• Journal of Ginseng Research
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• 제39권2호
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• pp.141-147
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• 2015

Background: Adipocytes, which are the main cellular component of adipose tissue, are the building blocks of obesity. The nuclear hormone receptor $PPAR{\gamma}$ is a major regulator of adipocyte differentiation and development. Obesity, which is one of the most dangerous yet silent diseases of all time, is fast becoming a critical area of research focus. Methods: In this study, we initially aimed to investigate whether the ginsenoside Rf, a compound that is only present in Panax ginseng Meyer, interacts with $PPAR{\gamma}$ by molecular docking simulations. After we performed the docking simulation the result has been analyzed with several different software programs, including Discovery Studio, Pymol, Chimera, Ligplus, and Pose View. All of the programs identified the same mechanism of interaction between $PPAR{\gamma}$ and Rf, at the same active site. To determine the drug-like and biological activities of Rf, we calculate its absorption, distribution, metabolism, excretion, and toxic (ADMET) and prediction of activity spectra for substances (PASS) properties. Considering the results obtained from the computational investigations, the focus was on the in vitro experiments. Results: Because the docking simulations predicted the formation of structural bonds between Rf and $PPAR{\gamma}$, we also investigated whether any evidence for these bonds could be observed at the cellular level. These experiments revealed that Rf treatment of 3T3-L1 adipocytes downregulated the expression levels of $PPAR{\gamma}$ and perilipin, and also decreased the amount of lipid accumulated at different doses. Conclusion: The ginsenoside Rf appears to be promising compound that could prove useful in antiobesity treatments.

• 벤처창업연구
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• 제12권4호
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• pp.109-119
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• 2017

글로벌 시장 진출의 중요성과 더불어 하이테크 기업의 수출에 대한 관심이 고조되고 있다. 본 연구는 자원기반관점에서 조직자원과 혁신능력을 중심으로 대구지역 하이테크 기업을 대상으로 수출 결정요인을 규명하였다. 실증분석 결과 조직연령과 해외IPR이 하이테크 기업의 핵심 수출 결정요인으로 규명되었다. 이는 정책적인 차원에서 하이테크 기업의 해외 수출을 강하하기 위해서는 상대적으로 창업 업력이 길며, 해외IPR을 획득하고 있는 기업을 중점적으로 지원할 필요성에 대한 시사점을 준다. 또한 하이테크 기업 실무 차원에서는 본(born) 글로벌 기업처럼 창업 초기부터 글로벌 시장을 대상으로 하기보다 자원기반관점에서 조직 업력과 해외IPR과 같은 내적 역량을 우선적으로 구축할 필요성을 시사하고 있다.

• 대한화학회지
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• 제60권5호
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• pp.327-341
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• 2016

This study explores the effective visual resources in the “regularity in chemical reactions” unit of ninth grade science textbooks (2009 revised version). The frequency and role of visual resources were initially examined, and the students’ perceptions of visual resources were investigated. The results of the analysis represented the learning material presentation (68%), motivational categories (14%), guide to inquiry procedures (9%), and inquiry results and summaries (8%). According to the investigation of the students’ perceptions of visual resources, the most effective visual resource for motivation is a photograph depicting physical and chemical changes, such as in bread baking and the most effective for learning material presentations in mass conservation, definite proportion, and stoichiometric concept units were a cartoon, graph, and formula representing stoichiometric phenomena, respectively. The most effective resource for guide to inquiry (experimental) procedures were photographs of both instruments and sequential experiment processes; and in the inquiry results and summary category, incomplete tables and graphs for students to work on themselves. The aims of this research are to increase the usefulness of visual resources in the teaching-learning activity and provide informative supplements for the development and improvement of visual resources, according to the students’ perceptions.

• 동력기계공학회지
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• 제20권4호
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• pp.44-51
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• 2016

An investigation on reliability of reanalysis wind data was conducted using the met mast wind data at four coastal regions, Jeju Island. Shinchang, Handong, Udo and Gangjeong sites were chosen for the met mast sites, and ERA-Interim and MERRA reanalysis data at two points on the sea around Jeju Island were analyzed for creating Wind Statistics of WindPRO software. Reliability of reanalysis wind data was assessed by comparing the statistics from the met mast wind data with those from Wind Statistics of WindPRO software. The relative error was calculated for annual average wind speed, wind power density and annual energy production. In addition, Weibull wind speed distribution and monthly energy production were analyzed in detail. As a result, ERA-Interim reanalysis data was more suitable for wind resource assessment than MERRA reanalysis data.

• 대한가정학회지
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• 제44권4호
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• pp.23-38
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• 2006

The purpose of this study was to investigate the strengths of single-parent families and the related variables based on the family strength approach. The major findings were as follows. First, good communication, family bond, children's adjustment and coping ability were characteristics of single-parent family strengths. Secondly, strengths of single-parent family were related to income and period of becoming a single-parent family. Thirdly, single parents who had a higher level of personal resources such as high self-esteem and economic stability perceived a higher level of family strengths. Fourth, single parents who had a higher level of social support perceived a higher level of family strength. Fifth, there was no interaction effect between personal resource and social resource on single-parent family strengths. Last, both personal and social resources had effects on the strength of single- parent family. Especially personal resource and self-esteem were the most important variables and had a strong influence on single-parent family strengths. The results of this study have important implications for theory, research and practice. Research on the strengths of the Korean single-parent family is new and more extensive investigation is required.

