• BMB Reports
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• v.50 no.3
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• pp.111-116
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• 2017

Natural product drugs, or botanical drugs, are drugs composed of natural substances which have constituents with healthenhancing or medicinal activities. In Korea, government-led projects brought attention to botanical drugs invigorating domestic botanical drug industry. Foreign markets, as well, are growing bigger as the significance of botanical drugs stood out. To follow along with the tendency, Korea puts a lot of effort on developing botanical drugs suitable for global market. However, standards for approving drug sales vary by countries. And also, thorough standardization, certification, clinical studies and data of these will be required as well as data confirming safety and effectiveness. Meanwhile, as an international exchange in botanical drug market continues, the importance of plant resources was emphasized. Thus countries' ownership of domestic natural resources became vital. Not only establishing a systematic method to secure domestic plant resources, but also cooperation with other countries on sharing natural resources is essential to procure natural resources effectively. Korea started to show visible results with botanical drugs, and asthma/COPD treatment made out of speedwell is one example. Sufficient investment and government's active support for basic infrastructure for global botanical drugs will bring Korea to much higher level of botanical drug development.

• Current Optics and Photonics
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• v.1 no.2
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• pp.118-124
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• 2017

Color rendering index (CRI) and luminous efficacy (LE) are two key performance factors of white LEDs (WLED). While most recent works in optics focus on methodology to improve these factors, little attention has been dedicated to chemical composition of materials. This paper studies the effect of $Sr_{2.4}1F_{2.59}B_{20.03}O_{74.8}:Eu_{0.12},Sm_{0.048}$ phosphor (SrSm), in terms of concentration and particle size on CRI and LE of 8500 K - WLEDs. Importantly, the molar mass of the componential ions in SrSm are calculated to shed light on the connection between the chemical composition of the material of interest and the performance of WLEDs. Results show that CRI can be improved to a value of around 86 by boosting red-light components in WLEDs, for all 3 major configurations: conformal, in-cup, and remote phosphor. CRI value tends to decrease with larger size of particles, while LE value goes in the reverse direction. On the other hand, both CRI and LE appear to be reduced at higher concentration of SrSm. This light attenuation is analyzed by using the Lambert-Beer law and Mie-scattering theory.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.05c
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• pp.149-153
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• 2003

Chemical mechanical polishing (CMP) technology for global planarization of multi-level inter-connection structure has been widely studied for the next generation devices. CMP process has been paid attention to planarized pre-metal dielectric (PMD), inter-layer dielectric (ILD) interconnections. Expecially, shallow trench isolation (STI) used to CMP process on essential. Recently, the direct STI-CMP process without the conventional complex reverse moat etch process has established by using slurry additive with the high selectivity between $SiO_2$ and $Si_3N_4$ films for the purpose of process simplification and n-situ end point detection(EPD). However, STI-CMP process has various defects such as nitride residue, tom oxide and damage of silicon active region. To solve these problems, in this paper, we studied the planarization characteristics using a high selectivity slurry(HSS). As our experimental results, it was possible to achieve a global planarization and STI-CMP process could be dramatically simplified. Also we estimated the reliability through the repeated tests with the optimized process conditions in order to identify the reproducibility of HSS STI-CMP process.

• Cross-Cultural Studies
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• v.19
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• pp.101-126
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• 2010

Narcissism is a pathological phenomenon and narcissistic subject always needs to put itself on the top and has interest in nothing but its own determination. The protagonist of Adversary by ?mmanuel Carr?re does pay careful attention to what others are thinking of him while he does not distinguish difference between object of love and himself. So he can be allegedly narcissistic subject. And it can be said that the behaviors of Mary in the movie Under the sand by Ozon are included in narcissism in that narcissistic subject has the characteristics that idealizes the object of libido. However, in this study, the heroine is examined based on such a point that the object of love and extreme idealization incline toward others. We call this case reverse-narcissism. In Part 2, it is investigated what relation narcissism as an unconscious psychological tool has with Oedipus complex, which plays an important role in forming human psyche. For instance, disappointment caused by prohibition at the oedipal stage is too severe, which creates superego and its idealization to protect in such a way that narcissistic regression can not be done. Cases of extremely big gap between ego and ideal type are perversion, impostor, mania, paranoia, etc, where narcissistic and oedipal elements are combined to affect.

