• IMMUNE NETWORK
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• v.8 no.1
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• pp.13-20
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• 2008

Background: Coptis chinensis rhizome has been used as a medicinal herb in traditional Oriental medicine. We investigated the effects of Coptis chinensis extract on inflammatory mediators and delayed type hypersensitivity in mice. Methods: The inhibitory effect of ethanolic extract of Coptis chinensis (CCE) on cell proliferation was evaluated using MTS assay. The lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the Con A-activated mouse splenocytes were cultured with various concentrations of CCE. Total nitric oxide (NO) production was determined by Griess reaction. The amounts of secreted prostaglandine E2 ($PGE_2$), interleukin (IL)-2 and IFN-${\gamma}$ were measured by ELISA. To investigate the in vivo anti-inflammatory effect of CCE, oxazolone-induced delayed type hypersensitivity (DTH) model was used. Results: The CCE at $100{\mu}g/ml$ significantly blocked the LPS-induced production of pro-inflammatory mediators (NO and PGE) in RAW264.7 macrophages. Also, it significantly inhibited cell proliferation and cytokine (IL-2 and IFN-${\gamma}$) production in splenocytes. Furthermore, when splenocytes from CCE fed mice (200 mg/kg for 2 weeks) were activated with Con A, cell proliferation and cytokine production were significantly inhibited. In addition, CCE decreased in vivo inflammation in oxazolone-induced DTH model mice. Conclusion: We suggest that Coptis chinensis can be used as an anti-inflammatory drug by exerting an inhibitory effect in inflammatory mediator- and cell-mediated inflammation.

• Korean Journal of Childcare and Education
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• v.11 no.1
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• pp.435-459
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• 2015

It is generally agreed that the 21st century is the era of postmodernism. Postmodernism emerged with opposition and resistance to modernism which pursued values like the absoluteness of truth and knowledge, the Enlightenment, rationalism, objectivism and consequentialism among others. Now postmodernism is currently given a great deal of attention as it is considered a new ideology that can help explain many of the different and continuous changes which are occurring in a variety of fields including politics, economy, society and culture, not to mention education. In this sense, this study's purpose is to examine postmodern aspects found specifically in the field of early childhood education. As a result, this study found that those aspects could be briefly described by four main phrases, or 'early childhood education whose contexts are based on relativity', 'early childhood education operating under the system of rhizome' 'early education in which inter-directionality is pursued' and 'early education in which process-orientation is being intensified'. In the chapter of conclusion, finally, this study discusses how those aspects are correlated with one another and what implications they may have for the field of early childhood education.

• Journal of Wetlands Research
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• v.17 no.1
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• pp.19-25
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• 2015

The purpose of this study is to reveal the effect of plant life cycle to plant settlement by 1 year monitoring. The subjects of monitoring are the plants (3 plant life cycle, 9 taxa) well established in the mesocosm. 18 mesocosms were divided into 3 sets and water levels were maintained at 0, 20 and 60 cm during 16 weeks from mid-May, respectively and at 0 cm except these 16 weeks. Height and population size of transplanted perennial plants (Scirpus tabernaemontani, Zizania caduciflora, Typha (Typha angustifolia and Typha orientalis)) at 1st year were not affected by diverse water level, though any more seedlings of these species were not settled at this condition. In contrast, water level condition strong influenced annual and biennial plant, relatively. As a result, timing and duration of flooding have great effect on successful settlement of annual and biennial plant without rhizome.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.17-29
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• 2009

Objectives: The present study is focused on the inhibitory effect of the rhizome hexane fraction extract of Zingiberis Rhizoma Crudus (ginger hexan extract; GHE) on the production of inflammatory mediators such as NO, $PGE_2$, and proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated BV2 cells, a mouse microglial cell line. Methods: We separated the hexane fraction from Zingiberis Rhizoma Crudus's methanol extract. The inhibitory and anti-inflammatory effect of GHE was examined on microglial activation. Results: GHE significantly inhibited the excessive production of NO, $PGE_2$, TNF-${\alpha}$, and IL-1${\beta}$ in LPS-stimulated BV2 cells. In addition, GHE attenuated the mRNA expressions and protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines. Conclusion: The anti-inflammatory properties of GHE may make it useful as a therapeutic candidate for the treatment of human neurodegenerative diseases.

• Korean Journal of Plant Resources
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• v.14 no.2
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• pp.152-156
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• 2001

This study was conducted to investigate the flower organ removal effect on Atractylodes macrocephala Koidz which was introduced from China. The results were summarized as follows; The plant height of Flower Organ Cutting(F.O.N.C.) treatment short by 1.7∼2.5 cm compared to Flower Organ Non-Cutting(F.O.N.C.) treatment. But number of stem and stem diameter of F.0.C treatment were similar to that of F.O.N.C. treatment. The fresh weight of above-ground part of F.O.N.C. treatment was decreased 48∼60% compare to F.O.C. treatments. The later was period of F.O.C., the higher was fresh weight of above-ground part. The growth of underground part was more F.O.C. at July 15 and Aug. 20 treatments than F.O.N.D treatment. The dry rhizome yield of F.O.C. at July 15 treatment was increased 40% compare to F.O.N.D treatment. Essential oil content of F.O.C. at July 15 treatment was increased 12% compare to F.O.N.D treatment.

