• IMMUNE NETWORK
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• 제7권3호
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• pp.124-132
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• 2007

Background: Regulatory T cells (Tregs) have been investigated intensively for some decades. These cells regulate the immune system, prevent overactivated immune responses and can be used therapeutically. For rheumatoid arthritis (RA), understanding the functions and status of Tregs is an important step for understanding immune regulation in this autoimmune disease. Methods: We investigated the percentages, phenotypes and suppressive functions of $CD4^+CD25^+$ Tregs in peripheral blood (PB) of patients with RA. Results: The percentages were higher in the patients (n=12) than in healthy controls (n=10), and the cells expressed the $CD45RB^{low}$, CTLA-4 and CCR7 phenotypes. We also investigated the expression of Foxp3 and secretion of interleukin (IL)-10 induced $CD4^+CD25^+$ Tcells by anti-CD3 antibody treatment. A suppressive function of the patients' cells was shown through coculture with $CD4^+CD25^-$ T cells in vitro. Conclusion: We suggest that, despite their increased numbers and suppressive function, they manage the ongoing inflammation ineffectively. It might be possible to apply IL-10 to induce the proliferation of IL-10-producing Tregs as therapy for RA.

• 한국비블리아학회지
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• 제23권4호
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• pp.109-124
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• 2012

본 연구는 정부출연연구기관의 연구기록물 관리의 첫 단계인 수집에서부터 효율적 관리 방안을 모색하는 것에 그 목적을 두었다. 이를 위해서 사례분석과 연구관리기관의 설문조사를 병행하여 수행하였다. 사례로서는 영국 정보시스템 합동위원회(JISC), 호주의 멜버른 대학교의 연구기록물 관리지침 그리고 캐나다 연구도서관협회(CARL)를 분석하였다. 설문조사는 과학기술연구회 연구기관, 기초기술연구회 소속 13개 기관, 산업기술연구회 소속 13개 기관, 경제 인문사회연구회 소속 23개 기관으로 총 49개 정부출연연구기관 사서가 응답한 설문지 43부를 토대로 분석하였다. 사례분석과 설문조사 내용을 바탕으로 정부출연연구기관 연구기록물의 효율적 관리를 위한 수집 개선 방안을 수집과 관리 부문으로 구분하여 제안하였다. 연구기관의 효율적인 연구기록물 수집을 위해서 우선 제도개선과 정책수립이 근본적으로 필요하며, 이를 기반으로 한 매뉴얼 작성과 이용이 현실적으로 요구된다. 이와 함께 전문인력으로써 연구기록물 담당자 배치가 시급하며, 담당자를 통한 연구기록물 수집의 적극적인 홍보와 노력이 중요하다.

• 보존과학연구
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• 통권29호
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• pp.239-254
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• 2008

In this division, regarding the establishment of operation system of Conservation Science Center, we have tried to find out research trends and advanced operation system of Italian conservation centers, which play an active part in the field of restoration of cultural properties internationally. And the results will be utilized for the establishment of Conservation Science Center. Italy is a country having a long history of restoring cultural properties. In this field, it is largely divided into research & development institutes. And restoration institute and they are operated under system in which research & development institute implement research projects for restoring cultural properties and restoration specialists take receive the results and utilize them. They have different business processing system compared to Conservation Science Center which will implement research-development and restoration(conservation treatment) concurrently. Each institute, carrying out differentiated and specialized research projects per region, maintains smooth cooperative relationship with national institutes, neighboring universities and even afflated schools through horizontal-mutual collaboration joint research, and sharing of equipments, in the field of cooperation between national institutes, cooperation with neighboring universities, and connection to belonging schools. There institutes show us a good example which can be utilized in the future organizational structure of Conservation Science Center. It is expected that their operation system and possessed technologies such as utilization of human resources pool and cooperation with relevant fields can be used usefully in the management and operation of Conservation Science Center.

• 디지털융복합연구
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• 제7권3호
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• pp.61-74
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• 2009

This research reviewed previous research related to Performance Measurement Models of Knowledge Management (PMMKM) in order to integrate their findings with more recent research and construct a new PMMKM. This new hypothetical PMMKM consists of an input sector, a process sector, an outcome sector, and an infrastructure sector. Each sector has three measurement items with the exception of the infrastructure sector which has two. Empirical analyses testing the overall performance model validity of the hypothetical PMMKM were favorable. However, it show be noted that the "share process" and "utilization process" items in the process sector merged into one single item. The same is true with the "individual outcome" and "organization outcome" items in the outcome sector found one single item. The study's results reveal three implications with respect to performance. First, there are derived integrated performance measurement sectors and items based on overall management process of knowledge management, which can be practically applied to the government related research entities. This became apparent after extensive review or previous theoretical studies related to the public sector and private sector. Second, weighted performance measurement of knowledge management using AHP (Analytic Hierarchy Process) Analysis makes it possible to propose PMMKM in government sponsored research institutes. Finally, measuring performance to management knowledge, as shown in this study, will prove useful for inside and outside experts who propose specific guidelines and methodologies for Knowledge management at government sponsored research institutes.

