• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.55-64
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• 1996

mouse chromesome2에 있는 agouti locus는 정상적으로는 털색깔을 조절하는 gene이다. mouse agouti gene은 최근에 cloning 되었고 131 amino acid peptide와 consensus signal peptide를 encode한다고 보고되었다. 이 논문에서 interspecies-DNA hybridization approach를 이용하여 mouse agouti gene의 human homologue를 cloning 하였다. Sequence analysis 결과, 이는 mouse gene에 85% 유사하였고 consensus signal peptide sequence 를 포함하는 132 amino acid를 coding하였다. somatic-cell hybrid mapping pannel과 Fluorescence-in-situ hybridization에 의한 chromosomal mapping을 한 결과, agouti gene은 MODY (maturity onset diabetes of the young), myeloid leukemia locus 등이 위치한 human chromosome 20q 11.2에 mapping 되었다. 성인 tissue로부터 추출한 RNA를 이용한 발현연구에 의하면 human agouti gene은 adipose tissue와 teatis에 발현되었다.

• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.441-448
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• 2003

To investigate the vegetation structure of mountain ridge from Nogodan to Goribong, 22 plots(500$m^2$) set up with random sampling method were surveyed Three groups Quercus mongolica-Fraxinus rhynchophylla community. Quercus mongolica- Pinus densinora community. Quercus mongolica community were classified by cluster analysis. Quercus mongolica was found as it major woody plant species in the ridge area from Nogodan to Goribong. And partly in lower elevation was occupied by deciduous broadleaved tree species and Pinus densiflora. In this area, Korean endemic species, Abies koreana was distributed small amounts. Species diversity(H') of investigated group were ranged 0.9274~1.2845 and it was similar to those of the ridgee area of the national parks in Baekdudaegan.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.3
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• pp.158-166
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• 2019

Objectives: Inferior alveolar nerve block (IANB) is the most frequently used treatment for mandibular molars. Successful IANB requires insertion of the dental needle near the mandibular foramen. In this study, we aimed to analyze the anatomic location of the mandibular lingula and evaluate the effects of internal oblique ridge (IOR)-guided IANB. Materials and Methods: The location of the mandibular lingula was measured using cone-beam computed tomography images of the mandibles obtained from 125 patients. We measured the distances from the occlusal plane to the lingula and from the IOR to the lingula in 250 mandibular rami. Based on the mean of these distances, alternative anesthesia was carried out on 300 patients, and the success rate of the technique was evaluated. Results: The mean vertical distance was $8.85{\pm}2.59mm$, and the mean horizontal distance was $14.68{\pm}1.44mm$. The vertical (P<0.001) and the horizontal (P<0.05) distances showed significant differences between the sex groups. The success rate of the IOR-guided technique was 97.3%. Conclusion: IANB-based location of mandibular lingula showed a high success rate. From this study, we concluded that analysis of the anatomic locations for mandibular lingula and IOR-guided IANB are useful for restorative and surgical dental procedures of the mandibular molars.

• Journal of Korean Dental Science
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• v.14 no.1
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• pp.1-11
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• 2021

Purpose: The alveolar ridge preservation (ARP) is widely conducted for implant placement. However, experimental results using deproteinized porcine bone mineral (DPBM) have been scarce. This retrospective study evaluated factors affecting the primary stability of implants in an area where ARP was performed using DPBM. Materials and Methods: Thirty-eight patients were divided into two groups based on the primary stability, with torque value of 30 Ncm as borderline. To determine the factors that affect the primary stability of implants, we collected data from patients' medical records including age, sex, reentry time, socket location, remaining bone wall at the time of extraction, and type of collagen membrane, as well as from radiographs and histomorphometric analysis. Result: The results showed statistically significant difference for the remaining extraction socket wall (P=0.014), residual graft (P=0.029), and fibrovascular tissue (P=0.02) between the two groups. There was an insignificant tendency toward the time of reentry surgery (P=0.052) and location (P=0.077). All implants placed in sites using DPBM functioned well up to 3 years. Conclusion: Within the limitations of the present study, extraction socket wall, residual graft, and fibrovascular tissue can affect the primary stability at the time of implant placement on grafted sites using DPBM and collagen membranes. In addition, reentry time and locations can be considered. In future studies, comparative experiments in quantified models will be required to supporting the findings.

