• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.596-605
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• 2022

Objectives: This study investigated the latest clinical studies on Korean medicine treatment of idiopathic edema in the Chinese National Knowledge Infrastructure Database (CNKI). Methods: We searched the last 9 years of clinical studies discussing Oriental medicine-based treatments for idiopathic edema in the CNKI database. The search focused on the authors, publication year, type of study, purposes of study, method and duration of treatment, evaluation criteria, and results of the selected articles. Results: The search identified 7 randomized controlled trials (RCTs) and 9 others. All studies used oral herbal medicine for treatment. The most commonly used herbs were Poria Sclerotium (茯苓), Atractylodis Rhizoma Alba (白朮), and Alismatis Rhizoma (澤瀉), which are the constituent herbs of Oryeong-san (五苓散). All 16 studies confirmed the efficacy of Oriental medicine treatments. Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for idiopathic edema. The results of this study could be used as basic data for further studies on idiopathic edema.

• The Korea Journal of Herbology
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• v.33 no.5
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• pp.19-37
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• 2018

Objectives : Oryeong-san was composed of Alismatis Rhizoma, Atractylodis Rhizoma Alba, Poria Sclerotium, Polyporus, Cinnamomi Cortex, and known to have hundreds of chemical compounds. The aim of this study was to screen chemical compounds constituting Oryeong-san with the drug-likeness and oral bioavailability from the analysis of their physicochemical properties. Methods : A list of chemical compounds of Oryeong-san was obtained from TM-MC(database of medicinal materials and chemical compounds in Northeast Asian traditional medicine). To remove redundant compounds, the SMILES (Simplified Molecular Input Line Entry System) strings of each compound were identified. All of the physicochemical properties for the compounds were calculated using the DruLiTo(Drug Likeness Tool). Drug-likeness was estimated by QED(Quantitative Estimate of Druglikeness) and OB(Oral bioavailability) was checked based on the Veber's rules. Results : A total of 475 compounds were obtained by eliminating duplication among 544 compounds of 5 medicinal materials. Analysis of the physicochemical properties revealed that the most common values were MW(molecular weight) 200~300 g/mol, ALOGP(octanol-water partition coefficient) 1~2, HBA(number of hydrogen bond acceptors) 0~1, HBD(number of hydrogen bond donors) 0, PSA(polar surface area) 0~50 angstrom, ROTB(number of rotatable bonds) 1, AROM(number of aromatic rings) 0, and ALERT(number of structural alerts) 1. QED had 93% of the values between 0.2 and 0.7, and OB had 90% of the value of TRUE. Conclusions : We in this paper screened the candidate active compounds of Oryeong-san using the QED and Veber's rules. In the future, we will use the screening results to analyze the mechanism of Oryeong-san based on systems pharmacology.

• Journal of Korean Medicine for Obesity Research
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• v.14 no.2
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• pp.72-79
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• 2014

The purpose of this study is analyzed of exploratory research potential as anti-obesity agents of Euiiin-tang. Four Korean databases and 2 Korean Journals (Riss4U, KISS, OASIS, DBPIA, and Journal of Korean Rehabilitation Medicine, Journal of Korean Medicine of Obesity Research) were searched using search word 'individual herbs' and 'obesity', 'weight loss', 'fat', 'hypertension', 'hyperlipidemia', 'diabetes'. Clinical and Experimental Research published in the journal were analyzed, review research, studies of pharmacopunctures and studies of mixed herbal medicine were excluded. We collected 23 studies. Seven studies of Coicis Semen, 10 stdies of Ephedra Herba, 2 study of Angelica gigas Nakai, 3 studies Atractylodis Rhizoma Alba, 1 studies of Glycyrrhiza inflata Batal. Most studies were experiment researches which were composed of in vivo or in vitro, and clinical trial was 5 studies of Ephedra Herba. Main constituent herb, Coicis Semen, Ephedra Herba were thought to represent an anti-obesity effect. Through the result, we can assume to be likely effect of Euiiin-tang as obesity medicine.