• 한국태양에너지학회 논문집
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• 제37권2호
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• pp.1-11
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• 2017

The investigation on reliability of ERA-Interim reanalysis wind data was conducted using wind data from the five met masts measured at inland and coastal areas, Jeju island. Shinchang, Handong, Udo, Susan and Cheongsoo sites were chosen for the met mast location. ERA-Interim reanalysis data at onshore and offshore twenty points over Jeju Island were analyzed for creating Wind Statistics using WindPRO software. Reliability of ERA-Interim reanalysis wind data was assessed by comparing the statistics from the met mast wind data with those predicted at the interest point using the Wind Statistics. The relative errors were calculated for annual average wind speed and annual energy production. In addition, the trend of the error was analyzed with distance from met mast. As a result, ERA-Interim reanalysis wind data was more suitable for offshore wind resource assessment than onshore.

• 한국식품영양과학회지
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• 제30권2호
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• pp.299-306
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• 2001

As a part of basic investigation for utilization of canned food processing by-products, a food components of the canned oyster processing waste water such as boiled and released water(BRW), wash water(WW) were investigated and compared with hot-water extracts from oyster. From the results of measuring heavy metal conte수, viable cells and coliform group, the canned oyster processing waste waters might not invoke health risk in using food resource. The contents of taste compounds (free amino acids, ATP related compounds, TMA (O) and total creatinine) of BRW and WW accounted for about 254% and 95%, respectively, in comparison with those of control (hot-water extract from oyster). The BRW showed a very high content of salt in comparing to the WW and control. In descending order, the values of whiteness index was WW, control and BRW. Sensory scores for color, oyster flavor intensity and saline taste were not significantly different between WW and control. But, BRW had the highest score in oyster flavor intensity, while had the lowest score in color and saline taste. But, the color and saline taste of BRW might be able to control by some pretreatment (concentration and drying in mild condition, desalination and recipe control etc). These results indicated that BRW and WW generated from various step during canned oyster processing could be a potential food resource by controlling of saline taste and color intensity.

• 한국동물위생학회지
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• 제35권1호
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• pp.63-67
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• 2012

An 8-months-old young Maltese bitch was presented for investigation of anorexia and occasional vomiting. The body weight was 2 kg. Abdominal sonography demonstrated abnormal enlargement of uterus. The dog had been clinically and pathologically examined. Also, ovariohystectomy was performed. Staphylococcus aureus was identified in the pus-like materials of the uterine lumen. This case was confirmed as pyometra induced by Staphylococcus aureus. Gross examination of the dissected uterus revealed enlarged uterine horn, which had yellowish or brownish pus-like materials in the lumen. Also, there was several segments formation between the enlarged areas of left and right uterine horns. Histopathologically, endometritis and necrosis were present in uterine wall. The bitch made a complete recovery following an ovariohystectomy. This case was spontaneous pyometra induced by Staphylococcus species. On our knowledge, this is a very rare report of pyometra occurrence in young dog and Staphylococcus species-induced pyometra. This study may provide a valuable data on the study of canine pyometra.

• 해양환경안전학회지
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• 제14권3호
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• pp.205-210
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• 2008

화석연료 사용으로 인한 환경오염 및 에너지원가 상승이 큰 문제로 대두되고 있는 현재의 상황을 타개하기 위한 하나의 방안으로 신 재생에너지에 대한 관심이 고조되고 있다. 특히 서해안에 위치하고 있는 새만금 지역은 광활한 면적과 서북서풍이라는 큰 장점을 가지고 있어 풍력발전의 적지로 예상된다. 본 연구는 이러한 예상을 뒷받침해 줄 수 있는 풍력자원을 조사한 것으로 군산지역의 평균풍속은 4 m/s 정도이며, 도서지방을 연계하는 해상풍력발전 단지의 최적지로 손색이 없음을 밝혔다. 또한, 풍력자원의 출현밀도를 판별하는 Weibull의 분포함수를 이용하여 계산하고, 형상계수를 매개변수로 하여 풍속밀도계산을 한 결과, 군산지방의 풍속출현을 예상할 수 있었다.

• 한국산학기술학회논문지
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• 제14권3호
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• pp.1474-1480
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• 2013

본 연구는 TBM 공법의 구경별 자원기반 적산(원가 계산) 방식에 의한 공사비 적산을 수행하여 직접공사비와 총공사비를 분석하고, 이를 근거로 회귀분석을 수행하여 TBM 공법 구경별 직접공사비 및 총공사비를 추정할 수 있는 개산 공사비(개략 공사비) 예측 식 모델을 제시하였다. 본 연구에서 제시한 TBM 공법의 구경별 개산 공사비 예측 식 모델은 향후 TBM 공법 적용 현장의 사업기획, 예비조사, 타당성조사, 기본설계 단계에서 개산 공사비를 추정하는데 효과적으로 적용할 수 있을 것이다.