• 정보처리학회논문지C
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• 제9C권6호
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• pp.911-918
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• 2002

미래의 PCS(Personal Communication Service) 네트워크 설계에서 하나의 중요한 문제는 위치 정보의 효율적인 관리이다. 이 논문에서, 우리는 n 위치 정보 데이터베이스들 중에 k개에 이동 단말의 위치를 저장하는 적응적 분산 동적 위치 관리 알고리즘을 제안한다. 제안하는 알고리즘은 무선 이동망 내의 위치 정보 데이터베이스들의 공간 지역성과 원격 이동 단말들로부터 로컬 이동 단말의 위치 질의 선호도에 따라 사본인자, k를 적응적으로 선택한다. 제안하는 알고리즘의 성능을 분석적 모델과 시뮬레이션을 통하여 평가한다. 성능 평가 결과, 호 이동율에 관계없이 제안한 알고리즘의 성능이 Krishnamurthi의 알고리즘에 비해 성능이 우수함을 알 수 있었다.

• International Journal of Internet, Broadcasting and Communication
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• 제11권2호
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• pp.1-10
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• 2019

Research classification of software modules was done to validate the approaches proposed for addressing limitations in existing classification approaches. The objective of this study was to replicate the experiments of a recently published research study and re-evaluate its results. The reason to repeat the experiment(s) and re-evaluate the results was to verify the approach to identify the faulty and non-faulty modules applied in the original study for the prioritization of test cases. As a methodology, we conducted this study to re-evaluate the results of the study. The results showed that binary logistic regression analysis remains helpful for researchers for predictions, as it provides an overall prediction of accuracy in percentage. Our study shows a prediction accuracy of 92.9% for the PureMVC Java open source program, while the original study showed an 82% prediction accuracy for the same Java program classes. It is believed by the authors that future research can refine the criteria used to classify classes of web systems written in various programming languages based on the results of this study.

• Molecules and Cells
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• 제44권12호
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• pp.861-878
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• 2021

The human genome contains many retroviral elements called human endogenous retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution. HERVs once were considered inactive junk because they are not replication-competent, primarily localized in the heterochromatin, and silenced by methylation. But HERVs are now clearly shown to actively regulate gene expression in various physiological and pathological conditions such as developmental processes, immune regulation, cancers, autoimmune diseases, and neurological disorders. Recent studies report that HERVs are activated in patients suffering from coronavirus disease 2019 (COVID-19), the current pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. In this review, we describe internal and external factors that influence HERV activities. We also present evidence showing the gene regulatory activity of HERV LTRs (long terminal repeats) in model organisms such as mice, rats, zebrafish, and invertebrate models of worms and flies. Finally, we discuss several molecular and cellular pathways involving various transcription factors and receptors, through which HERVs affect downstream cellular and physiological events such as epigenetic modifications, calcium influx, protein phosphorylation, and cytokine release. Understanding how HERVs participate in various physiological and pathological processes will help develop a strategy to generate effective therapeutic approaches targeting HERVs.

• 한국인터넷방송통신학회논문지
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• 제15권4호
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• pp.135-143
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• 2015

멀티플레이어 온라인 게임(MOG)은 수백 또는 수천명의 플레이어들을 위한 게임이며 대부분 인터넷을 이용하여 수행된다. MOG를 위한 P2P(peer-to-peer) 구조는 잠재적으로 규모조정성 증대, 비용 절감, 성능 향상 등이 가능하다. P2P 기반 게임의 기본 개념은 게임 상태를 플레이어들에게 분산 시켜서 각 플레이어가가 처리, 통신, 저장 업무를 수행하도록 하는 것이다. 객체에 대한 갱신 과정이 기본 사본에서 먼저 수행되는 기본 사본 기반 복제 기법에서도 객체들의 기본 사본은 플레이어들 간에 분산된다. 대부분의 멀티플레이어 게임은 각 객체마다 강한 일관성을 제공하기 위하여 기본 사본 모델을 사용한다. 게임은 여러 수준의 민감도를 가지며 각각의 일관성 요건에 따라 영역화될 수 있는 다양한 유형의 게임 액션들로 구성된다. 게임 내에서 각 액션의 유형마다 적절한 일관성 수준이 유지될 때 본 논문에서는 게임 개발업체가 성능과 일관성 간에 적절한 상충 관계를 선택할 수 있도록 한다. 기본 사본 모델을 갖는 P2P 게임 구조에 대한 성능 분석 결과가 기술된다.

