• 한국초등과학교육학회지:초등과학교육
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• 제31권3호
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• pp.298-310
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• 2012

The purpose of this study was to analyze the characteristics of elementary school students' prediction changes by the suggestion types in a multiple anomalous situation. We investigated the responses, the rate and time of changing prediction, and cognitive conflicts of the students when repeated anomalous situation was suggested in experimental or logical way in science classes focused on buoyancy. As the anomalous situation was repeated, the students to change the prediction increased in number and also the rates to choose the correct prediction became higher. The group who was exposed in experimental way changed their prediction more than in logical way. In addition, when we classified the students to change the prediction by types, the group in experimental way showed higher rate of NM, MM type and FFT type. With anomalous situation repeated, cognitive conflicts of the students has been gradually declining in both groups. But it seemed that the group in experimental way experienced higher mental conflicts. In particular, as students changed the prediction more and arrived at the correct answer after changing their prediction, all the more so. It is concluded that the degree of students' changing prediction and experiencing cognitive conflict can be different according to the suggestion types for situation. Therefore the correlation with cognitive conflict factors can be also observed with the types of students' reactions.

• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.79-90
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• 2014

Objectives : This study was carried out to evaluate the repeated dose oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Alismatis Rhizoma water extract of 500 mg/kg(low dosage group), 1,000 mg/kg(middle dosage group) and 2,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 14 days(twice a day). After 14 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight. Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not repeated dose oral toxicity and oral LD50 value was over 2,000 mg/kg in SD rats. As a result, we can determine Alismatis Rhizoma is a relatively safe substance.

• 한국학교수학회논문집
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• 제24권1호
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• pp.59-81
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• 2021

이 연구에서는 학습자가 수학 텍스트를 반복하여 읽을 때 나타나는 수학 학습 과정이 어떻게 변하는지를 조사하였다. 또한 수학 학습 방법으로써 반복 읽기의 효과를 점검하고 보다 효율적인 반복 읽기 교수·학습 전략에 대한 시사점을 모색하였다. 반복 읽기 수학 학습에는 국립대학교 수학교육과에 재학 중인 예비 수학교사 8명이 참가하였다. 예비 수학교사는 각각 4개의 그룹으로 구성되어 그룹에 따라 서로 다른 4개의 주기로 총 3회 반복 읽기를 시행하였다. 수학 학습 자료 읽기 과정에서 나타나는 예비 수학교사의 시선의 움직임을 추적하고 심박수를 측정하였다. 수집한 자료를 회차별 총 읽기 시간, 슬라이드별 총 읽기 시간, 각 회차와 슬라이드별 총 읽기 시간의 변화 추세, 슬라이드 읽기 순서, 회차별 심박수 변화 추세 등의 다섯 가지 측면에서 분석하였다. 첫 번째 읽기에서는 참가자의 대부분이 비슷한 양상을 보였으나, 두 번째와 세 번째 읽기에서는 개별 학습자에 따른 읽기 패턴의 변화가 보다 다양하게 드러났다. 또한, 첫 번째 읽기에서 반복 주기와 무관하게 가장 많은 시간이 소요되었고, 이후 반복적 읽기 시간에서는 개인별로 차이가 나타났다. 연구 결과에서 도출한 가장 중요한 결론은 반복 읽기를 통한 자기 주도적 수학 학습은 주기와 관계없이 효과적이라는 것이다. 추가적으로 반복 읽기 교수·학습 전략의 효율성을 증진시키기 위한 네 가지 전략을 제안하였다.

