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Acute Toxicity Study of Recombinant Granulocyte-Macrophage Colony Stimulating Factor (LBD-005) in ICR mice

  • Kim, Hyoung-Chin;Song, Si-Whan;Cha, Shin-Woo;Shin, Chun-Chul;Ha, Chang-Su;Han, Sang-Seop
    • Biomolecules & Therapeutics
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    • v.1 no.2
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    • pp.270-274
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    • 1993
  • The acute toxicity of a recombinant granulocyte-macrophage colony stimulating factor (code name: LBD-005) was evaluated in both sexes of ICR mice, 5~6 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results of the acute toxicity study, LBD-005 was not considered to induce any toxic effect on the mice in mortalities, clinical findings, body weights and gross findings. It is suggested that $LD_50$ values in mice would be >48 mg/kg in the oral route and >24 mg/kg in the subcutaneous or intravenous route.

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Acute Toxicity Study of Recombinant Human Interferon ${\alpha}A$ (LBD-007) in ICR Mice

  • Kim, Hyoung-Chin;Song, Si-Whan;Cha, Shin-Woo;Shin, Chun-Chul;Ha, Chang-Su;Han, Sang-Seop
    • Biomolecules & Therapeutics
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    • v.1 no.2
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    • pp.266-269
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    • 1993
  • The acute toxicity of a recombinant human interferon $\alpha$A (code name: LBD-007) was evaluated in both sexes of ICR mice, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007 was not considered to induce any toxic effect on the mice in mortalities, clinical findigs, body weights and gross findings. It is suggested that LD$_{50}$ values in mice would be $>48{\times}10^8$ IU/kg in the oral, subcutaneous or intravenous routes.s.

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Thermal Analysis of a High Speed Induction Motor Considering Harmonic Loss Distribution

  • Duong, Minh-Trung;Chun, Yon-Do;Park, Byoung-Gun;Kim, Dong-Jun;Choi, Jae-Hak;Han, Pil-Wan
    • Journal of Electrical Engineering and Technology
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    • v.12 no.4
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    • pp.1503-1510
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    • 2017
  • In this paper, a thermal analysis of a high speed induction motor with a PWM voltage source was performed by considering harmonic loss components. The electromagnetic analysis of the high speed induction motor was conducted using the time-varying finite element method, and its thermal characteristics were carried out using the lump-circuit method. Harmonic losses from tests in the high frequency region were divided into core loss and conductor loss components using various ratios, in order to determine the loss distributions for the thermal analysis. The results from both the calculations and experiment were validated using a high speed induction motor prototype operating at 20,000rpm.

Secondary Metabolites of Volvariella bombycina and Their Inhibitory Effects on Melanogenesis

  • Xu, Guang-Hua;Choo, Soo-Jin;Kim, Young-Hee;Ryoo, In-Ja;Seok, Soon-Ja;Ahn, Jong-Seog;Yoo, Ick-Dong
    • Journal of Microbiology and Biotechnology
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    • v.20 no.1
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    • pp.78-81
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    • 2010
  • Four compounds were isolated from the culture broth of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3), and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogenesis inhibitory effect in cultured B16 mouse melanoma cells.

Cloning of a novel ion channel candidate by in silico gene mining

  • Shim, Won-Sik;Kim, Man-Su;Yang, Young-Duk;Park, Seung-Pyo;Kim, Byung-Moon;Oh, Uh-Taek
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.192.2-193
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    • 2003
  • Capsaicin, a pungent ingredient in chili pepper, is known to excite sensory neurons that mediate pain sensation. This effect of capsaicin is determined by unique receptors and the capsaicin receptor (transient receptor potential subfamily V, member 1 (TRPV1)) was cloned recently. TRPV1 contains six transmembrane domains and three ankyrin repeats at N-terminal. This characteristic architecture is common in other ion channel in TRPV families. (omitted)

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