• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.1
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• pp.174-183
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• 2004

A program to analyze the performance characteristics of a hydraulic shimmy damper for automotive steering system was developed in this study. Dimensionless mathematical equations of the dynamics of shimmy damper for forward and reverse fluid flows were derived respectively and incorporated into the Simulink models. The program was validated by comparing the results of simulation and experiments for various frequencies of upstream ripple pressures into the damper. Low-pass filter characteristics of the shimmy damper at reverse flow was demonstrated which means that the shimmy damper could alleviate the high speed ripple pressures induced by the unbalance oscillation of tire in vehicle driving. The parameter sensitivity analysis was also conducted to identify the dominant parameters for the damper performance.

• Journal of Korean Society of Water and Wastewater
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• v.27 no.5
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• pp.555-560
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• 2013

A cost analysis method for pretreament processes of a large scale seawater desalination plant was considered using a cost estimation model, WaTER (Water Treatment Estimation Routine). This model is based on cost functions of U.S. EPA to conduct economic analysis of water treatment facilities. A virtual seawater desalination plant which has pretreatment production capacity of $100,000m^3$ per day was chosen as a model plant. Dual media filtration and microfiltration systems were compared as pretreatment process, and the following reverse osmosis process was modeled. As a result, microfiltration showed a price competitiveness in condition of operating with reverse osmosis process by reducing the loads of water treatment and membrane cleaning despite it's high annual cost.

• Geomechanics and Engineering
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• v.28 no.4
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• pp.405-419
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• 2022

Cavity expansion and contraction solutions for cylindrical and spherical cavities in unsaturated residual soils are presented in this paper. Varying soil state in the plastic zone is accounted by a numerical approach, wherein an element-by-element discretization of the plastic zone of both expanding and contracting cavities is carried out. Unlike existing methods utilizing self-similarity technique, the solution procedure enables the prediction of entire soil-state at any stage of expansion and subsequent contraction. It is also applicable for both cavity creation and expansion problems. The approach adopts constant contribution of suction to effective stress (constant X^s drainage condition) for analysis. The analysis procedure is validated by interpreting the previously reported pressuremeter test results in lateritic residual soil. The typical cavity expansion and contraction characteristics of unsaturated Indian lateritic soil were then examined using this solution procedure. The effect of initial soil-state on cavity limit pressure, plastic radius, reverse yield pressure, and reverse plastic radius are also presented.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.4
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• pp.467-472
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• 2018

Objective: Molecular cloning and bioinformatics analysis of annexin A2 (ANXA2) gene in sika deer antler tip were conducted. The role of ANXA2 gene in the growth and development of the antler were analyzed initially. Methods: The reverse transcriptase polymerase chain reaction (RT-PCR) was used to clone the cDNA sequence of the ANXA2 gene from antler tip of sika deer (Cervus Nippon hortulorum) and the bioinformatics methods were applied to analyze the amino acid sequence of Anxa2 protein. The mRNA expression levels of the ANXA2 gene in different growth stages were examined by real time reverse transcriptase polymerase chain reaction (real time RT-PCR). Results: The nucleotide sequence analysis revealed an open reading frame of 1,020 bp encoding 339 amino acids long protein of calculated molecular weight 38.6 kDa and isoelectric point 6.09. Homologous sequence alignment and phylogenetic analysis indicated that the Anxa2 mature protein of sika deer had the closest genetic distance with Cervus elaphus and Bos mutus. Real time RT-PCR results showed that the gene had differential expression levels in different growth stages, and the expression level of the ANXA2 gene was the highest at metaphase (rapid growing period). Conclusion: ANXA2 gene may promote the cell proliferation, and the finding suggested Anxa2 as an important candidate for regulating the growth and development of deer antler.

• Journal of Korean Society for Quality Management
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• v.48 no.1
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• pp.171-186
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• 2020

Purpose: The purpose of this study is conducting of predictive models that considered multicollinearity of independent variables in order to carry out more efficient and reliable predictions about differential pressure in seawater reverse osmosis. Methods: The main variables of each RO system are extracted through factor analysis. Common variables are derived through comparison of RO system # 1 and RO system # 2. In order to carry out the prediction modeling about the differential pressure, which is the target variable, we constructed the prediction model reflecting the regression analysis, the artificial neural network, and the support vector machine in R package, and figured out the superiority of the model by comparing RMSE. Results: The number of factors extracted from factor analysis of RO system #1 and RO system #2 is same. And the value of variability(% Var) increased as step proceeds according to the analysis procedure. As a result of deriving the average RMSE of the models, the overall prediction of the SVM was superior to the other models. Conclusion: This study is meaningful in that it has been conducting a demonstration study of considering the multicollinearity of independent variables. Before establishing a predictive model for a target variable, it would be more accurate predictive model if the relevant variables are derived and reflected.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10345-10350
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• 2015

Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is considered to be its primary centre of origin. Studies on pomegranate peel have revealed antioxidant, anti-inflammatory, anti-angiogenesis activities, with prevention of premature aging and reducing inflammation. In addition to this it is also useful in treating various diseases like diabetes, maintaining blood pressure and treatment of neoplasms such as prostate and breast cancer. Objectives: In this study we identified anti-cancer targets of active compounds like corilagin (tannins), quercetin (flavonoids) and pseudopelletierine (alkaloids) present in pomegranate peel by employing dual reverse screening and binding analysis. Materials and Methods: The potent targets of the pomegranate peel were annotated by the PharmMapper and ReverseScreen 3D, then compared with targets identified from different Bioassay databases (NPACT and HIT's). Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions. Results: A number of potent anti-cancerous targets were attained from the PharmMapper server according to their fit score and from ReverseScreen 3D server according to decreasing 3D scores. Conclusion: The identified targets now need to be further validated through in vitro and in vivo studies.