• Korean Journal of Medicinal Crop Science
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• v.10 no.5
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• pp.415-418
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• 2002

Ligusticum chuanxiong Hort. is one of the most important root-using medicinal crops in Korea. A new variety 'Sinto' (Suwon 2) was developed from the population of Muju local through phenotyptic restricted mass selection at National Crop Experiment Station, RDA. in 2001. The average yield of this variety was about 2,260 kg/ha in RYT at three location from 1999 to 2001 which were about 20% higher than that of Pyeongchang local. Sinto showed a strong resistance to powdery mildew. This variety may be well adaptable to mountainous mid-southern areas in Korean peninsula.

• Korean Journal of Medicinal Crop Science
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• v.14 no.3
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• pp.183-187
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• 2006

This study carried out to analize quality in the evaluation based on the grades such as raw ginseng and red ginseng between Korean (Panax ginseng C. A. Meyer) and American ginseng (Panax quinquefolium L). American ginseng was small in root length, root diameter and root weight and emergence many secondary root from rhizome and main root. Therefore body form was bad compared with Korean ginseng. As for yield of dry, Korean ginseng was 30.4 % and American ginseng was 33.8% but as for yield, Korean ginseng was 80.4% and American ginseng was 72.2%. There were as many Korean ginseng in raw ginseng first grade by about twice compared with American ginseng. However there were many American ginseng in second grade. On the other hand, Korean ginseng producted high Chunsam compared with American ginseng. The cause of decreasing quality was inside cavity and inside white in Korean and American ginseng. Especially, the inside white occurrence about 3 times compared with inside cavity in American ginseng. In the case of distribution of weight size, Korean ginseng was much above 20Ji but American ginseng was much under 20Ji.

• The Korean Journal of Ecology
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• v.12 no.3
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• pp.171-182
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• 1989

The structure, clonal grwoth, shoot modules dynamics and rhizome respiratory rate of the Phragmites longivalvis circular patch were studied in a 15-year-old reclaimed land on Mado of the western Korea for two growing seasons. Clonal growth by P. longivalvis resulted in subpopulations of shoot modules which may be separated into pioneer, mature and senile growth phase. The radial growth of circular patch was 208 cm per a year. The shoot phytomass, shoot height and spike frequency were the lowest in the senile phase, and were the highest in the mature phase. The maximum shoot phytomass of pioneer, mature and senile phase in August was 347, 536 and 195g/$\m^2$ for the first year, and 609, 748 and 248g/$\m^2$ for the second year, respectively. The birth rates of shoot modules were the highest during the early spring. Of all modules, the percemtage of spring cohort of pioneer, mature and senile growth phase were 52, 82 and 70% for the first year, and 83, 88 and 85% for the second year, respectively. The flowering shoots were only derived from spring cohorts. The death rates of shoot modules of the pioneer and mature phase were the highest in October. The module is an annual semelparous plant though the genet is a perennial iteroparous plant. Their survivorship curve was negatively (Deevey type I). The density of shoot modules of the pioneer, mature and senile growth phase increased as much as 4.0, 1.6 and 2.3 times for one year, respectively. The respiratory rate was the highest in the lowest in the senile growth phase.

• Journal of Society of Preventive Korean Medicine
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• v.20 no.3
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• pp.75-82
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• 2016

Objectives : The aim of this study is to analyze medicinal herbs, the ingredients of traditional Korean Tea, focusing on efficacy in the traditional Korean medicine. Through this study, for vitalizing traditional Korean Tea market, the researchers attempt to explain the superiority of traditional Korean Tea. And it will be used basis data on further traditional Korean Tea. Methods : We conducted a research targeting traditional Korean Tea in domestic market from June through December 2014, and finally 205 kinds of Tea were selected and analyzed. Results : 48 kinds of medicinal herbs were used alone as ingredients in the traditional Korean Tea containing just one medicinal Herb. and 87 kinds of medicinal herbs were used as ingredients in the traditional Korean Tea containing more than two kinds medicinal Herbs. In the classification of the medicinal Herbs by part for use, roots and rhizome is most used. In the classification of efficacy of medicinal herbs, tonifying and replenishing medicinal herbs are most popular as ingredients in the traditional Korean Tea. Conclusions : Medicinal herbs have been widely used in the traditional Korean Tea. Tea consumers concern about not only the efficacy but also the taste, scent and color. Therefore, further study about these things would be required to demonstrate the superiority of the traditional Korean Tea.

• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.438-445
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• 2016

Cyperi Rhizoma (CR), the rhizome of Cyperus rotundus L., exhibits neuroprotective effects in in vitro and in vivo models of neuronal diseases. Nevertheless, no study has aimed at finding the neuroactive constituent(s) of CR. In this study, we identified active compounds in a CR extract (CRE) using bioactivity-guided fractionation. We first compared the anti-oxidative and neuroprotective activities of four fractions and the CRE total extract. Only the ethyl acetate (EA) fraction revealed strong activity, and further isolation from the bioactive EA fraction yielded nine constituents: scirpusin A (1), scirpusin B (2), luteolin (3), 6'-acetyl-3,6-diferuloylsucrose (4), 4',6' diacetyl-3,6-diferuloylsucrose (5), p-coumaric acid (6), ferulic acid (7), pinellic acid (8), and fulgidic acid (9). The activities of constituents 1-9 were assessed in terms of anti-oxidative, neuroprotective, anti-inflammatory, and anti-amyloid-${\beta}$ activities. Constituents 1, 2, and 3 exhibited strong activities; constituents 1 and 2 were characterized for the first time in this study. These results provide evidence for the value of CRE as a source of multi-functional neuroprotectants, and constituents 1 and 2 may represent new candidates for further development in therapeutic use against neurodegenerative diseases.