• The KIPS Transactions:PartA
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• v.14A no.2
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• pp.107-116
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• 2007

In this paper, we present a method on the construction of multiple-valued circuits using Reed-Muller Expansions(RME). First, we discussed the input output interconnection of multiple valued function using Perfect Shuffle techniques and Kronecker product and designed the basic cells of performing the transform matrix and the reverse transform matrix of multiple valued RME using addition circuit and multiplication circuit of GF(4). Using these basic cells and the input-output interconnection technique based on Perfect Shuffle and Kronecker product, we implemented the multiple valued logic circuit based on RME. The proposed design method of multiple valued RME is simple and very efficient to reduce addition circuits and multiplication circuits as compared with other methods for same function because of using matrix transform based on modular structures. The proposed design method of multiple valued logic circuits is simple and regular for wire routing and possess the properties of concurrency and modularity of array.

• Clinical and Experimental Pediatrics
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• v.56 no.6
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• pp.235-241
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• 2013

Repair of tetralogy of Fallot (TOF) has shown excellent outcomes. However it leaves varying degrees of residual hemodynamic impairment, with severe pulmonary stenosis (PS) and free pulmonary regurgitation (PR) at both ends of the spectrum. Since the 1980s, studies evaluating late outcomes after TOF repair revealed the adverse impacts of residual chronic PR on RV volume and function; thus, a turnaround of operational strategies has occurred from aggressive RV outflow tract (RVOT) reconstruction for complete relief of RVOT obstruction to conservative RVOT reconstruction for limiting PR. This transformation has raised the question of how much residual PS after conservative RVOT reconstruction is acceptable. Besides, as pulmonary valve replacement (PVR) increases in patients with RV deterioration from residual PR, there is concern regarding when it should be performed. Regarding residual PS, several studies revealed that PS in addition to PR was associated with less PR and a small RV volume. This suggests that PS combined with PR makes RV diastolic property to protect against dilatation through RV hypertrophy and supports conservative RVOT enlargement despite residual PS. Also, several studies have revealed the pre-PVR threshold of RV parameters for the normalization of RV volume and function after PVR, and based on these results, the indications for PVR have been revised. Although there is no established strategy, better understanding of RV mechanics, development of new surgical and interventional techniques, and evidence for the effect of PVR on RV reverse remodeling and its late outcome will aid us to optimize the management of TOF.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9211-9216
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• 2014

CXCR7 is involved in tumor development and metastasis in multiple malignancies. However, the function and molecular mechanisms of action of CXCR7 in human cervical cancer are still unclear. In the present study a loss of-function approach was used to observe the effects of recombinant CXCR7 specific small interfering RNA pBSilence1.1 plasmids on biological behavior including proliferative activity and invasive potential, as indicated by MTT assays with the cervical cancer SiHa cell line in vitro. Reverse transcription polymerase chain reaction and Western blotting revealed that CXCR7 was downregulated in transfected compared with control cells, associated with inhibited cell growth, invasiveness and migration. The expression of CXCR7 and CXCL12 was also determined immunohistochemically in 152 paraffin-embedded, cervical squamous cell carcinoma (CSCC) and cervical intraepithelial neoplasia (CIN), or normal cervical epithelial to assess clinico-pathological pattern and CXCR7 status with respect to cell differentiation and lymph node metastasis in Uighur patients with CSCC. CXCR7 and CXCL12 expression was higher in cervical cancer than CIN and normal cervical mucosa, especially in those with higher stage and lymph node metastasis. CXCL12 appeared to be positively regulated by CXCR7 at the post-transcriptional level in CSCC. We propose that aberrant expression of CXCR7 plays a role in carcinogenesis, differentiation and metastasis of CSCC, implying its use as a potential target for clinical biomarkers in differentiation and lymph node metastasis.

• Journal of dental hygiene science
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• v.15 no.4
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• pp.488-494
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• 2015

A recent report showed that nuclear factor of activated T cell (NFATc) 1 is a member of the NFAT family and is strictly implicated osteoblast differentiation and bone formation. Furthermore, the precise expression and function of NFATc1 in periodontal tissue remains unclear. Therefore, the purpose of this study was to investigate the function of NFATc1 in osteoblastic differentiation, and the underlying mechanism regulating periodontal regeneration in human periodontal ligament cells (hPDLCs). NFATc1 messenger RNA (mRNA) and protein levels were accessed by reverse transcription-polymerase chain reaction (RT-PCR) and western blot assay, respectively. Cell proliferation determined using MTT assay. Differentiation was evaluated by alkaline phosphatase activity and formation of calcium nodule with alizarin red S staining. The mRNA expression of osteoblastic differentiation related genes were examined by RT-PCR. Marked upregulation of NFATc1 mRNA and protein was observed in cells grown in osteogenic medium (OS). NFATc1 transactivation was detected in hPDLCs that had been incubated in OS for 14 days. Treatment with $10{\mu}M$ cyclosporine A (CsA), a known calcineurin inhibitor, reduced the proliferation of hPDLCs, while $5{\mu}M$ CsA had no effect. Inhibition of the calcineurin/NFATc1 pathway by CsA, attenuated OS-induced osteoblastic differentiation in hPDLCs. In summary, this study demonstrates for the first time that NFATc1 plays a key role in osteoblastic differentiation of hPDLCs and activation of NFATc1 could provide a novel mechanism for periodontal bone regeneration.

