• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2008년도 정기학술발표대회 논문집
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• pp.388-391
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• 2008

향후 국내의 주택건설 산업은 신규 택지개발에 의한 주택공급 방식보다는 기존 주택의 재개발 및 재건축에 더 큰 비중을 둘 수밖에 없으며, 현재 그러한 추세가 급속하게 확산되고 있다. 또한 재고주택 중 공동주택이 50% 이상을 차지하고 있으며, 이들의 유지보수, 리모델링 및 재건축은 주거지의 슬럼화 방지, 건물성능 저하에 따른 재난방지 등을 위하여 반드시 필요한 분야가 되었다. 이에 따라 건설폐기물의 재활용에 대한 관심 또한 매우 커져가고 있다. 따라서 정부나 민간에서는 건설폐기물의 발생량을 줄이기 위해 많은 노력을 하고 있다. 그러나 건설폐기물의 발생량을 정확히 예측하고 관리하기 위한 시스템의 개발에 대한 노력은 거의 없는 실정이다. 폐기물의 발생량을 예측하기 위한 기준의 미비로 인해 많은 사회적 비용이 발생하고 있다. 따라서 본 연구에서는 CAD 도면과 3D object를 활용하여 건설폐기물의 발생량을 쉽게 예측할 수 있는 방안을 제시한다.

• 한국건축시공학회지
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• 제11권5호
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• pp.501-514
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• 2011

Recently, there have been many cases in which the difficulty of repair and replacement of principal elements in the bearing wall structure for apartment buildings, which is a major part of apartment buildings in Korea, has led to the reconstruction of buildings rather than their remodeling. To address this problem, the Korea government now allows a floor area ratio of up to 20 %, and has relaxed the building height limits to encourage the use of a rahmen structure instead of a bearing wall structure. However, since reinforced concrete rahmen structures have many problems, including higher floor height and greater construction cost, a great deal of research into rahmen composite precast concrete structures have been conducted. Green Frame, one of the developed prototypes, is expected to provide economic benefits through in-situ production for precast concrete column and beam. For in-situ production of composite precast concrete members, a detailed plan for production, curing, and installation is needed. However, it needs to be confirmed that the space is sufficient to produce the precast concrete members on-site before planning those activities. Therefore, this study proposes in-situ production analysis of composite precast concrete members of Green Frame with the evaluation of structural safety and available area on the parking structure. The result of this study shows that the in-situ production of precast concrete members is possible through a case study.

• 대한토목학회논문집
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• 제28권1D호
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• pp.73-81
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• 2008

향후 국내의 주택건설 산업은 신규 택지개발에 의한 주택공급 방식보다는 기존 주택의 재개발 및 재건축에 더 큰 비중을 둘 수밖에 없으며, 현재 그러한 추세가 급속하게 확산되고 있다. 또한 재고주택 중 공동주택이 50% 이상을 차지하고 있으며, 이들의 유지보수, 리모델링 및 재건축은 주거지의 슬럼화 방지, 건물성능 저하에 따른 재난방지 등을 위하여 반드시 필요한 분야가 되었다. 따라서 이러한 재개발 재건축 등의 활성화로 인하여 도심지 해체공사가 증가함에 따라 건설폐기물의 발생량이 대폭 증가하고 있다. 따라서 건설폐기물의 적정관리는 매우 중요한 사항이 되어 가고 있으나, 발생 폐기물을 정확히 예측하기 위한 연구가 부족하였다. 따라서 본 연구에서는 공동주택의 해체물량을 정확히 예측할 수 있는 건설폐기물 원단위 산정 기준을 제시한다. 이것은 해체공사시 발생 가능한 건설폐기물을 손쉽고 정확히 예측할 수 있으며, 이것은 국가 폐기물 정책에 매우 중요한 자료로 활용될 수 있을 것이다.

