• Journal of Korean Society of Transportation
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• v.17 no.4
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• pp.59-69
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• 1999

A Freeway corridor is a network consisting of a few Primary longitudinal roadways (freeway or major arterial) carrying a major traffic movement with interconnecting roads which offer the motorist alternative paths to his/her destination. Control measures introduced to ameliorate traffic performance in freeway corridors typically include ramp metering at the freeway entrances, and signal control at each intersections. During a severe freeway incident, on-ramp metering usually is not adequate to relieve congestion effectively. Diverting some traffic to the Parallel surface street to make full use of available corridor capacity will be necessary. This is the purpose of the traffic management system. So, an integrated traffic control scheme should include three elements. (a)on-ramp metering, (b)off-ramp diversion and (c)signal timing at surface street intersections. The purpose of this study is to develop an integrated optimal control model in a freeway corridor. By approximating the flow-density relation with a two-segment linear function. the nonlinear optimal control problem can be simplified into a set of Piecewise linear programming models. The formulated optimal-control Problem can be solved in real time using common linear program. In this study, program MPL(ver 4.0) is used to solve the formulated optimal-control problem. Simulation results with TSIS(ver 4.01) for a sample network have demonstrated the merits of the Proposed model and a1gorithm.

• 한국HCI학회:학술대회논문집
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• 2006.02c
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• pp.854-858
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• 2006

디지털화의 가속, 고속 통신 인프라의 확대 등으로 전자, 정보 통신 기기들이 단일 네트워크로 연결되어 영상 및 음향 정보를 서로 공유할 수 있으며, 생활 공간 내에서 실생활의 질 향상을 위한 지능적 정보 서비스와 자연스럽고 편한 내추럴 인터페이스 기술에 의한 지능형 반응 정보 서비스 공간 기술이 중요한 이슈로 등장하고 있다. 본 연구에서는 지능형 반응 공간의 물리적 객체로서 학교, 연구 기관 및 회사 등의 회의실을 선정한다. 그리고, 이를 대상으로 회의 참여자들이 자연스럽고 편리하게 의견 교환, 관련 자료 및 정보 처리를 할 수 있는 시스템 구축을 위한 아키텍처에 대하여 논의한다. 본 연구에서 제안하는 시스템 아키텍처는 회의와 관련된 문서나 회의 내용 등의 정보를 실감 가시화 노드로 추상화되고 메타 정보화함으로써 전체 회의 내용의 파악과 회의 정보에 대한 체계적이고 논리적인 관리를 가능하게 한다. 또한 여러 사람의 공동 작업을 필요로 하는 정보 또는 문서에 대한 동시 편집 기능과 자연스러운 동작에 의한 데이터 조작을 지원하는 실감 워크벤치 및 워크스크린 기술, 정보 핸들링의 다양성과 조작의 편리성을 위한 실감 아이콘에 의하여 자연스럽고 편리한 회의를 가능하게 한다. 그리고, 이러한 요소 기술들이 에이전트에 의해 회의 프로세스 및 요소 기술들의 시스템적 통합을 가능하게 한다.

• Journal of Trauma and Injury
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• v.33 no.1
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• pp.1-12
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• 2020

Purpose: Despite recent developments in the management of trauma patients in South Korea, a standardized system and guideline for trauma treatment are absent. Methods: Five guidelines were assessed using the Appraisal of Guidelines for Research and Evaluation II instrument. Results: Restrictive volume replacement must be used for patients experiencing shock from trauma until hemostasis is achieved (1B). The target systolic pressure for fluid resuscitation should be 80-90 mmHg in hypovolemic shock patients (1C). For patients with head trauma, the target pressure for fluid resuscitation should be 100-110 mmHg (2C). Isotonic crystalloid fluid is recommended for initially treating traumatic hypovolemic shock patients (1A). Hypothermia should be prevented in patients with severe trauma, and if hypothermia occurs, the body temperature should be increased without delay (1B). Acidemia must be corrected with an appropriate means of treatment for hypovolemic trauma patients (1B). When a large amount of transfusion is required for trauma patients in hypovolemic shock, a massive transfusion protocol (MTP) should be used (1B). The decision to implement MTP should be made based on hemodynamic status and initial responses to fluid resuscitation, not only the patient's initial condition (1B). The ratio of plasma to red blood cell concentration should be at least 1:2 for trauma patients requiring massive transfusion (1B). When a trauma patient is in life-threatening hypovolemic shock, vasopressors can be administered in addition to fluids and blood products (1B). Early administration of tranexamic acid is recommended in trauma patients who are actively bleeding or at high risk of hemorrhage (1B). For hypovolemic patients with coagulopathy non-responsive to primary therapy, the use of fibrinogen concentrate, cryoprecipitate, or recombinant factor VIIa can be considered (2C). Conclusions: This research presents Korea's first clinical practice guideline for patients with traumatic shock. This guideline will be revised with updated research every 5 years.

