• Bulletin of the Korean Chemical Society
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• v.35 no.3
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• pp.938-940
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• 2014

This paper discusses a coherence-gated three-dimensional imaging system based on photorefractive holography, which was applied to imaging through turbid media with a view to developing biomedical instrumentation. A rapid response photorefractive device doped with 2,4,7-trinitro-9-fluorenylidene malononitrile was used to generate the hologram grating. The estimated depth resolution was $20{\mu}m$, which corresponds to the coherence length of the light source. In this coherence imaging system, tomographic imaging of a 3-dimensional object composed of a $50{\mu}m$ thick cylindrical layer was achieved. The proposed coherence imaging system using an organic photorefractive material can be used as an optical tomography system for biological applications.

• Current Optics and Photonics
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• v.8 no.2
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• pp.183-191
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• 2024

High-resolution retinal imaging based on adaptive optics (AO) is important for early diagnosis related to retinal diseases. However, in practical applications, closed-loop AO correction takes a relatively long time, and traditional open-loop correction methods have low accuracy in correction, leading to unsatisfactory imaging results. In this paper, a SH-U-net-based open-loop AO wavefront correction method is presented for a retinal AO imaging system. The SH-U-net builds a mathematical model of the entire AO system through data training, and the Root mean square (RMS) of the distorted wavefront is 0.08λ after correction in the simulation. Furthermore, it has been validated in experiments. The method improves the accuracy of wavefront correction and shortens the correction time.

• Communications of the Korean Mathematical Society
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• v.16 no.3
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• pp.519-541
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• 2001

Magnetic Resonance Electrical Impedance Tomography(MREIT) is a new medical imaging technique for the cross-sectional conductivity distribution of a human body using both EIT(Electrical Impedance Tomography) and MRI(Magnetic Resonance Imaging) system. MREIT system was designed to enhance EIT imaging system which has inherent low sensitivity of boundary measurements to any changes of internal tissue conductivity values. MREIT utilizes a recent CDI (Current Density Imaging) technique of measuring the internal current density by means of MRI technique. In this paper, a mathematical modeling for MREIT and image reconstruction method called the alternating J-substitution algorithm are presented. Computer simulations show that the alternating J-substitution algorithm provides accurate high-resolution conductivity images.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3822-3830
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• 2023

The large-area Compton camera (LACC), featuring significantly high detection sensitivity, was developed for high-speed localization of gamma-ray sources. Due to the high gamma-ray interaction event rate induced by the high sensitivity, however, the multiplexer-based data acquisition system (DAQ) rapidly saturated, leading to deteriorated energy and imaging resolution at event rates higher than 4.7 × 10³ s^-1. In the present study, a new simultaneous multi-channel DAQ was developed to improve the energy and imaging resolution of the LACC even under high event rate conditions (10⁴-10⁶ s^-1). The performance of the DAQ was evaluated with several point sources under different event rate conditions. The results indicated that the new DAQ offers significantly better performance than the existing DAQ over the entire energy and event rate ranges. Especially, the new DAQ showed high energy resolution under very high event rate conditions, i.e., 6.9% and 8.6% (for 662 keV) at 1.3 × 10⁵ and 1.2 × 10⁶ s^-1, respectively. Furthermore, the new DAQ successfully acquired Compton images under those event rates, i.e., imaging resolutions of 13.8° and 19.3° at 8.7 × 10⁴ and 10⁶ s^-1, which correspond to 1.8 and 73 μSv/hr or about 18 and 730 times the background level, respectively.

• Journal of information and communication convergence engineering
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• v.14 no.1
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• pp.57-63
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• 2016

In generally, the resolution of reconstructed three-dimensional images can be seriously degraded by undesired occlusions in the integral imaging system, because the undesired information of the occlusion overlap the three-dimensional images to be reconstructed. To solve the problem of the undesired occlusion, we present an exemplar-based image restoration method in integral imaging system. In the proposed method, a minimum spanning tree-based stereo matching method is used to remove the region of undesired occlusions in each elemental image. After that, the removed occlusion region of each elemental images are re-established by using the exemplar-based image restoration method. For further improve the performance of the image restoration, the structure tensor is used to solve the filling error cause by discontinuous structures. Finally, the resolution enhanced three-dimensional images are reconstructed by using the restored elemental images. The preliminary experiments are presented to demonstrate the feasibility of the proposed method.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.55-63
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• 2005

