• Structural Engineering and Mechanics
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• 제66권2호
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• pp.249-262
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• 2018

In this paper, reaction of functionally graded (FG) thick nanoplates resting on a viscoelastic foundation to a moving nanoparticle/load is investigated. Nanoplate is assumed to be thick by using second order shear deformation theory and small-scale effects are taken into account in the framework of Eringen's nonlocal theory. Material properties are varied through the thickness using FG models by having power-law, sigmoid and exponential functions for material changes. FG nanoplate is assumed to be on a viscoelastic medium which is modeled using Kelvin-Voight viscoelastic model. Galerkin, state space and fourth-order Runge-Kutta methods are employed to solve the governing equations. A comprehensive parametric study is presetned to show the influence of different parameters on mechanical behavior of the system. It is shown that material variation in conjunction with nonlocal term have a significant effect on the dynamic deformation of nanoplate which could be used in comprehending and designing more efficient nanostructures. Moreover, it is shown that having a viscoelastic medium could play an important role in decreasing these dynamic deformations. With respect to the fresh studies on moving atoms, molecules, cells, nanocars, nanotrims and point loads on different nanosctructures using scanning tunneling microscopes (STM) and atomic force microscopes (AFM), this study could be a step forward in understanding, predicting and controlling such kind of behaviors by showing the influence of the moving path, velocity etc. on dynamic reaction of the plate.

• 가정∙방문간호학회지
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• 제24권3호
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• pp.264-274
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• 2017

Purpose: This study examined the current state of death preparedness and factors related to the death preparedness among community-dwelling older adults in Korea. Methods: A total of 6,879 older adults' data, selected from the Korean National Survey on the Elderly 2014 data, were analyzed. The criteria for selection were responding to the questionnaires directly and normal cognitive function. Stratified sampling logistic regression analysis was conducted on the compiled data. Results: It was seen that 37.3% of older adults were prepared for death; specifically, 28.6% had arranged for resting places, 10.7% had purchased burial clothes, 6.8% had subscribed to mutual aid societies, 0.7% participated in death education, and 0.6% had signed a will. The results of logistic regression indicated that the older adults who were females, older age, religious, highly educated, more satisfied with their economic status, living in rural areas, and participating in more social activities were more likely to prepare for their deaths compared to their counterparts. Conclusion: Education programs that prepare for death need to target marginalized groups in the community, such as male older adults and whose participation in social activities or satisfaction with their economic status are relatively low.

• Geomechanics and Engineering
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• 제7권4호
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• pp.355-374
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• 2014

An analytical solution of the fully coupled system of equations governing the plane strain deformation of a poroelastic medium with anisotropic permeability and compressible fluid and solid constituents is obtained. This solution is used to study the consolidation of a poroelastic clay layer with free permeable surface resting on a rough-rigid permeable or impermeable base. The stresses and the pore pressure are taken as the basic state variables. Displacements are obtained by integrating the coupled constitutive relations. The case of normal surface loading is discussed in detail. The solution is obtained in the Laplace-Fourier domain. Two integrations are required to obtain the solution in the space-time domain which are evaluated numerically for normal strip loading. Consolidation of the clay layer and diffusion of pore pressure is studied for both the bases. It is found that the time settlement is accelerated by the permeability of the base. Initially, the pore pressure is not affected by the permeability of the base, but has a significant effect, as we move towards the bottom of the layer. Also, anisotropy in permeability and compressibilities of constituents of the poroelastic medium have a significant effect on the consolidation of the clay layer.

• The Korean Journal of Physiology and Pharmacology
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• 제4권1호
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• pp.9-14
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• 2000

$K^+$ currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential. In this study, whole cell configuration of patch clamp technique had been applied to record the blocking effect of capsaicin, a lipophilic alkaloid, on the delayed rectifier $K^+$ current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the amplitude of $K^+$ current in dose dependent manner, and the concentration-dependence curve was well described by the Hill equation with $K_D$ value of $19.1{\mu}M.$ The blocking effect of capsaicin was reversible. Capsaicin $(10 {\mu}M)$ shifted the steady-state inactivation curve in the hyperpolarizing direction by about 15 mV and increased the rate of inactivation. The voltage dependence of activation was not affected by capsaicin. These multiple effects of capsaicin may suggest that capsaicin bind to the region of $K^+$ channel, participating in inactivation process.

• 사회경제평론
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• 제38호
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• pp.51-83
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• 2012

다수의 상품이 생산되는 경제에서 스라파(Sraffa) 균형가격 조건과 균제성장 및 상품시장 균형 조건이 성립하는 경우를 생각하자. 이 모형에서 임금율 결정식과 투자함수를 동시에 부여하면 전체 경제는 과잉결정 되며 균형이 존재하지 않는다. 본 연구는 이 과잉결정 현상을 불균형 상태로 해석하고, 불균형상태에서 실현되는 임금율과 자본축적률이 각각의 동학식을 따라 결정되는 것으로 해석한다. 그리고 이 해석의 유효성을 주장하기 위하여 전체 경제에 대한 단순한 동학모형을 구축하고, 임금율과 자본축적률의 동학경로를 분석한다. 본 연구의 동학모형은 로카-볼테라 식체계의 구성조건을 만족하며, 따라서 전체 경제의 성장경로는 내생적으로 순환변동하는 경로를 따라 결정된다.

