• 한국자원식물학회지
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• 제27권1호
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• pp.95-101
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• 2014

본 연구는 고사리삼과에 속하는 제주고사리삼 잎의 생장 패턴 및 식물계절학적 특성을 파악하기 위하여 실시하였다. 제주고사리삼은 지하경을 이용하여 무성번식 하는 종으로서 한 클론의 길이는 52 cm까지 자랐으며, 뿌리가 생장하는 동안 새로운 근경과 잎이 형성되었다. 제주고사리삼 잎은 7월에 출현하기 시작하였으며, 생장은 기온이 높고 강수량이 많은 7월 ~ 9월 동안에 활발하게 이루어졌다. 잎은 10월까지 생장을 마치고 이후 성숙된 포자낭에서 포자가 방출되기 시작하였으며, 11월부터 잎의 노화가 시작되어 이듬해 2월이 되면 대부분의 포자엽과 영양엽이 노화되고 4월 이후에는 잎 전체가 시들어 없어졌다. 이와 같이 제주고사리삼 잎의 생육기간은 7월에서부터 이듬해 4월까지 10개월이었으며, 노화의 시기는 자생지 마다 다소 차이를 나타냈다. 이는 자생지의 미세 환경의 차이에 의한 것으로 생각되며 이에 대한 연구가 진행되어야 할 것으로 판단된다.

• Molecules and Cells
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• 제41권5호
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• pp.476-485
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• 2018

Although tectorigenin (TG), a major compound in the rhizome of Belamcanda chinensis, is conventionally used for the treatment of inflammatory diseases, its effects on osteogenesis and osteoclastogenesis have not been reported. The objective of this study was to investigate the effects and possible underlying mechanism of TG on in vitro osteoblastic differentiation and in vivo bone formation, as well as in vitro osteoclast differentiation and in vivo bone resorption. TG promoted the osteogenic differentiation of primary osteoblasts and periodontal ligament cells. Moreover, TG upregulated the expression of the BMP2, BMP4, and Smad-4 genes, and enhanced the expression of Runx2 and Osterix. In vivo studies involving mouse calvarial bone defects with ${\mu}CT$ and histologic analysis revealed that TG significantly increased new bone formation. Furthermore, TG treatment inhibited osteoclast differentiation and the mRNA levels of osteoclast markers. In vivo studies of mice demonstrated that TG caused the marked attenuation of bone resorption. These results collectively demonstrated that TG stimulated osteogenic differentiation in vitro, increased in vivo bone regeneration, inhibited osteoclast differentiation in vitro, and suppressed inflammatory bone loss in vivo. These novel findings suggest that TG may be useful for bone regeneration and treatment of bone diseases.

• 한국약용작물학회지
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• 제15권6호
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• pp.417-428
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• 2007

국내 유통 중인 한약재 대부분을 수입에 의존하고 있으나, 관리시설이 빈약하여 해충들에게 쉽게 노출될 수 있는 환경에 놓여 있다. 이 연구는 총 67과 134속 158종의 저장 한약재들을 대상으로 이들에서 발생하고 있는 저장물해충들을 조사하였다. 그 결과, Cassia 속의 육계, Juniperus 속의 자단향 그리고 Artemisia 속 애엽을 비롯한 44종의 한약재들에서는 곤충의 발생을 확인할 수 없었다. 한약재들에서 나타난 해충들의 발생빈도는 쌀머리대장 (A. advena) 12.3%, 권연벌레 (L. serricorne) 11.5%, 머리대장가는납작벌레 (O. surinamensis) 10.3%, 거짓쌀도둑거저리 (T. castaneum) 9.4%, 인삼벌레 (S. paniceum) 8.4% 그리고 화랑곡나방 (P. interpunctella) 7.9% 순이었다. 또한 이들 곤충들은 저장 중인 한약재들 중에서도 뿌리 또는 뿌리줄기 형태의 한약재들을 가장 선호한 것으로 보였다. 이 연구는 천연물 연구자들에게 곤충들이 발생하지 않았던 한약재들에 대한 기본 정보를 제공해줌으로써 향후 이들이 살충활성 또는 훈증활성물질을 탐색하는데 있어 이들 한약재들을 우선적으로 검토할 수 있는 유용한 자료로서 활용될 수 있을 것이다.

