• Title/Summary/Keyword: Response bias

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Serum vitamin D status and metabolic syndrome: a systematic review and dose-response meta-analysis

  • Lee, Kyueun;Kim, Jihye
    • Nutrition Research and Practice
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    • v.15 no.3
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    • pp.329-345
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    • 2021
  • BACKGROUD/OBJECTIVES: Evidence has suggested an association between serum vitamin D and metabolic syndrome (MetS), but prospective studies are very limited. The objective was to assess the dose-response association between serum vitamin D concentration and MetS risk using a systematic review and meta-analysis of updated observational studies. MATERIALS/METHODS: Using MEDLINE, PubMed, and Embase, a systematic literature search was conducted through February 2020 and the references of relevant articles were reviewed. A random-effects model was used to estimate the summary odds ratio/relative risk and 95% confidence interval (CI). Heterogeneity among studies was evaluated with I2 statistic. In total, 23 observational studies (19 cross-sectional studies, and four cohort studies) were included in the meta-analysis. RESULTS: The pooled estimates (95% CI) for MetS per 25-nmol/L increment in serum vitamin D concentration were 0.80 (95% CI, 0.76-0.84; I2 = 53.5) in cross-sectional studies, and 0.85 (95% CI, 0.72-0.98; I2 = 85.8) in cohort studies. Similar results were observed, irrespectively of age of study population, study location, MetS criteria, and adjustment factors. There was no publication bias for the dose-response meta-analysis of serum vitamin D concentrations and MetS. CONCLUSIONS: Dose-response meta-analysis demonstrated that a 25-nmol/L increment in the serum vitamin D concentration was associated with 20% and 15% lower risks of MetS in cross-sectional studies and cohort studies, respectively.

Penalized quantile regression tree (벌점화 분위수 회귀나무모형에 대한 연구)

  • Kim, Jaeoh;Cho, HyungJun;Bang, Sungwan
    • The Korean Journal of Applied Statistics
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    • v.29 no.7
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    • pp.1361-1371
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    • 2016
  • Quantile regression provides a variety of useful statistical information to examine how covariates influence the conditional quantile functions of a response variable. However, traditional quantile regression (which assume a linear model) is not appropriate when the relationship between the response and the covariates is a nonlinear. It is also necessary to conduct variable selection for high dimensional data or strongly correlated covariates. In this paper, we propose a penalized quantile regression tree model. The split rule of the proposed method is based on residual analysis, which has a negligible bias to select a split variable and reasonable computational cost. A simulation study and real data analysis are presented to demonstrate the satisfactory performance and usefulness of the proposed method.

COMPARISONS OF MTSAT-1R INFRARED CHANNEL MEASUREMENTS WITH MODIS/TERRA

  • Han, Hyo-Jin;Sohn, Byung-Ju;Park, Hye-Suk
    • Proceedings of the KSRS Conference
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    • v.2
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    • pp.651-654
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    • 2006
  • Infrared channels of newly launched Japanese geostationary satellite, MTSAT-1R are compared with well calibrated MODIS/Terra infrared measurements at 3.7, 6.7, 11, 12 ${\mu}m$ bands. There are four steps in this intercalibration method: 1) data collection, 2) spectral response function correction, 3) data collocation, and 4) calculation of mean bias and conversion coefficients. In order to minimize the navigation error of MTSAT-1R, comparisons are made over the area in which the viewing angle of MTSAT-1R is less than 50$^{\circ}$. The calibration method was tested for August 2005 and within the 40$^{\circ}N$-40$^{\circ}S$, 100$^{\circ}$E-180$^{\circ}$E domain. The differences of spectral response functions were corrected through radiative transfer model simulation. Constructing collocated data differences in viewing geometry, observation time and space were taken into account. In order to avoid the radiance variation induced by cloud presence, clear-sky targets are selected as intercalibration target. The mean biases of 11, 12, 6.7, and 3.7 ${\mu}m$ bands are about -0.16, 0.36, 1.31, and -6.69 K, suggesting that accuracies of 3.7 ${\mu}m$ is questionable while other channels are comparable to MODIS

