• The Korean Journal of Physiology and Pharmacology
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• v.17 no.5
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• pp.441-446
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• 2013

In the present study, the anti-depressant like effect of methyl gallate (MG) isolated from the stem bark of Acer barbinerve was examined in ICR mice. Body weight (BDW) and blood glucose (BDG) levels significantly decreased in the repeated restraint stress (RRS) group (2 h/day for 14 days) compared to the no stress (NS) group. To examine the effect of MG on RS-induced BDW loss and hypoglycemia, MG (10 mg/kg) and the anti-depressant fluoxetine (10 mg/kg) were administered daily for 14 days. Orally administered MG and fluoxetine significantly attenuated the RS-induced BDW loss and hypoglycemia. Interestingly, MG administered mice showed increased BDG levels in the normal and glucose feeding condition. Chronic RS-subjected mice showed immobilized and depressed behaviors. The effect of MG on the depressed behaviors was evaluated using the tail-suspension test (TST) and the forced swimming test (FST). In both tests, RS-induced immobilized behaviors were significantly reversed in MG and fluoxetine administered groups. Taken together, MG significantly attenuated the RS-induced BDW loss, hypoglycemia, and depressed behaviors. Considering that decreased BDG levels (hypoglycemia) can cause depression, MG may exert its anti-depressant like effect by preventing hypoglycemia. Our results suggest that MG isolated from A. barbinerve can exert anti-depressant like effect, and could be used as a new and natural anti-depressant therapy.

• Journal of Welding and Joining
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• v.28 no.2
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• pp.60-65
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• 2010

Although two dimensional axi-symmetric modeling is useful for calculating the residual stresses of a cylindrical weldment such as a core barrel, this conventional axi-symmetric modeling can not express the behavior of shrinkage well in the locally heated weld zone. New technique of two dimensional axi-symmetric modeling using a virtual fixture is suggested to simulate the behavior of dimensional changes in the weld zone during the heating period of the welding. The virtual fixture in the model has a role to restrain the expansion of the high temperature heated region, which simulates equivalent intrinsic restraint effect of the weldment. In the restraint condition of the virtual fixture above the critical yield strength, the calculated shrinkages by using the suggested axi-symmetric model agreed well with those measured in a welded mock-up. The calculated residual stresses by using the suggested axi-symmetric model also agreed well with those calculated by using conventional axi-symmetric model which has beenused for calculating residual stresses in the weldment.

• Structural Engineering and Mechanics
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• v.82 no.2
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• pp.233-244
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• 2022

Following a loss of control, the impact against a road barrier in a turn predominates among the most severe motorcyclist accidents. These road restraint devices can be equipped with a motorcycle screen, the function of which is to restrain the rider and minimize the consequences of the impact in terms of the severity of injuries. The performance of these screens is evaluated by the European normative procedure EN1317-8, which specifies the test conditions, based on one or two configurations. In practice, however, these impact conditions are very diverse, difficult to extrapolate from accident analysis and therefore poorly investigated. This study is interested in improving knowledge of these impact conditions in terms of impact speed, impact angle and particularly position of the rider. A finite element model has been developed to simulate the dynamic behavior of the rider from loss of control to impact on the screen. Statistical analysis of the results shows a high variability of the impact conditions, in particular with regard to the direction of turn (to the right or to the left). Some improvements are suggested in order to overcome the limitations inherent in standard procedures.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.11a
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• pp.591-594
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• 2005

Concrete structure that has been constructed in real field is on multi-axial stress state condition. After placing of concrete, hydration heat and shrinkage of concrete can cause various stress conditions with respect to the restraint level and condition. So, to predict the early age behavior of concrete structure, multi-axial material model is required and microplane model is acceptable. Recently, many studies have been performed on the microplane model, but the model developed up to now has been related to hardened concrete that material property is constant with concrete age. So, it is inappropriate to apply this model immediately to analyze the early age behavior of concrete. In this study, microplane model that can predict early age behavior of concrete was developed and cracking analysis using that was performed to describe cracking behavior for massive concrete sturucture.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.5
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• pp.1-10
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• 2008

Residual stress caused in the weldments with high restraint force are often during welding observed in the weldments of large size nozzles or radial tanks. The reason is that quantitative analysis about thermal stresses during welding is lack for this weldments. To verify Finite Elements Method(FEM) theory, the temperature was measured with thermocouple in a real time in this paper. Also analysis of the thermal stress for welding condition is performed by ABAQUS program package on various welding condition in 304 stainless steel butt welding.