• 한국약용작물학회지
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• 제19권4호
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• pp.217-226
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• 2011

The study was conducted to investigate candidate materials as anti-inflammation agent from plant resources. Activities of 33 plant parts extracts with the final concentration of 5${\mu}g/ml$ were evaluated on the several inflammation-related markers such as the release of proinflammatoty cytokine [tumor necrosis factor-alpha (TNF-${\alpha}$) & interleukin-6 (IL-6)], nitric oxide (NO), the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and inhibitor of nuclear factor kappa-B alpha ($I{\kappa}-B{\alpha}$) in lipopolysaccharide (LPS)-treated RAW 264.7 cells. The extracts in the final concentration of 10 ${\mu}g/ml$ were also screened on peroxynitrite (ONOO$^-$) scavenging activity. Eleven extracts selected from the screening assay were verified on the inhibition activity on peroxynitrite and total reactive species oxygen (ROS) in the several concentrations. As results, Alpinia officinarum Hance (rhizome), Inula britannica var. chinensis Regel (flower), Ulmus arvifolia Jacq (trunk peel) and Aster scaber Thunb. (aerial part) showed comparatively potent anti-inflammatory activities in vitro cells or chemical level systems, and then these four plant parts should be studied on the antiinflammatory mechanism by further studies.

• 분석과학
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• 제11권1호
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• pp.54-61
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• 1998

토천궁과 일천궁이 한방이나 가공시 기초 자료로 활용될 수 있도록 기본적인 화학 성분을 분석하였다. 일반성분은 토천궁이 조단백 함량이 높았으며, 무기질은 일천궁이 토천궁에 비해 칼륨과 나트륨이 높은 반면, 그외는 토천궁이 전체척으로 높았다. 유리당 조성은 sucrose만 검출되었고, fructose와 glucose는 검출되지 않았다. 지방산 조성은 linoleic acid, oleic acid, palmitic acid, linolenic acid 순으로 구성되었고, 토천궁과 일천궁의 주요 구성아미노산은 글루탐산, 아르기닌, 아스파르트산, 발린 순으로, 대부분 필수아미노산도 고루 분포되어 있었다.

• 한국약용작물학회지
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• 제25권4호
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• pp.217-223
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• 2017

Background: In Korea, 6-year-old ginseng root is economically more important than 4 or 5-year-old roots. In general, the root age is determined by counting the number of stem vestiges. However, this method does not accurately estimate ginseng root age. Methods and Results: In this study, the stem vestige counting method was used to survey a total of 18,395 fresh ginsengs cultured in 2014, and 2015, to determine the accuracy of this method. The proportion of 6-year-old roots, with more than four stem vestiges, was 46.1% in 2014. For the cultivar Chunpoong cultivated in Eumseong and Goesan countries in 2015, the proportion of more than four stem vestiges was 55.9%, and 43.5%, respectively. The proportion of more than four stem vestiges for the Gumpoong cultivated in Eumseong and Yangpyeong countries was 67.0%, and 35.1%, respectively, whereas that for the cultivar Yunpoong was 36.0% and 61.0%, respectively. Moreover, it was confirmed that differences in the levels of Rg1 will enable root age determination. Conclusions: Root age determination by the stem vestige test was found to differ depending on the environmental and cultivation conditions. To determine the age of ginseng roots, a comprehensive method, such as counting stem vestiges and evaluating differences in ginsenoside levels, should be applied.

• 대한한방내과학회지
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• 제3권1호
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• pp.23-32
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• 1986

As a result of administration of Coptidis Rhizoma extract and Zingiberis Rhizoma extract to Rat and Rabbit, its effect to the Gastric Juice Volume, Acidity, Pepsin out put of Rat and the movement of Intestine, Pulse Rate of Rabbit was as follows; 1. In the secretion of Gastric Juice, the Juice Volume in Coptidis Rhizoma administered group in contrast to Control Group, has increased in 30mg the increasing rate 21.4%, and has decreased in 300mg the decreasing rate 113.9%. But the Juice Volume in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60, 120mg, and has remarkably decreased in 60mg the decreasing rate 62.9%. 2. The Gastric Acidity in Coptidis Rhizome administered group, in contrast to Control Group, has increased in 30, and 75mg, but no significant value, and has decreased in 300mg the decreasing rate 104.7%. But the Gastric Acidity in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60 120mg, and has remarkably decreased in 60mg the decreasing rate 105.6%. 3. The Pepsin out-put in Coptids Rhizoma administered group, in contrast to Control group, has increased in 30mg the increasing rate 30.3%, and has decreased in 150, 300mg, no significant value. But the Pepsin out-put in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60, 120mg, and has remarkably decreased in 60mg the decreasing rate 86.4%. 4. In the movement of Intestine, the contraction Coptidis Rhizoma administered group, in contrast before the administration, has increased in 12mg, but has begun to decrease in 30mg, and has remarkably decreased in 70mg. The contraction in Zingiberis Rhizoma administered group, in contrast before the administration, has all increased in 30, 60, 120mg. 5. In Pulse Rate, the pulsation, in contrast to Control group after 60, 120 180, 240min. has decreased in Coptidis Rhizoma administered group, and has increased in Zingiberis Rhizoma administered group, but no significant value.

