• 제목/요약/키워드: Response Surface Analyzing Method

검색결과 37건 처리시간 0.025초

칠게 외골격 표면 거칠기를 이용한 노출 독성 평가: 새로운 융합적 연구 (Toxicological Assessment to Environmental Stressors Using Exoskeleton Surface Roughness in Macrophthalmus japonicus: New Approach for an Integrated End-point Development)

  • 박기연;곽인실
    • 생태와환경
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    • 제54권4호
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    • pp.265-271
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    • 2021
  • 갑각류 외골격은 키틴질로 이루어져 있고 외부자극에 보호와 지지를 위해 주요한 기능을 한다. 수환경은 물리적 변화뿐만 아니라 다양한 해양 오염에 끊임없이 영향을 받고 그 환경에 서식하는 생물은 생존을 위해 생물학적으로 반응한다. 본 연구에서는 이르가롤 독성노출이나 퇴적환경 중금속 분포에 따라 서식하는 칠게의 외골격 표면조도 분석을 통한 생태독성 종말점이 될 수 있음을 제시하였다. 칠게의 외골격 표면 조도는 이르가롤 노출에 대해 거칠기(Ra)도 감소하고 조도 변이(variation)도 줄어들었다. 또한 해양 연안 퇴적물 내 중금속(Cd, Pb, Hg) 분포에 따라 서식하는 칠게에서 표면 거칠기 및 변이가 변화하는 것을 확인하였다. 이러한 외골격 표면 거칠기의 변화는 외부환경 스트레스 요인에 따른 칠게의 생물학적인 반응 종말점(end-point)을 나타내며 나아가 외골격의 보호, 지지, 수송 등의 기능적 면에 영향을 미칠 수 있음을 시사한다. 이러한 접근방법은 공학과 생물의 융합적 기술로 수환경 모니터링을 위한 유용한 방법으로 활용될 수 있을 것이다.

애플망고 젤리의 제조 최적화를 위한 반응표면분석법의 적용 (Application of Response Surface Methodology for Optimization of Applemango Jelly Processing)

  • 오현빈;심현정;백채완;장현욱;황영;조용식
    • 한국식품영양학회지
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    • 제35권6호
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    • pp.473-480
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    • 2022
  • This study aimed to develop an optimal processing method for the production of apple-mango jelly for domestic suppliers, by analyzing the quality attributes of the jelly. According to the central composite design, a total of 11 experimental points were designed including the content of apple-mango juice (X1), and the sugar content (X2). The responses were analyzed including the color values (CIE Lab and color difference), physicochemical properties (water activity, sweetness, pH, and total acidity), and textural properties (hardness and gel strength). Regression analysis was conducted, except for total acidity, and showed no significant difference for all the experimental points (p<0.05). Quadratic model was derived for all responses with an R square value ranging from 0.8590 to 0.9978. Based on regression model, the appropriate mixing ratio of apple-mango jelly was found to be 31.11% of apple mango juice and 14.65% of sugar. Through this study, the possibility for developing jelly product using apple-mango was confirmed, and it is expected that these findings will contribute to the improvement of the agricultural industry.

Determination of nickel and cadmium in fish, canned tuna, black tea, and human urine samples after extraction by a novel quinoline thioacetamide functionalized magnetite/graphene oxide nanocomposite

  • Naghibzadeh, Leila;Manoochehri, Mahboobeh
    • Carbon letters
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    • 제26권
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    • pp.43-50
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    • 2018
  • In this research, a novel and efficient quinoline thioacetamide functionalized magnetic graphene oxide composite ($GO@Fe_3O_4@QTA$) was synthesized and utilized for dispersive magnetic solid phase preconcentration of Cd(II) and Ni(II) ions in urine and various food samples. A number of diverse methods were employed for characterization of the new nanosorbent. The design of experiments approach and response surface methodology were applied to monitor and find the parameters that affect the extraction performance. After sorption and elution steps, the concentrations of target analytes were measured by employing FAAS. The highest extraction performance was achieved under the following experimental conditions: pH, 5.8; sorption time, 6.0 min; $GO@Fe_3O_4@QTA$ amount, 17 mg; 2.4 mL $1.1mol\;L^{-l}$ $HNO_3$ solution as the eluent and elution time, 13.0 min. The detection limit is 0.02 and $0.2ng\;mL^{-1}$ for Cd(II), and Ni(II) ions, respectively. The accuracy of the new method was investigated by analyzing two certified reference materials (sea food mix, Seronorm LOT NO 2525 urine powder). The interfering study revealed that there are no interferences from commonly occurring ions on the extractability of target ions. Finally, the new method was satisfactorily employed for rapid extraction and determination of target ions in urine and various food samples.

