• Nuclear Engineering and Technology
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• v.50 no.4
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• pp.542-552
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• 2018

Operators face challenges to plan alternative countermeasures when no procedure exists to address the current plant state. A model-based approach is desired to aid operators in acquiring plant resources and deriving response plans. Multilevel flow modeling (MFM) is a functional modeling methodology that can represent intentional knowledge about systems, which is essential in response planning. This article investigates the capabilities of MFM to plan alternatives. It is concluded that MFM has a knowledge capability to represent alternative means that are designed for given ends and a reasoning capability to identify alternative functions that can causally influence the goal achievement. The second capability can be applied to find originally unassociated means to achieve a goal. This is vital in a situation where all designed means have failed. A technique of procedure synthesis can be used to express identified alternatives as a series of operations. A case of station blackout occurring at the boiling water reactor is described. An MFM model of a boiling water reactor is built according to the analysis of goals and functions. The accident situations are defined by the model, and several alternative countermeasures in terms of operating procedures are generated to achieve the goal of core cooling.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1208-1216
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• 2003

Stress is known to influence the immune function via an effect on the central nervous system. To investigated the effects of Kwibitang water extract (KBT) on the specific immune response in C57BL/6 mice stressed by immobilization, we evaluated the changes in the cell viability, DNA fragmentation and subpopulation of thymocytes and splenocytes. KBT enhanced the cell viability of thymocytes and splenocytes decreased by immobilization stress. Also, KBT decreased DNA fragmentation of thymocytes and splenocytes increased by immobilization stress. KBT decreased the population of CD4/sup +/ cells and CD8/sup +/ cells in thymocytes and Thy1/sup +/ cells in splenocytes increased by immobolization stress, but increased the population of B220/sup +/ cells decreased by immobilization stress. In addition, KBT enhanced the production of ν-interferon and IL-2 decreased by immobilization stress. These results indicate that KBT may be useful for the prevention and treatment of stress via enhancement of the specific immune response

• Structural Engineering and Mechanics
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• v.46 no.5
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• pp.713-734
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• 2013

Bridges are vital components of the railroads. High speed of travel, the periodic and oscillatory nature of the loads and the comparable vehicle bridge weight ratio distinguish the railway bridges from the road bridges. The close proximity between estimations by some numerical methods and the measured data for the bridge-vehicle dynamic response under the moving load conditions has boosted the confidence in the numerical analyses. However, there is hardly any report regarding the responses of the railway bridges under the effect of the trains entering from the opposite directions while running at unequal speed and having dissimilar geometries. It is the purpose of this article to present an analytical method for the dynamic analysis of the railway bridges under the influence of two opposing series of moving loads. The bridge structural damping and many modes of vibrations are included. The concept of modal superposition is used to solve for the system motion equations. The method of solution is indeed a computer assisted analytical solution. It solves for the system motion equations and gives output in terms of the bridge deflection. Some case studies are also considered for the validation of the proposed method. Furthermore, the effects of varying some parameters such as the distance between the bogies, and the bogie wheelset distance are studied. Also, the conditions of resonance and cancellation in the dynamic response for a variety of vehicle-bridge specifications are investigated.

• Structural Engineering and Mechanics
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• v.76 no.1
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• pp.115-127
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• 2020

This study presents an analytical approach to investigate the thermodynamic behavior of functionally graded beam resting on elastic foundations. The formulation is based on a refined deformation theory taking into consideration the stretching effect and the type of elastic foundation. The displacement field used in the present refined theory contains undetermined integral forms and involves only three unknowns to derive. The mechanical characteristics of the beam are assumed to be varied across the thickness according to a simple exponential law distribution. The beam is supposed simply supported and therefore the Navier solution is used to derive analytical solution. Verification examples demonstrate that the developed theory is very accurate in describing the response of FG beams subjected to thermodynamic loading. Numerical results are carried out to show the effects of the thermodynamic loading on the response of FG beams resting on elastic foundation.

• Advances in concrete construction
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• v.8 no.4
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• pp.277-283
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• 2019

In evaluating explosion-protection capacity, safety distance is broadly accepted as the distance at which detonation of a given explosive causes acceptable structural damage. Safety distance can be calculated based on structural response under blast loading and damage criteria. For the applicability of the safety distance, the minimum required stand-off distance should be given when the explosive size is assumed. However, because of the nature of structures, structural details and material characteristics differ, which requires sensitivity analysis of the safety distance. This study examines the safety-distance sensitivity from structural and material property variations. For the safety-distance calculation, a blast analysis module based on the Kingery and Bulmash formula, a structural response module based on a Single Degree of Freedom model, and damage criteria based on a support rotation angle were prepared. Sensitivity analysis was conducted for the Reinforced Concrete one-way slab with different thicknesses, reinforcement ratios, reinforcement yield strengths, and concrete compressive strengths. It was shown that slab thickness has the most significant influence on both inertial force and flexure resistance, but the compressive strength of the concrete is not relevant.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.10
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• pp.1470-1476
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• 2001