• Journal of Biomedical Engineering Research
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• v.29 no.4
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• pp.316-322
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• 2008

The purpose of this study was to investigate muscle activation of lower extremity such as rectus femoris, tibialis anterior and soleus according to 0cm(bare foot), 4cm and 7cm heel height of shoe on the rocking surface in older women. 20 older women who did not have any lower musculoskeletal and neurological disorders in the past were participated in this study. Each subject was standing for 15 seconds on the level 8 of Biodex Stability System (BSS) while wearing 4cm and 7cm heel height shoes including bare foot. Electromyography was used to measure muscle activation of lower extremity, and the muscle activation was expressed as a percentage of maximal voluntary isometric contraction (% MVIC). We measured % MVIC of three muscles during 5 seconds except for the first 5 seconds and last 5 seconds. SPSS 12.0 program was used for this study. Repeated one-way analysis of variance(ANOVA) was performed to compare the significant difference among the muscles of lower extremities according to heel heights of shoe on the rocking plate. % MVIC of each muscle such as rectus femoris, tibialis anterior and soleus regarding heel heights of shoe had statistically significant differences (p<0.05). The results of contrast test were as follows; 1) % MVIC of rectus femoris had significant differences between barefoot and 4cm, and barefoot and 7cm. 2) % MVIC of tibialis anterior had significant differences between barefoot and 4cm, barefoot and 7cm, and 4cm and 7cm. 3) % MVIC of soleus had significant differences between barefoot and 7cm, 4cm and 7cm. The results indicate that all commonly responsive muscle on the conditions of barefoot, 4cm, and 7cm shoe height on the rcoking surface is tibialis anterior muscle. We found out that the more heels of shoe high, the more muscle activation increases. High-heeled shoes above 7cm remarkably increase the muscle activation of lower extremity and may result in muscle fatigue. Thus, these shoes may summate risk factors of falls in older women. We can acknowledge that the heels above 4 cm affect each muscle activation in lower extremity on the rocking surface.

• Journal of Korean Society of Transportation
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• v.25 no.3
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• pp.137-144
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• 2007

This study involves an analytical approach to determine transit dispatching schedules (headways) Determining a time schedule is an important process in transit system planning. In general, the transit headway should be shorter during the peak hour than at non-peak hours for demand-responsive service. It allows passengers to minimize their waiting time under inelastic, fixed demand conditions. The transit headway should be longer as operating costs increase, and shorter as demand and waiting time increase. Optimal headway depends on the amount of ridership. and each individual vehicle dispatching time depends on the distribution of the ridership. This study provides a theoretical foundation for the dispatching scheme consistent with common sense. Previous research suggested a dispatching scheme with even headway. However, according to this research, that is valid for a specific case when the demand pattern is uniform. This study is a general analysis expanding that previous research. This study suggests an easy method to set a time table without a complex and difficult calculation. Further. if the time axis is changed to the space axis instead, this study could be expanded to address the spacing problems of some facilities such as roads. stations, routes and others.

• Korean Chemical Engineering Research
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• v.47 no.4
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• pp.453-458
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• 2009

Recently, new methods to synthesize and process polymers without toxic organic solvents are needed in order to solve environmental problems. The use of supercritical carbon dioxide as a solvent for the polymer synthesis is attractive since it is non-toxic, non-flammable, naturally abundant, and the product may be easily separated from the solvent. In this study, we developed the method using super critical $CO_2$ to prepare P(MAA-co-EGMA) hydrogel nanoparticles as an intelligent drug delivery carrier. The effects of concentrations of PtBuMA-PEO as a dispersion stabilizer and AIBN as an initiator on the particle synthesis were investigated. When PtBuMA-PEO concentration increased, the particle size decreased. However, there was no significant difference in the particle size according to the AIBN concentration. There was a drastic change of the equilibrium weight swelling ratio of P(MAA-co-EGMA) hydrogel nanoparticles at a pH of around 5, which is the $pK_a$ of PMAA. At a pH below 5, the hydrogels were in a relatively collapsed state but at a pH higher than 5, the hydrogels swelled to a high degree. In release experiments using Rh-B as a model solute, the P(MAA-co-EGMA) hydrogel nanoparticles showed a pH-sensitive release behavior. At low pH(pH 4.0) a small amount of Rh-B was released while at high pH(pH 6.0) a relatively large amount of Rh-B was released from the hydrogels.

• Korean journal of communication and information
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• v.32
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• pp.147-168
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• 2006

This study attempts to evaluate the Korean terrestrial television networks‘ internet site effectiveness, specifically in addressing user motivations and user evaluations and in gauging the broadcasters' feedback. The result shows that the primary motive for using a broadcaster's internet homepage was to obtain information. Overall, the users tended to be dissatisfied with the services, especially with regards to its navigational structure and design and with the insufficient number of appropriate content items. The reason cited highest for dissatisfaction was the fee-based services. Among the three networks, Seoul Broadcasting System, the sole commercial network, received the most complaints from the respondents in this respect. The study results reveal that broadcasters' feedback systems to users were deemed responsive and timely, but a true interactivity between the broadcasters and the viewers was lacking. In conclusion, network televisions' internet sites and increased content access through them have provided a platform for increased communication with their viewers, however, these sites are not yet being fully utilized as effective interactive communication feedback channels but more as a unidirectional information source. In addition, the network television services seem to be lacking in providing users with efficient navigational structure, good design, or adequate content level and quality. Thus, to better serve the public, it is recommended that they improve internet homepage usability by assessing and applying qualitative researches regarding the users.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.11
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• pp.1824-1836
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• 2020