Partial safety factors for retaining walls and slopes: A reliability based approach

  • GuhaRay, Anasua;Baidya, Dilip Kumar
    • Geomechanics and Engineering
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    • 제6권2호
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    • pp.99-115
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    • 2014
  • Uncertainties in design variables and design equations have a significant impact on the safety of geotechnical structures like retaining walls and slopes. This paper presents a possible framework for obtaining the partial safety factors based on reliability approach for different random variables affecting the stability of a reinforced concrete cantilever retaining wall and a slope under static loading conditions. Reliability analysis is carried out by Mean First Order Second Moment Method, Point Estimate Method, Monte Carlo Simulation and Response Surface Methodology. A target reliability index ${\beta}$ = 3 is set and partial safety factors for each random variable are calculated based on different coefficient of variations of the random variables. The study shows that although deterministic analysis reveals a safety factor greater than 1.5 which is considered to be safe in conventional approach, reliability analysis indicates quite high failure probability due to variation of soil properties. The results also reveal that a higher factor of safety is required for internal friction angle ${\varphi}$, while almost negligible values of safety factors are required for soil unit weight ${\gamma}$ in case of cantilever retaining wall and soil unit weight ${\gamma}$ and cohesion c in case of slope. Importance of partial safety factors is shown by analyzing two simple geotechnical structures. However, it can be applied for any complex system to achieve economization.

TBM 굴착으로 인한 굴착손상영역 범위 추정 - 대변형 수치해석 연구 (Evaluation of excavation damage zone during TBM excavation - A large deformation FE analysis study)

  • 김세헌;김도현
    • 한국터널지하공간학회 논문집
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    • 제26권1호
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    • pp.1-17
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    • 2024
  • 터널 굴착으로 인한 지반의 거동 분석은 대변형 영역의 거동을 고려해야 한다. 따라서 본 논문에서는 TBM 터널 굴착으로 인한 주변 지반에 대한 영향을 실제 현장 조건과 동일 조건에서 분석하기 위하여 대변형 유한요소 해석을 수행하였다. 지반의 대변형 거동을 모사하고 예측함에 있어 가장 널리 활용되는 두 가지 해석 기법 - coupled Eulerian Lagrangian (CEL)과 auto-remeshing (AR) 기법 - 을 적용하여 TBM 굴착 과정을 모사하였고 그에 따른 주변 지반에 발생하는 손상영역의 범위를 예측하였다. 굴착손상영역의 범위는 두 기법을 통해 도출된 결과와 굴착손상영역을 정의하는 실험적인 기준을 종합하여 추정하였다. 해석 결과, 두 대변형 해석 기법을 이용하여 도출된 굴착손상영역은 서로 비슷한 크기로 수렴하였고, 기존 연구의 실험 및 계측을 통해 확인된 굴착손상영역 크기와 모양, 경향과도 일치하는 것으로 나타났다. 굴착 되는 지반의 RMR 등급이 좋을수록 굴착손상영역의 크기는 더 커지고, 터널의 직경과는 정비례하는 것으로 나타났다. 반면에, 터널의 심도가 깊을수록 지반의 구속압이 커져서 굴착손상영역은 상대적으로 작게 형성되는 것으로 확인되었다.

정적 공탄성 해석과 최적화 문제에서의 동적 격자의 효용성 (Efficiency of Dynamic Mesh in Static Aeroelastic Analysis and Design Optimization Problem)

  • 김병곤;전상욱;전용희;김정화;이동호
    • 한국항공우주학회지
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    • 제35권2호
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    • pp.87-93
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    • 2007
  • 항공기 설계를 할 때에는 CFD를 이용한 해석 과정을 수반하는 것이 일반적이다. 그러나 CFD 해석은 많은 계산 시간과 비용이 소요되는데 동적 격자를 이용하면 다양한 모델의 해석 시 격자의 재구성 과정에 소요되는 시간을 줄일 수 있다. 뿐만 아니라 공탄성 해석처럼 격자를 갱신하면서 해석을 수행하는 경우, 설계 모델의 최적화 과정과 같이 다양한 격자를 구성해야 하는 경우에 동적 격자를 사용하면 전체 해석 시간을 줄일 수 있으므로 효율적인 해석이 가능하다.

반응표면법과 ANOVA 기반의 수소 누출에 대한 유효인자 분석 (Analyzing Effective Factors on Hydrogen Release Based on Response Surface Method and Analysis of Variance)

  • 이준서;오세현;안승효;김은희;마병철
    • 한국수소및신에너지학회논문집
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    • 제34권6호
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    • pp.712-721
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    • 2023
  • While hydrogen is widely used, it has a low minimum ignition energy, raising safety concerns when using it. This research studied which parameters are the key variables in the hydrogen release and diffusion. These parameters were divided into six process variables in the initial release and two environmental variables in the dispersion. One hundred and twenty cases were selected through design of experiment, and the end-point in each case were analyzed using PHAST. Afterwards, an end-point prediction model was developed using RSM and ANOVA, and the impact of each variable on the endpoint was analyzed. As a result, the influence of eight variables was graded. The nozzle diameter had the greatest influence on the end-point, while the pipe roughness coefficient had no effect on the end-point. It is expected that these results will be used as basic data to improve safety across all fields of hydrogen handling facilities.

