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Antinociceptive, anti-inflammatory, and cytotoxic properties of Origanum vulgare essential oil, rich with β-caryophyllene and β-caryophyllene oxide

  • Moghrovyan, Armenuhi;Parseghyan, Lilya;Sevoyan, Gohar;Darbinyan, Anna;Sahakyan, Naira;Gaboyan, Monica;Karabekian, Zaruhi;Voskanyan, Armen
    • The Korean Journal of Pain
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    • v.35 no.2
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    • pp.140-151
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    • 2022
  • Background: Essential oils are of great interest for their analgesic and anti-inflammatory properties. We aimed to study the content of the essential oil of the Origanum vulgare of the Armenian highlands (OVA) in different periods of vegetation and to investigate its antinociceptive and anti-inflammatory effects in mice (in vivo) and cytotoxic action in cultured cells (in vitro). OVA essential oil was extracted from fresh plant material by hydro-distillation. Methods: For OVA essential oil contents determination the gas chromatography-mass spectrometry method was used. Formalin and hot plate tests and analysis of cell viability using the methyl-thiazolyl-tetrazolium (MTT) assay were used. Results: The maximal content of β-caryophyllene and β-caryophyllene oxide in OVA essential oil was revealed in the period of blossoming (8.18% and 13.36%, correspondently). In the formalin test, 4% OVA essential oil solution (3.5 mg/mouse) exerts significant antinociceptive and anti-inflammatory effects (P = 0.003). MTT assay shows approximately 60% cytotoxicity in HeLa and Vero cells for 2.0 µL/mL OVA essential oil in media. Conclusions: The wild oregano herb of Armenian highlands, harvested in the blossoming period, may be considered as a valuable source for developing pain-relieving preparations.

Deep Learning based Domain Adaptation: A Survey (딥러닝 기반의 도메인 적응 기술: 서베이)

  • Na, Jaemin;Hwang, Wonjun
    • Journal of Broadcast Engineering
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    • v.27 no.4
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    • pp.511-518
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    • 2022
  • Supervised learning based on deep learning has made a leap forward in various application fields. However, many supervised learning methods work under the common assumption that training and test data are extracted from the same distribution. If it deviates from this constraint, the deep learning network trained in the training domain is highly likely to deteriorate rapidly in the test domain due to the distribution difference between domains. Domain adaptation is a methodology of transfer learning that trains a deep learning network to make successful inferences in a label-poor test domain (i.e., target domain) based on learned knowledge of a labeled-rich training domain (i.e., source domain). In particular, the unsupervised domain adaptation technique deals with the domain adaptation problem by assuming that only image data without labels in the target domain can be accessed. In this paper, we explore the unsupervised domain adaptation techniques.

Yeast Extract: Characteristics, Production, Applications and Future Perspectives

  • Zekun Tao;Haibo Yuan;Meng Liu;Qian Liu;Siyi Zhang;Hongling Liu;Yi Jiang;Di Huang;Tengfei Wang
    • Journal of Microbiology and Biotechnology
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    • v.33 no.2
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    • pp.151-166
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    • 2023
  • Yeast extract is a product prepared mainly from waste brewer's yeast, which is rich in nucleotides, proteins, amino acids, sugars and a variety of trace elements, and has the advantages of low production cost and abundant supply of raw material. Consequently, yeast extracts are widely used in various fields as animal feed additives, food flavoring agents and additives, cosmetic supplements, and microbial fermentation media; however, their full potential has not yet been realized. To improve understanding of current research knowledge, this review summarizes the ingredients, production technology, and applications of yeast extracts, and discusses the relationship between their properties and applications. Developmental trends and future prospects of yeast extract are also previewed, with the aim of providing a theoretical basis for the development and expansion of future applications.

Anatomy of Sentiment Analysis of Tweets Using Machine Learning Approach

  • Misbah Iram;Saif Ur Rehman;Shafaq Shahid;Sayeda Ambreen Mehmood
    • International Journal of Computer Science & Network Security
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    • v.23 no.10
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    • pp.97-106
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    • 2023
  • Sentiment analysis using social network platforms such as Twitter has achieved tremendous results. Twitter is an online social networking site that contains a rich amount of data. The platform is known as an information channel corresponding to different sites and categories. Tweets are most often publicly accessible with very few limitations and security options available. Twitter also has powerful tools to enhance the utility of Twitter and a powerful search system to make publicly accessible the recently posted tweets by keyword. As popular social media, Twitter has the potential for interconnectivity of information, reviews, updates, and all of which is important to engage the targeted population. In this work, numerous methods that perform a classification of tweet sentiment in Twitter is discussed. There has been a lot of work in the field of sentiment analysis of Twitter data. This study provides a comprehensive analysis of the most standard and widely applicable techniques for opinion mining that are based on machine learning and lexicon-based along with their metrics. The proposed work is helpful to analyze the information in the tweets where opinions are highly unstructured, heterogeneous, and polarized positive, negative or neutral. In order to validate the performance of the proposed framework, an extensive series of experiments has been performed on the real world twitter dataset that alter to show the effectiveness of the proposed framework. This research effort also highlighted the recent challenges in the field of sentiment analysis along with the future scope of the proposed work.