Kou Woan Lao is an oriental-style dairy product, which is coagulated by milk-clotting enzyme from the culture filtrate of lao-chao. The product appears smooth, sweet, slightly wine flavour, and the flavour differs from yogurt. The aim of this study was to search for the optimum model to shorten the period of manufacture, and to improve the quality of Kou Woan Lao. A response surface design was used for studying the effects of addition of carrageenan, locust bean gum, and culture filtrate from lao-chao on the curd firmness, viscosity, and syneresis. Results indicated that the best rheological property, preservative quality and acceptability of Kou Woan Lao could be obtained by the combination of 0.22% carrageenan, 0.21 % locust bean gum and 12% culture filtrate from lao-chao. The curd firmness, viscosity and syneresis of resultant product were 29.3 g, 21,347.7 cps, and 8.92%, respectively and the microstructure of the curd revealed a relatively complete three-dimensional spider web-like structure.

• Journal of Microbiology and Biotechnology
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• v.19 no.11
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• pp.1374-1378
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• 2009

Response surface methodology (RSM) examining the effects of five-level-three-factors and their mutual interactions was utilized to optimize the fermentation conditions to enhance capsular polysaccharide (CPS) production of Streptococcus pneumoniae type 3. Twenty experiments conducted in an 8-l lab-scale fermentor were designed to assess fermentation pH, supplemented glucose concentration, and stirring rate. The predicted highest CPS production by the obtained optimization model equation was 256.14 mg/l at optimal conditions [pH 7.5, stirring rate 180 rpm, and supplemented glucose concentration 1% (w/v)]. The validity of the response model was confirmed by the good agreement between the predicted and experimental results. The maximum amount of CPS obtained was $255.03\pm2.23$ mg/l.

• Current Research on Agriculture and Life Sciences
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• v.32 no.2
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• pp.67-73
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• 2014

Mulberry fruits were semi-dried using hot air ($60-100^{\circ}C$) or cool air ($20-40^{\circ}C$), and the effects of the drying temperature and processing time on the quality of the final dried mulberry fruits were investigated. Response surface methodology was employed to establish a statistical model and predict the conditions resulting in minimal loss of the total phenolic content (TPC) and ascorbic acid. Thus, using overlapped contour plots, the optimal conditions for producing semi-dried mulberry fruits, which reduced the moisture residue to 45% and minimized the nutrient losses of TPC and ascorbic acid, were determined for the hot-air process ($60.7^{\circ}C$ for 5.4 h) and cool-air process ($34.8^{\circ}C$ for 23.3 h). Plus, a higher drying temperature was found to lead to a faster loss of moisture and ascorbic acid, while the TPC was significantly decreased in the cool-air dried mulberry fruits due to the higher activity of polyphenol oxidase between 30 and $40^{\circ}C$.

• International Journal of Aeronautical and Space Sciences
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• v.11 no.1
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• pp.49-57
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• 2010

Several pyrotechnic devices are employed over the course of satellite's missions, generally for the separation of structural subsystems and deployment of appendages. Firing of pyrotechnic devices results in impulsive loads characterized by high peak acceleration and high frequency content which can cause failures of various flight hardware elements and small components. Thus, accurate prediction of acceleration level in various components of spacecraft due to pyrotechnic devices is important. In this paper, two methods for pyroshock prediction, an empirical model and statistical energy analysis in conjunction with virtual mode synthesis, are applied to predict shock response of a low altitude earth observation satellite during launch vehicle separation. The predicted results are then evaluated through comparison with the shock test results.

• Food Science of Animal Resources
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• v.31 no.2
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• pp.176-182
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• 2011

The bacteriocin-producing lactic acid bacteria Enterococcus faecium DB1 was isolated from Korean traditional gajami sikhae. Culture conditions were optimized by response surface methodology (RSM) to maximize bacteriocin DB1 production. E. faecium DB1 displayed the highest bacteriocin activity when grown in modified MRS medium containing sucrose, rather than glucose, as a carbon source. The effects of temperature, initial pH, and sucrose concentration were tested to determine the optimum conditions for maximum bacteriocin production by E. faecium DB1. A central composite design was used to control the three variables in the experiment. RSM revealed that the optimum values for bacteriocin production were 27.66 g/L sucrose, temperature of $34.37^{\circ}C$, and an initial pH of 6.54. A 2.08-fold increase in bacteriocin production was obtained with sucrose-containing MRS medium compared to production in standard MRS medium.