• Journal of Oral Medicine and Pain
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• v.38 no.2
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• pp.121-136
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• 2013

It has been known that saliva may affect the most of oral diseases. On the contrary, several systemic conditions may affect salivary flow and cause oral dryness and psychosocial stress especially may a crucial role in the etiology of hyposalivation and oral dryness. Many studies have focused on macroscopic effects of the stress on the salivary glands by autonomic response, but on the other hand it has hardly been reported on cellular microscopic effects of the stress on the salivary glands. Therefore, this study was performed to examine clusterin, a antiapoptotic and cytoprotective protein, in the parotid glands under restraint stress condition. For this study, 18 rats were divided into 3 groups; 1) 2 rats of group I were selected as a normal control. 2) 2 rats of group II, as a experimental control were placed in the restraint cone for 2 hours 3) 14 rats of group III were placed in the restraint cone for 2 hours once a day. The rats were sacrificed immediately(group II, as a experimental control), 1, 2, 3, 4, 5, 6 and 7 days after application of the stress and the both parotid glands were excised. Immunohistochemistry and electron microscopy were performed. The finding were as follows: 1. In parotid glands, repeated stress denaturalize the acinar cells, interacinous tissues and interacinous connective tissues were separated to individual acinar cells. After 4 days of experiment, there were lots of vacuoles and intercalated ducts. 2. In parotid glands, repeated stress make the rER which is in acinar cells swollen after 3 days of experiment and it was intensified to 4 days. After 5 days of experiment the edema got worse and degenerated. 3. In parotid glands, clusterin was reduced in ductal cell cytoplasm but in intercalated duct clusterin was slightly stained until 3 days prominently increased until 4 days and then decreased again after 5 days of experiment.

• Journal of Welding and Joining
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• v.18 no.5
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• pp.84-89
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• 2000

Friction welding of titanium and aluminium is numerically modeled by the axisymmetric thermal elastic-plastic analysis. In titanium/aluminium friction welding, heat transfers into the titanium substrate to a distance of z=10(mm) on the side of the bondline and into the whole region of the aluminium substrate having the large thermal conductivity. Adjacent to the bondline, $^{\sigma}r\;and\;^{\sigma\theta}$ are tensile in the substrate whose thermal shrinkage is large, and are compressive in the substrate whose thermal shrinkage is small. $\sigma_z$ along the radial direction is large tensile at the periphery of the component. Plastic strain occurs only close to the bondline in the aluminium substrate. In the components of plastic strain, $\varepsilon^p_r\;and\;\varepsilon^p_{\theta}$ have positive values and $\varepsilon^p_r$ has large negative value. However, $\varepsilon^p_r$ is produced not because of the severity of the mechanical restraint condition, but on purpose to satisfy the condition of the volume constant. A plastic work is proposed as a measure to evaluate the mechanical severity. The plastic work is larger in the aluminium substrate than that in the titanium substrate. The mechanical condition is severer in the aluminium substrate.

• Journal of the Korean association of regional geographers
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• v.14 no.5
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• pp.587-603
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• 2008

The Woong-Chi region is located between Wan-ju and Jin-an had experienced transportation route change from past continuously. The difference of relative height especially steep slope of western side is given to the most difficulty for transportation route open in Woong-Chi region. For the overcome this restraint geomorphological condition, multi-route were developed according to available purpose in walking period. They effort to decrease of slope and curve in route continual1y, and only used the conditioned route for automobile from 1910s in automobile period. The social aspect in transportation route change on this region is, firstly, the transportation route has trend from variety to simplicity. Secondary, new transportation route is opened by social needs such as traffic accident and social big event. Thirdly, the regional range was extended for overcome restraint condition. Fourthly, the rise and fall of route related settlement is influenced by transportation route change. The used technical method for the overcome the geomorphological condition is make a tunnel, alleviate the curve radius, alleviate the slop and consider the direction of the sunny than shady side.

• Journal of the Korea Concrete Institute
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• v.27 no.5
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• pp.569-577
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• 2015

The aim of this study is to qualitatively evaluate the cracking control effects of expansive concrete used in reinforced concrete building. The result of experiments in laboratory shows that autogenous shrinkage and drying shrinkage are suppressed by using expansive additive. The tensile stress-strength ratio is lower in expansive concrete than normal concrete under fully restrained condition. Compression stress could be effectively generated in early age in the walls in buildings by the use of expansive additive, and tensile stress due to drying shrinkage at later age eventually decreased. Additionally, visual observation at long-term ages shows that the cracking area of expansive concrete was approximately 35% of normal concrete, which confirms that the use of expansive additive reduces concrete cracking in reinforced concrete buildings.

• Journal of the Korean Society for Railway
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• v.12 no.6
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• pp.1024-1029
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• 2009

According to increase of massive concrete structures, Thermal crack done by heat of hydration have been increased in a process of the execution. In case of a subway concrete box structure, thickness of structures are almost over 1 meter, and penetrating crack by external restraint takes a bad effect on the durability with a water leakage and deterioration in especially concrete wall. A try of shortening a constructing period often occurs as subway is generally constructed according to a road to decrease a traffic jam. The research proposes executing method by skipping one block as a plan of shortening a constructing period and investigate an influence on thermal cracking control. Additionally, sensitivity analysis is accomplished by changing a height of a concrete wall, and concrete placing and air temperature met with a field condition.