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Two-Stage Estimator Design Using Stable Recursive FIR Filter and Smoother

  • Kim, Jong-Ju;Kim, Jae-Hun;Lyou, Joon
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.2532-2537
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    • 2005
  • FIR(Finite Impulse Response) filter is well known to be ideal for the finite time state-space model, but it requires much computation due to its inherent non-recursive structure especially when the measurement interval grows to a large extent. And often a fixed-lag smoother based on the finite time interval is needed to monitor the soundness of the system model and the measurement model, but the computation burden of FIR-type smoother imposes much restriction of its usage for real-time application. Conventional recursive forms of FIR estimator[1]-[4] could not be used for real time applications, since they are numerically unstable in their recursive equations. To cope with this problem, we suggest a stable recursive form FIR estimator(SRFIR) and its usefulness is demonstrated for designing the real-time fixed-lag smoother on the finite time window through an example of detection of rate bias in the anti-aircraft gun fire control system.

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Design of LDO Regulator with Two Output (두 개의 출력을 갖는 LDO 레귤레이터 설계)

  • Kwon, Min-Ju;Kim, Chea-Won;Kwak, Jae-Chang
    • Journal of IKEEE
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    • v.21 no.2
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    • pp.154-157
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    • 2017
  • This paper proposes the Low-Dropout regulator with two output. Each of the two output has feedback, and shared feedback loop. PMOS is added to solve the problem the occur when sharing the feedback loop. Thus eased the Load Transient Response. Also Using one of the bias citcuit and one of the pass transistor, Area is reduce by half compared to Existing Area that used to obtain output of two output.

Evaluation of Electrospun TiO2/PVP/LiCl Nanofiber Array for Humidity Sensing (전기방사를 이용한 TiO2/PVP/LiCl 나노섬유 습도 센서의 제작과 평가)

  • Ryu, Hyobong;Kim, Bumjoo;Kwon, Hyukjin Jean;Heo, Joonseong;Lim, Geunbae
    • Journal of Sensor Science and Technology
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    • v.23 no.1
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    • pp.42-45
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    • 2014
  • Recently, tremendous application utilizing electrospun nanofibers have been actively reported due to its several advantages, such as high surface to volume ratio, simple fabrication and high-throughput manufacturing. In this paper, we developed highly sensitive and consistent nanofiber humidity sensor by electrospinning. The humidity sensor was fabricated by rapid electrospinning (~2 sec) $TiO_2$/PVP/LiCl mixed solution on the micro-interdigitated electrode. In order to evaluate the humidity sensing performances, we measured current response using DC bias voltage under various relative humidity levels. The results show fast response / recovery time and marginal hysteresis as well as long-term stability. In addition, with the aid of micro-interdigitated electrode, we can reduce a total resistance of the sensor and increase the total reaction area of nanofibers across the electrodes resulting in high sensitivity and enhanced current level. Therefore, we expect that the electrospun nanofiber array for humidity sensor can be feasible and promising for diverse humidity sensing application.

연속 파장 가변시 현상론적인 비 선형 이득 포화 효과가 다전극 DBR 레이저의 변조 특성에 미치는 영향

  • Lee, S.;Park, N.;Park, H. L.;Choi, W. J.;Han, I. K.;Lee, J. I.;Kang, K. N.
    • Korean Journal of Optics and Photonics
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    • v.4 no.3
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    • pp.301-308
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    • 1993
  • Phenomenological nonlinear gain saturation effect on the modulation characteristics in a multi-electrode DBR laser, when the lasing wavelength changes, continuously is analized theoretically. FM efficiency, 3 dB bandwidth, and resonance frequency decrease with increasing bias current to the passive section, except increasing the flat FM response. It is found that the nonlinear gain saturation effect severely affects the modulation characteristics such as FM/IM response, 3 dB bandwidth, resonance frequency and CPR, but hardly affects the behavior of continuous frequency tuning.

