복잡한 형태의 혼합 전단층이 존재한다. 연소실 입구에 링이 설치되어 있고 질량분사가 있는 실린더 유동에 대하여 압축성 효과를 고려한 LES(Large Eddy Simulation) 기법을 적용하여 수치계산을 수행하였다. 최근의 실험에 의하면 연료 중간에 링과 같은 다이아프램이 설치된 경우, 연소율의 증가가 관찰되었다. 계산 결과에 따르면, 축방향 유동과 벽면 분출 유동이 상호 간섭하여 발생하는 벽면 와류가 국부적인 연료 표면으로의 열전달을 증가시켜 실험에서 관찰되는 딤플이 생성되는 것을 확인하였다. 또한 연소실 입구에 설치된 링에 의하여 발생되는 와류는 벽면 와류가 보다 활발하게 생성되고 열전달과 혼합을 향상시키는 역할을 하며 이 때문에 연소율이 증가되는 것으로 보인다.