• Structural Engineering and Mechanics
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• 제10권6호
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• pp.517-532
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• 2000

A direct output feedback control scheme was recently proposed by the authors for single-story building structures resting on flexible soil body. In this paper, the control scheme is extended to mitigate the seismic responses of multi-story buildings. Soil-structure interaction is taken into account in two parts: input at the soil-structure interface/foundation and control algorithm. The former reflects the effect on ground motions and is monitored in real time with accelerometers at foundation. The latter includes the effect on the dynamic characteristics of structures, which is formulated by modifying the classical linear quadratic regulator based on the fundamental mode shape of the soil-structure system. Numerical result on the study of a $\frac{1}{4}$-scale three-story structure, supported by a viscoelastic half-space of soil mass, have demonstrated that the proposed algorithm is robust and very effective in suppressing the earthquake-induced vibration in building structures even supported on a flexible soil mass. Parametric studies are performed to understand how soil damping and flexibility affect the effectiveness of active tendon control. The selection of weighting matrix and effect of soil property uncertainty are investigated in detail for practical applications.

• Wind and Structures
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• 제32권5호
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• pp.405-421
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• 2021

To gain insight into the wind-induced safety concerns associated with attached tower cranes during the construction of super-tall buildings, a 606 m level frame-core tube super-tall building is selected to investigate the wind-induced vibration response and fragility of an outer-attached tower crane at all stages of construction. The wind velocity time history samples are artificially generated and used to perform dynamic response analyses of the crane to observe the effects of wind velocity and wind direction under its working and non-working resting state. The adverse effects of the relative displacement response at different connection supports are also identified. The wind-resistant fragility curves of the crane are obtained by introducing the concept of incremental dynamic analysis. The results from the investigation indicate that a large relative displacement between the supports can substantially amplify the response of the crane at high levels. Such an effect becomes more serious when the lifting arm is perpendicular to the plane of the connection supports. The flexibility of super-tall buildings should be considered in the design of outer-attached tower cranes, especially for anchorage systems. Fragility analysis can be used to specify the maximum appropriate height of the tower crane for each performance level.

• Journal of Obesity & Metabolic Syndrome
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• 제27권4호
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• pp.203-212
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• 2018

Dynamic energy balance can give clinicians important answers for why obesity is so resistant to control. When food intake is reduced for weight control, all components of energy expenditure change, including metabolic rate at rest (resting energy expenditure [REE]), metabolic rate of exercise, and adaptive thermogenesis. This means that a change in energy intake influences energy expenditure in a dynamic way. Mechanisms associated with reduction of total energy expenditure following weight loss are likely to be related to decreased body mass and enhanced metabolic efficiency. Reducing calorie intake results in a decrease in body weight, initially with a marked reduction in fat free mass and a decrease in REE, and this change is maintained for several years in a reduced state. Metabolic adaptation, which is not explained by changes in body composition, lasts for more than several years. These are powerful physiological adaptations that induce weight regain. To avoid a typically observed weight-loss and regain trajectory, realistic weight loss goals should be established and maintained for more than 1 year. Using a mathematical model can help clinicians formulate advice about diet control. It is important to emphasize steady efforts for several years to maintain reduced weight over efforts to lose weight. Because obesity is difficult to reverse, clinicians must prioritize obesity prevention. Obesity prevention strategies should have high feasibility, broad population reach, and relatively low cost, especially for young children who have the smallest energy gaps to change.

• 식품과학과 산업
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• 제51권1호
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• pp.8-15
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• 2018

Functional food research has been struggling to demonstrate their beneficial effects in human, however, the physiological changes in humans who are in the target for functional food are very subtle and long term. In addition, it is difficult to obtain significant beneficial effect because of the necessity of using relatively healthy subjects. Relatively healthy subjects are homeostatic, and most of the biomarkers maintain a certain level under the "normal" or "resting" state. Moreover, due to wide inter-individual variation, it is difficult to detect significant changes. To address this problem, research has been actively conducted to identify the efficacy of natural products using 'omics' and 'bioinformatics' technology. In this review, we would like to introduce the human intervention studies applied homeostatic challenge model.

• Communications for Statistical Applications and Methods
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• 제27권6호
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• pp.603-624
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• 2020

There is an emerging interest in brain functional connectivity (FC) based on functional Magnetic Resonance Imaging in Alzheimer's disease (AD) studies. The complex and high-dimensional structure of FC makes it challenging to explore the association between altered connectivity and AD susceptibility. We develop a pipeline to refine FC as proper covariates in a penalized logistic regression model and classify normal and AD susceptible groups. Three different quantification methods are proposed for FC refinement. One of the methods is dimension reduction based on common component analysis (CCA), which is employed to address the limitations of the other methods. We applied the proposed pipeline to the Alzheimer's Disease Neuroimaging Initiative (ADNI) data and deduced pathogenic FC biomarkers associated with AD susceptibility. The refined FC biomarkers were related to brain regions for cognition, stimuli processing, and sensorimotor skills. We also demonstrated that a model using CCA performed better than others in terms of classification performance and goodness-of-fit.