Scientific Analysis of Daekumeumja and Pyungwesan by the Metabolism of Hesperidin

Hesperidin 대사에 의한 대금음자(對金飮子)와 평위산(平胃散)의 처방해석

  • Kim, Nam-Jae (East-West Medical Research Institute, Kyunghee University) ;
  • Bae, Eun-Ah (Department of Food and Nutrition, Kyunghee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition, Kyunghee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyunghee University)
  • 김남재 (경희대학교 동서의학연구소) ;
  • 배은아 (경희대학교 식품영양학과) ;
  • 한명주 (경희대학교 식품영양학과) ;
  • 김동현 (경희대학교 약학대학 약학과)
  • Published : 1998.06.30

Abstract

To analyze scientifically the polyprescription principle of Daekumeumja(對金飮子), which has been used for alcoholic damage, and Pyungwesan(平胃散), which has been used for indigestion, the transforming rate of hesperidin of these polyprescriptions to hesperetin was investigated. The transforming rate of the former was higher 3 times than that of the latter. The transforming rate of hesperidin of Aurantii nobilis Pericarpium was inhibited by Magnoliae Cortex, but was activated by Glycyrrhizae Radix. The activity of trypsin was inhibited by Glycyrrhizae Radix and Daekumeuja. However, Aurantii nobilis Pericarpium, Atractylodis Rhizoma, Magnoliae Cortex and Pyungwesan did not inhibited it. When human intestinal microflora were cultured with the media containing Daekumeumja, Pyungwesan and herbal medicines consisting of them, Aurantii nobilis Pericarpium and Magnoliae Cortex inhibited the activity of ${\beta}$-glucosidase. These results suggests that the therapeutic effect of Daekumeumja may be better than that of Pyungwesan on alcoholic damage and the therapeutic effect of Pyungwesan may be better than that of Daekumeumja on indigestion, although these prescriptions are consisted of the same herbal medicines.

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