• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.23 no.1
• /
• pp.8-13
• /
• 2012

Objectives : Urocanase domain containing 1 (UROC1) has never been studied in prior studies on autism spectrum disorders (ASDs). UROC1 causes urocanic aciduria, one of the symptoms of which is mental retardation. The aim of this study was to investigate the association between the UROC1 gene and ASDs in a Korean population. Methods : A total of 258 control and 214 patients with ASD were used as subjects of this study. SNPs selected from UROC1 were genotyped using Illumina Golden-Gate Genotyping assay with VeraCode$^{(R)}$ technology. Statistical analysis was performed using SAS and Plink software. Results : We found no association of the 12 SNPs in the UROC1 gene with ASDs in a Korean population. Conclusion : Our study suggests that the 12 SNPs (11 SNPs and 1 SNP in the intron and 3'UTR region, respectively) in the UROC1 were not associated with ASDs in a Korean population. Further study on the exon region of UROC1 is needed.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.3 no.1
• /
• pp.93-97
• /
• 2000

We experienced a case of pathologic aerophagia in a 10-year-old girl who has mental retardation. It was observed that the abdomen was non-distended in the morning and became maximally distended in the evening. Increased passage of flatus, but normal eructation, was noted. Roentgenographic examination showed 'esophageal air sign', abnormal air shadow on proximal esophagus adjacent to the trachea, in simple chest X-ray and visible air swallowing fluoroscopically. We tried a percutaneous endoscopic gastrostomy (PEG) to decompress swallowed air in stomach. We suggest that placement of a PEG catheter in early life, especially in mentally retarded patients, that can be used as desufflator, can prevent the complications of aerophagia. 'Esophageal air sign' may be very helpful for early detection of pathologic aerophagia.

• Korean Journal of Food Science and Technology
• /
• v.29 no.6
• /
• pp.1275-1280
• /
• 1997

The possible use of tea catechins as natural preservatives for kimchi was investigated in this study. Tea catechins separated from tea leaves had antimicrobial activity against microorganisms related to kimchi fermentation, such as Leuconostoc mesenteroides, Lactobacillus plantarum, Lactobacillus brevis, Pediococcus cerevisiae, Streptococcus faecalis. The degree of antimicrobial activity of catechins were different among microorganisms; that is 2 mg/mL to Leuconostoc mesenteroides, Lactobacillus plantarum, and Pediococcus cerevisiae, 4 mg/mL to Streptococcus faecalis, and 5 mg/mL to Lactobacillus brevis; however, Saccharomyces cerevisiae can not be inhibited. The effect of tea catechins on retardation of kimchi fermentation was tested by measuring changes in pH and acidity. The changes of pH and acidity of baechu-kimchi and mul-kimchi were remarkably inhibited by adding the tea catechins at the level of 2 mg/g fresh baechu. These results suggest that the tea catechins can be successfully used for the extension of shelf-life of kimchi.

• Proceedings of the KIEE Conference
• /
• 1996.07c
• /
• pp.1588-1590
• /
• 1996

The fractal characteristics of AC electrical tree grown in DGEBA/MDA/ SN/HQ system was investigated. As the applied voltage decreased, tree initiated after retardation. All the trees were fractals in spite of tile applied voltage. Fractal dimension increased with tree length. When the tree grew slowly, the fractal dimension or tile degree of treeing deterioration increased.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1994.10a
• /
• pp.826-830
• /
• 1994

Making Brinell indentations facing each other near the crack tip is very effective method in increasing fatigue life. In this paper, fatigue test was performed after indentation to investigate the effect of thickness of specimen. The results show that fatigue lives increased my making indentation and retardation cycle is inverse proportional to thickness of specimen.

• Journal of the Korean Society of Manufacturing Technology Engineers
• /
• v.6 no.4
• /
• pp.80-88
• /
• 1997

An experimental investigation of the fatigue through crack growth behavior under simple stepped variable loading condition has been performed using Al7075-T651. Experiments were carried out by using cantilever bending type specimens, with chevron notches on a small electro-magnetic test machine. Tensile overloads have a retarding effect on the fatigue crack growth rates, therefore tensile overloads were used for the beneficial effect on the fatigue life. While in most cases compressive overloads have only a vanishing effect on crack growth rates, some experiments with single edge crack tension specimens reveal a marked growth retardation. The stress ratios used in this investigations varies from R=0.32 to 0.81, from R=0.04 to 0.76, from R=-0.15 to 0.73, and from R=-0.33 to 0.68 and the peak load for each case was not varied. The crack growth and crack closure were measured by Kikukawa's compliance method with a strain gauge mounted on the backside of each specimens. The results obtained are as follows. When the stepped variable load was applied, the smaller the stress ration was, the larger the delayed retardation of the crack growth rate was. The fatigue crack growh rate data obtained for through cracks were plotted well against the effective stress intensity factor range from 4.0 to 20.0MP{a^{SQRT}m}. It was found that the effective stress intensity factor range ratio was related well to the opening stress intensity factor, the maximum stress intensity factor, and crack length.