• 농촌계획
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• 제22권2호
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• pp.19-29
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• 2016

Disasters that occur most frequently in rural areas are drought, flood, damages from wind and cold weather. Among these, damages from storm and flood and drought are the main disasters and recently, these are occurring on a large scale due to unusual weather conditions. Under such circumstances, projects and researches on disasters in rural areas are under way but they are mostly targeting one area or making approaches focusing on repair facilities, maintenance project of facilities in small streams, and disaster management, so there have not been enough studies on the current status of overall damaged facilities in the rural areas. Against this backdrop, through the analysis of the current status of damaged facilities due to storm and flood in rural areas, this study aims to provide base data for policies needed for disaster recovery planning and maintenance work of rural areas. For the analysis of damaged facilities due to storm and flood in rural areas, using the annual report on disasters issued by Ministry of Public Safety and Security and based on the occurrence rate of estimated damage in each city and district for the past 10 years(2004~2013), 8 areas with the highest number of occurrence and cost of damage were found from each province and target areas were selected. Then, regarding the selected target areas, the General Plan for Reducing Damages from Storm and Flood, which is the report on top-level plan for preventing disasters, was secured and the current status of damaged facilities were analyzed. After organizing the analysis of current status, the tendency of damaged facilities due to storm and flood in rural areas, the items of damaged facilities depending on the types of storm and flood damages, and risk factors were suggested. Based on this result, in order to generalize the results of follow-up researches, it is thought that disaster recovery planning and establishing the system of remodeling items necessary for maintenance work would be possible by analyzing damage investigation items recorded in additional researches on rural areas, researches on natural disasters, and recovery plan instructions and by conducting on-site investigation on the damaged villages from storm and flood in rural areas.

• 환경위생공학
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• 제7권2호
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• pp.95-110
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• 1992

Much progress has been made in understanding the subcellular events of the human lung injuries after acute exposure to environmental air pollutants. Host of those events represent oxidative damages mediated by reactive oxygen species such as superoxide, hydrogen peroxide, and the hydroxy, free radical. Recently, nitric oxide (NO) was found to be endogenously produced by endothelial cells and cells of the reticulo-endothelial system as endothelialderived relaxation factor (EDRF) which is a vasoactive and neurotransmitter substance. Together with superoxide, NO can form another strong oxidant, peroxonitrite. The relative importance of exogenous sources of $N0/N0_2$ and endogenous production of NO by the EDRF producing enzymes in the oxidative stresses to the heman lung has to be elucidated. The exact events leading to chronic irreversible damage are still yet to be known. From chronic exposure to oxidant gases, progressive epithelial and interstitial damages develop. Type I epithelial cells become thicker and cover a smaller average alveolar surface area while thee II cells proliferate instead. Under acute damages, the extent of loss of the alveolar epithelial cell lining, especially type II cells appears to be a good predictor of the ensuing irreversible damage to alveolar compartment. Interstitial matrix undergo remodeling during chronic exposure with increased collagen fibers and interstitial fibroblasts. However, Inany of these changes can be reversed after cessation of exposure. Among chronic lung injuries, genetic damages and repair responses received particular attention in view of the known increased lung cancer risks from exposure to several air pollutants. Heavy metals from foundry emission, automobile traffics, and total suspended particulate, especially polycystic aromatic hydrocarbons have been positively linked with the development of lung cancer. Asbestos in another air pollutant with known risk of lung cancer and mesothelioma, but asbestos fibers are nonauthentic in most bioassays. Studies using the electron spin resonance spin trapping method show that the presence of iron in asbestos accelerates the production of the hydroxy, radical in vitro. Interactions of these reactive oxygen species with particular cellular components and disruption of cell defense mechanisms still await further studies to elucidate the carcinogenic potential of asbestos fibers of different size and chemical composition. The distribution of inhaled pollutants and the magnitude of their eventual effects on the respiratory tract are determined by pollutant-independent physical factors such as anatomy of the respiratory tract and level and pattern of breathing, as well as by pollutant-specific phyco-chemical factors such as the reactivity, solubility, and diffusivity of the foreign gas in mucus, blood and tissue. Many of these individual factors determining dose can be quantified in vitro. However, mathematical models based on these factors should be validated for its integrity by using data from intact human lungs.

