• 한국소음진동공학회논문집
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• 제24권4호
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• pp.310-316
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• 2014

The location template matching(LTM) method is a technique of identifying an impact location on a structure, and requires a certain measure of similarity between two time signals. In general, the correlation coefficient is widely used as the measure of similarity, while the group delay based method is recently proposed to improve the accuracy of the impact localization. Another possible measure is the frequency response assurance criterion(FRAC), though this has not been applied yet. In this paper, these three different measures of similarity are examined comparatively by using experimental data in order to understand the properties of these measures of similarity. The comparative study shows that the correlation coefficient and the FRAC give almost the same information while the group delay based method gives the shape oriented information that is best suitable for the location template matching method.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 춘계학술대회 논문집
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• pp.506-511
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• 2014

The location template matching (LTM) method is a technique of identifying an impact location on a structure, and requires a certain measure of similarity between two time signals. In general, the correlation coefficient is widely used as the measure of similarity, while the group delay based method is recently proposed to improve the accuracy of the impact localization. Another possible measure is the frequency response assurance criterion (FRAC), though this has not been applied yet. In this paper, these three different measures of similarity are examined comparatively by using experimental data in order to understand the properties of these measures of similarity. The comparative study shows that the correlation coefficient and the FRAC give almost the same information while the group delay based method gives the shape oriented information that is best suitable for the location template matching method.

• 대한의용생체공학회:의공학회지
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• 제32권1호
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• pp.74-78
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• 2011

Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.

• BMB Reports
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• 제39권5호
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• pp.511-515
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• 2006

Alanine aminotransferase (AAT) is mainly synthesized in the liver, and its level in mammalian serum is elevated after acute phase induction. Here we demonstrated that sheep anti-human AAT antibody cross-reacted with amphioxus humoral fluids as well as human serum; and the concentration of AAT in the humoral fluids in amphioxus increased after the acute challenge with lipopolysaccharide, while the level of total proteins remains unchanged. These suggest the presence of the same acute phase response pattern in amphioxus, as observed in some mammalian species. Immunohistochemically, AAT was localized in the hepatic diverticulum, ovary and testis. It appears that the hepatic diverticulum in amphioxus is functionally homologous to the vertebrate liver in respect of AAT synthesis, supporting the hypothesis that the vertebrate liver evolved from the hepatic diverticulum of an amphioxus-like ancestor during early chordate evolution.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2000년도 춘계학술대회논문집
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• pp.9-12
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• 2000

The importance of the role of plastic spin in the rate-dependent response of materials at large deformations is the main objective of this work. After a brief presentation of a general consitutive framework for visco-rigid plasticity at large strains an isotropic/kinematic hardening and a visco-rigid plastic model are used to analyze the stress-strain response under simple shear. A clear understanding of the role of plastic spin is achieved by obtaining numerical analyzed results for different stress values in which the plastic spin consititutive parameters interrelaste with the strain rate and other more conventional model constants, Especially this paper is concerned with introducing behaviors of Al7075

• Molecules and Cells
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• 제22권2호
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• pp.228-232
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• 2006

The Drosophila protein, Rbp9, is homologous to human Hu, which is reported to be involved in small cell lung cancer. Rbp9 functions in cystocyte differentiation, and mutations in Rbp9 cause ovarian tumors. Here we show that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form. Upregulation seems to result from activation of the NF-${\kappa}B$ pathway since we detected nuclear localization of Relish in Rbp9 mutant ovaries but not in wild type ovaries. Inactivation of NF-${\kappa}B$ in the Rbp9 mutant allows prolonged survival of malformed egg chambers. We conclude that Drosophila initiates an anti-tumor defense response via activation of NF-${\kappa}B$.