• Journal of Oriental Neuropsychiatry
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• v.31 no.1
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• pp.39-47
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• 2020

Objectives: The purpose of this study was to review the research trends in the treatment on narcolepsy in traditional Chinese medicine. Methods: We searched articles in the China National Knowledge Infrastructure (CNKI) October 2009-September 2019. Keywords were 发作性睡病, 嗜睡病, and 嗜睡症. Results: Among a total of 81 articles, 12 articles were selected. The International Classification of Sleep Disorders was most frequently used as a diagnostic criteria. Feng Chi (GB20) and Baek Hoi (GV20) are the most commonly used acupoints in acupuncture treatment. Glycyrrhizae Radix (甘草), Atractylodis Rhizoma Alba (白朮), and Poria (Hoelen) (茯苓) are the most commonly used preparations in herbal medicine. The effective rate is most commonly used as an outcome measurement. Conclusions: Acupuncture and herbal medicine could be considered to improve the symptoms of narcolepsy. In the future, this study could be primary data for the development of more clinical research on the treatment on narcolepsy in Korean medicine.

• Korean Journal of Pharmacognosy
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• v.37 no.4 s.147
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• pp.253-257
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• 2006

We examined anti-angiogenic effects of water extracts from 32 plant materials (20 Korean medicinal plants and 12 western herbs) using cell-based anti-angiogenic assay, HUVEC tube formation assay, and then we found that 7 plant extracts inhibited HUVEC tube formation strongly. The plant materials which showed anti-angiogenic effects are Cinnamomi Ramulus, Atractylodis Rhizoma alba, Polygalae Radix, Myristicae Semen, Artemisiae Iwayomogii Herba, leaves of Rosmarinus officinalis, and leaves of Melissa officinalis. We also investigated inhibitory effects of these anti-angiogenic herbal extracts on MMP (matrix metalloproteinase) activity which has important roles in angiogenesis. Among extracts tested in this study, water extract of Melissa officinalis showed the most potent anti-angiogenic and MMP inhibitory activity.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.3
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• pp.24-36
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• 2017

Objectives The purpose of this study is to provide clinical evidence of herbal medicine treatment for cerebral palsy by reviewing randomized controlled trials conducted in China. Methods We searched literatures dated up to 17 May, 2017 in China National Knowledge Infrastructure (CNKI), and evaluated methodological quality of those studies using 'Risk of Bias' tool. Results Sixteen studies were selected for analysis. These studies indicated that the total effective rate, motor function, self-care, muscle spasticity were significantly improved in the herbal medicine treatment group, as compared to the control group. The most-commonly-used herbs were Poria (茯?), Astragali Radix (黃?), Glycyrrhizae Radix (甘草), and Atractylodis Rhizoma Alba (白朮). There were no serious adverse events found that were associated with herbal medicine treatment. The methodological quality of included studies was generally unclear or low. Conclusions This study shows that the herbal medicine treatment can be effective and safe in treating cerebral palsy. Further well-designed clinical trials with high methodological quality and appropriate assessment tools need to be performed to solidify these findings.

• Korean Journal of Pharmacognosy
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• v.30 no.1
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• pp.12-17
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• 1999