From Ambient to Interactive: Human-Digital Art Interaction on Public Display Based on the Spatial Relationship (공공디스플레이에서 공간적 상관관계를 고려한 인간과 디지털 아트의 상호작용)

  • An, Mi-Hye;Wohn, Kwang-Yun
    • 한국HCI학회:학술대회논문집
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    • 2009.02a
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    • pp.1069-1074
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    • 2009
  • Public displays are evolving from a one-way display to an interactive medium which contains dynamic transition of various media. This study focuses on the interaction between human and digital technology-based art on public display from a HCI point of view, while several viewpoints exist on interactive public displays. We present a new interaction model which suggests different interactions depending on the viewer's distance and direction so that public display could offer rich media experiences. We have also and built an installation art to examine the efficacy of our interaction model. As such, we introduced two methodologies from HCI to derive our final interaction model. First of all, we analyze previous distance-dependent interaction models for public display in terms of context analytic approach, and propose an effective model for human-digital art interaction. Second, we introduce the concept of aura in HCI as user analytic approach to redefine interaction depending on the viewer's direction of attention. Thus, this study aims to suggest a new interaction model based on the previous two analyses to improve interaction between human and digital technology-based art on public display.

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Distribution and Characteristics of Acidotolerant Heterotrophic and Naphthalene­Degrading Bacteria in Acidic Soils (산성토양에서 내산성 종속영양세균과 나프탈렌분해세균의 분포 및 특성)

  • Moon Yong-Suk;Chu Kwang-Il;Kim Jongseol
    • Korean Journal of Microbiology
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    • v.40 no.4
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    • pp.313-319
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    • 2004
  • The distribution and characteristics of acidotolerant heterotrophic and naphthalene-degrading bacteria were investigated in two forest areas, one near Ulsan petrochemical industrial complex (Sunam) and the other in countryside (Daeam). Average values of soil pH at Sunam and Daeam were 3.8 and 4.6, respectively. When het­erotrophic and naphthalene-degrading bacteria were enumerated by most probable number (MPN) procedures at Sunam, the median values of heterotrophs growing at pH 7.0 and pH 4.0 were $5.3{\times}10^7\;and\;3.3{times}10^7$ MPN/g, whereas those of naphthalene-degraders were $5.6{\times}10^4\;and\;4.0{times}10^5$ MPN/g, respectively. While the medians of heterotrophs at Daeam were larger than those at Sunam, the concentrations of naphthalene-degraders were higher at Sunam compared to those at Daeam. From the MPN tubes and enrichment cultures, we obtained 17 isolates of naphthalene-degraders which were identified as Sphingomonas paucimobilis, Brevundimonas vesic­ularis, Burkholderia cepacia, Ralstonia pickettii, Pseudomanas fluorescens, and Chryseomonas luteola. Among them, 6 isolates showed higher naphthalene-degrading activity on minimal media of pH 4 compared to pH 7, whereas the extent of growth was not greater at pH 4 than at pH 7 when they were inoculated on nutrient-rich media. It is plausible that the pH may affect naphthalene-degrading activity of the isolates by changing fatty acid composition of bacterial membrane.

Internet Service Paradigm Shift Driven by Emergence of Open Social Networking Service: Focusing on Facebook (개방형 소셜 네트워킹 서비스 플랫폼 출현에 따른 인터넷 서비스 시장의 패러다임 변화 : Facebook을 중심으로)

  • Yoon, Young-Seog;Choi, Mun-Kee;Kim, Sang-Kwon;Lee, Hyun-Jin;Cho, Kee-Sung
    • Journal of Service Research and Studies
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    • v.1 no.1
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    • pp.29-48
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    • 2011
  • Recently not only industry but also academy have shown an intense interest in social networking service. However, reckless imitation will not guarantee the successful eco-system of social networking service without rich understanding of growth driver and business model. Hence, this study aims at analyzing open platform strategy and business model conducted by a representative social networking service provider in order to provide platform operator, network operator, and portal provider with meaningful implications. Advertisers may pay great attention to social networking service because it has strong ability to provide users with spontaneous motivation to manage and update their profile, and these valuable information can be utilized for providing personalized advertisement on social networking service. As a result, one side of consumers in two side market, advertisers, tend to pay more expenditure to place advertisements. In addition, the open platform adopted by social networking service providers causes pro-sumers to participate in the eco-system, and thereby the explosive quantitative growth is realized. The fact of that this open social networking service can invade other web service area via an unified platform indicates that it may expand its service scope into a wide variety of web service areas. Hence, domestic portal services providers and network providers should consider social networking service not as one of new web services but as an disruptive service platform. Corresponding to the emergence of social networking service, especially if their business area is related to display advertising market, they should seek a way to provide social networking service access users's newly updated information and develop innovative media technologies to enter context awareness ads market.

