• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1585-1593
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• 2005

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-tang on the stress were studied with cDNA microarray analyses, RT-PCR on hypothalamus using an immobilization-stress mice as an animal model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hrs once a day, and this challenge was repeated for seven· consecutive days. In the change of body weight it showed that the Boshimgeonbi-tang is effected recovery on weight loss caused by the immobilization-stress. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with $CyDye^{TM}$ fluorescence dyes and then hybridized to CDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix4000 series scanner and GenePix $Pro^{TM}$ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis-, stress protein, transcriptional factor, and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosysthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 5.5 fold. The 11 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Ogg1 (DNA repair), Aatk (apoptosis), Dffa (apoptosis), Fkbp5 (protein folding) were restored to the normal one by the treatment of Boshimgeonbi-tang.

• Journal of the Korean Geosynthetics Society
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• v.9 no.3
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• pp.9-18
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• 2010

A series of model tests were performed to investigate the load transfer by soil arching in geosynthetic-reinforced and pile-supported(GRPS) embankment systems. In the model tests, model piles with isolated cap were inserted in the model container and geosynthetics was laid on the pile caps below sand fills. The settlement of soft ground was simulated by rubber form. The loads acting on pile caps and the tensile strain of geosynthetics were monitored by data logging system. At the given interval ratio of pile caps, the efficiency in GRPS embankment systems increased with increasing the height of embankment fills, then gradually converged at constant value. Also, at the given height of embankment fills, the efficiency decreased with increasing the pile spacing. The embankment loads transferred on pile cap by soil arching increased when the geosynthetics installed with piles. This illustrated that reinforcing with the geosynthetics have a good effect to restraint the movement of surrounding soft grounds. The load transfer in GRPS embankment systems was affected by the interval ratio, height of fills, properties of grounds and tensile stiffness and so on.

• Journal of The Korean Society of Agricultural Engineers
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• v.50 no.4
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• pp.39-50
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• 2008

A study on fugitive dust dispersion was conducted at Saemanguem reclaimed area located at the west coastal area of Jeon-buk Province Total reclaimed area is 40,100ha developed by building a 33km long sea dike through Gunsan, Gimje, and Buan. (Land: 28,300ha, Fresh Water Lake: 11,800ha) After this area was completely reclaimed in 2006, there has been high possibility of dust generation and dispersion to the neighboring area. The dust generated at the reclaimed land was composed mainly of minerals with high salinity, and it could make harmful effect on crop production as well on to human's health such as eye irritation and respiratory disease. Especially, when those aerosol particles are reached on the leaves of farm crops, the photosynthesis and respiration of the plants can be under restraint resulting in the decrease of agricultural productivity of the nearby farm areas. Furthermore, highly concentrated salty particles can directly damage the leaf cells. In this study, field experiment has been conducted to regularly measure the locally suspended dust particles and analyze how they were dispersed to the neighboring areas. The collected dust particles were analyzed to examine theirs sizes, concentrations, and components. The SPSS statistical program was also used to separate the dust concentration generated by the reclaimed land from the total dust concentration measured at the measuring locations.

• Journal of Oral Medicine and Pain
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• v.32 no.2
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• pp.201-210
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• 2007

Many diseases occur by stress or effect of stress. The basis for using hormones in research of stress is the observation that most systems in the body show changes during stress and that hormonal markers in these changes are related with stress. Conceptually, the central role of sympathetic nervous system(SNS) and hypothalamus-pituitary-adrenal(HPA) axis activity in stress provides copious justification for measuring hormonal changes. Catecholamines like epinephrine and norepinephrine, cortisol, testosterone and growth hormone and so on show sensitive reaction to stress. The major advantage of salivary sample to stress research is that its sampling technique can be performed in non-stressful conditions and without physical restraint and ethical problems. Because hormone levels in saliva is a good reflection of hormone levels in plasma, application of stress hormones in saliva is very useful for research of orofacial pain related with stress.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.1118-1125
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• 2009

