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Developments of Small Animal Imaging Systems in Korea

소동물 영상시스템의 국내 개발 현황

  • Lee, Soo-Yeol (Dept. of Biomedical Engineering, Kyung Hee University)
  • 이수열 (경희대학교 동서의료공학과)
  • Published : 2009.02.28

Abstract

Many types of small animal imaging modalities, like micro-CT, micro-PET, and micro-SPECT, have been recently developed worldwide. Small animal imaging systems are now recognized as indispensable tools to validate efficacy and safety of new drugs or new therapeutic methods using the animal disease models. With increasing demands for small animal imaging in biomedical research, multimodal small animal imaging systems, like micro-PET/CT or micro PET/MRI, are now also being developed. Small animal imaging with spatial resolution and sensitivity comparable to human imaging is quite challenging since laboratory small animals are much smaller than human beings. Research activities in Korea on small animal imaging systems are reviewed in this paper. In the field of micro-CT and micro-PET, many world-class technologies have been developed successfully in Korea. It is expected that the developed animal imaging system technologies can be used in the development of clinical imaging systems in Korea in the near future.

Keywords

References

  1. M.G. Pomper, 'Molecular imaging: an overview,' Acad. Radiol., vol. 8, pp. 1141-1153, 2001 https://doi.org/10.1016/S1076-6332(03)80728-6
  2. R. Weissleder, and U. Mahmood, 'Molecular imaging,' Radiology, vol. 219, pp. 316-333, 2001 https://doi.org/10.1148/radiology.219.2.r01ma19316
  3. T.F. Massoud, and S.S. Gambhir, 'Molecular imaging in living subject: seeing fundamental biological processes in a new light,' Genes & Development, vol. 17, pp. 545-580, 2003 https://doi.org/10.1101/gad.1047403
  4. J. H. Jung, Y. Choi, K.J. Hong, B.J. Min, W.H, and J.H. Kang, 'Recent advances in nuclear medicine imaging instrumentation,' Nucl. Med. Mol. Imaging, vol. 42, pp.1-14, 2008
  5. C.T. Badea, M. Drangova, D.W. Holdsworth, and G.A. Johnson, 'In vivo small-animal imaging using micro-CT and digital subtraction angiography,' Phys. Med. Biol., vol. 53, pp. R319-R350, 2008 https://doi.org/10.1088/0031-9155/53/19/R01
  6. M.J. Paulus, H. Sari-Sarraf, S.S. Gleason, M. Bobrek, J.S. Hicks, D.K. Johnson, J.K. Behel, L.H. Thompson, and W.C. Allen, 'A new x-ray computed tomography system for laboratory mouse imaging,' IEEE. Trans. Nucl. Sci., vol. 46, pp. 558-564, 1999 https://doi.org/10.1109/23.775579
  7. M.J. Paulus, S.S. Gleason, H. Sari-Sarraf, D.K. Johnson, C.J. Foltz, D.W. Austin, M.E. Easterly, E.J. Michaud, M.S. Dhar, P.R. Hunsicker, J.W. Wall, and M. Schell, 'High-resolution x-ray CT screening of mutant mouse models,' in Proc. SPIE, San Jose, CA, USA, Jan, 2000, vol. 3291, pp. 270-279
  8. S.Y. Wan, A.P. Kiraly, E.L. Ritman, and W.E. Higgins, 'Extraction of the hepatic vasculature in rats using 3-D micro-CT images,' IEEE. Trans. Med. Imag., vol. 19, pp. 964-971, 2000 https://doi.org/10.1109/42.887843
  9. E.L. Ritman, 'Molecular imaging in small animals-roles for micro-CT,' J. Cell. Biochem. Supp., vol. 39, pp. 116-124, 2002
