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http://dx.doi.org/10.5352/JLS.2020.30.7.651

The Potential Therapeutic Effects of Endothelial Progenitor Cells in Ischemic Cardiovascular Disease  

Kim, Da Yeon (Department of Physiology, Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine)
Kim, Bo Min (Pusan National University School of Medicine)
Kim, So Jung (Pusan National University School of Medicine)
Choi, Jin Hee (Pusan National University School of Medicine)
Kwon, Sang-Mo (Department of Physiology, Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine)
Publication Information
Journal of Life Science / v.30, no.7, 2020 , pp. 651-659 More about this Journal
Abstract
Cardiovascular disease is one of the leading causes of death across the world, and gold-standard treatments such as percutaneous coronary intervention and artery bypass grafting have various limitations including myocardial damage and subsequent maladaptive cardiac remodeling. To overcome this, stem-cell therapies are emerging as a promising strategy for cardiovascular regeneration. Endothelial progenitor cells (EPCs) have high potential to proliferate and differentiate into endothelial cells for vascularization and tissue regeneration, and several clinical trials have explored EPC function in tissue repair in relation to clinical safety and improving cardiac function. Consequently, EPC has been suggested as a feasible stem-cell therapy. However, autologous EPC transplantation in cardiovascular disease patients is restricted by risk factors such as age, smoking status, and hypertension that lead to reduced bioactivity in the EPCs. New approaches for improving EPC function and stem-cell efficacy have therefore been suggested, including cell priming, organoid culture systems, and enhancing transplantation efficiency through 3D bioprinting methods. In this review, we provide a comprehensive understanding of EPC characteristics, therapeutic approaches, and the current state of clinical research into EPCs as stem-cell therapy for cardiovascular disease.
Keywords
Cell priming; endothelial progenitor cells; ischemic cardiovascular disease; stem cell therapy;
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