This study, as basic research which was intended to develope the surface reinforcement method using reinforcement material which is applicable to very soft ground in Korea, was aimed at proposing Bearing Capacity Evaluation method for the surface ground improvement method. To that end, a wide width tensile test using geotextile, geogrid and steel bar (substitute for bamboo) and 21 kinds of the laboratory model tests with the end restraint conditions of the reinforcement that comprises the constrained and partially constrained (3 types) conditions were conducted. According to result of tests, Terzaghi's bearing capacity method is adequate to calculate bearing capacity in non-stiff material(geotextile, geogrid). But, It can't adequate to stiff material(bamboo net). So, New bearing capacity method suggest surface reinforcement method of very soft ground which Terzaghi's bearing capacity method modify for effect of stiffness.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.14 no.4
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• pp.23-30
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• 2000

Cogeneration systems are seen as a significant innovation for dispersed energy generation since they are both environmentally friendly and has comparatively high degrees of efficiency. It is especially suited for the decentralized provision of electricity and heat. However, it causes operational problems such as voltage regulation, voltage variation, protection and safety. Especially, it is expected that the interconnection/disconnection operation of cogeneration system has an effect on distribution voltage regulation and variation. Recently, with the increased use of customer-owned computers and other sensitive electronic equipment, electric power quality has become an important concerns. Therefore, the voltage quality problems with cogeneration system should be investigated because the voltage quality is an important part of electrical power quality. In this paper, the momentary voltage dips associated with the interconnection/disconnection operation of cogeneration system are analyzed, including restraint solutions at the customer level. In addition, the unit capacity of cogeneration systems per feeder are evaluated from the view point of momentary voltage variations. The results of this paper are useful analysis data for interconnection standards/guidelines of cogeneration systems and dispersed generation (DG)

• Steel and Composite Structures
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• v.46 no.4
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• pp.539-551
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• 2023

In order to study the fire resistance of castellated composite beams with ortho-hexagonal holes and different beam-end restraints, temperature rise tests with constant load were conducted on full-scale castellated composite beams with ortho-hexagonal holes and hinge or rigid joint constraints to investigate the temperature distribution, displacement changes and failure patterns of castellated composite beams with two different beam-end constraints during the whole course of fire. The results show that (1) During the fire, the axial pressure and horizontal expansion deformation generated in the rigid joint constrained composite beam were larger than those in the hinge joint constrained castellated composite beam, and their maximum horizontal expansion displacements were 30.2 mm and 17.8 mm, respectively. (2) After the fire, the cracks on the slab surface of the castellated composite beam with rigid joint constraint were more complicated than hinge restraint, and the failure more serious; the lower flange and web at the ends of the castellated steal beams with hinge and rigid joint constraint produced serious local buckling, and the angles of the ortho-hexagonal holes at the support cracked; the welds at both ends of the castellated composite beam with rigid joint constraint cracked. (3) Based on the simplified calculation method of solid-web composite beam, considering the effect of holes on the web, this paper calculated the axial force and displacement of the beam-end constrained castellated composite beams under fire. The calculation results agreed well with the test results.

• Journal of the Korea Institute of Military Science and Technology
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• v.26 no.1
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• pp.83-90
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• 2023

The external store fitted to the aircraft may affect the flight characteristics and flight safety of the aircraft, which requires the analyses and testing on it. The purpose of this study is to identify and analyze types of failures that can affect the flight safety of aircraft due to the installation of external stores, and to check the flight safety of aircraft through dropping tests of the external stores. After identifying the types of failures that could affect the flight safety of the aircraft, the criticality was calculated to analyze the effect on the flight safety of the aircraft. Four types of failures were selected: unintentional dropping, failure of dropping, unintentional main wing deployment, and release of tail wing restraint of the external store, which are considered to affect the flight safety of the aircraft due to the operation of the external store. As a result of the aircraft's flight safety analysis on the failure types, the criticality requirements were met. Based on this, after obtaining the airworthiness certification, the drop test was successfully performed to confirm the flight safety of the aircraft by mounting an external store on the aircraft. However, in addition to the four hazards carried out in this study, the real external stores of the military aircraft may have various factors affecting the flight safety of the aircraft, so further research will be needed.