Objective: On the hypothesis that grazing of cattle prompts organs to secrete or internalize circulating microRNAs (c-miRNAs) in parallel with changes in energy metabolism, we aimed to clarify biological events in adipose, skeletal muscle, and liver tissues in grazing Japanese Shorthorn (JSH) steers by a transcriptomic approach. Methods: The subcutaneous fat (SCF), biceps femoris muscle (BFM), and liver in JSH steers after three months of grazing or housing were analyzed using microarray and quantitative polymerase chain reaction (qPCR), followed by gene ontology (GO) and functional annotation analyses. Results: The results of transcriptomics indicated that SCF was highly responsive to grazing compared to BFM and liver tissues. The 'Exosome', 'Carbohydrate metabolism' and 'Lipid metabolism' were extracted as the relevant GO terms in SCF and BFM, and/or liver from the >1.5-fold-altered mRNAs in grazing steers. The qPCR analyses showed a trend of upregulated gene expression related to exosome secretion and internalization (charged multivesicular body protein 4A, vacuolar protein sorting-associated protein 4B, vesicle associated membrane protein 7, caveolin 1) in the BFM and SCF, as well as upregulation of lipolysis-associated mRNAs (carnitine palmitoyltransferase 1A, hormone-sensitive lipase, perilipin 1, adipose triglyceride lipase, fatty acid binding protein 4) and most of the microRNAs (miRNAs) in SCF. Moreover, gene expression related to fatty acid uptake and inter-organ signaling (solute carrier family 27 member 4 and angiopoietin-like 4) was upregulated in BFM, suggesting activation of SCF-BFM organ crosstalk for energy metabolism. Meanwhile, expression of plasma exosomal miR-16a, miR-19b, miR-21-5p, and miR-142-5p was reduced. According to bioinformatic analyses, the c-miRNA target genes are associated with the terms 'Endosome', 'Caveola', 'Endocytosis', 'Carbohydrate metabolism', and with pathways related to environmental information processing and the endocrine system. Conclusion: Exosome and fatty acid metabolism-related gene expression was altered in SCF of grazing cattle, which could be regulated by miRNA such as miR-142-5p. These changes occurred coordinately in both the SCF and BFM, suggesting involvement of exosome in the SCF-BFM organ crosstalk to modulate energy metabolism.

• Journal of Veterinary Clinics
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• v.26 no.2
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• pp.181-184
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• 2009

Immune-mediated hemolytic anemia(IMHA) is one of the most common causes of anemia in small animals and immune-mediate thrombocytopenia(IMT) is also an immune mediated disease that affects small animals. The initial treatment for IMHA and IMT is medical suppression of the immune system with glucocorticoids and other immunosuppressive drugs. However, even with appropriate treatments, some animals are not responsive to the treatment and may need further immunosuppressive therapies or some alternative medicines. An eight-year-old spayed female Siamese cat with IMHA and an eight-year-old castrated male King Charles Spaniel dog with IMT were referred to the traditional medical service of the veterinary medical center. Both animals were unresponsive to steroids or other immunosuppressive treatments. Gui-Pi-Tang, one of the traditional herbal medicines, was administered to the animals. After 1-month of Gui-Pi-Tang administration, the packed cell volume(PCV) of the cat and platelets count of the dog had showed remarkable improvement. After four months of follow up in the cat, and 18 months of follow up in the dog, the improved PCV and platelet counts of the animals were maintained normally. Therefore, Gui-Pi-Tang might be considered as an alternative treatment in small animals with immune-mediated blood disorders.

• Journal of Life Science
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• v.17 no.2 s.82
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• pp.235-240
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• 2007

AvrRpt2 protein triggers hypersensitive response (HR) and strong disease resistance when it is translocated from a bacterial pathogen Pseudomonas sp. to host plant cells containing a cognate RPS2 resistance protein through Type III Secretion System (TTSS). However, AvrRpt2 protein can function as the effector that suppresses a basal defense and enhances the disease symptom when functional RPS2 resistance protein is absent in the infected plant cells. Using Affymetrix Arabidopsis DNA chip, we found that many genes were specifically regulated by AvrRpt2 protein in the rps2 Arabidopsis mutant. Here, we showed that expression of AtERF11 that is known as a member of B1a subcluster of AP2/ERF transcription factor family was down regulated specifically by AvrRpt2. To determine its function in plant resistance, we also generated the Arabidopsis thaliana transgenic plants constitutively overexpressing AtERF11 under CaMV 355 promoter, which conferred an enhanced resistance against a bacterial pathogen, Pseudomonas syringae pv. tomato DC3000. Thus, these results collectively suggest that AtERF11 plays a role as a positive regulator for disease resistance against biotrophic bacterial pathogen in plant.