A novel imaging system for High-resolution Ultrasonic Transmission Tomography (HUTT) and soft tissue differentiation methodology for the HUTT system are presented. The critical innovation of the HUTT system includes the use of sub-millimeter transducer elements for both transmitter and receiver arrays and multi-band analysis of the first-arrival pulse. The first-arrival pulse is detected and extracted from the received signal (i.e., snippet) at each azimuthal and angular location of a mechanical tomographic scanner in transmission mode. Each extracted snippet is processed to yield a multi-spectral vector of attenuation values at multiple frequency bands. These vectors form a 3-D sinogram representing a multi-spectral augmentation of the conventional 2-D sinogram. A filtered backprojection algorithm is used to reconstruct a stack of multi-spectral images for each 2-D tomographic slice that allow tissue characterization. A novel methodology for soft tissue differentiation using spectral target detection is presented. The representative 2-D and 3-D HUTT images formed at various frequency bands demonstrate the high-resolution capability of the system. It is shown that spherical objects with diameter down to 0.3㎜ can be detected. In addition, the results of soft tissue differentiation and characterization demonstrate the feasibility of quantitative soft tissue analysis for possible detection of lesions or cancerous tissue.

• Journal of Biomedical Engineering Research
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• v.30 no.1
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• pp.1-9
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• 2009

Many types of small animal imaging modalities, like micro-CT, micro-PET, and micro-SPECT, have been recently developed worldwide. Small animal imaging systems are now recognized as indispensable tools to validate efficacy and safety of new drugs or new therapeutic methods using the animal disease models. With increasing demands for small animal imaging in biomedical research, multimodal small animal imaging systems, like micro-PET/CT or micro PET/MRI, are now also being developed. Small animal imaging with spatial resolution and sensitivity comparable to human imaging is quite challenging since laboratory small animals are much smaller than human beings. Research activities in Korea on small animal imaging systems are reviewed in this paper. In the field of micro-CT and micro-PET, many world-class technologies have been developed successfully in Korea. It is expected that the developed animal imaging system technologies can be used in the development of clinical imaging systems in Korea in the near future.

• Journal of Korean Neurosurgical Society
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• v.49 no.6
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• pp.370-372
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• 2011

Dissection of the middle cerebral artery (MCA) is less frequent compared with dissection of the vertebrobasilar system or carotid artery. Recently, high-resolution cross sectional MR imaging (HRMRI) has emerged as a potential technique for atherosclerotic plaque imaging in MCA, We introduce the findings of HRMRI in a 56-year-old woman with traumatic MCA dissection, HRMRI showed an intimal flap and tapered pseudolumen with intra-luminal hemorrhage, We performed stent deployment about MCA dissection after failed medical treatment Three months later, there was no in-stent restenosis and no further neurological deficit were noted.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.32B no.1
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• pp.110-119
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• 1995

The lateral resolution in an ultrasound imaging system is one of the most important factors for quality of the image and is determined by the beam focusing. For the better lateral resolution SDF(Sampled Delay Focusing) capable of digital focusing was proposed. The second-order sampling, one of band-width sampling methods, is suggested as being the best suitable for SDF because it allows total digital processing and is simple and economical. By proving that it introduces too much error, this article shows the second-order sampling is not appropriate for sampling of the wide-band signal generally used in ultrasound imaging systems. Also, this article suggests new sampling methods that maintain the advantages and reduce the unavoidable errors of the second-order sampling method. From computer simulation it is expected that the proposed methods reduce the errors of the second-order sampling method and can be used in real applications.

• Applied Microscopy
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• v.43 no.1
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• pp.9-13
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• 2013

The helium ion microscope (HIM) has recently emerged as a novel tool for imaging and analysis. Based on a bright ion source and small probe, the HIM offers advantages over the conventional field emission scanning electron microscope. The key features of the HIM include (1) high resolution (ca. 0.25 nm), (2) great surface sensitivity, (3) great contrast, (4) large depth-of-field, (5) efficient charge control, (6) reduced specimen damage, and (7) nanomachining capability. Due to the charge neutralization by flood electron beam, there is no need for conductive metal coating for the observation of insulating biological specimens by HIM. There is growing evidence that the HIM has substantial potential for high-resolution imaging of uncoated insulating biological specimens at the nanoscale.