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A literature review on RSM-based robust parameter design (RPD): Experimental design, estimation modeling, and optimization methods (반응표면법기반 강건파라미터설계에 대한 문헌연구: 실험설계, 추정 모형, 최적화 방법)

  • Le, Tuan-Ho;Shin, Sangmun
    • Journal of Korean Society for Quality Management
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    • v.46 no.1
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    • pp.39-74
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    • 2018
  • Purpose: For more than 30 years, robust parameter design (RPD), which attempts to minimize the process bias (i.e., deviation between the mean and the target) and its variability simultaneously, has received consistent attention from researchers in academia and industry. Based on Taguchi's philosophy, a number of RPD methodologies have been developed to improve the quality of products and processes. The primary purpose of this paper is to review and discuss existing RPD methodologies in terms of the three sequential RPD procedures of experimental design, parameter estimation, and optimization. Methods: This literature study composes three review aspects including experimental design, estimation modeling, and optimization methods. Results: To analyze the benefits and weaknesses of conventional RPD methods and investigate the requirements of future research, we first analyze a variety of experimental formats associated with input control and noise factors, output responses and replication, and estimation approaches. Secondly, existing estimation methods are categorized according to their implementation of least-squares, maximum likelihood estimation, generalized linear models, Bayesian techniques, or the response surface methodology. Thirdly, optimization models for single and multiple responses problems are analyzed within their historical and functional framework. Conclusion: This study identifies the current RPD foundations and unresolved problems, including ample discussion of further directions of study.

Differences of Psychophysiological Responses due to Individual Sensitivity of Simulator Sickness (Simulator Sickness의 개인적인 민감도에 따른 심리생리학적 반응의 차이)

  • 정순철;민병찬;정은지;이봉수;이정한;김철중
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.25 no.2
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    • pp.11-18
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    • 2002
  • Psychological and physiological effects of the simulator sickness could be important bias factors for the sensibility evaluation. The purpose of the present study was to clear the differences of psychophysiological responses due to individual sensitivity of simulator sickness. The present experiment tried to investigate the simulator sickness objectively by observing the change of the simulator sickness for the different level of sickness groups (sick and non_sick group). The subjective evaluations using Simulator Sickness Questionnaire (SSQ) and physiological responses were measured every five minutes when they were driving as 60km/h in the driving graphic simulator. Response level of the subjective evaluation for all subjects on the simulator sickness was linearly increased with time for every item, and the response level of sick group was bigger than that of non_sick group. When the analysis on central nervous system was done separately on the sick and the non_sick group, there was significant difference in the parameter $\theta$/total at Fz and Cz. Although the analysis on autonomic nervous system for all subjects showed the increased activation of sympathetic nervous system, there was no significant difference between the sick and non_sick group. In summary, it is necessary to select the subjects who feel less simulator sickness in order to be accurate sensibility evaluation. The parameters to distinguish between the sick and non_sick group were the change on $\theta$/total and subjective evaluation using SSQ.

Effectiveness of methylene blue photosensitizers compared to that of corticosteroids in the management of oral lichen planus: a systematic review and meta-analysis

  • Waingade, Manjushri;Medikeri, Raghavendra S;Rathod, Pooja
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.22 no.3
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    • pp.175-186
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    • 2022
  • This study aimed to systematically review the effectiveness of methylene blue (MB) photosensitizers in the management of symptomatic oral lichen planus (OLP). Electronic online databases and manual searches were performed for randomized controlled trials (RCTs) published in English between January 2010 and February 2022. RCTs comparing photodynamic therapy (PDT) and corticosteroid therapy at baseline and follow-up period were identified. The Cochrane risk of bias tool was used to assess the quality of the included studies. A meta-analysis was performed regarding visual analog scale (VAS) scores, Thongprasom sign scores, lesion size, response to treatment, and exacerbation of lesions after therapy. The clinical severity was analyzed qualitatively. Five RCTs consisting of 180 samples fulfilled the inclusion and exclusion criteria. All parameters of VAS score, Thongprasom sign score, lesion size, and response to treatment were statistically non-significant. Our results indicate that both MB-PDT and corticosteroid therapy are effective for the management of OLP. Moreover, MB-PDT is an effective alternative treatment option for OLP when corticosteroids are contraindicated. However, conclusive evidence cannot be ascertained owing to the heterogeneity among the studies.