• Journal of Preventive Medicine and Public Health
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• 제49권5호
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• pp.253-259
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• 2016

Objectives: Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on central adiposity have rarely been examined. A recent study focusing on Caucasians discovered the novel gene early B-cell factor 1 (EBF1), which was associated with central obesity-related traits via interactions with stress levels. We aimed to evaluate EBF1 gene-by-stress interaction effects on central adiposity traits, including visceral adipose tissue (VAT), in Korean adults. Methods: A total of 1467 Korean adults were included in this study. We selected 22 single-nucleotide polymorphisms (SNPs) in the EBF1 gene and analyzed their interactions with stress on central adiposity using additive, dominant, and recessive genetic modeling. Results: The four SNPs that had strong linkage disequilibrium relationships (rs10061900, rs10070743, rs4704967, and rs10056564) demonstrated significant interactions with the waist-hip ratio in the dominant model ($p_{int}$<0.007). In addition, two other SNPs (rs6556377 and rs13180086) were associated with VAT by interactions with stress levels, especially in the recessive genetic model ($p_{int}$<0.007). As stress levels increased, the mean values of central adiposity traits according to SNP genotypes exhibited gradual but significant changes (p<0.05). Conclusions: These results suggest that the common genetic variants for EBF1 are associated with central adiposity through interactions with stress levels, emphasizing the importance of managing stress in the prevention of central obesity.

• 한국보건간호학회지
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• 제12권2호
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• pp.107-121
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• 1998

The purpose of this study was to test the revised Health Promotion Model of Pender and to determine the factors to promote health behavior for adolescents' smoking behavior. The subjects of the study was 783 boys of 4 high school students. among 39. schools locating in Daejeon metropolitan city. The data was collected from July 1st to 15th. 1997 by school health nurse The research tool were HPLP of Walker. Pender. General self-efficacy scale of Sherer. control scale was measured by subconcept of hardiness scale of Pollock. and perceived barrier. perceived benefit. activity-related-affect tool were made by researcher via literature review The data were analyzed by SAS program using frequency. t-test. ANOVA. Schefee test. regression. The results were as follows 1. The mean of total health promoting behavior was $2.27\pm.35$. Among sub domain of health promoting behavior, the highest score was interpersonal support$(2.72\pm.60)$. and the lowest was health responsibility $(1.58\pm.44)$. 2. There were statistically significant difference in total health promoting behavior according to religion. parenting style. school performance. girl friend. father's smoking of individual characteristics. 3. The socioeconomic status. smoking, parent pattern. family structure of individual characteristics and experience domain associated with perceived benefit. perceived barrier. activity-related affect. interpersonal influence of behavior-specific cognition and affect domain. The perceived barrier. self-efficacy. girl friend and father's smoking of interpersonal influence. and control explained $25.8\%$ of variance of health promoting behavior. From above results school health nurse has to emphasize on health responsibility for health promotion of adolescent. But they couldn't intervene for parent pattern. socioeconomic status. family structure of individual characteristics and experience domain. it could be possible for school health nurse to promote health of adolescents through improving perceived barrier. also develop program to increase self-efficacy and through parent health class for fathers. Above results point to the importance of including parents in smoking prevention effort targeting adolescents. Because increasing control also promotes health of adolescents. it should be studied further about the specific measure. To verify the variables for increasing the fitness of health promoting model. it needs further replication of the research.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.14-14
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• 2017

The discipline of plant breeding is experiencing a renaissance impacting crop improvement as a result of new technologies, however fundamental questions remain for predicting the phenotype and how the environment and genetics shape it. Inexpensive DNA sequencing, genotyping, new statistical methods, high throughput phenotyping and gene-editing are revolutionizing breeding methods and strategies for improving both quantitative and qualitative traits. Genomic selection (GS) models use genome-wide markers to predict performance for both phenotyped and non-phenotyped individuals. Aerial and ground imaging systems generate data on correlated traits such as canopy temperature and normalized difference vegetative index that can be combined with genotypes in multivariate models to further increase prediction accuracy and reduce the cost of advanced trials with limited replication in time and space. Design of a GS training population is crucial to the accuracy of prediction models and can be affected by many factors including population structure and composition. Prediction models can incorporate performance over multiple environments and assess GxE effects to identify a highly predictive subset of environments. We have developed a methodology for analyzing unbalanced datasets using genome-wide marker effects to group environments and identify outlier environments. Environmental covariates can be identified using a crop model and used in a GS model to predict GxE in unobserved environments and to predict performance in climate change scenarios. These new tools and knowledge challenge the plant breeder to ask the right questions and choose the tools that are appropriate for their crop and target traits. Contemporary plant breeding requires teams of people with expertise in genetics, phenotyping and statistics to improve efficiency and increase prediction accuracy in terms of genotypes, experimental design and environment sampling.

