• 한국자동차공학회논문집
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• 제12권1호
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• pp.174-183
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• 2004

A program to analyze the performance characteristics of a hydraulic shimmy damper for automotive steering system was developed in this study. Dimensionless mathematical equations of the dynamics of shimmy damper for forward and reverse fluid flows were derived respectively and incorporated into the Simulink models. The program was validated by comparing the results of simulation and experiments for various frequencies of upstream ripple pressures into the damper. Low-pass filter characteristics of the shimmy damper at reverse flow was demonstrated which means that the shimmy damper could alleviate the high speed ripple pressures induced by the unbalance oscillation of tire in vehicle driving. The parameter sensitivity analysis was also conducted to identify the dominant parameters for the damper performance.

• 상하수도학회지
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• 제27권5호
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• pp.555-560
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• 2013

A cost analysis method for pretreament processes of a large scale seawater desalination plant was considered using a cost estimation model, WaTER (Water Treatment Estimation Routine). This model is based on cost functions of U.S. EPA to conduct economic analysis of water treatment facilities. A virtual seawater desalination plant which has pretreatment production capacity of $100,000m^3$ per day was chosen as a model plant. Dual media filtration and microfiltration systems were compared as pretreatment process, and the following reverse osmosis process was modeled. As a result, microfiltration showed a price competitiveness in condition of operating with reverse osmosis process by reducing the loads of water treatment and membrane cleaning despite it's high annual cost.

• Geomechanics and Engineering
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• 제28권4호
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• pp.405-419
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• 2022

Cavity expansion and contraction solutions for cylindrical and spherical cavities in unsaturated residual soils are presented in this paper. Varying soil state in the plastic zone is accounted by a numerical approach, wherein an element-by-element discretization of the plastic zone of both expanding and contracting cavities is carried out. Unlike existing methods utilizing self-similarity technique, the solution procedure enables the prediction of entire soil-state at any stage of expansion and subsequent contraction. It is also applicable for both cavity creation and expansion problems. The approach adopts constant contribution of suction to effective stress (constant X^s drainage condition) for analysis. The analysis procedure is validated by interpreting the previously reported pressuremeter test results in lateritic residual soil. The typical cavity expansion and contraction characteristics of unsaturated Indian lateritic soil were then examined using this solution procedure. The effect of initial soil-state on cavity limit pressure, plastic radius, reverse yield pressure, and reverse plastic radius are also presented.

• Asian-Australasian Journal of Animal Sciences
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• 제31권4호
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• pp.467-472
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• 2018

Objective: Molecular cloning and bioinformatics analysis of annexin A2 (ANXA2) gene in sika deer antler tip were conducted. The role of ANXA2 gene in the growth and development of the antler were analyzed initially. Methods: The reverse transcriptase polymerase chain reaction (RT-PCR) was used to clone the cDNA sequence of the ANXA2 gene from antler tip of sika deer (Cervus Nippon hortulorum) and the bioinformatics methods were applied to analyze the amino acid sequence of Anxa2 protein. The mRNA expression levels of the ANXA2 gene in different growth stages were examined by real time reverse transcriptase polymerase chain reaction (real time RT-PCR). Results: The nucleotide sequence analysis revealed an open reading frame of 1,020 bp encoding 339 amino acids long protein of calculated molecular weight 38.6 kDa and isoelectric point 6.09. Homologous sequence alignment and phylogenetic analysis indicated that the Anxa2 mature protein of sika deer had the closest genetic distance with Cervus elaphus and Bos mutus. Real time RT-PCR results showed that the gene had differential expression levels in different growth stages, and the expression level of the ANXA2 gene was the highest at metaphase (rapid growing period). Conclusion: ANXA2 gene may promote the cell proliferation, and the finding suggested Anxa2 as an important candidate for regulating the growth and development of deer antler.

• 품질경영학회지
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• 제48권1호
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• pp.171-186
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• 2020

Purpose: The purpose of this study is conducting of predictive models that considered multicollinearity of independent variables in order to carry out more efficient and reliable predictions about differential pressure in seawater reverse osmosis. Methods: The main variables of each RO system are extracted through factor analysis. Common variables are derived through comparison of RO system # 1 and RO system # 2. In order to carry out the prediction modeling about the differential pressure, which is the target variable, we constructed the prediction model reflecting the regression analysis, the artificial neural network, and the support vector machine in R package, and figured out the superiority of the model by comparing RMSE. Results: The number of factors extracted from factor analysis of RO system #1 and RO system #2 is same. And the value of variability(% Var) increased as step proceeds according to the analysis procedure. As a result of deriving the average RMSE of the models, the overall prediction of the SVM was superior to the other models. Conclusion: This study is meaningful in that it has been conducting a demonstration study of considering the multicollinearity of independent variables. Before establishing a predictive model for a target variable, it would be more accurate predictive model if the relevant variables are derived and reflected.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10345-10350
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• 2015

Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is considered to be its primary centre of origin. Studies on pomegranate peel have revealed antioxidant, anti-inflammatory, anti-angiogenesis activities, with prevention of premature aging and reducing inflammation. In addition to this it is also useful in treating various diseases like diabetes, maintaining blood pressure and treatment of neoplasms such as prostate and breast cancer. Objectives: In this study we identified anti-cancer targets of active compounds like corilagin (tannins), quercetin (flavonoids) and pseudopelletierine (alkaloids) present in pomegranate peel by employing dual reverse screening and binding analysis. Materials and Methods: The potent targets of the pomegranate peel were annotated by the PharmMapper and ReverseScreen 3D, then compared with targets identified from different Bioassay databases (NPACT and HIT's). Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions. Results: A number of potent anti-cancerous targets were attained from the PharmMapper server according to their fit score and from ReverseScreen 3D server according to decreasing 3D scores. Conclusion: The identified targets now need to be further validated through in vitro and in vivo studies.