• Coupled systems mechanics
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• 제7권6호
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• pp.669-690
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• 2018

This paper deals with numerical modeling of dynamic failure phenomena in rate-sensitive brittle and/or ductile materials. To this end, a two-dimensional continuum viscodamage-embedded discontinuity model, which is based on our previous work (see Do et al. 2017), is developed. More specifically, the pre-peak nonlinear and rate-sensitive hardening response of the material behavior, representing the fracture-process zone creation, is described by a rate-dependent continuum damage model. Meanwhile, an embedded displacement discontinuity model is used to formulate the post-peak response, involving the macro-crack creation accompanied by exponential softening. The numerical implementation in the context of the finite element method exploiting the second-order mid-point scheme is discussed in detail. In order to show the performance of the model several numerical examples are included.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2003-2007
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• 2015

Background: Elevated serum alpha-fetoprotein (AFP) levels in adults are considered abnormal. This parameter is used mostly in the diagnosis and follow-up of hepatocellular carcinomas and yolk sac tumors. Among the other rare tumors accompanied with elevated serum AFP levels, gastric cancer is the most common. In this study, we evaluated the follow-up and comparison of the treatment and marker response of patients with metastatic gastric cancer who had elevated serum AFP levels. Materials and Methods: We performed a retrospective study, including all consecutive patients with advanced gastric cancer, who received systemic chemotherapy with elevated AFP level. Results: Seventeen metastatic gastric cancer patients with elevated AFP levels at the time of diagnosis were evaluated. Fourteen (82.4%) were males and three (17.6%) were females. The primary tumor localization was the gastric body in 8 (76.4%), cardia in 7 (41.2%), and antrum in 2 (11.8%). Hepatic metastasis was observed in 13 (76.4%) at the time of diagnosis. When the relationship of AFP levels and carcinoembryonic antigen (CEA) response of the patients with their radiologic responses was evaluated, it was found that the radiologic response was compatible with AFP response in 16 (94.1%) patients and with CEA response in 12 (70.6%); however, in 5 (29.4%) patients no accordance was observed between radiological and CEA responses. Conclusions: Follow-up of AFP levels in metastatic gastric cancer patients with elevated AFP levels may allow prediction of early treatment response and could be more useful than the CEA marker for follow-up in response evaluation.

• 대한의생명과학회지
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• 제5권2호
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• pp.155-165
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• 1999

호르텐스극구흡충을 흰쥐에게 경구 감염시키고 4주 후에 성충을 획득하여 고정, 포매 및 절편하여 조직항원 분포 부위를 관찰하였다. 호르텐스극구흡충의 항체는 호르텐스극구흡충 피낭유충을 흰쥐에게 경구 감염시키고 4주 후에 채혈한 혈청과 호르텐스극구흡충 조항원을 면역증강제와 함께 흰쥐에게 근육 주사하여 채혈한 혈청을 이용하였으며, 이 혈청을 반응시켜서 호르텐스극구흡충 조직내의 항원성 분포를 규명하였다. 한편, 면역황금표식법에 의한 미세조직의 항원성 반응 여부는 조직에 표지된 황금입자로 판정하였다. 그 결과 충체 조직에서 황금입자와 강하게 반응하는 미세조직은 표피층의 표지합포체, 난황세포의 구성물질, 유연조직의 분비과립 그리고 배설낭의 구성물질 등에서 반응이 강하게 나타났다. 이상의 결과를 볼 때 호르텐스극구흡충의 항원은 생식세포와 소화분비 및 소화관계통에서 분비 유래되는 것으로 분석되었다.

• 한국음향학회지
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• 제37권4호
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• pp.196-205
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• 2018

본 논문은 선박소음 데이터에 음선 역전파 기법을 적용하여 수동 선박 위치 추정 알고리듬을 제시한다. 기존의 방법 [S. H. Abadi, D. Rouseff and D. R. Dowling, J. Acoust. Soc. Am. 131, 2599-2610 (2012)]은 음선 기반 블라인드 디컨벌루션 및 음선 역전파 기법을 활용하여 배열의 기울기가 없는 근거리 환경에서 음원의 위치를 추정하였다. 하지만 위 방법은 배열의 기울기에 따른 위치 추정 오차가 크게 발생한다는 단점이 존재한다. 이를 극복하기 위해 본 논문에서는 음선 기반 블라인드 디컨벌루션 및 음선 역전파 기법을 사용하되, 배열의 기울기를 보정하여 음원의 위치를 추정할 수 있는 알고리듬을 제안한다. 제안된 알고리듬의 성능은 SAVEX15(Shallow-water Acoustic Variability EXperiment in 2015)해상 실험의 선박소음 데이터를 이용하여 검증하였다.