• Tuberculosis and Respiratory Diseases
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• 제77권2호
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• pp.73-80
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• 2014

Background: Low levels of serum vitamin D is associated with several lung diseases. The production and activation of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of emphysema. The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells. Methods: HFL-1 cells were cast into three-dimensional collagen gels and stimulated with or without interleukin-$1{\beta}$ (IL-$1{\beta}$) in the presence or absence of 100 nM 25-hydroxyvitamin D (25(OH)D) or 1,25-dihydroxyvitamin D ($1,25(OH)_2D$) for 48 hours. Trypsin was then added into the culture medium in order to activate MMPs. To investigate the activity of MMP-2 and MMP-9, gelatin zymography was performed. The expression of the tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) was measured by enzyme-linked immunosorbent assay. Expression of MMP-9 mRNA and TIMP-1, TIMP-2 mRNA was quantified by real time reverse transcription polymerase chain reaction. Results: IL-$1{\beta}$ significantly stimulated MMP-9 production and mRNA expression. Trypsin converted latent MMP-2 and MMP-9 into their active forms of MMP-2 (66 kDa) and MMP-9 (82 kDa) within 24 hours. This conversion was significantly inhibited by 25(OH)D (100 nM) and $1,25(OH)_2D$ (100 nM). The expression of MMP-9 mRNA was also significantly inhibited by 25(OH)D and $1,25(OH)_2D$. Conclusion: Vitamin D, 25(OH)D, and $1,25(OH)_2D$ play a role in regulating human lung fibroblast functions in wound repair and tissue remodeling through not only inhibiting IL-$1{\beta}$ stimulated MMP-9 production and conversion to its active form but also inhibiting IL-$1{\beta}$ inhibition on TIMP-1 and TIMP-2 production.

• 한국문헌정보학회지
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• 제45권1호
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• pp.125-147
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• 2011

최근 도서관 건축 및 리모델링이 많아지고, 전국의 공공도서관수도 최근 2년간 100여개 이상 증가하는 상황에서 도서관용품에 대한 관심과 수요가 증가하고 있다. 본 연구에서는 도서관용품에 대한 정보제공과 원활한 유통을 위한 기초 연구단계로서 도서관용품에 대한 정의를 명확히 내리고자 하였으며, 이를 기반으로 도서관용품 분류체계를 개발하고자 하였다. 본 연구에서는 도서관용품(Library Goods)은 도서관자료의 수집, 정리, 서비스 등의 활동을 효과적으로 수행하기 위해 요구되는 모든 물품으로 정의를 내리고, 크게 비품 (비소모품)과 소모품으로 구분하였다. 도서관비품(library equipment)은 근본적인 동일성과 일정기간 이상의 유용성을 보유하고 있는 비소모품적 성질의 도서관용 각종 가구, 기기 및 기구 등의 품목을 말하고, 도서관소모품(library supplies)은 도서관에서 도서관자료의 정리 및 보수 등을 위해 사용되는 것으로, 쓰는 대로 닳거나 줄어들어 없어지거나 못 쓰게 되는 물품을 말한다. 위의 정의를 기반으로 도서관용품 분류체계를 개발하였다. 즉 도서관비품을 가구와 도서관시스템솔루션, 컴퓨터 및 멀티미디어기기로, 소모품을 도서관 정리 및 보수용품, 사인시스템, 그리고 기타용품으로 구분하였으며, 최종적으로 6개 영역 117개의 용품을 제시하였다.

• 생명과학회지
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• 제30권7호
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• pp.651-659
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• 2020

허혈성 심혈관질환은 전 세계적으로 치사율이 높은 질병 중 하나이다. 이를 치료하기 위해 수술적 방법이 시행되고 있으나, 손상된 심근조직 회복의 어려움과 수술 후 부작용의 한계가 남아있다. 이러한 한계점을 극복하기 위해, 최근 줄기세포를 기반으로 한 심혈관질환의 세포치료제가 각광받고 있는데 그 중에서도 특히 혈관내피전구세포(EPC)는 높은 증식능과 분화능을 기반으로 손상된 혈관을 재생하고, 주변 조직의 재생을 돕는다는 장점이 있다. 또, EPC는 임상적으로 안전하며, 환자의 심근 기능을 회복시켜주기에 잠재적인 심혈관질환 치료제로서의 가능성이 대두되었다. 하지만, 환자 유래 EPC를 이용한 치료법은, 고령, 흡연 여부, 기저질환 등의 이유로 환자의 EPC 기능이 저하되어 있어, 그 치료 효능을 기대하기 어렵다. 따라서, 최근에는 세포 프라이밍 기법, 오가노이드 배양법과 같이 EPC의 생리학적 활성도를 올리는 체외 배양법의 개발과 3D 바이오프린팅 기법을 이용한 EPC의 이식 효율을 높여 치료 효능을 개선시킬 수 있는 새로운 접근법이 연구되고 있다. 본 연구에서는 EPC의 특징과 세포치료제로서의 임상적용 가능성에 대해 살펴보고자 한다.

