• International Journal of Precision Engineering and Manufacturing
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• 제5권2호
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• pp.60-67
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• 2004

For improving the motion accuracy of hydrostatic tables, a corrective machining algorithm is proposed in this paper. The algorithm consists of three main processes. The reverse analysis is performed firstly to estimate the rail profile from the measured linear and angular motion error, in the algorithm. For the next step, the corrective machining information is obtained based upon the estimated rail pronto. Finally, the motion errors on the correctively machined rail are analyzed by using the motion error analysis method. These processes are iterated until the analyzed motion errors are satisfactory within the target accuracy. In order to verify the validity of the algorithm theoretically, the motion errors calculated by the estimated rail after the corrective machining process, are compared with those by the true rail which is previously assumed as the initially measured value. The motion errors calculated using the estimated rail show good agreement with the assumed values, and it is shown that the algorithm is effective in acquiring the corrective machining information to improve the accuracy of hydrostatic tables.

• BMB Reports
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• 제36권4호
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• pp.344-348
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• 2003

Protein kinase CKII is composed of two catalytic ($\alpha$ or $\alpha$') subunits and two regulatory ($\beta$) subunits. The $CKII{\beta}$ subunit is thought to mediate the tetramer formation and interact with other target proteins. However, its physiological function remains obscure. In this study, point mutants of $CKII{\beta}$ that are defective for the L41 binding were isolated by using the reverse two-hybrid system. A sequence analysis of the point mutants revealed that Asp-26, Met-52, and Met-78 of $CKII{\beta}$ are critical for L41 binding; Asn-67 (and/or Lys-139) and Met-52 are important for $CKII{\beta}$ homodimerization. Two point mutants, R75 and R83, of $CKII{\beta}$ interacted with L5, topoisomerase $II{\beta}$, and CKBBP1/SAG, but not with the wild-type $CKII{\beta}$. This indicates that $CKII{\beta}$ homodimerization is not a prerequisite for its binding to target proteins. These $CKII{\beta}$ point mutants may be useful in exploring the biochemical physiological functions of $CKII{\beta}$.

• 약학회지
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• 제48권1호
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• pp.6-12
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• 2004

Near-infrared spectra of methanol-water mixtures and acetonitrile-water mixtures were acquired to find interactions between solvents widely used for reverse-phase liquid chromatography. Mixtures were prepared to give a series of increasing mole fractions of methanol or acetonitrile in water. Data matrices of acquired spectra were analyzed to determine the proper number of principal components of each mixture system using Malinowski's factor indicator function. Initial guess of score matrix and loading matrix were calculated by nonlinear iterative partial least squares (NIPALS) algorithm for faster computation. Iterative target transform factor analysis (ITTFA) was applied to convert the initial estimation of score matrix to true concentration profile and loading matrix to pure spectra of pure components of the mixtures. In case of methanol-water the number of principal components was found to be 4 and those initial guess of factors were converted to the pure spectra of water methanol and two kinds of complexes. In case of acetonitrile-water the number of pure components of the mixtures was found to be 3 and the pure spectrum of acetonitrile-water complex was found. The nonlinear characteristics of concentration profiles of complexes in the solvent mixtures may give a good criteria in understanding their elution characteristics in reverse-phase liquid chromatogrsphy.

• 한국지반공학회지:지반
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• 제10권3호
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• pp.17-32
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• 1994

역재하시에 나타나는 흙의 비등방거동을 모델하기 위하여, 본 연구에서는 일반 등방경화규칙에 근거한 비등방 경화이론을 개발하였다. 일반 등방규칙은 등방경화의 기준이 되는 중심응력텐서가 임의의 응력상태에서 존재할 수 있도록 허용하므로, 역재하과정에서 발생하는 소성변형을 예측할 수가 있다. 제안된 구성모델은 단순한 경화함수만을 이용하여 수식화되었고, 일반등방경 화규칙에 적용된 개념을 기존의 비등방경화규칙과 비교하여 서술하였다. 검증을 위하여, 배수 및 비배수조건, 과압밀상태, Ko 압밀등의 초기조건이 상이한 점토에 대하여 관측된 삼축압축시료의 거동을 예측하였다.

• Membrane and Water Treatment
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• 제8권2호
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• pp.125-136
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• 2017

Reverse osmosis technology is being used on large scale for treatment of ground water, brackish water, wastewater and sea water. The most challenging issue in RO process is carbonate scaling which is directly linked with the efficiency and economy. Considering the natural phenomena of carbonate scaling different adaptations have been made to control scaling on the surface of RO membrane including acid dosage and antiscalant addition. As carbonate scaling is directly related with pH level of feed water, present study describes an experimental approach to reduce scaling on RO membrane by lowering the feed water pH by purging $CO_2$. In this comparative study four different conditions including control process (without any scale inhibitor), with dosage of antiscalant, with purging of $CO_2$ and with co addition of antiscalant and $CO_2$ in a feed stream line; it was established that $CO_2$ is a better appliance to reduce carbonate scaling on the membrane surface by reduce pH of feed stream. It was also observed that $CO_2$ and antiscalant mutually function better for scale control.