• Journal of Power Electronics
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• v.19 no.2
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• pp.363-379
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• 2019

Resonant converters have attracted a lot of attention because of their high efficiency due to the soft-switching performance. An isolated high step-up converter with secondary-side resonant loops is proposed and analyzed in this paper. By placing the resonant loops on the secondary side, the current stress for the resonant capacitors is greatly reduced. The power loss caused by the equivalent series resistance of the resonant capacitor is also decreased. Clamp diodes in parallel with the resonant capacitors ensure a unique discontinuous current mode in the converter. Under this mode, the active switches can realize soft-switching during both turn-on and turn-off transitions. Meanwhile, the reverse-recovery problems of diodes are also alleviated by the leakage inductor. The converter is essentially a step-up converter. Therefore, it is helpful for decreasing the transformer turn-ratio when it is applied as a high step-up converter. The steady-state operation principle is analyzed in detail and design considerations are presented in this paper. Theoretical conclusions are verified by experimental results obtained from a 500W prototype with a 35V-42V input and a 400V output.

• The Korean Journal of Food And Nutrition
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• v.35 no.5
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• pp.332-342
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• 2022

Nonalcoholic fatty liver disease (NAFLD) is recognized one of the leading metabolic diseases globally, and the younger age population with the disease is rapidly growing, especially in developed countries. Since there has been no approved medicine, losing weight is known to be the only best remedy to control or reverse the disease. Recently, the field of microbiome has attracted much attention to offer more practical choices for patients. Here, we provide experimental evidence that Streptococcus thermophilus LM1012 (LM1012), a safe probiotic strain, is effective for improving NAFLD indexes. In the methionine-choline deficient (MCD) diet induced C57BL/6 mouse model, administration of LM1012 promoted marked reductions of aspartate transaminase (23.8%), total bilirubin (27.8%), hydroxycholesterol (64.2%), triglyceride (29.7%) and IL-1β (68.3%) compared to the MCD diet alone group. Also, the histopathological data imply that LM1012 inhibited fat accumulation and inflammation in the liver, which are the key biomarkers for progression of the disease. Together, these findings suggest that human consumption of LM1012 as a healthy nutritional supplement, may be helpful in reducing the risk of liver damages in NAFLD patients.

• Research in Plant Disease
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• v.29 no.1
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• pp.88-93
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• 2023

To investigate the incidence status of viruses in major cultivated areas of watermelon and melon in Chungbuk Province, samples were collected from 2020 to 2021 in vinyl greenhouse of Jincheon and Eumseong and examined for virus infection using reverse transcription polymerase chain reaction. Of the six viruses on watermelon that was analyzed in this study, watermelons were infected with cucumber mosaic virus (CMV), watermelon mosaic virus (WMV), cucumber green mottle mosaic virus (CGMMV), and cucurbit aphid-borne yellows virus (CABYV). The incidence rate of CMV was 20.9-35.0%, WMV 0.4-15.8%, CGMMV 1.6-38.5%, and CABYV was 3.5-3.7% from 2020 to 2021. But strangely, there were no incidence of zucchini yellow mosaic virus and cucurbit chlorotic yellows virus (CCYV) during investigation. From this result, we knew the major virus was CGMMV on watermelon in Chungbuk Province. Molecular diagnosis assays of the two melon viruses, showed that melons were infected with CABYV and CCYV from 2020 to 2021. The incidence rate of CABYV was 53.9-92.2% and CCYV was 2.7-20.8%. The incidence of CABYV was high in melon cultivation of Jincheon and Eumseong, Chungbuk. Afterwards, it is necessary to establish a control management strategy for reduce the incidence of CABYV. Furthermore, we must pay attention that of CCYV even if the incidence was low.