• Journal of Society of Preventive Korean Medicine
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• v.20 no.3
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• pp.55-65
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• 2016

Objectives : Mibyeong is a korea medicine have original concept of the disease. However, no previous report has effect of mibyeong herbal medicine in fatigue types of mibyeong. This study investigated the question of whether Dang Gui Bo Hyul-tang(DGBHT) of effect on fatigue types of Mibyeong. Methods : C57BL/6 mice were randomaly divided into three group (n=10). The mice were then group (1) Nocontrol, (2) Restraunt stress(veh), (3) Dang Gui Bo Hyul-tang 200mg/kg. The administered Dang Gui Bo Hyul-tang 200mg/kg or distilled water (orally) 1 hr prior to daily exposure to repeated restraint stress (2 h) for 15 days. The performed behavior test (Mechanical hyperalgesia test,, Open-field test, Forced swimming test, Sucrose preference test and immunostaining and biochemical measured in serum. Results : Stress fatigue induced mices significantly increased lethargic, hyperalgesia through behavior test (Mechanical hyperalgesia test (decrease 43%), Open-field test ($4,809{\pm} 226.13cm$ vs. $3121{\pm}226.64cm$), Forced swimming test ($11.45{\pm}3.96$ vs. $79.10{\pm}8.12sec$), Sucrose preference test (decrease 58%)). In addition, chronic fatigue model evidently increased corticosterone level ($122.54{\pm}18.88$ vs. $186.94{\pm}18.26ng/ml$), AST level ($46.22{\pm}3.23$ vs. $31.40{\pm}3.86U/L$), ALT level ($38.78{\pm}5.72$ vs. $17.60{\pm}1.30$), liver necrosis, lateral ventricle size. These alterations were significantly ameliorated by DGBHT. DGBHT significantly attend the elevated serum concentrations of corticosterone ($155.90{\pm}6.29ng/ml$), AST ($31.40{\pm}3.86U/L$), ALT ($17.60{\pm}1.30U/L$). Moreover, DGBHT improved lethargic, hyperalgesia when compared the stress fatigue (Mechanical hyperalgesia test (improve 28%), Open-field test ($4,038{\pm}615.81cm$), Forced swimming test ($7.56{\pm}1.88sec$), Sucrose preference test (increase 21%) Conclusions : Theses result suggest that DGBHT have improved lethargic, hyperalgesia and fatigue-associated hormone and liver protective on stress fatigue model. It will be necessary to research to present evidences on benefits and effects of Korean medical treatment for Mibyeong through clinical researches based on benefits and effects of those animal models.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.299-308
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• 2018

This study was conducted to examine the mediating effect of executive function deficiencies on the relationship between smartphone addiction and memory impairment and to suggest treatment implications for adults with smartphone addiction symptoms. For this study, 300 adults(146 males and 154 females) were conducted smartphone addiction scale, Barkley Deficits in Executive Functioning Scale-Short Form(BDEFS-SF), and Multifactorial Memory Questionnaire(MMQ). The results are as follows. First, correlation analyses showed that smartphone addiction, executive function deficiencies, and memory impairment were positively correlated. Second, Smartphone addiction group showed significantly higher scores on all of the subfactors of executive function and memory impairment. Third, Stepwise regression analyses revealed that self-organization/problem solving, self-management to time, self-restraint, and withdrawal were the best predictors of memory impairment. Forth, Executive function deficiencies fully mediated the relationship between smartphone addiction and memory impairment. These findings were considered to suggest that treatment programs for smartphone addiction group needed to include training for cognitive improvement such as executive function rehabilitation.