• Archives of Plastic Surgery
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• 제48권1호
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• pp.133-143
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• 2021

Background Extensive research has been conducted on islet transplantation as a possible cure for diabetes. Islet transplantation in the liver via the portal vein has shown remarkable results, but numerous other recipient sites are currently being investigated. We aimed to show the effectiveness of using a muscle flap as a recipient site for islet transplantation. Methods Islet cells were harvested from 12 isogenic Lewis rats, and then diabetes was induced in another 12 isogenic Lewis rats by streptozotocin injection. In six rats, 3,000 islets were transplanted into gastrocnemius muscle flaps, and in the other six rats, the same number of islets were transplanted into the gastrocnemius muscle. The transplanted islet cell function between the two groups was compared by means of blood glucose tests, glucose tolerance tests, immunohistochemistry, and real-time reverse transcription polymerase chain reaction. Results In the muscle flap group, blood glucose levels significantly decreased after islet transplantation. Blood glucose levels were significantly different between the two groups at 3 weeks after transplantation. The muscle flap group showed nearly normoglycemic results upon the glucose tolerance test, whereas the muscle group was hyperglycemic. Immunohistochemical evaluation showed positive results against insulin and glucagon in biopsies of both groups, and the islet cell density was higher in the muscle flap group. There were no statistically significant differences between the two groups in real-time reverse transcription polymerase chain reaction results. Conclusions Our results suggest that muscle flaps are promising candidates for islet cell transplantation.

• Clinical and Experimental Pediatrics
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• 제52권7호
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• pp.752-755
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• 2009

It is well known that hemodynamic load is one of the most important determinants of cardiac structure and function. Circadian variations in blood pressure (BP) are usually accompanied by consensual changes in peripheral resistance and/or cardiac output. In recent years, reduction in circadian variations in BP and, in particular, loss of nocturnal decline of BP were observed in hypertensive patients with left ventricular hypertrophy (LVH). The patients with only a slight or no loss of nocturnal decline of BP were considered "non-dippers". Regression of LVH was observed after prolonged antihypertensive therapy. Restoration of the circadian rhythm of BP was also observed. However, the classification of patients into "dippers" and "non-dippers" is arbitrary and poorly standardized and repeatable, and in the recent studies, most hypertensive patients with LVH were "dippers". Therefore, we should be particularly cautious about the conclusions drawn using this index. On the other hand, reduced activity of low-pressure cardiopulmonary baroreceptors and impaired day-to-night modulation of autonomic nervous system activity were observed in patients with only LVH. Therefore, alterations in cardiac structure may impair BP modulation. On the other hand, the reverse can also be trueprimary alterations in BP modulation, through a persistently elevated afterload, can increase cardiac mass. Thus, the interrelationship between cardiac structure and BP modulation is complex. Hence, new and more specific methods of evaluating circadian changes in BP are needed to better clarify the abovementioned reciprocal influences.

• 한국전기전자재료학회논문지
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• 제18권3호
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• pp.259-263
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• 2005

The changes in secondary electron emission coefficient(${\gamma}$) and work function($\Phi$$_{\omega}$) have been studied on the surface of MgO protective layer aster plasma(Ar. $O_2$) treatment using ${\gamma}$-focused ion beam (${\gamma}$-FIB) system. The values of ${\gamma}$ varied as follows: $O_2$-treated MgO > Ar-treated MgO > Non-treated MgO, and the work functions varied in the reverse order. The result indicates that both the physical etching and the chemical reaction of $O_2$-plasma removed the contaminating materials from the surface of MgO.

• Steel and Composite Structures
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• 제20권3호
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• pp.513-543
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• 2016

Third order shear deformation theory is used to evaluate electro-elastic solution of a sandwich plate with considering functionally graded (FG) core and composite face sheets made of piezoelectric layers. The plate is resting on the Pasternak foundation and subjected to normal pressure. Short circuited condition is applied on the top and bottom of piezoelectric layers. The governing differential equations of the system can be derived using Hamilton's principle and Maxwell's equation. The Navier's type solution for a sandwich rectangular thick plate with all edges simply supported is used. The numerical results are presented in terms of varying the parameters of the problem such as two elastic foundation parameters, thickness ratio ($h_p/2h$), and power law index on the dimensionless deflection, critical buckling load, electric potential function, and the natural frequency of sandwich rectangular thick plate. The results show that the dimensionless natural frequency and critical buckling load diminish with an increase in the power law index, and vice versa for dimensionless deflection and electrical potential function, because of the sandwich thick plate with considering FG core becomes more flexible; while these results are reverse for thickness ratio.

• 스마트미디어저널
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• 제6권3호
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• pp.9-14
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• 2017

본 논문은 사물인터넷 환경의 초소형 기기에서 사용될 수 있는 경량 블록암호 알고리듬인 LEA의 암호화 및 복호화 블록의 하드웨어 구현에 관한 연구이다. 128비트, 192비트 및 256비트 크기의 모든 비밀키를 수용하고 암 복호화 기능을 통합한 구현을 목표로 하며, 성능향상을 위해 파이프라인 기법을 적용한 설계 결과를 제시한다. 복호화 기능을 실행할 때, 라운드키가 암호화 기능의 역순으로 사용되는데, 이때 발생되는 성능저하를 최소화한 효율적인 하드웨어 구현방법을 제시한다. 비밀키 크기에 따라 라운드 횟수가 24, 28 또는 32회 동작함을 고려하여, LEA 파이프라인은 매 파이프라인 단계에서 4번의 라운드 함수 연산이 수행되도록 구현하였다.