• Journal of Dental Rehabilitation and Applied Science
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• v.26 no.4
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• pp.463-476
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• 2010

Inadequate or unstable posterior support cause extrusion of antagonistic teeth and overloading of remaining teeth. Extrusion of antagonistic teeth result in collapsed occlusal plane and decreased prosthetic space. Also, overloading of remaining teeth increase occlusal wear or anterior extrusion of anterior teeth, which is resulting in loss of anterior guidance, disharmony of occlusion and decreased prosthetic space. In this case, careful evaluation of OVD(occlusal vertical dimension) is the general first trial to regain appropriate function and esthetics. Simultaneously, adequate anterior guidance and harmonious occlusal plane should be established in the repeatable reference position of the mandible. We report this case because severely worn dentition achieved functional and esthetic results from full mouth rehabilitation with increased vertical dimension and use of centric relation.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.16 no.4
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• pp.22-29
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• 2002

Usually, much harmonics are included and cause harmonic loss of motor, torque pulsation, electro-magnetic noise and shock etc. by switching function of inverter when drive induction motor variableness inside. It applied partial resonant Buck converter and three phase voltage type SPWM inverter circuit to induction motor driving system in this paper that see to solve such problem. Changed operation condition variously to do input current of circuit that propose sine-wave by unit power factor almost and capacitor supplied bringing back to life voltage by power supply arranging properly assistance diode and electric power switching. Power factor and efficiency improved as that minimize variation of input at power supply voltage polarity reverse by that add voltage reversal function. Also, by using output filter, reduced harmonic of output line to line voltage components, and introduce state space analysis and forecast operation of rectifier. Such all items confirmed validity through simulation and an experiment.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.8
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• pp.1553-1560
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• 2016

In this paper, we design a program that controls the execution permissions for the running application in the Windows system environment. It does not allow general users to execute the program converting the specific location information of the execution program, to any of the bit values with the formal structure information in window program. The converted bit value can be returned to the original bit value in the case of an authorized user, so that the original program can be normally performed. By doing so, it can be more safely used in the risk of reverse engineering for Windows executable program. We implemented the control program for the program execution authority we proposed in this paper, and the experiment was performed. At the results of experiments, it was confirmed that the control function to permit execution for the user program was working properly in the Windows environment.

• Science of Emotion and Sensibility
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• v.20 no.1
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• pp.57-66
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• 2017

Emotional image quality optimization methodologies are investigated using technological image quality controls based on the eye tests of various image samples. The images are evaluated based on various contrast, lightness and saturation image quality metric tone curves. The order of importance to image quality enhancements is contrast, saturation and brightness. The slopes of emotional image qualities with respect to technical image quality metric changes are found to be composed of mathematical function modelling with nearly zero, intermediate and maximum slope regions in general, which can reflect well known log and saturated as well as conventional reverse U shape natures. Image quality improvements are analyzed not only with just single but also with multiple image quality metrics. To ease the unified image quality metric analysis and control, a new function is presented to utilize both the newly found and conventional emotional image quality behaviors. It is found that the overall image quality enhancement can be realized only in a few limited cases of multiple image quality metric controls. It is also found that the kinds of image quality enhancement methodologies are not strongly dependent on image contents (genre).

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.29 no.1
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• pp.175-189
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• 1999

The purpose of this study was to established the characteristic radiographic features in salivary gland diseases by means of sialography and scintigraphy. Sialograms and scintigrams with diseases of salivary gland were examined. In this group were 5 salivary stones, 14 sialadenitis, 17 Sjogren's syndromes and 8 benign tumors. The obtained results were as follows; 1. In the configuration of the shape of main duct, those revealed that modified curvilinear and curvilinear types were predominant in Sjogren's syndromes but reverse sigmoid and angular types were in sialolithiasis and sialadenitis combined with sialodochitis. 2. In the configuration of the course of main duct, those revealed that smooth types were predominant in sialadenitis and irregular types were predominant in Sjogren's syndromes and benign tumors and irregular types were seen in all salivary stones and sialadenitis combined with sialodochitis, 3. In the type of intraglandular pattern, those revealed that destructive changes of salivary duct system and parenchyma were severe in sialadenitis and salivary stones and predominantly severe in Sjogren's syndromes. 4. The function of salivary gland was decreased severely in Sjogren's syndrome. and also decrease in salivary stone and sialadenitis. In benign tumor, the uptake of radioisotope was not seen in lesion and the function of salivary gland decreased in its remaining normal parenchyma.

• Molecules and Cells
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• v.43 no.6
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• pp.517-529
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• 2020

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.