A novel coupled finite element method for hydroelastic analysis of FG-CNTRC floating plates under moving loads

  • Nguyen, Vu X.;Lieu, Qui X.;Le, Tuan A.;Nguyen, Thao D.;Suzuki, Takayuki;Luong, Van Hai
    • Steel and Composite Structures
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    • 제42권2호
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    • pp.243-256
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    • 2022
  • A coupled finite element method (FEM)-boundary element method (BEM) for analyzing the hydroelastic response of functionally graded carbon nanotube-reinforced composite (FG-CNTRC) floating plates under moving loads is firstly introduced in this article. For that aim, the plate displacement field is described utilizing a generalized shear deformation theory (GSDT)-based FEM, meanwhile the linear water-wave theory (LWWT)-relied BEM is employed for the fluid hydrodynamic modeling. Both computational domains of the plate and fluid are coincidentally discretized into 4-node Hermite elements. Accordingly, the C1-continuous plate element model can be simply captured owing to the inherent feature of third-order Hermite polynomials. In addition, this model is also completely free from shear correction factors, although the shear deformation effects are still taken into account. While the fluid BEM can easily handle the free surface with a lower computational effort due to its boundary integral performance. Material properties through the plate thickness follow four specific CNT distributions. Outcomes gained by the present FEM-BEM are compared with those of previously released papers including analytical solutions and experimental data to validate its reliability. In addition, the influences of CNT volume fraction, different CNT configurations, water depth, and load speed on the hydroelastic behavior of FG-CNTRC plates are also examined.

뇌졸중 환자의 상지에서 근육협응 패턴과 관절협응 패턴의 유사성에 관한 연구 (A Study of Symmetry in the Patterns of Muscle Coordination and Interjoint Coordination in the Upper Limb Activity Among Subjects With Stroke)

  • 이정아;신화경;정이정;조상현
    • 한국전문물리치료학회지
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    • 제13권1호
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    • pp.54-60
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    • 2006
  • This study aimed to compare movement patterns of shoulder joints between the right and left symmetry in stroke patients and control subjects. This study proposes use of the voluntary response index (VRI) calculated from quantitative analysis of surface electromyographic (sEMG) and motion data recorded during voluntary movement as a feeding task. The VRI is comprised of two numeric values, one derived from the total muscle activity recorded for the voluntary motor task (magnitude), and the other from the sEMG distribution across the recorded muscles with the similarity index (SI). Five stroke patients and five age-matched healthy controls were recruited. Feeding motion was performed using the provided spoon five times with rests taken on a chair in between tasks. EMG data were digitized and analyzed on the basis of the root mean square (RMS) envelope of activity. The average amplitude of responses was calculated. Responsiveness and clinically meaningful levels of discrimination between stroke patients and control for EMG magnitude and SI were determined. The similarity index of the results from two successive examinations of both sides apart for stroke patients and control subjects were .86 and .95 in motion analysis and .84 and .99 in electromyographic analysis. The SI of sEMG data and motion data was significantly correlated in stroke patients. The data suggest that SI is a sensitive program for comparing and analyzing the symmetry of muscle activity and motion in both sides. This analysis method has a clinical value in grading muscular activity and movement impairment after brain injury.

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Box-willson 실험계획법 기반 고강도 자기충전형 콘크리트의 최적설계방법 (Box-Wilson Experimental Design-based Optimal Design Method of High Strength Self Compacting Concrete)

  • 도정윤;김두기
    • 한국구조물진단유지관리공학회 논문집
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    • 제19권5호
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    • pp.92-103
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    • 2015
  • Box-Wilson 실험계획법은 보통 중심합성계획법으로 알려져 있으며, 변동성이 존재하는 정보를 실험 계획적 방법으로 수집하는 설계 기법이다. 이 방법은 최소의 설계비용으로 가능한 많은 정보를 얻는 목적으로 고안되었다. 본 연구에서는 60 MPa급 고강도 자기충전형 콘크리트(HSSCC)를 대상으로 다양한 성능에 대한 여러 배합인자들의 효과를 효율적으로 파악하고 최적배합을 찾는 과정에 이 방법을 적용하였다. HSSCC의 배합인자(요인)와 물리적 성능(반응) 사이의 비선형적 관계는 2차 다항식으로 반응표면을 근사화 모델링하였으며, 요인점=25=32개, 축점=2k=10개, 중심점은 각 축에서 2번 씩 10개, 총 52개의 실험점에서 물시멘트비, 단위시멘트량, 잔골재비, 단위플라이애쉬량, 단위고성능감수량의 총 5개의 인자에 따른 압축강도, 통과능력, 재료분리저항성, 제조비용, 밀도 등의 총 5개의 반응을 파악하기 위한 실험이 실시되었다. 연구의 결과 Box-Wilson 실험계획법은 배합인자와 반응 사이의 관계를 과학적인 방법으로 계획하고 객관적으로 해석하는 데 매우 효과적이었으며, 수치해석적인 방법으로 최적배합을 계산할 수 있었다.