• The Korean Journal of Health Service Management
• /
• v.7 no.2
• /
• pp.101-111
• /
• 2013

To develop the Korean-Version-Improvement program for ordinary people, we investigate how Korean-High-Intelligent people use their cognitive function, intellectual capacity and Intelligent Quotient test. Using Mensa iq test, we classify intelligent examination tool into various components; visual, geometrical component and cognitive interpretation component. Also we organized each component, got database of intelligent subjects sample, classified itemized availability. Based on these things, we prove efficiency of intelligent examination tool. We found out that high intelligent people showed high Intelligent Index using visual cognitive stimulation with cognitive function when subjects were exposed to certain situation; solving the problem. This intelligent examination tool is low price and safe and easily carrying out with personal computer. If we develop intelligence quotient examination customized with mental retardation populations, a variety of subjects will improve their cognition with efficiency and inexpensively.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.8 s.179
• /
• pp.2074-2082
• /
• 2000

In this study, to investigate and to predict the crack growth behavior under variable amplitude loading, crack growth tests are conducted on 7075-T6 aluminum alloy. The loading wave forms are generated by normal random number generator. All wave forms have same average and RMS(root mean square) value, but different standard deviation, which is to vary the maximum load in each wave. The modified Forman's equation is used as crack growth equation. Using the retardation coefficient D defined in previous study, the load interaction effect is considered. The variability in crack growth process is described by the random variable Z which was obtained from crack growth tests under constant amplitude loading in previous work. From these, a statistical model is developed. The curves predicted by the proposed model well describe the crack growth behavior under variable amplitude loading and agree with experimental data. In addition, this model well predicts the variability in crack growth process under variable amplitude loading.

• The Journal of Korean Physical Therapy
• /
• v.12 no.1
• /
• pp.119-127
• /
• 2000

In this case report we demonstrated the improvemen of gait pattern and the facilitation of postwalk locomotion on the child who has severe mental retardation with Incomplete gait pattern. Treatments included to stimulate vestibular using balance board and vestibular stimulator, to train weight hearing and shifting, to facilitate visual perception motor coordination, and to train walk ann postwalk locomotion in environment similar to actual daily life. It was performed 130 sessions for 10 months. With this treatment, she could accomplished dynamic stability so that she didn't fall at walk after $1\~2$ months of treatment, and could have done climbing up and down without hand support after 10 months. In gross motor function measure(GMFM), total motor function was improved to $89.98\%$ from $73.53\%$.

• Journal of mucopolysaccharidosis and rare diseases
• /
• v.5 no.1
• /
• pp.29-33
• /
• 2021

Prader-Willi Syndrome (PWS) is a neurodevelopmental genomic imprinting disorder involving a lack of gene expression from the paternal chromosome 15q11-q13 region. This is typically due to paternal 15q11-q13 deletions (in approximately 60% of cases), maternal uniparental disomy 15, or when both 15s are from the mother (about 35% of cases). An imprinting center controls the expression of imprinted genes in the chromosome 15q11-q13 region. PWS is a neurodevelopmental disorder characterized by mental retardation and distinct physical, behavioral, and psychiatric features. Characteristic behavioral disturbances in PWS include excessive interest in food, skin picking, difficulty with a change in routine, temper tantrums, obsessive and compulsive behaviors, and mood fluctuations. Individuals with PWS typically have intellectual disabilities (borderline to mild/moderate mental retardation) and exhibit a higher overall level of behavior disturbances compared to individuals with similar intellectual disabilities. This condition severely limits social adaptations and quality of life. Different factors have been linked to the intensity and form of these behavioral disturbances, but there is no consensus regarding the cause. Consequently, there is still controversy surrounding management strategies and there is a need for new data. PWS is a multisystem disorder. Family members, caregivers, physicians, dieticians, and speech-language pathologists all play an important role in the management and treatment of symptoms in an individual with PWS. Here we analyze behavioral problems in children and adults with PWS by age and review appropriate management and treatment strategies for these symptoms.