• The Journal of Advanced Prosthodontics
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• v.13 no.2
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• pp.117-125
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• 2021

PURPSE. The aim of this study was to evaluate the labio-lingual alterations of the alveolar bone where the implant was placed immediately after tooth extraction. MATERIALS AND METHODS. Implants were placed immediately after tooth extraction on anterior alveolar ridges in the maxilla and mandible. The pinguide system was used to help determine the location and path of implants during the surgical process. The horizontal distance from implants to the outer border of alveolar bone was measured at the rim and middle of the implants in the cone beam computed tomography images. The alteration of alveolar bone was evaluated comparing the horizontal distances measured immediately after surgery and 3 months after surgery. RESULTS. The results show that more resorption occurred towards the labial bone than the lingual bone in the maxilla. A similar amount of labial and lingual bone resorption was observed in the mandible. CONCLUSION. Considering the horizontal alteration of alveolar bone, labio-lingual positioning of the implant towards the lingual bone in the maxilla and at the center of the alveolar ridge in the mandible is recommended when it is placed immediately after tooth extraction.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.31 no.3
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• pp.207-215
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• 2009

Purpose: The aim of the present study is to evaluate the long term bone healing after horizontal ridge augmentation using auto block bone graft for implant installation timing. Materials and Methods: Five Beagle dogs(which were 14 months old and weighted approximately 10kg). In surgery 1(extraction & bone defect), premolars(P2, P3,P4) were extracted and the buccal bone plate was removed to create a horizontally defected ridge. After three months healing, in surgery 2(ridge augmentation). Auto block bone grafts from the mandibular ramus were used in filling the bone defects were fixed with stabilizing screws. The following fluorochrome labels were given intravenously to the beagle dogs: oxytetracycline 1week after the surgery, alizarin red 4 weeks after the surgery, calcein blue 8 weeks after the surgery. The tissue samples were obtained from the sacrificed dogs of 1, 4, 8, 12, 16 weeks after the surgery. Non-decalcified sections were prepared by resin embedding and microsection to find thickness of $10{\mu}m$ for the histologic examination and analysis. Results: 1. We could achieve the successful reconstruction of the horizontal bone defect by auto block bone graft. The grafted bone block remained stable morohologically after 16 weeks of the surgery. 2. In the histologic view. We observed osteoid tissue from the sample $4^{th}$ week sample and active capillary reconstruction in the grafted bone from the $12^{th}$ week sample. Healing procedures of auto bone grafts were compared to that of the host bone. 3. Bone mineralization could be detected from the $8^{th}$ week sample. 4. Fluorochrome labeling showed active bony changes and formation at the interface of the host bone and the block graft mainly. Bony activation in the grafted bone could be seen from the $4^{th}$ week samples. Conclusions: Active bone formation and remodeling between the grafted bone and host bone can be seen through the revascularization. After the perfect adhesion to host bone, Timing of successful implant installation can be detected through the ideal ridge formation by horizontal ridge augmentation.

• Journal of Dental Rehabilitation and Applied Science
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• v.34 no.3
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• pp.167-174
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• 2018

Purpose: The purpose of present study was to retrospectively analyze the survival rate of implant placed after alveolar ridge preservation by initial stability and radiographic measurements. Materials and Methods: In total, 19 patients who received 21 sandblasted, large-grit, acid-etched (SLA) implants were enrolled in this retrospective study. Implants placed after alveolar ridge preservation technique (ARP) 2 - 3 months healing period, Periotest value (PTV) measured at implant placement and before placed prosthodontics. Marginal bone level (MBL) was measured at implant placement and final recall check. Results: Overall survival rate of implant was 100%. Mean PTV at implant placement was $-0.06{\pm}8.33$ and mean PTV before placed prosthodontics was $-5.75{\pm}1.7$. The range of MBL change was from -0.55 mm to 1.6 mm (Mean: $0.19{\pm}0.58mm$). Conclusion: The findings of present study suggest that the implant paced after alveolar ridge preservation appear high survival rates and stable MBL.