• Korean Journal of Legislative Studies
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• v.27 no.1
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• pp.5-40
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• 2021

This study attempts to analyze gender gaps in voter turnout for three different types of elections held since 2017 at the aggregate level using the Central Election Management Commission's turnout data, paying attention to the importance of women's voting. The findings are as follows. First, modern gender gaps in voter turnout at the aggregate level are confirmed in most regions regardless of election types. Second, the gender gap in turnout varies with age. The gender difference is verified in the "widowhood effect," where turnout decreases in the oldest-old. In the new voter group, modern gender gaps appear in most regions. The reversed gender difference in turnout in the late 20s, which reflects the Korean society's characteristics, is confirmed in all elections. Third, it is unclear whether the reverse gender gap in turnout becomes more pronounced in urbanized districts. As urbanization progressed, modern gender differences in voter turnout across age groups are observed at the population-based size level. Paradoxically, the modern gender gap tends to be weak and turns into the traditional gender gap in younger age groups (in the late thirties) in Gangnam-gu and Seocho-gu, the most modernized districts in Seoul. These results show that the modern gender gap in turnout is now a common phenomenon and continues to be strengthened by newly recruited voters in Korea. Thus we should pay more attention to female voters' political behavior and a new approach beyond the developmental theory to understand the causal mechanism to generate the modern gender gap in voter turnout.

• Journal of Digital Convergence
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• v.12 no.1
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• pp.273-280
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• 2014

This study deals with the digital policy proposal through the study about the relation of the sustainable use and the addiction to social media such as facebook. Researcher tried to figure out the antecedents and consequence factors about the service addiction recognized by the social media users and to obtain the measures for the sustainable use of service and the implications for the prevention of addiction. Research results showed that 1) the individual innovation had an effect on the service satisfaction, the addiction, and the sustainable use, 2) the service satisfaction influenced on the addiction and the sustainable use, 3) the perceived service addiction had a reverse effect on the sustainable use. This is described that user's addiction recognition is the obstacle of sustainable growth in service. The proposed policy of this research is summarized as the following two. 1) When the users act the addictive using behavior, service provider has to pay attention to user's withdrawal from the service because of their addiction. 2) The government should offer healing facilities, service etc. for the addicted users and the prevention of the service addiction when they recognized their discomfort.

• Journal of Ginseng Research
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• v.39 no.3
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• pp.213-220
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• 2015

Background: Korean ginseng (Panax ginseng Meyer) is a perennial herb prone to various root diseases, with Phytophthora cactorum being considered one of the most dreaded pathogens. P. cactorum causes foliar blight and root rot. Although chemical pesticides are available for disease control, attention has been shifted to viable, eco-friendly, and cost-effective biological means such as plant growth-promoting rhizobacteria (PGPR) for control of diseases. Methods: Native Bacillus amyloliquefaciens strain HK34 was isolated from wild ginseng and assessed as a biological control agent for ginseng. Leaves from plants treated with HK34 were analyzed for induced systemic resistance (ISR) against P. cactorum in square plate assay. Treated plants were verified for differential expression of defense-related marker genes using quantitative reverse transcription polymerase chain reaction. Results: A total of 78 native rhizosphere bacilli from wild P. ginseng were isolated. One of the root-associated bacteria identified as B. amyloliquefaciens strain HK34 effectively induced resistance against P. cactorum when applied as soil drench once (99.1% disease control) and as a priming treatment two times in the early stages (83.9% disease control). A similar result was observed in the leaf samples of plants under field conditions, where the percentage of disease control was 85.6%. Significant upregulation of the genes PgPR10, PgPR5, and PgCAT in the leaves of plants treated with HK34 was observed against P. cactorum compared with untreated controls and only pathogen-treated plants. Conclusion: The results of this study indicate HK34 as a potential biocontrol agent eliciting ISR in ginseng against P. cactorum.