  10. S.C. Lee, H.K. Kim, I.K. Chun, M.H. Cho, S.Y. Lee, and M.H. Cho, 'A flat-panel detector based micro-CT system: performance evaluation for small-animal imaging,' Phys. Med. Biol., vol. 48, pp. 4173-4185, 2003 https://doi.org/10.1088/0031-9155/48/24/014
  11. D.A. Jaffray, and J.H. Siewerdsen, 'Cone-beam computed tomography with a flat-panel imager: initial performance characterization,' Med. Phys., vol. 27, pp. 1311-1123, 2000 https://doi.org/10.1118/1.599009
  12. I.K. Chun, M.H. Cho, S.C. Lee, M.H. Cho, and S.Y. Lee, 'X-ray micro-tomography system for small-animal imaging with zoomin imaging capability,' Phys. Med. Biol., vol. 49, pp. 3889-3902, 2004 https://doi.org/10.1088/0031-9155/49/17/005
  13. M.H. Cho, D.H. Lee, B.H. Han, and S.Y. Lee, 'Rotating-gantrybased x-ray micro-tomography system with the sliding mechanism capable of zoom-in imaging,' J. Biomed. Eng. Res., vol. 29, pp. 107-113, 2008
  14. L.A. Feldkamp, L.C. Davis, and J.W. Kress, 'Practical conebeam algorithm,' J. Opt Soc. Am. A, vol. 1, pp. 612-619, 1984 https://doi.org/10.1364/JOSAA.1.000612
  15. C. Chavarrias, J.J. Vaquero, A. Sisniega, A. Rodriguez-Ruano, M.L. Soto-Montenegro, P. Garcia-Barreno, and M. Desco, 'Extraction of the respiratory signal from small-animal CT projections for a retrospective gating method,' Phys. Med. Biol., vol. 53, pp. 4683-4695, 2008 https://doi.org/10.1088/0031-9155/53/17/015
  16. R.D. Kapadia, G.B. Stroup, A.M. Badger, B. Koller, J.M. Levin, R.W. Coatney, R.A. Dodds, X. Liang, M.W. Lark, and M. Gowen, 'Application of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis,' Technol. Health Care, vol. 6, pp. 361-372, 1998
  17. I.K. Chun, M.H. Cho, J.H. Park, and S.Y. Lee, 'In vivo trabecular thickness measurement in cancellous bones: longitudinal rat imaging studies,' Physio. Meas., vol. 27, pp. 695-702, 2006 https://doi.org/10.1088/0967-3334/27/8/004
  18. S.M. Jorgensen, O. Demirkaya, and E.L. Ritman, 'Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with x-ray micro-CT,' Am. J. Physiol., vol. 275, pp. H1103-1114, 1998
  19. S.Y. Wan, E.L. Ritman, and W.E. Higgins, 'Multi-generational analysis and visualization of the vascular tree in 3D micro-CT images,' Comput. Biol. Med., vol. 32, pp. 55-71. 2002 https://doi.org/10.1016/S0010-4825(01)00034-8
  20. A.A. Kurth, and R. Muller, 'The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model,' Skeletal Radiol., vol. 30, pp. 94-98, 2001 https://doi.org/10.1007/s002560000287
  21. T.Y. Song, Y. Choi, J.H. Jung, B.J. Min, K.J. Hong, Y.S. Choe, et al. 'Performance vamelioration for small animal SPECT using optimized pinhole collimator and image correction technique,' IEEE Trans. Nucl. Sci., vol.52, pp.1396-400, 2005 https://doi.org/10.1109/TNS.2005.858265
  22. T.Y. Song Y. Choi, Y.H. Chung J.J. Jung, Y.S. Choe, K.-H. Lee, et al, 'Optimization of pinhole collimator for small animal SPECT using Mote Carlo simulation,' IEEE Trans. Nuc.l Sci., vol. 50, pp.327-332, 2003 https://doi.org/10.1109/TNS.2003.812448
  23. D.W. Townsend, 'Multimodality imaging of structure and function,' Phys. Med. Biol., vol. 53, pp. R1-R39, 2008 https://doi.org/10.1088/0031-9155/53/4/R01
  24. C. Catana, Y. Wu, M.S. Judenhofer, J. Qi, B.J. Pichler, and S.R. Cherry, 'Simultaneous acquisition of multislice PET and MR images: Initial results with a MR- compatible PET scanner,' J. Nucl. Med. vol. 47, pp. 1968-76, 2006