• The Journal of Korean Academy of Prosthodontics
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• v.30 no.1
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• pp.25-42
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• 1992

The purpose of this study was to analyze the magnitude and distribution of stress using a photoelastic model from a unilateral distal extention removable partial dentures with five kinds of the direct retainers, that is, the bilaterally designed bar clasp of the cross-arch lingual bar and the unilaterally designed bar clasp, circumferential clasp, mini-Dalbo attachment, and telescope retainer. A photoelastic model for mandible was made of the epoxy resin(PL-1) and hardner (PLH-1) with the acrylic resin teeth used and was coated with plastic cement-1 at the lingual surface of the model, and then five kinds of removable partial dentures were set, A unilateral vertical load of about 16Kg was applied on the first molar and the stress pattern of the photoelastic model under each condition was analyzed by the reflective circular polariscope. The following results were obtained: 1. The conventional removable partial denture with the bilaterally cross arch lingual bar produced the most favorable stress distribution on the residual ridge and supporting structure of abutment teeth than the unilaterally designed removable partial dentures. 2. The unilaterally designed removable partial denture with the bar clasp produced the stress distribution on the residual ridge, except sligtly higher stress concentration on the supporting structure of the abutment teeth, similar to the conventional removable partial denture with the bilaterally designed cross arch lingual bar. 3. On the unilaterally designed removable partial dentures, the bar clasp produced greater stress distribution on the residual ridge and supporting structure of the abutment teeth than the circumferential clasp. 4. On the unilaterally designed removable partial dentures, the mimi-Dalbo attachment produced relatively higher stress concentration on the residual ridge, but produced lesser stress concentration on the supporting structure of the abutment teeth than the other direct retainers. 5. On the unilaterally designed removable partial dentures, the telescope retainer produced uniform stress distribution on the residual ridge, but produced higher stress concentration at the root apex of the terminal abutment tooth than the other direct retainers. 6. On the unilaterally designed removable partial dentures the circumferential clasp and telescope retainer produced slightly higher stress concentration on the residual ridge and supporting structure of the abutment teeth than the bar clasp and mini- Dalbo attachment.

• Journal of Dental Rehabilitation and Applied Science
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• v.39 no.4
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• pp.214-221
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• 2023

In order to fabricate stable dentures in patients with severe resorption of residual ridges, various factors must be considered. One of them is the neutral zone, which is defined as the potential region in which the pressure of the tongue outward in the oral cavity and the pressure of the cheeks and lips directed inward from the outside of the oral cavity equalize during functioning. In patients with severe ridge resorption, if the teeth are usually arranged above the residual ridge, the teeth are located on the lingual side rather than the original position. Therefore, the functional space of the tongue is invaded, the tongue is positioned backward, and the sealing of the lingual border is broken, which acts as a factor reducing the maintenance of denture. In addition, it is also important for the stability of dentures to assume an interalveolar crest line connecting the maxillary and mandibular ridge crests, and to arrange the maxillary and mandibular artificial teeth to match the masticatory force to the interalveolar crest line. Therefore, good clinical results were obtained by fabricating dentures for the patient with poor alveolar residual ridge using neutral zone impression and ridge relationship analysis.

• Journal of the Korean Institute of Landscape Architecture
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• v.35 no.1 s.120
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• pp.79-87
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• 2007

The objective of this study was to delineate forest patches in the cities around the Geum-buk mountains at the north of the Geum River using multiplesatellite remote sensing data. Landsat visible and near-infrared satellite images obtained at multiple dates in the growing season were used to create a forest distribution map. Fragstats 3.3 was used to get the landscape indices delineating the distribution of forest patches. Additional ground truth data was used to assess the accuracy of the classification. Factor analysis was used to get the 26 landscape indices clustered into 4 factors. Factor I was labeled as' size of forest patches', factor II as 'fragmentation of forest patches', factor III as 'shape of forest patches', and factor IV as 'complexity of forest patches'. Factor I described large patches and their core area, while others did small patches and their shape and complexity. Cities including Cheonan, Gongju, Cheongyang, and Boryeong near the main ridge of the Geumbuk Mtns. had a small number of large-sized forest patches. However, cities including Taean, Seosan, Dangjin, Hongseong near the ridge of the western Geumbuk Mtns. had a large number of small-sized forest patches. Finally, this study showed that the region near the coast line in Chung-nam province has various types of forest patches having an irregular forest edge due to the elevation and slope lower than the one of the region far from the coast line which is near the ridge of the Geum-buk Mountains. Remote sensing data were useful to understand the distribution of forest patches, and landscape indices could be keys to delineate the relationship between forest patches. And the factor analysis, which simplified 26 landscape indices into 4 landscape patterns allowed us to understand the distribution and relationship of forest patches in an easy way.