• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.24 no.4
• /
• pp.310-316
• /
• 2014

The location template matching(LTM) method is a technique of identifying an impact location on a structure, and requires a certain measure of similarity between two time signals. In general, the correlation coefficient is widely used as the measure of similarity, while the group delay based method is recently proposed to improve the accuracy of the impact localization. Another possible measure is the frequency response assurance criterion(FRAC), though this has not been applied yet. In this paper, these three different measures of similarity are examined comparatively by using experimental data in order to understand the properties of these measures of similarity. The comparative study shows that the correlation coefficient and the FRAC give almost the same information while the group delay based method gives the shape oriented information that is best suitable for the location template matching method.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2014.04a
• /
• pp.506-511
• /
• 2014

The location template matching (LTM) method is a technique of identifying an impact location on a structure, and requires a certain measure of similarity between two time signals. In general, the correlation coefficient is widely used as the measure of similarity, while the group delay based method is recently proposed to improve the accuracy of the impact localization. Another possible measure is the frequency response assurance criterion (FRAC), though this has not been applied yet. In this paper, these three different measures of similarity are examined comparatively by using experimental data in order to understand the properties of these measures of similarity. The comparative study shows that the correlation coefficient and the FRAC give almost the same information while the group delay based method gives the shape oriented information that is best suitable for the location template matching method.

• Journal of Biomedical Engineering Research
• /
• v.32 no.1
• /
• pp.74-78
• /
• 2011

Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.

• BMB Reports
• /
• v.39 no.5
• /
• pp.511-515
• /
• 2006

Alanine aminotransferase (AAT) is mainly synthesized in the liver, and its level in mammalian serum is elevated after acute phase induction. Here we demonstrated that sheep anti-human AAT antibody cross-reacted with amphioxus humoral fluids as well as human serum; and the concentration of AAT in the humoral fluids in amphioxus increased after the acute challenge with lipopolysaccharide, while the level of total proteins remains unchanged. These suggest the presence of the same acute phase response pattern in amphioxus, as observed in some mammalian species. Immunohistochemically, AAT was localized in the hepatic diverticulum, ovary and testis. It appears that the hepatic diverticulum in amphioxus is functionally homologous to the vertebrate liver in respect of AAT synthesis, supporting the hypothesis that the vertebrate liver evolved from the hepatic diverticulum of an amphioxus-like ancestor during early chordate evolution.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2000.04a
• /
• pp.9-12
• /
• 2000

The importance of the role of plastic spin in the rate-dependent response of materials at large deformations is the main objective of this work. After a brief presentation of a general consitutive framework for visco-rigid plasticity at large strains an isotropic/kinematic hardening and a visco-rigid plastic model are used to analyze the stress-strain response under simple shear. A clear understanding of the role of plastic spin is achieved by obtaining numerical analyzed results for different stress values in which the plastic spin consititutive parameters interrelaste with the strain rate and other more conventional model constants, Especially this paper is concerned with introducing behaviors of Al7075

• Molecules and Cells
• /
• v.22 no.2
• /
• pp.228-232
• /
• 2006

The Drosophila protein, Rbp9, is homologous to human Hu, which is reported to be involved in small cell lung cancer. Rbp9 functions in cystocyte differentiation, and mutations in Rbp9 cause ovarian tumors. Here we show that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form. Upregulation seems to result from activation of the NF-${\kappa}B$ pathway since we detected nuclear localization of Relish in Rbp9 mutant ovaries but not in wild type ovaries. Inactivation of NF-${\kappa}B$ in the Rbp9 mutant allows prolonged survival of malformed egg chambers. We conclude that Drosophila initiates an anti-tumor defense response via activation of NF-${\kappa}B$.

• Coupled systems mechanics
• /
• v.7 no.6
• /
• pp.669-690
• /
• 2018

This paper deals with numerical modeling of dynamic failure phenomena in rate-sensitive brittle and/or ductile materials. To this end, a two-dimensional continuum viscodamage-embedded discontinuity model, which is based on our previous work (see Do et al. 2017), is developed. More specifically, the pre-peak nonlinear and rate-sensitive hardening response of the material behavior, representing the fracture-process zone creation, is described by a rate-dependent continuum damage model. Meanwhile, an embedded displacement discontinuity model is used to formulate the post-peak response, involving the macro-crack creation accompanied by exponential softening. The numerical implementation in the context of the finite element method exploiting the second-order mid-point scheme is discussed in detail. In order to show the performance of the model several numerical examples are included.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.5
• /
• pp.2003-2007
• /
• 2015

Background: Elevated serum alpha-fetoprotein (AFP) levels in adults are considered abnormal. This parameter is used mostly in the diagnosis and follow-up of hepatocellular carcinomas and yolk sac tumors. Among the other rare tumors accompanied with elevated serum AFP levels, gastric cancer is the most common. In this study, we evaluated the follow-up and comparison of the treatment and marker response of patients with metastatic gastric cancer who had elevated serum AFP levels. Materials and Methods: We performed a retrospective study, including all consecutive patients with advanced gastric cancer, who received systemic chemotherapy with elevated AFP level. Results: Seventeen metastatic gastric cancer patients with elevated AFP levels at the time of diagnosis were evaluated. Fourteen (82.4%) were males and three (17.6%) were females. The primary tumor localization was the gastric body in 8 (76.4%), cardia in 7 (41.2%), and antrum in 2 (11.8%). Hepatic metastasis was observed in 13 (76.4%) at the time of diagnosis. When the relationship of AFP levels and carcinoembryonic antigen (CEA) response of the patients with their radiologic responses was evaluated, it was found that the radiologic response was compatible with AFP response in 16 (94.1%) patients and with CEA response in 12 (70.6%); however, in 5 (29.4%) patients no accordance was observed between radiological and CEA responses. Conclusions: Follow-up of AFP levels in metastatic gastric cancer patients with elevated AFP levels may allow prediction of early treatment response and could be more useful than the CEA marker for follow-up in response evaluation.

• Biomedical Science Letters
• /
• v.5 no.2
• /
• pp.155-165
• /
• 1999

This study involved applying rat sera (control, infected and immunized) to adult worm tissue in order to measure the antigenic response. A serum was obtained from rats infected with E. hortense metacercaria for 4 weeks. Another immunized serum was taken from rats given a muscle injection with crude adult worm antigen. The detection of antigenic response in E. hortense tissue was made by immunogold labeling method and measured through gold particles impregnated in the tissue. The antigenic sites, those with the highest density of gold particles, were the tegmental syncytium, vitelline cells, seminal receptacle and cecum.

• The Journal of the Acoustical Society of Korea
• /
• v.37 no.4
• /
• pp.196-205
• /
• 2018

This paper presents an algorithm for passive localization of a ship by applying the ray back-propagation technique to the ship radiation noise data. The previous method [S. H. Abadi, D. Rouseff and D. R. Dowling, J. Acoust. Soc. Am. 131, 2599-2610 (2012)] estimates the position of a sound source in the near-field environment with no array tilt by using the RBD (Ray-based Blind Deconvolution) and ray back-propagation techniques. However, when there exists an array tilt, the above method leads to a large position estimation error. In order to overcome the problem, this study proposes an algorithm that estimates the position of a sound source by correcting the array tilt using the RBD and ray back-propagation techniques. The proposed algorithm was verified by using the ship noise of SAVEX15 (Shallow-water Acoustic Variability EXperiment in 2015) experimental data.