• 대한한방내과학회지
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• 제27권3호
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• pp.677-687
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• 2006

Objective : Hypothyroidism is a common disease of the endocrinal system. characterized by fatigue, cold intolerance, bradycardia, and so on. Clinically, Levothyroxine(L-T4) has been usually used for replacement therapy, but it often has side effects. so many hypothyroidism patients wants oriental medical therapy. Zingiberis rhizoma, traditionally has been used in treatment of coldness, fatigue, and bradycardia. In this study. I investigated the therapeutic effects of Zingiberis rhizoma on PTU induced hypothyroidism in rats. Methods : I used two-month-old rats administered PTU and induced with hypothyroidism. After 2 weeks. Zingiberis rhizoma and thyroxine were daily administered, respectively. Body weights was measured every weeks. After 4 weeks, blood samples were taken and analyzed biochemically and T4 and TSH were measured by ELISA kits. Results : In comparison with normal groups, control groups showed hypothyroidism with low T4 and high TSH level. In Zingibris rhizoma administration groups were observed T4 level elevation, this elevation was dependent on the dose of Zingibris rhizoma. Between experimental groups and control groups, there was no difference in TSH level, statistically. Changes of biochemistry were not observed in any experimental groups. Conclusions : These findings suggest that Zingiberis rhizoma makes thyroid cells producing thyroid hormones. There is also a non-toxic effect on the cardiovascular system, liver and kidney function. So, Zingiberis rhizoma should be an effective agents for treating hypothyroidism.

• Biomolecules & Therapeutics
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• 제17권2호
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• pp.211-216
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• 2009

To understand the relationship between the metabolism of wogonoside from the rhizome of Scutellaria baicalensis, and its anti-pruritic effect, we anaerobically incubated it with human fecal microflora, identified its metabolite identified, and investigated its anti-pruritic effect in compound 48/80 or histamineinduced pruritic mice. Wogonoside was metabolized to wogonin, with metabolic activity of $6.9{\pm}5.1\;nmol/h/mg$ wet weight of fecal microflora. Orally administered wogonoside had more potent anti-scratching behavioral effect in compound 48/80 or histamine-treated mice than intraperitoneally treated one, apart from orally administered its metabolite, wogonin, which was more potent than the orally administered one. Wogonoside showed more potent anti-pruritic effects when administered at 5 h prior to the pruritic agent treatment than when administered at 1 h before. However, wogonin orally administered 1 h before the treatment with pruritic agents showed a more potent anti-pruritic effect than when treated at 5 h before. Orally administered wogonoside may be metabolized to wogonin in the intestine and its anti-scratching behavioral effect may be dependent on its metabolism by intestinal microflora.

• 한국산학기술학회논문지
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• 제13권8호
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• pp.3698-3703
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• 2012

건축설계과정은 프로그래밍 단계와 디자인 단계로 구분된다. 현대물리학 개념에 기초한 현대건축이론은 자료를 통합하는 디자인 단계에 적용되어 설계된다. 건축장 또한 디자인 단계에서 진행된다. 건축장은 건축장 특성으로 일체성, 상호성, 영역성을 구현하여 설계가 된다. 그리고 이 특성은 설계 시 고려하는 사항 및 접근하는 관점과 사고의 범위에 따라 영역성, 상호성, 일체성의 설계과정으로 진행이 된다. 영역성 설계는 주변 환경 및 구조물 등과 대지의 관계조직체계를 계획한다. 상호성 설계는 건축물이나 공간 등 상호 영향을 주고받는 상호간의 관계망을 계획한다. 일체성 설계는 공간과 건축물이 만나는 방식을 설계하는 것이다. 영역성과 상호성에서 설정된 설계 방향을 구현하고자 어떠한 방식이나 형상을 계획할 것인지에 관하여 구체적인 내용을 계획하게 된다. 결론적으로 건축장 특성을 정의하는 일련의 설계과정에 의하여 건축장이 만들어 진다.