• 대한수학교육학회지:학교수학
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• 제11권1호
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• pp.17-37
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• 2009

자연수 곱셈의 개념과 모델은 단일하지 않다. 곱셈의 개념으로는 동수누가, 배, 곱집합이 있으며, 곱셈의 모델로는 측정, 격자, 조합, 수직선 모델이 있다. 초등수학 교과서에서 곱셈 개념을 도입할 때 어떤 개념과 모델에 중심을 두어야하는가 하는 문제는 교수학적인 논점이 많은 문제이다. 이 논문에서는 먼저, 곱셈의 개념과 모델에 대한 수학적이고 교수학적인 분석을 하였고, 이어서 배 개념을 중심에 둔 곱셈 도입방안을 구체적으로 구안하였으며, 마지막으로 이 지도안을 실제 학급에 적용하여 교수 실험하고 그 결과를 분석하였다. 5차시에 걸친 실험수업의 결과를 분석한 결과는 다음과 같았다. 첫째, 학생들의 배 개념의 이해도가 높지 않았다. 둘째, 단위량과 배 값이 주어졌을 때 전체량을 구하는 문항(전형적인 곱셈값 문제)보다 전체량과 단위량이 주어졌을 때 배 값을 구하는 문항의 정답률이 더 높았다. 셋째, 조합모델은 곱셈의 다양한 응용상황중의 하나로서 충분히 다루어질 수 있다. 넷째, 등수누가 계산문항의 정답률은 매우 높았다. 전체적으로 볼 때, 배 개념을 중심으로 곱셈을 지도하는 방안은 기존 방법의 문제점을 보완할 수 있는 하나의 대안이 될 수 있음을 확인하였다.

• Communications for Statistical Applications and Methods
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• 제6권2호
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• pp.601-610
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• 1999

Crossover design is officially except for special occasions recommended by KFDA and FDA for assessing Bioequivalence between two drugs one for reference and the other for innovator. Such design is regarded as a special case of latin square split-polt or repeated measurement design and its main difference with other designing methods is that each subject in an experiment is exposed two drugs in sequence. Therefore general statistical analysis is not suitable since the model for this experiment includes carryover effect in addition to period and sequence effect. in this paper analysis for crossover model with two drugs and its interpretation are mainly discussed and an example is given for illustration.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.1499-1502
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• 2008

This paper proposes an efficient data compression for the conventional method of reducing EMI in a 10 bit LCD timing controller (TCON). In addition, we develop a new method to reduce EMI in a LCD TCON through repeated data on adjacent blocks. The novel technique reduced EMI by 10 dB for a 52" FHD 10it LCD TV.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1988년도 한국자동제어학술회의논문집(국제학술편); 한국전력공사연수원, 서울; 21-22 Oct. 1988
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• pp.1037-1040
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• 1988

In this study, we performed the recognition test on Korean vowel using peripheral auditory model. In addition, for the purpose of objective comparision, the recognition test is performed by extracting LPC cepstrum coefficients from the same data. And the same speech data are mixed with the Guaussian white noise quantitatively, then we repeated the same test, too. So we verified that this auditory model has a adaptability on noise.

• 대한수의학회지
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• 제43권1호
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• pp.57-66
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• 2003

Single and 28-day repeated dose toxicity studies of botulimnn toxin type A were carried out in ICR mice and Sprague-Dawley rats, respectively. In the single dose toxicity study, botulinwn toxin was injected intraperitoneally to male and female mice at a single dose of 40, 59, 89 133 and 200 ng/10 ml saline/kg. All animals died from 59 ng/kg group. Some clinical signs, such as decrease in locomotor activity, dyspnea, prone position and ptosis, were observed in most of both sexes from 59 ng/kg group, but no signs were seen in all animals at 40 ng/kg group. The results showed that the median lethal dose of botulinum toxin might be in the range of 40-59 ng/kg in both sexes. In the repeated dose toxicity study, the test material was administered intradermally for 28 days at doses of 0 (vehicle-treated control), 1.25, 2.5, 5.0 and $10.0ng/head/50{\mu}{\ell}$ saline in male and female rats. No test material-related changes were noted in survivals, clinical signs, food and water consumptions and gross finding in any group. Botulinum toxin treatment significantly decreased the body weight gain rate in male of 5.0 ng/head group and over and in female of 10.0 ng/head group compared to vehicle-treated control. One or more relative organ weights (i.e., spleen, thymus, liver and kidney) were increased significantly from 5.0 ng/head group compared to vehicle-treated control in both sexes. Serum biochemistry revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase, total protein and albumin in male, and increases in AST and ALT and decreases in $K^+$ and $Cl^-$ in female without dose-pendent manners. In the histopathological study, physical stimulation by needle caused slight inflammations of dennis. In addition, botulinum toxin treatment induced denervation of nerve cell and disuse of muscle, resulting in atrophy of skeletal muscle in both sexes from 2.5 ng/head group. When the antibodies to toxin were determined in all animals, a significant increase in serum antibodies was observed from 5.0 ng/head group. The results showed that the NOAEL of botulinum toxin might be 1.25 ng/head for 28-day repeated dose toxicity in rats.

