Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.192.2-193
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- 2003
Cloning of a novel ion channel candidate by in silico gene mining
- Shim, Won-Sik (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University) ;
- Kim, Man-Su (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University) ;
- Yang, Young-Duk (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University) ;
- Park, Seung-Pyo (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University) ;
- Kim, Byung-Moon (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University) ;
- Oh, Uh-Taek (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy. Seoul National University)
- Published : 2003.04.01
Abstract
Capsaicin, a pungent ingredient in chili pepper, is known to excite sensory neurons that mediate pain sensation. This effect of capsaicin is determined by unique receptors and the capsaicin receptor (transient receptor potential subfamily V, member 1 (TRPV1)) was cloned recently. TRPV1 contains six transmembrane domains and three ankyrin repeats at N-terminal. This characteristic architecture is common in other ion channel in TRPV families. (omitted)
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