• Spatial Information Research
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• 제18권4호
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• pp.33-41
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• 2010

우리나라에는 100여개의 GPS 상시관측소가 설치되어 있으나 대략 10개의 관측소만이 GPS 전용 기상센서를 보유하고 있다. 따라서 전국을 대상으로 하는 GPS 가강수량 산출을 위해서는 주변 AWS의 가상자료 보간에 의한 GPS 관측소 기상정보의 생성이 필요하다. 이 연구에서는 가상자료 보간 방법인 역해면경정과 크리깅의 보간 정확도를 분석하였다. 그 결과 역해변경정법의 RMSE가 기압의 경우 약 7배, 기온의 경우 약 2배 더 정확함을 확인하였다. PWV 정확도 분석을 위해 역해면경정법으로 보간된 기상자료와 GPS 관측자료를 이용해 2008년 여름철에 대한 GPS PWV를 산출하였다. 보간 기상 자료를 이용한 GPS PWV를 GPS 전용 기상센서의 값을 사용한 PWV, 라디오존데 PWV와 비교하였다. 비교 결과 보간 기상자료를 이용한 GPS PWV 가 요구 정확도 3mm이내를 만족함을 확인하였다.

• 한국정보통신학회논문지
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• 제3권1호
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• pp.229-234
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• 1999

측정 온도 변화와 n-형 실리콘 기판 농도의 변화를 갖는 백금 쇼트키 다이오드에서 신뢰성 특성을 분석하였다. 신뢰성 측정분석의 파라미터는 순방향 바이어스에서 포화전류, 임계전압과 이상인자이고, 소자의 모양에 따라서 역방향 바이어스에서 항복전압이다. 소자의 모양은 가장자리 효과를 위한 긴직사각형과 정사각형이다. 결과로써, 백금과 엔-실리콘 접합 부분에서 증가된 농도에 의해 순방향 임계전압, 장벽높이와 역방향 항복전압은 감소되었지만 이상인자와 포화전류는 증가되었다. 순방향과 역방향 바이어스 하에서 신뢰성 특성의 추출된 전기적 파라미터 값들은 측정온도(실온,$50^{\circ}C$, $75^{\circ}C$)에서 더 높은 온도에서 증가되었다. 긴직사각형 소자가 가장자리 부분의 터널링 효과에 의해 역방향 항복 특성에서 정사각형 소자보다 감소되었다.

• Journal of Veterinary Science
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• 제24권5호
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• pp.67.1-67.15
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• 2023

Background: Feline immunodeficiency virus (FIV) causes an acquired immunodeficiency-like syndrome in cats. FIV is latent. No effective treatment has been developed for treatment the infected cats. The first and second generations non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment, nevirapine (NVP) and efavirenz (EFV), and rilpivirine (RPV), were used to investigate the potential of NNRTIs for treatment of FIV infection. Objective: This study aims to use experimental and in silico approaches to investigate the potential of NNRTIs, NVP, EFV, and RPV, for inhibition of FIV reverse transcriptase (FIV-RT). Methods: The FIV-RT and human immunodeficiency virus reverse transcriptase (HIV-RT) were expressed and purified using chromatography approaches. The purified proteins were used to determine the IC₅₀ values with NVP, EFV, and RPV. Surface plasmon resonance (SPR) analysis was used to calculate the binding affinities of NNRTIs to HIV-RT and FIV-RT. The molecular docking and molecular dynamic simulations were used to demonstrate the mechanism of FIV-RT and HIV-RT with first and second generation NNRTI complexes. Results: The IC₅₀ values of NNRTIs NVP, EFV, and RPV against FIV-RT were in comparable ranges to HIV-RT. The SPR analysis showed that NVP, EFV, and RPV could bind to both enzymes. Computational calculation also supports that these NNRTIs can bind with both FIV-RT and HIV-RT. Conclusions: Our results suggest the first and second generation NNRTIs (NVP, EFV, and RPV) could inhibit both FIV-RT and HIV-RT.

• 한국콘텐츠학회논문지
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• 제21권10호
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• pp.457-475
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• 2021

한국사회가 고령사회에 진입하며, 노동현장에서 다양한 세대가 공존하는 상황이 증가하고 있다. 본 연구는 기업의 리버스 멘토링(reverse mentoring)을 세대 교류의 차원에서 분석해보고자 하였다. 문헌연구와 인터뷰를 이용한 사례분석을 통하여 국내외 기업의 리버스멘토링 도입목표를 유형화하고, 의도적 표집방법으로 추출된 미국의 A사와 국내의 B사의 사례를 중심으로 리버스 멘토링 프로그램의 성공적인 실행요소를 분석하였다. 분석틀로는 사회교환이론, 조직연령이론, 세대연대이론을 바탕으로 1) 상호이익성 2) 동등한 기여, 3) 지속가능성의 세가지 명제를 제시하였다. 사례분석결과, 리버스멘토링의 도입 목표는 크게 세 가지로 소셜미디어 교육, 기업의 다양성 증진, 젊은 세대의 트렌드 이해로 나타났다. 미국의 A사와 국내의 B사의 경우 상호이익성과 동등한 기여에서는 유사성이 나타났으며 지속가능성의 경우 미국의 A사와는 달리, 한국의 B사에서는 개선의 여지가 있는 것으로 나타났다. 연구 결과, 앞으로 다양한 세대가 공존하는 노동 조직 내에서 리버스멘토링이 세대교류의 성공을 위한 중요한 함의를 제공할 것이라고 기대된다.