• Toxicological Research
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• 제23권4호
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• pp.405-413
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• 2007

This study was to investigate single and repeated-dose toxicities of Tensolin-$F^{(R)}$, an anti-wrinkle agent, in Sprague-Dawley (SD) rats or ICR mice. In single-dose oral toxicity study, the test materials were administered once by gavage to male and female SD rats at dose levels of 0 and 2,000 mg/kg. No dead animals and abnormal necropsy findings were found in control and Tensolin-$F^{(R)}$ treated group. Therefore, the approximate lethal dose of Tensolin-$F^{(R)}$ was considered to be higher than 2,000 mg/kg in rats. In the 4-week repeated oral toxicity study, the test material was administered once daily by gavage to male and female ICR mice at dose levels of 0, 25, 50 and 100 mg/kg/day for 4-weeks. In the results, no abnormality was observed in mortality, clinical findings, body weight changes, food and water consumptions, opthalmoscopic findings, necropsy findings, histopathological findings. In hematological analysis, there was a trend of increase in reticulocyte at male 25 mg/kg, although such changes were in normal ranges. On the other hand, there was a trend of decrease in hemoglobin at female 50, 100 mg/kg, such changes were in normal ranges. In addition, serum biochemical parameters including sodium, BUN and chloride increased at 25, 50 and 100 mg/kg. Relative organ weights of right testis, brain, lung and left epididymis were increased in 100 mg/kg groups of male rats in contrast to not change in female groups. However, these changes of relative organ weights, hematological and serum biochemical parameters were not accompanied with related signs such as histopathological changes or clinical findings. In conclusion, 4-week repeated oral dose of Tensolin-$F^{(R)}$ to ICR mice did not cause apparent toxicological change at the dose of 25, 50, 100 mg/kg body weight. Consequently the no-observed-adverse-effect level (NOAEL) for Tensolin-$F^{(R)}$ in ICR mice following gavage for at least 4-week is higher than 100 mg/kg/day.

• 지질공학
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• 제31권4호
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• pp.493-506
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• 2021

액상화 현상이란 지반이 포화된 느슨한 사질토 지반에 지진과 같은 동적하중이 급속히 작용할 때 과잉간극수압이 발생하고, 지반이 유효응력을 상실하고 액체화 되는 현상을 말한다. 액상화 평가를 위한 실내반복시험은 반복삼축압축시험과 반복전단시험을 통하여 확인이 가능하다. 이와 관련하여 본 연구에서는 반복삼축압축시험을 이용한 모래의 상대밀도와 입도분포에 따른 액상화 저항 강도를 확인하고자 하였고, 실험장비의 신뢰도 검증과 결과의 타당성을 확인하고자 기존의 선행연구와 대조하여 비교·분석하였다. 실험결과, 흙의 분류에 상관없이 상대밀도가 증가함에 따라 액상화 저항 강도가 높아짐을 확인하였고, 모래의 입도분포에 따른 액상화 저항강도는 SW에 가까운 SP시료의 액상화 저항강도가 상당히 높게 확인되었다. 또한 세립분 0% 대비 세립분 30%를 분석한 결과, 상대밀도 40~70%까지 증가함에 따라 액상화 저항강도가 5~20% 가까이 감소하였고, 국내 풍화토 지반이 주문진 표준사 대비 액상화 저항 강도가 세립분이 10%일 때는 30% 이상, 세립분이 30%일 때는 50% 이상 낮게 측정되었다.