• Journal of Korean Society of Water and Wastewater
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• v.19 no.1
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• pp.98-105
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• 2005

The effects of chlorination on the elimination of three estrogenic chemicals such as $17{\beta}$-estradiol (E2), nonylphenol (NP) and bis-phenol A (BPA) were investigated using yeast two-hybrid assay (YTA), estrogen receptor competition assay (ER-CA), and high-performance liquid chromatography/mass spectrometer (LC/MS). Results of YTA, ECA and the analysis of LC/MS indicated that the estrogenic activity of above mentioned three endocrine disruptors were significantly reduced as the result of chlorination. The decrease in estrogenic activity paralleled with decrease in estrogenic chemicals under the influence of free chlorine. One common characteristic of estrogenic chemicals is the presence of a phenolic ring. Considering that a phenolic ring is likely to undergo some sort of transformation in aqueous chlorination solution, the above mentioned results may be applied to the rest of the other estrogenic chemicals in natural waters.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 1996.09a
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• pp.89-94
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• 1996

In this paper A methode for design of hybrid-ring couplers having sections of lenth λ/n is proposed. Assuming only one - axis symmitry and isolation of output arms general expressions for the scattering parameters are obtained. The new design method using λ/n sections for 3 dB couplers is derived, . The calculated frequency reponse of the new design has been compared with that of conventional ones, . A new design using λ/5 section and having an overall length 13λ/10 is found to be superior to the 7λ/6 design is expected to have a low insertion loss by virtue of its shorter length.

• Journal of Korea Society of Industrial Information Systems
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• v.20 no.1
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• pp.1-7
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• 2015

In this paper, a 12-bit high resolution, power and area efficiency hybrid digital pulse width modulator (DPWM) with process and temperature (PT) calibration has been proposed for digital controlled DC-DC converters. The hybrid structure of DPWM combines a 6-bit differential tapped delay line ring-mux digital-to-time converter (DTC) schema and a 6-bit counter-comparator DTC schema, resulting in a power and area saving solution. Furthermore, since the 6-bit differential delay line ring oscillator serves as the clock to the high 6-bit counter-comparator DTC, a high frequency clock is eliminated, and the power is significantly saved. In order to have a simple delay cell and flexible delay time controllability, a voltage controlled inverter is adopted to build the deferential delay cell, which allows fine-tuning of the delay time. The PT calibration circuit is composed of process and temperature monitors, two 2-bit flash ADCs and a lookup table. The monitor circuits sense the PT (Process and Temperature) variations, and the flash ADC converts the data into a digital code. The complete circuits design has been verified under different corners of CMOS 0.18um process technology node.

• Journal of Industrial Technology
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• v.26 no.A
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• pp.95-99
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• 2006

In this paper, we proposed the new wavelength tunable filter for wide tunability of fiber ring laser. The proposed filter consists of the cascaded connection of Fiber Reflection Mach-Zehnder Interferometer and Sagnac filter or of hybrid filter and Fiber Reflection Mach-Zehnder Interferometer. The simulation shows that the continuous tunable range of 50nm can be obtained and that more stable single mode operation of ring laser can be expected due to narrow FWHM. of filter spectrum.

• Journal of Satellite, Information and Communications
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• v.11 no.2
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• pp.29-35
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• 2016

High-availability seamless redundancy (HSR) is a fault-tolerant protocol for Ethernet networks that provides two frame copies for each frame sent. Each copy is forwarded on a separate physical path. HSR is a potential candidate for several fault-tolerant Ethernet applications, including smart-grid communications. However, the major drawback of the HSR protocol is that it generates and circulates unnecessary frames within connected rings regardless of the presence of a destination node in the ring. This downside degrades network performance and can deplete network resources. Two simple but efficient approaches have previously been proposed to solve the above problem: quick removing (QR) and port locking (PL). In this paper, we will present a hybrid approach, QRPL, by combining QR with PL, resulting in further traffic reductions. Our analysis showed that network traffic is significantly reduced for a large-sized HSR connected ring network compared to the standard HSR protocol, QR, and PL.

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4079-4083
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• 2012

The mechanism of the cycloaddition reaction between singlet state dichlorosilylene germylidene ($Cl_2Si=Ge:$) and acetone has been investigated with B3LYP/6-$31G^*$ and B3LYP/6-$31G^{**}$ method, from the potential energy profile, we predict that the reaction has one dominant reaction pathway. The presented rule of the reaction is that the two reactants firstly form a Si-heterocyclic four-membered ring germylene through the [2+2] cycloaddition reaction. Because of the 4p unoccupied orbital of Ge atom in the Si-heterocyclic four-membered ring germylene and the ${\pi}$ orbital of acetone forming a ${\pi}{\rightarrow}p$ donor-acceptor bond, the Si-heterocyclic four-membered ring germylene further combines with acetone to form an intermediate. Because the Ge atom in the intermediate hybridizes to an $sp^3$ hybrid orbital after the transition state, then, the intermediate isomerizes to spiro-heterocyclic ring compound involving Si and Ge (P4) via a transition state.

