• The Korean Journal of Physiology
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• v.28 no.2
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• pp.143-150
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• 1994

The whole-cell mode of the patch clamp technique was used to study $Ca^{2+}-activated\;Cl^-\;current$ $(I_{Cl_{Ca}})$ in gastric antral myocytes. Extracellular application of caffeine evoked $Ca^{2+}-activated\;current$. In order to isolate the chloride current from background current, all known systems were blocked with specific blockers. The current-voltage relationship of caffeine-induced current showed outward rectification and it reversed at around $E_{Cl^-}$. The shift of reversal potential upon the alteration of external and internal chloride concentrations was well fitted with results which were calculated by the Nernst equation. Extracellular addition of N-phenylanthranilic acid and niflumic acid which are known anion channel blockers abolished the caffeine induced current. Intracellular application of a high concentration of EGTA also abolished this current. Application of c-AMP, c-GMP, heparin, or $AIF^-_4$ made no remarkable changes to this current. Sodium replacement with the impermeable cation N-methylglucamine or with $Cd^{2+}$ rarely affected this current. From the above results it is suggested that the caffeine induced current was a $Cl^-$ current and it was activated by intracellular $Ca^{2+}$.

• Journal of Ginseng Research
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• v.25 no.2
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• pp.74-81
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• 2001

The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC$\_$50/, 0.70$\pm$0.17 $\mu$M into 3.57$\pm$1.42 $\mu$M, and Hill coefficient, 2.14$\pm$0.60 into 1.52$\pm$1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.

• The Transactions of the Korean Institute of Power Electronics
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• v.20 no.4
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• pp.375-387
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• 2015

This study investigates an economic and highly efficient power-converter topology and its modulation scheme for 60 kW rapid EV charger system. The target system is a three-phase three-switch buck-type rectifier topology. A new carrier-based PWM scheme, which is characterized by simple implementation using logic gates, is introduced in this paper. This PWM scheme replaces the diode rectifier equivalent switching state with an active switching state to produce the same effective current flowing path. As a result, the distortion of input current during the polarity reversal of capacitor line voltage can be mitigated. The proposed modulation technique is confirmed through simulation verification. The proposed modulation technique and its implementation scheme can expand the operation range of the three-phase three-switch buck-type rectifier with high-quality AC input and capacitor ripple current.

• Nuclear Engineering and Technology
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• v.48 no.1
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• pp.228-235
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• 2016

Flaws at dissimilar metal welds (DMWs), such as reactor coolant systems components, Control Rod Drive Mechanism (CRDM), Bottom Mounted Instrumentation (BMI) etc., in nuclear power plants have been found. Notably, primary water stress corrosion cracking (PWSCC) in the DMWs could cause significant reliability problems at nuclear power plants. Therefore, phased array ultrasound is widely used for inspecting surface break cracks and stress corrosion cracks in DMWs. However, inspection of DMWs using phased array ultrasound has a relatively low probability of detection of cracks, because the crystalline structure of welds causes distortion and splitting of the ultrasonic beams which propagates anisotropic medium. Therefore, advanced evaluation techniques of phased array ultrasound are needed for improvement in the probability of detection of flaws in DMWs. Thus, in this study, an investigation of focusing and steering phased array ultrasound in DMWs was carried out using a time reversal technique, and an adaptive focusing technique based on finite element method (FEM) simulation. Also, evaluation of focusing performance of three different focusing techniques was performed by comparing amplitude of phased array ultrasonic signals scattered from the targeted flaw with three different time delays.

• Journal of Biomedical Engineering Research
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• v.39 no.5
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• pp.220-228
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• 2018

