• Radiation Oncology Journal
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• 제2권2호
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• pp.237-243
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• 1984

Thirty Patients with loco-regional recurrence following curative surgery for adenocarcinoma of the rectum were retrospectively evaluated to determine factors influencing survival and the efficacy of radiation therapy. In this review of 30 patients undergoing radiation therapy, more than 50 percent(17/30) had definite symptomatic and objective response. Ninety percent of patients(27/30) received significant palliation. Over all 2 year survival rate was $7.4\%$ and their median survival was 13.0 months. Grade of response and Sex were statistically related to survival.

• Structural Engineering and Mechanics
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• 제64권5호
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• pp.557-566
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• 2017

Fiber reinforced polymer (FRP) sheets are the most efficient structural materials in terms of strength to weight ratio and its application in strengthening and retrofitting of a structure or structural elements are inevitable. The performance enhancement of structural elements without increasing the cross sectional area and flexible nature are the major advantages of FRP in retrofitting/strengthening work. This research article presents a detailed study on the inelastic response of conventional and retrofitted Reinforced Concrete (RC) frames using Carbon Fibre Reinforced Polymers (CFRP) and Glass Fiber Reinforced Polymers (GFRP) subjected to quasi-static loading. The hysteretic behaviour, stiffness degradation, energy dissipation and damage index are the parameters employed to analyse the efficacy of FRP strengthening of brick in-filled RC frames. Repair and retrofitting of brick infilled RC frame shows an improved load carrying and damage tolerance capacity than control frame.

• Journal of Pharmaceutical Investigation
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• 제9권1호
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• pp.7-14
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• 1979

The relative efficacy on the renal function of rabbits by oral administration of furosemide and 1 : 2 furosemide-PVP coprecipitate was compared by measuring the urine volume in response to maximal response and the amounts of electrolytes excreted in urine. The furosemide produced a rapid onset, short duration of diuresis, in contrast, the 1: 2 furosemide-PVP coprecipitate, a rapid onset, significantly larger magnitude, and longer duration of diuresis and therefore the bioavailability of furosemide from the coprecipitate were increased significantly. The average urine volume and the amount of sodium and potassium excreted in urine were increased about 2.9-, 14.8-, and 1.8-fold from furosemide, and about 6.2-, 24.2-, and 3.6-fold from 1 : 2 furosemide- PVP 40,000 coprecipitate, rerpectively, comparing by their control values.

• Earthquakes and Structures
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• 제9권6호
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• pp.1153-1179
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• 2015

This paper focuses on presenting modeling considerations and insight into the performance of typical straight, curved, and skewed box-girder bridges in California which form the bulk of the bridge inventory in the state. Three case study bridges are chosen: Meloland Road Overpass, Northwest Connector of Interstate 10/215 Interchange, and Painter Street Overpass, having straight, curved, and skewed superstructures, respectively. The efficacy of nonlinear dynamic analysis is established by comparing the response from analytical models to the recorded strong motion data. Finally insights are provided on the component behavioral characteristics and shift in vulnerability for each of the bridge types considered.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 가을 학술발표회 논문집
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• pp.225-232
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• 1999

For the study of the seismic-response control, it is necessary to use an experimental system with an earthquake simulator and control devices employing a hydraulic actuator system. However, such system is too expensive to prepare at the university laboratory. In this research, an economical experimental system is developed which has a small-sized earthquake simulator and an AMD using AC servo motors. An accurate mathematical model of the three-degree-of-freedom tests structure with an AMD is developed from the measurement of the input/output relationships of the structure. This paper demonstrates experimentally the efficacy of the frequency domain optimal control algorithm H$_2$in reducing the response of seismically excited building to verify the performance of the experimental system.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1999년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Spring
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• pp.202-216
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• 1999

To control the motion of building structures under earthquakes their response should be measured first by various sensors and transformed into the control forces using some control algorithms. Of many control algorithms linear quadratic control is widely used as it is easy to implement and analyze. However the algorithms has the disadvantage that it needs the real-time measurements of all state variables(i.e, building's displacements and velocities) which are difficult to achieve for the building structures under earthquakes. Thus the practical algorithms employing output feedback are developed. In this paper LQG algorithm is used for the control of the building model with an active mass driver. The building's acceleration is used to obtain the control gain and the Kalman filter gain. The LQG control strategy is verified with the experimental study on the one-storybuilding model equipped with the active mass driver. This paper demonstrates experimentally the efficacy of the LQG algorithm based on the active mass driver system in reducing the response of seismically excited buildings.