The youngkaechulgamtang (Y) composed of four herb drugs, including Hoelen (H). Cinnamomi Ramulus (C). Atractylodis Rhizoma Alba (A) and Glycyrrhizae Radix (G). In oriental medicine literatures, Youngkaechulgamtang is described to be effective in headache, inflammation, uremia, gastritis, diarrhea and hypertension. To estimate the clinical effectiveness of Youngkaechulgamtang, several pharmacological experiments were carried out. The results are summerized as follows; On acetaminophen-induced hepatotoxicity, C+A, Y-G, Y-H, MIX and Y showed the significant elevation of glutathione-S-transferase. But, C+A, Y-G, Y-H, MIX and Y showed the significant suppression of serum aminotransferases. On ANIT-induced cholestasis, U (Ursodesoxycholic acid 50 mg/kg)+$Y_l$ (760 mg/kg) showed the significant increase of bile juice volume. $Y_l,\;Y_2$ (1520 mg/kg), U, $U+Y_l$ showed the remarkable increase of cholic acid. U and $U+Y_l$ showed the significant decrease of total bilirubin. From these results, it is suggest that Y shows liver protective effect against various hepatic injury. Especially, Youngkaechulgamtang was more effective than mixture of 4 ingredients in the elevation of glutathione-S-transferase in acetaminophen-induced hepatotoxicity.

• Korean Journal of Pharmacognosy
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• v.22 no.2
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• pp.124-127
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• 1991

In the preceding paper, it was reported that total 63 traditional Korean herbal medicines listed in the Korean Pharmacopoeia and Korean Natural Drug Standards were found to be different plants in terms of systematic botany when those were compared with other two countries' drug compendia, Chinese Pharmacopoeia, Japanese Pharmacopoeia and Japanese Natural Drug Standards. Among 63 traditional Korean herbal drugs, 28 items were subject to the chemical identification test by using official methods that are described in the Korean Pharmacopoeia and the Korean Natural Drug Standards. In addition, 5 items were also tested by using the official methods described in Chinese and Japanese drug compendia, since there are no official chemical tests available in the Korean drug compendia. It was found that most of chemical tests appeared to be suitable. It was noted that the chemical test for Atractylodis Rhizoma(蒼朮) was incorrect and unapplicable. Those chemical tests for Clematidis Radix(威靈仙), Rubi Fructus(覆盆子) and Viticis Fructus(蔓荊子) are desirable to be revised for more accurate identification.

• Korean Journal of Pharmacognosy
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• v.29 no.2
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• pp.136-141
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• 1998

To analyze scientifically the polyprescription principle of Daekumeumja(對金飮子), which has been used for alcoholic damage, and Pyungwesan(平胃散), which has been used for indigestion, the transforming rate of hesperidin of these polyprescriptions to hesperetin was investigated. The transforming rate of the former was higher 3 times than that of the latter. The transforming rate of hesperidin of Aurantii nobilis Pericarpium was inhibited by Magnoliae Cortex, but was activated by Glycyrrhizae Radix. The activity of trypsin was inhibited by Glycyrrhizae Radix and Daekumeuja. However, Aurantii nobilis Pericarpium, Atractylodis Rhizoma, Magnoliae Cortex and Pyungwesan did not inhibited it. When human intestinal microflora were cultured with the media containing Daekumeumja, Pyungwesan and herbal medicines consisting of them, Aurantii nobilis Pericarpium and Magnoliae Cortex inhibited the activity of ${\beta}$-glucosidase. These results suggests that the therapeutic effect of Daekumeumja may be better than that of Pyungwesan on alcoholic damage and the therapeutic effect of Pyungwesan may be better than that of Daekumeumja on indigestion, although these prescriptions are consisted of the same herbal medicines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.903-906
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• 2010

The spleen is the source of gi, blood, body fluid and plays a vital role in maintaining life. The function of the spleen is to transform food nutrients and water, and to transport them to the heart and the lung. The movement of splenic gi is marked by elevation. The spleen governs the activity of elevating the lucid. The function of transportation and transformation is usually disturbed in the state of Gi deficiency of the spleen. The main clinical manifestations of gi deficiency of the spleen can be divided into as followers: anorexia, loose stool if the digesting and absorbing functions are disturbed; phlegm and edema if dampness and water are retained due to unhealthy water metabolism. Sagunja-tang can be applied for gi deficiency syndrome of the spleen. Ingredient bakchul(Rhizoma Atractylodis Macrocephalae) and bokryeung(Poria) can be used as monarch drug to eliminate dampness and strengthen the spleen.