• 산업융합연구
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• 제14권2호
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• pp.39-46
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• 2016

The purpose of this Study is to present the tasks and means of improving the operational system of public culture and arts institutes in the future on the basis of the analysis of the effectiveness of operation of public culture and arts institutes. The summary of the results of analysis in this Study is as follows: Firstly, it was found that the factor variables that impart effect on the operation of public culture and arts institutes included (1) artistic value, (2) convenience and (3) organizational management, while the performance variable of public culture and arts institutes was (4) operational performance. Secondly, in the analysis of the structure that explains the operational effects of public culture and arts institutes, convenience and organizational management were found to impart effects on the operational performances. However, artistic value was found to have no effect on operational performances. Therefore, these results of analysis imply that organizational management and convenience, rather than artistic value, need to be fortified in order to elevate the operational performances of public culture and arts institutes.

• 한국유전체학회:학술대회논문집
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• 한국유전체학회 2002년도 The 11th Korea Genome Conference
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• pp.40.2-40.2
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• 2002

• 한국자동차공학회논문집
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• 제19권4호
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• pp.78-83
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• 2011

Natural gas is one of the most promising alternatives to gasoline and diesel fuels because of its high thermal efficiency and lower harmful emissions, including $CO_2$. Although the high octane value of natural gas increases engine output and efficiency due to the high compression ratio, this fuel is prone to such difficulties as a narrow limit of inflammability and a slow combustion speed in the lean burn operation domain, leading to unstable combustion and higher emissions of harmful exhaust gases. Hydrogen blended with natural gas can extend the lean burn limit while maintaining stable, efficient combustion and achieving lower NOx, hydrocarbon and green house gas emissions. In this study, the effect of hydrogen addition on an engine performance and NOx emission characteristics was investigated in a heavy duty natural gas engine. The results showed that thermal efficiency was increased and NOx emissions were reduced due to the expansion of lean operation range under stable operation. NOx emission can be significantly reduced with the retard of spark advance timing.

• Biomolecules & Therapeutics
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• 제11권4호
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• pp.205-213
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• 2003

Various angiogenesis inhibitors target vascular endothelial cells and block tumor angiogenesis. Angiostatin is a specific endogenous angiogenesis inhibitor in clinical trials, which contains only the first four triple loop structures, known as kringle domains. Its generated by proteolytic cleavage of its parent molecule plasminogen, which itself does not exhibit antiangiogenic activity. Kringle domains from prothrombin, apolipoprotein, hepatocyte growth factor, urokinase and tissue-type plasminogen activator also elicit anti-angiogenic or antitumor activities in several model systems, albeit low amino acid sequence identity between angiostatin and each individual kringle. However, the differential effects of each kringle domain on endothelial cell proliferation, and migration observed in these kringle domains, suggest that the amino acid sequence of the primary structure is still important although kringle architecture is essential for anti-mlgiogenic activity. If it is further studied as to how amino acid sequence and kringle architecture contributes in anti-angiogenic activity, with studies on underlying mechanisms of anti-angiogenesis by kringle-based angiogenesis inhibitors, it will provide basis for the development of new potent anti-angiogenesis inhibitors and improvement of the efficacy of angiogenesis inhibitors.

• 산업경영시스템학회지
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• 제43권4호
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• pp.84-92
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• 2020

In order to analyze the organizational performance of government-funded research institutes, four independent variables (organization size, organization age, evaluation system, organization location) and goal ambiguity were empirically analyzed. Although there are existing studies on institutional evaluation, which is the organizational performance of government-funded research institutes, there are differences in research in that it is an empirical analysis analyzed from the perspective of goal ambiguity and that the evaluation system, which is the specificity of institutional evaluation, is included in the analysis. As a result of the analysis, organizational location was the only independent variable that had a direct significant effect on organizational performance, and goal ambiguity showed a significant mediating effect for all independent variables. This indicates that goal ambiguity plays an important role in the organizational performance of government-funded research institutes, and to reduce this, increase the size of the organization, pay attention to establishment of the organization for organizational age, and that it is desirable to have an independent research group in the government department for the organization location. In addition, it was supported that the improvement effect of the evaluation system is proceeding in a desirable direction in terms of goal ambiguity.

• Investigative Magnetic Resonance Imaging
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• 제25권4호
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• pp.229-251
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• 2021

Arteriosclerosis is the leading cause of stroke, with a fatality rate surpassing that of ischemic heart disease. High-resolution vessel wall magnetic resonance imaging is generally recognized as a non-invasive and panoramic method for the evaluation of arterial plaque; however, this method requires improved signal-to-noise ratio and scanning speed. Recent advances in high-density head and neck coil arrays are characterized by broad coverage, multiple channels, and closefitting designs. This review analyzes fast magnetic resonance imaging from the perspective of accelerated algorithms for vessel wall imaging and demonstrates the need for effective algorithms for signal acquisition using advanced radiofrequency system. We summarize different phased-array structures under various experimental objectives and equipment conditions, introduce current research results, and propose prospective research studies in the future.