• Spatial Information Research
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• v.18 no.4
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• pp.33-41
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• 2010

Approximately 100 permanent GPS stations are currently operational in Korea. However, only 10 sites have their own weather sensors connected directly to the GPS receiver. Thus. calculation of meteorological data through interpolation of AWS data are needed to determine precipitable water vapors at a specific GPS station without a meteorological sensor. This study analyzed the accuracy of two meteorological data interpolation methods called reverse sea level correction and kriging. As a result, the root-mean square-error of reverse sea level correction were seven times more accurate in pressure and twice more accurate in temperature than the kriging method. For the analysis of PWV accuracy, we calculated GPS PWV during the summer season in :2008 by using GPS observation data and interpolated meteorological data by reverse sea level correction. And, we compared GPS PWV s based on interpolated meteorological data with those from radiosonde observations and GPS PWV s based on onsite GPS meteorological sensor measurements. As a result, the accuracy of GPS PWV s from our interpolated meteorological data was within the required operational accuracy of 3mm.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.3 no.1
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• pp.229-234
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• 1999

We analyzed the reliability characteristics in platinum schottky diodes with variations of n-type silicon substrates concentrations and temperature variations of measurements. The parameters of reliability measurement analysis are saturation current. turn-on voltage and ideality factor in the forward bias, the breakdown voltage in the reverse bias with device shapes. The shape of devices are square type and long rectangular type for edge effect. As a result, we analyzed that the forward turn-on voltage, barrier height, dynamic resistance and reverse breakdown voltage were decreased but ideality factor and saturation current were increased by increased concentration in platinum and n-silicon junction parts. In measurement temperature(RT, $50^{\circ}C$, $75^{\circ}C$), the extracted electrical parameter values of reliability characteristics were increased at the higher temperature under the forward and reverse bias. The long rectangular type devices were more decreased than the square type in reverse breakdown voltage by tunneling effects of edge part.

• Journal of Veterinary Science
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• v.24 no.5
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• pp.67.1-67.15
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• 2023

Background: Feline immunodeficiency virus (FIV) causes an acquired immunodeficiency-like syndrome in cats. FIV is latent. No effective treatment has been developed for treatment the infected cats. The first and second generations non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment, nevirapine (NVP) and efavirenz (EFV), and rilpivirine (RPV), were used to investigate the potential of NNRTIs for treatment of FIV infection. Objective: This study aims to use experimental and in silico approaches to investigate the potential of NNRTIs, NVP, EFV, and RPV, for inhibition of FIV reverse transcriptase (FIV-RT). Methods: The FIV-RT and human immunodeficiency virus reverse transcriptase (HIV-RT) were expressed and purified using chromatography approaches. The purified proteins were used to determine the IC₅₀ values with NVP, EFV, and RPV. Surface plasmon resonance (SPR) analysis was used to calculate the binding affinities of NNRTIs to HIV-RT and FIV-RT. The molecular docking and molecular dynamic simulations were used to demonstrate the mechanism of FIV-RT and HIV-RT with first and second generation NNRTI complexes. Results: The IC₅₀ values of NNRTIs NVP, EFV, and RPV against FIV-RT were in comparable ranges to HIV-RT. The SPR analysis showed that NVP, EFV, and RPV could bind to both enzymes. Computational calculation also supports that these NNRTIs can bind with both FIV-RT and HIV-RT. Conclusions: Our results suggest the first and second generation NNRTIs (NVP, EFV, and RPV) could inhibit both FIV-RT and HIV-RT.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.457-475
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• 2021

As Korean society enters an aged society, there is an increasing situation in which various generations coexist in the workplace. This study aimed to analyze corporate reverse mentoring in light of generational exchange. Through the case study methods using literature research and interviews, we categorized the objectives of starting reverse mentoring programs in domestic and foreign companies, and analyzed the possibility of generational exchange with the cases of company A in the US and B in Korea extracted by purposive sampling. Based on social exchange theory, organizational age theory, and generational solidarity theory, the analysis framework presented three propositions: 1) mutual benefit 2) balanced contribution, and 3) sustainability. As a result of the case analyses, there were three main objectives of introducing reverse mentoring: learning IT/social media, promoting corporate diversity, and understanding new trends in the younger generation. In the case of A company in the US and B company in Korea, there was a similarity in mutual benefit and balanced contribution. However, regarding sustainability, there was room for improvement in company B in Korea unlike company A in the US. We expect that reverse mentoring will provide important criteria for success in terms of generational exchange within organizations where various generations coexist in the future.