The internal resistance of microbial fuel cell (MFC) using stainless steel skein for oxidizing electrode was investigated and the factors affecting the voltage generation were identified. We also investigated the effect of power management system (PMS) on the usability for MFC and the removal efficiency of organic pollutants. The performance of a stack microbial fuel cell connected with (PMS) or PMS+LED was analyzed by the voltage generation and organic matter reduction. The maximum power density of the unit cells was found to be $5.82W/m^3$ at $200{\Omega}$. The maximum current density was $47.53A/m^3$ without power overshoot even under $1{\Omega}$. The ohmic resistance ($R_s$) and the charge transfer resistance ($R_{ct}$) of the oxidation electrode using stainless steel skein electrode, were $0.56{\Omega}$ and $0.02{\Omega}$, respectively. However, the sum of internal resistance for reduction electrode using graphite felts loaded Pt/C catalyst was $6.64{\Omega}$. Also, in order to understand the internal resistance, the current interruption method was used by changing the external resistance as $50{\Omega}$, $300{\Omega}$, $5k{\Omega}$. It has been shown that the ohm resistance ($R_s$) decreased with the external resistance. In the case of a series-connected microbial fuel cell, the reversal phenomenon occurred even though two cells having the similar performance. However, the output of the PMS constantly remained for 20 hours even when voltage reversal occurred. Also the removal ability of organic pollutants (SCOD) was not reduced. As a result of this study, it was found that buffering effect for a certain period of time when the voltage reversal occurred during the operation of the microbial fuel cell did not have a serious effect on the energy loss or the operation of the microbial fuel cell.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.8
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• pp.1105-1110
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• 2011

This paper presents an improved direct torque control based on artificial neural networks technique. The major problem that is usually associated with DTC drive is the high torque(speed) ripple. To overcome this problem a torque hysteresis band with variable amplitude is proposed based on artificial neural networks. The artificial neural networks proposed controller is shown to be able to reducing the torque(speed) ripple and dependency on motor parameter and to improve performance DTC especially at high speed and reversal running.

• Journal of Chest Surgery
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• v.52 no.6
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• pp.416-419
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• 2019

Flow reversal and thromboexclusion constitute a valuable alternative for aortic surgeons to have within their technical armamentarium for the treatment of aortic aneurysmal disease. Although not usually a preferred treatment for general aortic pathologies, this technique can be considered as a treatment option in select situations, such as mycotic aneurysm, a hostile surgical field, and a poor condition of the patient. Here, we present a case of extra-anatomic bypass and thromboexclusion for recurrent aortic aneurysm after previous extra-anatomic bypass and thromboexclusion surgery.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.12
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• pp.53-58
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• 1996

In this paper, a simple fabrication technique of an air-bridge for interconnection of isolated electrodes of microwave active and passive devices and MMIC's is proposed. The proposed air-bridge proceses are mainly combinations of thermal evaporation, positive photoresist and image reversal processes for easy lift-off of up to 2.0 .mu.m thick metal. According to the resutls of air-birdge processes, it is confirmed that air-gap and thickness of theair-bridge are about 3.5.mu.m, and 2.0.mu.m, respectively. And it is also possible to make the fine air-bridge with widths of 5~60.mu.m and post-intervals of 25~200.mu.m withot collapse. finally, GaAs power MESFET's and rectangular spiral inductors are fabricatd and measured in order to confirm of feasibility of the proposed air-bridge processes. The MAG of the fabricated power MESFET's is 10dB at 10GHz, and the inductance of the (200.mu. * 6 turns) rectangular spiral inductors 4.5 nH inX-band.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.31A no.7
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• pp.69-75
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• 1994

A very fine pattern formation process using double exposure is investigated, which can overcome the resolution limit of optical wafer stepper. The very fine pattern can be obtained by moving the edge profile of large pattern by means of moving the stepper stage. The simulation results show that the light transmittance decrease bellow 9%, and the contrast increase to 16.6% for the 0.3$\mu$m photoresist pattern exposeed by the double exposure using i-line wafer stepper. And the experimental results show that fine photoresist pattern as short as 0.2$\mu$m can be obtained without a loss of photoresist thickness. Also, it proves that the depth of focus for 0.3$\mu$m pattern is longer than $1.5\mu$m. And, the very fine negative photoresist pattern was formmed by using the double exposure technique and the image reversal process.

• Journal of the Korean Society of Visualization
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• v.9 no.3
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• pp.16-23
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• 2011

Experiment and numerical investigation are performed on swirling water flow in a vertical circular tube. This kind of flow is used in heat exchangers, combustion chambers, thermal power plants, and other mechanical equipment to move slurries or to convey materials. However, limited information on swirling flow in vertical circular tubes is available. In the current paper, the three-dimensional particle image velocimetry(PIV) technique is employed to compare the measured velocity profiles of water along the vertical circular tube with those of non-swirl flow. In addition, computational fluid dynamics(CFD) code was applied to calculation of the flow velocities with swirl.