• Journal of Pharmaceutical Investigation
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• v.34 no.5
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• pp.351-362
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• 2004

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.

• Journal of Korean Library and Information Science Society
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• v.38 no.2
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• pp.353-372
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• 2007

This study aims at providing ideas to develop a new plan after the completion of the first five year School Library Development Plan(2003-2007) initiated by the Ministry of Education(MOE). In doing so, it analyzes cooperative systems and collaborative efforts between school and public libraries in the City of Seoul and its outskirts. Major research methods used are associated with the following (1) case studies in the city of Seoul, Inchon, and the Kyung-Gi province and (2) questionnaire and interviewing techniques for those who are engaged In the collaborative systems. In sum, this study analyzes the strengths and limitations of the cooperative systems in different regional areas. It also suggests ideas to improve the shortcomings of current systems.

• Journal of Korea Society of Industrial Information Systems
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• v.13 no.5
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• pp.124-132
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• 2008

Most companies in Korea that are implementing six sigma programs evaluate belt's project performance based on their own evaluation systems. Financial performance is a major criterion to evaluate project performance. New project evaluation systems which are based on not only financial performance but also non-financial performance need to be presented for better performance system. The study presents the integration system of balanced scorecard and six sigma project evaluation systems to show balanced view points of performance. Each evaluation index of four view points are presented in the study and could be utilized for alternative project evaluation systems.

• Industrial Engineering and Management Systems
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• v.11 no.1
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• pp.70-81
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• 2012

The subject of "Design Requirements" (DR) is central to the design of software and engineering systems. The main reason for this is that quality aspects are usually closely tied to requirements, among other things. In this review paper, we consider how the subject of requirements is being managed in these two seemingly different design disciplines. Two important aspects are covered, namely: (a) requirements development, describing various activities leading to requirements documentation, and (b) requirements change management, describing various activities needed for the proper treatment of the inevitable changes in requirements. Similarities and differences on how these two aspects are handled in software and engineering systems are highlighted. It is concluded from this literature survey that the management of software requirements is quite coherent and well established as a science. On the other hand, management of engineering systems requirements suffer from being unstructured, in particular when requirements changes are involved. Important gaps and future important research areas are identified.

• Journal of Korea Society of Industrial Information Systems
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• v.28 no.1
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• pp.1-8
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• 2023

In this paper, we developed a mid-range automotive radar systems based on the performance requirements and test procedures of the intelligent transport systems, that is lane change decision aid systems (LCDAS). The mid-range automotive radar has the maximum detection range up to 80m and an update time within 50ms. The computational loads of a signal processing were reduced by using ROI preprocessing technique. Considering actual driving environments, radar performance evaluations were conducted in two driving scenarios at an automotive proving ground.

• International Journal of Computer Science & Network Security
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• v.23 no.5
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• pp.109-120
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• 2023

With the increasing interest in blockchain technology and its employment in diverse sectors and industries, including: finance, business, voting, industrial and many other medical and educational applications. Recently, the blockchain technology has played significant role in preventing fraud transactions in accounting systems, as the blockchain offers high security measurements, reduces the need for centralized processing, and blocks access to the organization information and system. Therefore, this paper studies, analyses, and investigates the adoption of blockchain technology with accounting systems, through analyzing the results of several research works which have employed the blockchain technology to secure their accounting systems. In addition, we investigate the performance of applying the deep learning and machine learning approaches for the purpose of fraud detection and classification. As a result of this study, the adoption of blockchain technology will enhance the safety and security of accounting systems, through identifying and classifying the possible frauds that may attack the accounting and business organizations.

• Information Systems Review
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• v.4 no.2
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• pp.95-109
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• 2002

The purpose of this research is to investigate a way to increase interoperability between information systems. We proposed a technical reference model (TRM) and a standard profile (SP) that are components of ITA as tools to secure information system interoperability. First, we composed TRM by choosing technology field that need standardization for information system interoperability. And, we choose standards to apply in each technology field of TRM as a interoperability common SP.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.9
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• pp.1412-1422
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• 2022

The importance of interoperability between weapon systems is continuously increasing. Usually it is implemented by data exchange. The existence of information heterogeneities between systems decreases the efficiency and quality of the implementations enterprise-widely. Many other developed countries increase the efficiency and quality of the implementations by using information exchange model commonly. However, Korean military is still not aware of the importance and necessity of the model. This study explains the necessity of development and adaptation of the Korea command and control information exchange model(KC2IEM), and presents the methodology for the development of the model, and verifies and improves it through a prototype model development. The completion of the information exchange model could not be possible by academic research, therefore this study contributes as a motivation and a stepping stone for the following developments.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.10a
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• pp.636-639
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• 2004

Information security keeps enterprises information from the unintended disclose, modification and destruction and plays important roles especially in enterprise owing Internet based information systems. This study recognizes the importance of information security policy, analyzes factors influencing adoption of information security policy, and provides the factors for enterprises utilize them.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.531-540
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• 2022

Due to the high incidence of malignant melanoma, the establishment of in vitro models that recapitulate the tumor microenvironment is of great biological and clinical importance for tumor treatment and drug research. In this study, 3D printing technology was used to prepare GelMA/PEGDA composite scaffolds that mimic the microenvironment of human malignant melanoma cell (A375) growth and construct in vitro melanoma micro-models. The GelMA/PEGDA hybrid scaffold was tested by the mechanical property, cell live/dead assay, cell proliferation assay, cytoskeleton staining and drug loading assay. The growth of tumor cells in two- and three-dimensional culture systems and the anti-cancer effect of luteolin were evaluated using the live/dead staining method and the Cell Counting Kit-8 (CCK-8) method. The results showed a high aggregation of tumor cells on the 3D scaffold, which was suitable for long-term culture. Cytoskeleton staining and immunofluorescent protein staining were used to evaluate the degree of differentiation of tumor cells under 2D and 3D culture systems. The results indicated that 3D bioprinted scaffolds were more suitable for tumor cell expansion and differentiation, and the tumor cells were more aggressive. In addition, luteolin was time- and dose-dependent on tumor cells, and tumor cells in the 3D culture system were more resistant to the drug.