• Earthquakes and Structures
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• 제13권1호
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• pp.51-58
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• 2017

Passive dynamic vibration absorbers (DVAs) are often used to suppress the excessive vibration of a large structure due to their simple construction and low maintenance cost compared to other vibration control techniques. A new type of passive DVA consists of two pendulums connected with spring and dashpot element is investigated. This research evaluated the performance of the DVA in reducing the vibration response of a two degree of freedom shear structure. A model for the two DOF vibration system with the absorber is developed. The nominal absorber parameters are calculated using a Genetic Algorithm(GA) procedure. A parametric study is performed to evaluate the effect of each absorber parameter on performance. The simulation results show that the optimum condition for the absorber frequencies and damping ratios is mainly affected by pendulum length, mass, and the damping coefficient of the pendulum's hinge joint. An experimental model validates the theoretical results. The simulation and experimental results show that the proposed technique is able be used as an effective alternative solution for reducing the vibration response of a multi degree of freedom vibration system.

• Nuclear Engineering and Technology
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• 제54권1호
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• pp.374-385
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• 2022

In order to investigate the application of 3D base-seismic isolation system in nuclear power plants (NPPs), comprehensive analysis of constitution and design theory for 3-dimensional combined isolation bearing (3D-CIB) was presented and derived. Four different vertical stiffness of 3D-CIB was designed to isolate the nuclear island (NI) building. This paper aimed at investigating the isolation effectiveness of 3D-CIB through modal analysis and dynamic time-history analysis. Numerical results in terms of dynamic response of 3D-CIB, relative displacement response, acceleration and floor response spectra (FRS) of the superstructure were compared to validate the reliability of 3D-CIB in mitigating seismic response. The results showed that 3D-CIB can significantly attenuate the horizontal acceleration response, and a fair amount of the vertical acceleration response reduction of the upper structure was still observed. 3D-CIB plays a significant role in reducing the horizontal and vertical FRS, the vertical FRS basically do not vary with the floor height. The smaller the vertical stiffness of 3D-CIB is, the better the vertical isolation effectiveness is, whereas, it will increase the displacement and the rocking effect of superstructure. Although the advantage of 3D-CIB is that the vertical stiffness can be flexibly adjusted, it should be designed by properly accounting for the balance between the isolation effectiveness and displacement control including rocking effect. The results of this study can provide the technical basis and guidance for the application of 3D-CIB to engineering structure.

• 생약학회지
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• 제50권4호
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• pp.277-284
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• 2019

Rumex crispus is known to have anticancer, antioxidant, antibacterial, and bone loss inhibitory activities. Mast cells are critical immune cells that induce a type 1 IgE-mediated allergic reaction. However, there are no reports of inhibitory effects of Rumex crispus on mast cells and allergic reactions. In this study, we performed some experiments to investigate whether Rumex crispus ethanol extract(RCE) has any inhibitory effect on antigen-induced type I allergic response in vitro and in vivo. RCE inhibited degranulation of IgE-mediated mast cells(IC₅₀, ~57 ㎍/ml) and cytokine production such as TNF-α and IL-4 in a dose-dependent manner. In vivo, RCE significantly inhibited passive cutaneous anaphylaxis(PCA)(ED₅₀, ~198 mg/kg) in mice. Furthermore, RCE inhibited degranulation of MCs in ear tissue of mice with PCA. Mechanism studies showed that RCE inhibited the activation of Syk and Syk-dependent pathway such as LAT, PLC-γ, Akt, and MAP Kinase. Our results demonstrate for the first time that RCE inhibits type I hypersensitive response by suppressing the activity of Syk in mast cells, thereby reducing degranulation and cytokine production. Taken together, RCE could be used as a novel therapeutic material to suppress allergic diseases.

• Earthquakes and Structures
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• 제4권2호
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• pp.203-217
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• 2013

In recent decades, it has been realized that increasing the lateral stiffness of structure subjected to lateral loads is not the only parameter enhancing safety or reducing damage. Factors such as ductility and damping govern the structural response due to lateral loads. Despite the significant contribution of damping in resisting lateral loads, especially at resonance, there is no accurate mathematical representation for it. The main objective of this study is to develop a damping identification procedure for linear systems based on a mixed numerical-experimental approach, assuming viscous damping. The proposed procedure has been applied to a laboratory experiment associated with a numerical model, where a hollow rectangular steel cantilever column, having three lumped masses, has been fixed on a shaking table subjected to different exciting waves. The modal damping ratio has been identified; in addition, the effect of adding filling material to the hollow specimen has been studied in relation to damping enhancement. The results have revealed that the numerically computed response based on the identified damping is in a good fitting with the measured response. Moreover, the filling material has a significant effect in increasing the modal damping.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권1호
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• pp.114-125
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• 2017

This paper addresses a study of inner-tank sloshing effect on motion responses of a Floating Liquefied Natural Gas (FLNG) system, through experimental analysis and numerical modeling. To investigate hydrodynamic characteristics of FLNG under the conditions of with and without LNG-tank sloshing, a series of numerical simulations were carried out using potential flow solver SESAM. To validate the numerical simulations, model tests on the FLNG system was conducted in both liquid and solid ballast conditions with 75% tank filling level in height. Good correlations were observed between the measured and predicted results, proving the feasibility of the numerical modeling technique. On the verified numerical model, Response Amplitude Operators (RAOs) of the FLNG with 25% and 50% tank filling levels were calculated in six degrees of freedom. The influence of tank sloshing with varying tank filling levels on the RAOs has been presented and analyzed. The results showed that LNG-tank sloshing has a noticeable impact on the roll motion response of the FLNG and a moderate tank filling level is less helpful in reducing the roll motion response.