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An Analysis of the Infographics Features of Visualization Materials in Section 'Information and Communication' of Physics I Textbook (물리 I 교과서의 '정보와 통신' 단원에 제시된 시각화 자료의 인포그래픽 특징 분석)

  • Noh, Sang Mi;Son, Jeongwoo
    • Journal of The Korean Association For Science Education
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    • v.34 no.4
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    • pp.359-366
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    • 2014
  • In this study, we try to examine its features by using the methods of systematic infographics analysis for visualization materials that are used in Physics I textbooks. Thus, after developing the analytical framework infographics, visualization materials is described in the section "information and communication" and have been analyzed separately as "data visualization" and "Infographics." The results of this study are as follows. First, the analysis framework of infographics can be classified contents of the information, visual representation, and media method. Second, the visualization materials that are displayed in the section "information and communication" of Physics I textbook are of higher quality than most schematized data that are graphically, simple information. Third, the features of visualization materials in textbooks have many relations & functions on 'information content', text & metaphor on 'visual element', illustration & comparison on 'expression type', graphic on 'expression mode', printed matter on 'media method', and horizontal & vertical type on 'the flow of attention'. From the analysis results, in the section "information and communication" of Physics I textbook uses a lot of visualization materials, however it does not provide rich infographics but only simple graphical materials. By utilizing the results of the analysis of textbook and analysis framework of infographics, which has been developed through the this study, let us hope that the opportunity to be able to grasp the importance of infographics in science education be provided.

Effect of Deep Seawater on Expression of μ-Opioid Receptor in Cultured Rat Hippocampal Neurons (배양된 쥐 해마신경세포에서 μ-아편양 수용체의 발현에 대한 해양심층수의 영향)

  • Moon, Il-Soo;Kim, Seong-Ho
    • Journal of Life Science
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    • v.21 no.2
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    • pp.176-182
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    • 2011
  • Deep seawater (DSW) generally refers to seawater at depths equal to or greater than 200 meters. DSW is rich in inorganic materials which have attracted attention for its various applications. In this study we investigated the effects of the DSW upwelled from the East Sea, offshore Yang Yang (KangWon-do, Korea), on the expression of ${\mu}$-opioid receptor (MOR) of cultured rat hippocampal neurons. Neurons were grown in a minimal essential medium containing 10% (v/v) fetal bovine serum and either 25% (v/v) distilled water, or hardness (H) 800, or H 1000 DSW. Cultures grown in the presence of DSW with H 800 and H 1000 exhibited robust MOR immunoreactive signals in both neurons and astrocytes. Interestingly, the increase in MOR immunoreactive signals was more dramatic in astrocytes than in neurons. Statistical analysis revealed that the relative intensities for MOR clusters increased approximately 4-fold in astrocytes cultured in H 800 and H 1000 media. These increases were statistically very significant (p<0.001). In contrast, the increase in intensities for MOR immunoreactive signals was relatively less dramatic in neurons, where only the increase in the H 1000 culture was statistically very significant (p<0.001). These results indicated that DSW promotes expression of MOR in both neurons and astrocytes, and more significantly in the latter.

Classification of Representative Emotions to Measure Emotions Expressed by Traditional Korean-style house (한국 전통가옥에서 느껴지는 감성 측정을 위한 대표 감성 분류)

  • Park, Eun Jung;Seo, Jong Hwan;Jeong, Sang Hoon
    • Smart Media Journal
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    • v.7 no.3
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    • pp.43-50
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    • 2018
  • Hanok (a traditional Korean-style house) has recently become a popular attraction for tourists all over the world. Jeonju Hanok Village, for example, attracted about 10 million visitors for 2 consecutive years. Observing Hanok's popularity, many local governments drew up plans to improve tourism dynamics by strengthening the advantages of Hanok. Emotionally rich experience is required to offer a greater satisfying experience that meets the demands of tourists. However, very few studies yet have addressed how to measure those emotions felt by users while experiencing Hanok. As an attempt to improve this situation, 182 emotional words were collected from earlier studies and classified into 33 groups with the Delphi method. Among the emotional words in each of the 33 groups, those of overlapping concepts on the characteristics of Hanok were re-grouped, and extracted the most appropriate 68 words. Additionally, a survey was conducted with 325 people who had experienced Hanok to gather 30-most representative emotions for measuring emotions felt from Hanok. The factor analysis of the 30 representative emotions resulted in classified 6 factors based on common features of emotional words: senses of aesthetics, happiness, novelty, ownership, balance and relaxation. The 30 representative emotions and six emotion categories found out by this study can help measure how much people feel certain emotions while experiencing hanoks. Further study will explore the degree of emotions hanok users feel about objects of hanok, such as roof materials and shapes, and body shapes.