• 대한치과교정학회지
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• 제18권1호
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• pp.189-207
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• 1988

In almost all biologic systems, mechanically induced electric charge separation is a fundamental phenomenon. Since the hypothesis was established that the generation of electric potentials in bone by mechanical stress including muscular force might control the activity in bone by mechanical stress including muscular force might control the activity of osseous cells and their biopolymeric byproduct, the concept of electrically mediate growth mechanism, which involves biological growth and bone remodeling by any means, in living systems has been applied clinically and experimentally to orthopedic fracture repair, the regulation of orthodontic tooth movement, epiphyseal cartilage regeneration, etc. On the other hand, recent numerous research data available show apparently that the mandibular condyle has the characteristics of growth center as well as growth site. In addition, there exists a considerable difference of opinion as to the role of external pterygoid muscle in condylar growth. In view of these evidences, this. experiment was performed to investigate the effect of the galavic current on the growth of the mandible and condyle for elucidating the nature of condylar growth. The bimetallic device was composed of silver and platinum electrode connected with resistor (3.9 Mohm), which was expected to produce galvanic current of 23.6 nA according to the galvanic principle. The 25 Sprague-Dawley rats were divided into two group, 2 week group comprising 8 animals exposed to satanic current for 2 weeks and 3 control animals not exposed for 2 weeks, 4 week group comprising 10 animals in experimental group and 4 animals in control group applied for 4 weeks respectively. The experimental rats were subjected to application of the galvanic current invasively to codylar head surface and the control groups with sham electrode. On the basis of anatomic and histologic data from the mandibular condyle of experimental and control group, the following results were obtained. 1. After 2 weeks, there was no increase of mandibular size in experimental group over that of the control group. 2. After 4 weeks, the size of the condylar head was larger in experimental group than that of the control. 3. In 2 week group, the thickness of the mitotic compartment and hypertrophic chondroblastic layer was increased in experimental group. 4. In 4 week group, the number and the size of the hypertrophic chondroblasts were increased significantly on experimental group over that of the control group. 5. The application of the satanic current caused an increase in chondrocytic hypertrophy and intercellular matrix in both groups.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제15권1호
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• pp.63-79
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• 1993

To repair bony defects with tansplanted bone in the body, fresh autogenous bone is undoubtly, the most effective bone graft for clinical applications. But the demineralized bone has the matrix-induced bone formation which was suggested by Urist in 1965. Many authors assisted that demineralized bone powder induces phenotypic conversion of mesenchymal cells into osteoblasts, with high-density bone formation. The process of inducing differentiated cells becomes osteogenic properties. The purpose of this study was to evaluate the osteoinductive capacity of allogenic freeze-dried demineralized bone block (FDD, $7{\times}7mm$) and to compare FDD with the same sue of deep-frozen allogenic bone(DF), fresh autogenous bone (A) after implantation. The histological and ultrastructural features of tissue responses were examined after 1, 2, 4, 6, 8 weeks implantation of each experimental groups in the operative site of the New Zealand white rabbits. The results were as follows : 1. Inflammatory cell infiltration generally has appeared at 1 week, but reduced at 4 weeks in each group, but most severe in DF group. 2. Osteoblastic activity has increased for 4 weeks, but decreased at 6 weeks in each group and there was no significant difference among experimental groups. 3. New bone formation has begun at 1week, least activations in A groups, and showed the revesal line of bone formation among each group at 6 to 8 weeks. 4. Bone resorption has appeared at 1 week, but disappeared at 4 weeks in both A and DF groups, but more severe in DF than A groups. 5. In ultrastructural changs, the DF group have showed the most remarkable osteoclastic activities among experimental groups. 6. Osteoid or tangled collagen fibrils near the implanted sites were replaced by more mature, lamellated bony trabeculae during bone remodeling. There was little difference among each experimental groups. 7. During the convertion osteoblasts to osteocytes which embedded within the bone matrix, there was organ-less-poor cytoplasm, increased nuclear chromatin, abundant rough endothelial reticulum (RER) in each groups. From the above the findings, the DF group shored more bone resorption and foreign body reaction than FDD and A groups, and FDD group showed more new bone formation or osteoblastic activity than DF and A groups in early stage. There was no significant difference of cellular activities among the FDD DF, and A groups according to the time.