• Earthquakes and Structures
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• 제21권5호
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• pp.461-475
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• 2021

Strategic structures are a potential target of the growing terrorist attacks, so their performance under explosion hazard has been paid attention by researchers in the last years. In this regard, the aim of this study is to evaluate the blast-resistance performance of lead-rubber bearing (LRB) base isolation system based on a probabilistic framework while uncertainties related to the charge weight and standoff distance have been taken into account. A sensitivity analysis is first performed to show the effect of explosion uncertainty on the response of base-isolated buildings. The blast fragility curve is then developed for three base-isolated steel moment-resisting buildings with different heights of 4, 8 and 12 stories. The results of sensitivity analysis show that although LRB has the capability of reducing the peak response of buildings under explosion hazard, this control system may lead to increase in the peak response of buildings under some explosion scenarios. This shows the high importance of probabilistic-based assessment of isolated structures under explosion hazard. The blast fragility analysis shows effective performance of LRB in mitigating the probability of failure of buildings. Therefore, LRB can be introduced as effective control system for the protection of buildings from explosion hazard regarding uncertainty effect.

• Structural Engineering and Mechanics
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• 제64권2호
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• pp.233-241
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• 2017

Earlier numerous studies have been done on implementation of Tuned Liquid Damper (TLD) for structural vibration control by many researchers. As per current review there is no significant study on a sloped bottom TLD. TLD's are passive devices. A TLD is a tank rigidly attached to the structure and filled partially by liquid. When fundamental linear sloshing frequency is tuned to structure's natural frequency large sloshing amplitude is expected. In this study set of experiments are conducted on flat bottom and sloped bottom TLD at beach slope $20^{\circ}$, $30^{\circ}$ and $45^{\circ}$, for different types of structures, mass ratio, and depth ratio to investigate the overall effectiveness of TLD and specific effect of TLD parameters on structural response. This experimental study shows that a properly designed TLD reduces structural response. It is also observed that effectiveness of TLD increases with increase in mass ratio. In this experimental study an effectiveness of sloped bottom TLD with beach slope $30^{\circ}$ is investigated and compared with that of flat bottom TLD in reducing the structural response. It is observed from this study that efficiency of sloped bottom TLD in reducing the response of structure is more as compared to that of flat bottom TLD. It is shown that there is good agreement between numerical simulation of flat bottom and sloped bottom TLD and its experimental results. Also an attempt has been made to investigate the effectiveness of sloped bottom TLD with beach slope $20^{\circ}$ and $45^{\circ}$.

• 응용통계연구
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• 제27권7호
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• pp.1229-1241
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• 2014

이상점과 무응답이 동시에 존재하는 경우에는 무응답만 있는 경우에 비해 무응답 대체의 성능이 떨어지게 된다. 이러한 경우에는 먼저 이상점을 탐지하고, 탐지된 이상점의 영향력을 축소한 후 무응답 대체를 실시하여야 한다. 본 논문에서는 이상점의 영향력을 축소하여 무응답 대체법의 성능을 향상시키는 방법을 연구하였다. 이를 위해 She and Owen (2011)이 제안한 이상점 탐지법을 살펴보았고, 탐지된 이상점의 영향력을 줄이기 위한 방법으로 흔히 사용되는 가중치 조정법과 이상점 대체법을 살펴보았다. 또한 이상점 처리 방법을 적용한 무응답 대체법을 살펴보았으며 모의실험과 사례분석을 통하여 이상점 영향력 축소 효과를 살펴보았다.

• 폴리머
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• 제37권3호
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• pp.323-331
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• 2013

헤스페리딘은 혈관 순환계 보호 효과, 항암 효과, 항산화 효과, 항염증 효과 등의 작용이 있다고 알려져 있다. 본 연구에서는 헤스페리딘을 함유한 poly(lactic-co-glycolic acid)(PLGA) 필름을 조직공학적 세포담체로 이용하고 생체 내/외의 실험을 통하여 헤스페리딘과 염증 반응의 상관관계를 알아보고자 하였다. 세포담체에서의 세포의 증식과 부착을 확인하고자 PLGA/헤스페리딘 필름에 세포(RAW 264.7, NIH/3T3)를 파종하여 1, 3일 후에 MTT와 SEM을 통하여 분석하였다. 또한 항산화 효과와 염증 완화 효과를 알아보고자 ELISA, RT-PCR, FACS 등을 평가한 결과 PLGA 필름보다는 헤스페리딘이 첨가된 PLGA 필름에서 염증 반응이 감소하는 것을 확인하였다. In vivo 실험에서도 헤스페리딘이 PLGA에 의해 유도된 염증세포와 섬유피막 축적을 감소시켜 헤스페리딘의 항염증 효과를 볼 수 있었다. 이 실험 결과 PLGA 필름보다는 PLGA/헤스페리딘 필름에서 염증 반응이 감소함을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제27권3호
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• pp.514-523
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• 2017

Carbon catabolite repression is a crucial regulation mechanism in microorganisms, but its characteristic in Rhizopus is still unclear. We extracted a carbon regulation gene, cre, that encoded a carbon catabolite repressor protein (CRE) from Rhizopus stolonifer TP-02, and studied the regulation of CRE by real-time qPCR. CRE responded to glucose in a certain range, where it could significantly regulate part of the cellulase genes (eg, bg, and cbh2) without cbh1. In the comparison of the response of cre and four cellulase genes to carboxymethylcellulose sodium and a simple carbon source (lactose), the effect of CRE was only related to the concentration of reducing sugars. By regulating the reducing sugars to range from 0.4% to 0.6%, a glucose-containing medium with lactose as the inducer could effectively induce cellulases without the repression of CRE. This regulation method could potentially reduce the cost of enzymes produced in industries and provide a possible solution to achieve the largescale synthesis of cellulases.