• Journal of Veterinary Science
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• 제22권2호
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• pp.18.1-18.12
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• 2021

Background: We previously elucidated the protective mechanism of Korean red ginseng oil (RGO) against Brucella abortus infection, and our phytochemical analysis revealed that palmitic acid (PA) was an abundant component of RGO. Consequently, we investigated the contribution of PA against B. abortus. Objectives: We aimed to investigate the efficacy of PA against B. abortus infection using a murine cell line and a murine model. Methods: Cell viability, bactericidal, internalization, and intracellular replication, western blot, nitric oxide (NO), and superoxide (O₂^-) analyses and flow cytometry were performed to determine the effects of PA on the progression of B. abortus infection in macrophages. Flow cytometry for cytokine analysis of serum samples and bacterial counts from the spleens were performed to determine the effect of PA in a mouse model. Results: PA did not affect the growth of B. abortus. PA treatment in macrophages did not change B. abortus uptake but it did attenuate the intracellular survivability of B. abortus. Incubation of cells with PA resulted in a modest increase in sirtuin 1 (SIRT1) expression. Compared to control cells, reduced nitrite accumulation, augmented O₂^-, and enhanced pro-inflammatory cytokine production were observed in PA-treated B. abortus-infected cells. Mice orally treated with PA displayed a decreased serum interleukin-10 level and enhanced bacterial resistance. Conclusions: Our results suggest that PA participates in the control of B. abortus within murine macrophages, and the in vivo study results confirm its efficacy against the infection. However, further investigations are encouraged to completely characterize the mechanisms involved in the inhibition of B. abortus infection by fatty acids.

• BMB Reports
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• 제56권4호
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• pp.258-264
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• 2023

As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is highly recurrent and malignant. UPS is categorized as a tumor of uncertain differentiation and has few options for treatment due to its lack of targetable genetic alterations. There are also few cell lines that provide a representative model for UPS, leading to a dearth of experimental research. Here, we established and characterized new cell lines derived from two recurrent UPS tissues. Cells were obtained from UPS tissues by mincing, followed by extraction or dissociation using enzymes and culture in a standard culture environment. Cells were maintained for several months without artificial treatment, and some cell clones were found to be tumorigenic in an immunodeficient mouse model. Interestingly, some cells formed tumors in vivo when injected after aggregation in a non-adherent culture system for 24 h. The tissues from in vivo study and tissues from patients shared common histological characteristics. Pathways related to the cell cycle, such as DNA replication, were enriched in both cell clones. Pathways related to cell-cell adhesion and cell-cell signaling were also enriched, suggesting a role of the mesenchymal-to-epithelial transition for tumorigenicity in vivo. These new UPS cell lines may facilitate research to identify therapeutic strategies for UPS.

• 한국수자원학회논문집
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• 제52권8호
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• pp.515-529
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• 2019

하천망과 유역 등 하천 네트워크 관련 공간자료는 각종 하천관리, 하천계획 및 설계, 수리수문학적 해석 등의 근간을 이루는 기초자료로 활용되고 있다. 기존 RIMGIS 등에서 제공하는 하천정보도 현행화 및 적절한 관리 부족으로 공간정보시스템간 불일치와 실제 하천지형과 이격이 나타나고 있는 실정이다. 또한, 고해상도 수치지형도(DEM)이 국가하천 주변 등 일부 지역에서만 제공되어, 저해상도 DEM으로부터 추출된 하천네트워크 정보의 신뢰도가 낮고 가용한 기수립 하천네트워크 정보와의 불일치는 DEM 기반 다양한 하천정보 추출 및 탄력적 활용을 저하시키고 있는 실정이다. 본 연구에서는 우선 국내 하천공간정보시스템이 제공하는 하천망 정보의 공간정확도, 정보체계간 일치성 등을 평가하고, 낮은 해상도의 DEM에 기수립된 하천망을 DEM에 강제로 각인시키는 방법으로 DEM을 개선하여 추후 하천망 혹은 유역 추출 시 기수립 하천망 혹은 유역대로 재현이 가능하게 하여 하천분야에 DEM의 활용성을 높일 수 있는 방법론과 소프트웨어(Forced river Network Striation and Delineation tool: FNSD)을 개발하고자 하였다. 개발된 FNSD는 ArcGIS의 ModelBuilder에서 순차적으로 관련 모듈을 연계시켜 자동화되도록 설계되었고, 한강수계의 섬강 유역에 시범 적용되었으며 항공사진 정보를 기반으로 수작업을 통해 도출된 하천망을 기수립 하천망으로 간주하여 30 m 저해상도 DEM에 각인시켜 하천망을 재추출한 후 주어진 기수립 하천망과 비교하여 재현 정확도를 검토하였다. 섬강유역에 적용한 결과 FNSD는 기수립 하천망을 정확하게 재현할 수 있음을 확인하였다. 이러한 검증결과는 각인된 DEM이 다양한 차수의 하천망 및 유역을 신뢰성 있게 재현할 수 있어 저해상도 DEM의 하천활용도를 높이는데 기여할 가능성이 있음을 의미한다.