• BMB Reports
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• 제52권1호
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권1호
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• pp.31-36
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• 2014

Purpose: Infliximab (IFX) is considered safe and effective for the treatment of ulcerative colitis (UC) in both adults and children. The aim of this study was to evaluate the short- and long-term clinical course of IFX in Korean children with UC. Methods: Pediatric patients with UC who had received IFX infusions between November 2007 and May 2013 at Samsung Medical Center were retrospectively investigated. The clinical efficacy of IFX treatment was evaluated at 8 weeks (short term) and 54 weeks (long term) after the initiation of IFX treatment using the Pediatric Ulcerative Colitis Activity Index (PUCAI). The degree of response to IFX treatment was defined as complete response (PUCAI score=0), partial response (decrement of PUCAI score${\geq}20$ points), and non-response (decrement of PUCAI score <20 points). Adverse events associated with IFX treatment were also investigated. Results: Eleven pediatric patients with moderate to severe UC had received IFX. The remission rate after IFX treatment was 46% (5/11) and 82% (9/11) at 8 weeks and 54 weeks after IFX treatment, respectively. All patients who were steroid-dependent before treatment with IFX achieved remission at 54 weeks and were able to stop treatment with corticosteroids, while all steroid-refractory patients failed to achieve remission at 54 weeks after treatment with IFX. Conclusion: Response to IFX treatment after 8 weeks may predict a favorable long-term response to IFX treatment in Korean pediatric UC patients.

• 한국임상약학회지
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• 제12권1호
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• pp.1-6
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• 2002

Central Cancer Registry of Korean National Cancer Center in 1999 reported that mortality from lung cancer is higher than mortality from stomach cancer or hepatocellular carcinoma in Korean male. Lung cancer is classified into small cell cancer and non-small cell lung cancer (NSCLC), and NSCLC patients account for $70\%$ of the whole lung cancer patients. The purpose of this study was to evaluate the efficacy and toxicity of docetaxel and cisplatin combination in Korean patients with NSCLC. All patients who had received the combination therapy of docetaxel and cisplatin for histologically confirmed NSCLC in Ajou University Hospital between 2000. $2\~2001$. 4 were retrospectively evaluated for the responses and toxicities of that combination therapy. Nineteen patients were treated with docetaxel 75 $mg/m^2$ on Day 1 and cisplatin 25 $mg/m^2$ on Day 1-3 every 4 weeks. The response for combination regimen was evaluated by CT scans after 2 or 3 cycles of treatments. Seventeen patients were evaluated for the responses and the 19 patients far the toxicities. Among the 19 patients (14 men and 5 women), there were one patient $(5.3\%)$ with stage I disease, 4 patients $(21.1\%)$ with stage III disease, and 14 patients $(73.1\%)$ with stage IV disease. Of the 17 patients who were evaluable for response, complete response (CR) was not observed in any patient while partial response (PR) was observed in 5 patients $(29.4\%)$. The overall response rate (CR+PR) was $29.4\%$. Stable disease (SD) was observed in 11 patients $(64.7\%)$ and progressive disease (PD) in 1 patient $(5.9\%)$. The toxicities were graded by NCI (National Cancer Institute) Common Toxicity Criteria for the evaluable 70 cycles. Grade 3 or 4 neutropenia occurred in 53 cycles $(76\%)$. Four patients were hospitalized due to febrile neutropenia. The combination chemotherapy of docetaxel and cisplatin was effective as NSCLC treatments, however, the regimen must be administered carefully due to its hematological side effects.

• Earthquakes and Structures
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• 제10권2호
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• pp.293-311
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• 2016

A parametric study on the nonlinear seismic response of isolated reinforced concrete structural frame is presented. Three prototype frames designed according to the 1954 Hellenic seismic code, with number of floor ranging from 1 to 3 were considered. These low rise frames are representative of many existing reinforced concrete buildings in Greece. The efficacy of the implementation of both lead rubber bearings (LRB) and friction pendulum isolators (FPI) base isolation systems were examined. The selection of the isolation devices was made according to the ratio $T_{is}/T_{fb}$, where Tis is the period of the base isolation system and $T_{bf}$ is the period of the fixed-base building. The main purpose of this comprehensive study is to investigate the effect of the isolation system period on the seismic response of inadequately designed low rise buildings. Thus, the implementation of isolation systems which correspond to the ratio $T_{is}/T_{fb}$ that values from 3 to 5 is studied. Nonlinear time history analyses were performed to investigate the response of the isolated structures using a set of three natural seismic ground motions. The evaluation of each retrofitting case was made in terms of storey drift and storey shear force while in view of serviceability it was made in terms of storey acceleration. Finally, the maximum developed displacements and the residual displacements of the isolation systems are presented.