• Title/Summary/Keyword: Research and development

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Phytochemical Constituents from the Rhizomes of Osmunda japonica Thunb and Their Anti-oxidant Activity

  • Woo, Kyeong wan;Jung, Ja Kyun;Lee, Hyun Joo;Kim, Tae Muk;Kim, Min Suk;Jung, Ho Kyung;An, Byeongkwan;Ham, Seong Ho;Jeon, Byung Hun;Cho, Hyun Woo
    • Natural Product Sciences
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    • v.23 no.3
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    • pp.217-221
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    • 2017
  • Eleven compounds (1-11) were isolated from the rhizomes of Osmunda japonica, and their structures were elucidated based on $^1H$, $^{13}C-NMR$ and LC-IT-TOF MS data. Of these compounds, all compounds (1 - 11) have been previously reported, although five (6 - 9, 11) have not previously been isolated from this plant. The antioxidant activities of isolated compounds (1 - 11) were measured by DPPH and ABTS assays, and compound 10 showed the high antioxidant activity.

An Efficient Method for the Large-Scale Synthesis of Atorvastatin Calcium

  • Lee, Hong-Woo;Kim, Young-Min;Yoo, Choong-Leol;Kang, Sung-Kwon;Ahn, Soon-Kil
    • Biomolecules & Therapeutics
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    • v.16 no.1
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    • pp.28-33
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    • 2008
  • Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Efficient hydrolysis of boronate compound 9 aimed at the viable synthesis for commercial production and purification of Atorvastatin calcium is reported. Detail studies of evaluation procedure are also reported.

Effects of Salinity and Standard Toxic Metal(Cu, Cd) on Fertilization and Embryo Development Rates in the Sea Urchin(Hemicentrotus pulcherrimus) (염분과 표준 독성물질(Cu, Cd)이 말똥성게(Hemicentrotus pulcherrimus)의 수정 및 배 발생률에 미치는 영향)

  • Hwang, Un-Ki;Rhee, Choong-Won;Kim, Kwang-Seob;An, Kyoung-Ho;Park, Seung-Youn
    • Environmental Analysis Health and Toxicology
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    • v.24 no.1
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    • pp.9-16
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    • 2009
  • Effects of salinity and standard toxic metals on fertilization and embryo development rates were investigated in the sea urchin, Hemicentrotus pulcherrimus. Spawning was induced by injecting $1{\sim}2$ mL of 0.5 M KCl into the coelomic cavity. Males released white or cream-colored sperms and females released yellow or orange-colored eggs. The fertilization rate was below 30% when salinity was 20 psu and lower, but was almost above 90% when salinity was 25 psu and higher. The embryo development rate was below 60% when salinity was 25 psu and lower, but was above 80% when salinity was between 30 and 35 psu. The fertilization and embryo development rates in the control condition(not including Cu and Cd) were greater than 90%, but decreased a high negative correlation with the increasing of Cu(r=-0.80, r=-0.78) and Cd(r=-0.90, r=-0.82) concentrations, respectively. The fertilization and embryo development rates were significantly inhibited in the addition of Cu($EC_{50}$=17.30 ppb, $EC_{50}$=10.32 ppb) and Cd($EC_{50}$=364.57 ppb, $EC_{50}$=244.04 ppb), respectively. These results suggest that salinity concentrations for successful fertilization and normal embryogenesis of H. pulcherrimus are above 25 psu and 30 psu, respectively, and the biological assays of fertilization and embryo development rates using H. pulcherrimus are useful methods for the ecological toxicity test of marine pollution elements.

Two Hippolytid Shrimps (Crustacea: Decapoda: Caridea) from the Deepwater of the East Sea, Korea

  • Kim, Jung-Nyun;Choi, Jung-Hwa;Hong, Byeong-Gyu;Hwang, Kang-Seok;Chun, Young-Yull
    • Animal Systematics, Evolution and Diversity
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    • v.23 no.2
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    • pp.199-203
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    • 2007
  • Two hippolytid shrimps, Spirontocaris spinus (Sowerby, 1805) and Lebbeus unalaskensis (Rathbun, 1902) are described on the basis of material collected from the deepwater of the East Sea, Korea at 310-810 m. The former has been incorrectly known as Spirontocaris arcuata Rathbun, 1902 in Korea and the latter is a new member of the Korean fauna. Morphological and distributional accounts of these species are presented with illustrations.

Modeling buoyant surface discharges in a shallow channel with steady flow (정상흐름하 천해역 수로에서의 저밀도수 표층방출 모델링)

  • Jung, Kyung-Tae;Jin, Jae-Youll;Park, Jin-Soon;Yum, Ki-Dai;Park, Chang-Wook;Kim, Sung-Dae;Suk Yoon
    • Proceedings of the Korean Society of Coastal and Ocean Engineers Conference
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    • 2002.08a
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    • pp.191-197
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    • 2002
  • The prediction of the dynamic behaviors of buoyant water discharges into a large volume of water bodies, the flows of water accompanying the density differences due to temperature differences and sometimes also to salinity differences, have attracted great concern over several decades. Heated water surface discharges from power plants and freshwater discharges in estuaries are typical examples of the buoyant flows. (omitted)

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Total Phenolic Contents and Biological Activities of Korean Seaweed Extracts

  • Kim, So-Jung;Woo, Seon-Ock;Yun, Hee-Young;Yum, Seung-Shic;Choi, Eun-Seok;Do, Jeong-Ryong;Jo, Jin-Ho;Kim, Dong-Giun;Lee, Suk-Chan;Lee, Taek-Kyun
    • Food Science and Biotechnology
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    • v.14 no.6
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    • pp.798-802
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    • 2005
  • Crude extracts of thirty seaweeds collected in Korea were obtained using 50% ethanol, and total phenolic contents and antioxidant activities were compared. Two brown algae, Ecklonia cava (E. cava) and Sargassum siliquastrum (S. siliquastrum), showing high antioxidant activity based on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and superoxide anion radical scavenging activity were further investigated for their inhibitory effects on tyrosinase activity. The E. cava extract had the highest total phenolic content among the seaweeds extracts. Total phenolic contents were strongly correlated with antioxidant activity in the thirty seaweed extracts ($R^2\;=\;0.9169$). The E. cava and S. siliquastrum extracts exhibited higher inhibition to tyrosinase activity than butylated hydroxytoluene (BHT) and epigallocatechin gallate (EGCG).