• Journal of Korean Tunnelling and Underground Space Association
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• v.14 no.1
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• pp.55-77
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• 2012

A Modern Rock TBM is a tunnel excavation method combining the conventional tunnelling method with the mechanized tunnelling method. It is a hybrid system that excavates a tunnel with TBM and supports the ground by ring beam, wire mesh, rock bolt, shotcrete, i.e., conventional tunnelling method. In the Modern Rock TBM, a ring beam is similar to a steel rib in NATM in the way that uses H-beam. But using a ring beam is more effective than a steel rib because it is installed in a closed-circle. Therefore, improving the performance of the ring beam is a key factor for achieving tunnel stability. In this respect, this study introduces a pressurized ring beam that might be functioning more effectively by confining convergence during tunnel excavation. In order to verify the effect of the pressurized ring beam, a three-dimensional numerical analysis was conducted. The numerical analysis confirms an increase in the minimum principal stress and reduction in the plastic strain that triggers excessive displacement. The analysis result also indicates a decrease in the relative displacement occurring after installing the ring beam, and expansion in spacing between the ring beams.

• BMB Reports
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• v.35 no.6
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• pp.629-636
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• 2002

Protein kinase CKII (CKII) is required for progression through the cell division cycle. We recently reported that the $\beta$ subunit of protein kinase CKII ($CKII{\beta}$) associates with CKBBP1 that contains the Ring-H2 finger motif in the yeast two-hybrid system. We demonstrate here that the Ring-H2 finger-disrupted mutant of CKBBP1 does not interact with purified $CKII{\beta}$ in vitro, which shows that the Ring-H2 finger motif is critical for direct interaction with $CKII{\beta}$. The CKII holoenzyme is efficiently co-precipitated with the wild-type CKBBP1, but not with the Ring-H2 finger-disrupted CKBBP1, from whole cell extracts when epitope-tagged CKBBP1 is transiently expressed in HeLa cells. Disruption of the Ring-H2 finger motif does not affect the cellular localization of CKBBP1 in HeLa cells. The increased expression of either the wild-type CKBBP1 or Ring-H2 finger-disrupted CKBBP1 does not modulate the protein or the activity levels of CKII in HeLa cells. However, the stable expression of Ring-H2 finger-disrupted CKBBP1 in HeLa cells suppresses cell proliferation and causes the accumulation of the G1/G0 peak of the cell cycle. The Ring-H2 finger motif is required for maximal CKBBP1 phosphorylation by CKII, suggesting that the stable binding of CKBBP1 to CKII is necessary for its efficient phosphorylation. Taken together, these results suggest that the complex formation of $CKII{\beta}$ with CKBBP1 and/or CKII-mediated CKBBP1 phosphorylation is important for the G1/S phase transition of the cell cycle.

• Biomedical Science Letters
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• v.13 no.1
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• pp.1-10
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• 2007

Nebulin, a giant modular protein from muscle, is thought to act as molecular ruler in sarcomere assembly. In skeletal muscle, the C-terminal ${\sim}50 kDa$ region of nebulin extends into the Z-line lattice. The most recent studies implicated highlighting its extensive isoform diversity and exciting reports revealed its expression in cardiac and non-muscle tissues containing brain. Also these novel findings are indicating that nebulin is actually a multifunctional filament system, perhaps playing roles in signal transduction, contractile regulation, and myofibril force generation, as well as other not yet defined functions. However the binding protein of nebulin and function in brain is still unknown. A novel binding partner of nebulin C-terminal region was identified by screening a human brain cDNA library using yeast two-hybrid system. Nebulin C-terminus binding protein 51 (NCBP51) was contained a RING-finger domain and identified a new isoform of RING finger protein 125 (RNF125). The interaction was confirmed using the GST pull-down assay. NCBP51 belongs to a family of the RING finger proteins and its function remains to be identified in brain. The role of nebulin and NCBP51 will be studied by loss-of-function using siRNA technique in brain.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.40 no.9
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• pp.745-751
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• 2012

Hybrid rocket shows interesting characteristics of complicated mixing layers developed by interactions between turbulent oxidizer flow and mass flow from surface due to fuel vaporization. In this study, compressible LES with a ring structure attached at the entrance of the combustor are performed. According to one recent report, adding a ring structure in the middle of the combustor helps increasing regression rate. From the numerical results, it is seen that vortex structures near the wall becomes stronger due to the interaction with surface mass injection, and the local heat flux increases due to the vortices. This phenomenon is obviously related to the generation of dimple structures which are seen in the number of experiments. Also, the ring structure at the entrance induces strong vortex flow which enhances heat transfer to the wall surface and mixing between fuel and oxidizer as well as reaction efficiency.