• Proceedings of the Korean Institute of Building Construction Conference
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• 2015.11a
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• pp.81-82
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• 2015

BIM has been a reliable construction project management tool to handle various kinds of construction information generated in the facility life cycle. To take these advantages, researchers have been promoted numerous studies in a residential, a commercial, and an educational facilities with a large number of on-going projects. However, despite running as the role of essential energy supplier, power plant related BIM research is relatively insufficient than others. In particular, due to the extending of the facility service period and the requirement of the complicated construction project management for 'overhaul' and 'repowering' in the power plant maintenance phase, the needs for using BIM have been increased gradually. For using BIM based maintenance, it is needed to consider an information collecting methods and necessary to develop an appropriate breakdown structure to share information. Therefore, 'EBS' is produced by reviewing the previous research related to BIM and analyzing the repair activities in the maintenance phase. Proposed 'EBS' must be useful not only a judgment between capital expenditure versus revenue expenditure but also appropriate maintenance strategies development for property management.

• BMB Reports
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• v.50 no.2
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• pp.58-59
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• 2017

The beneficial paracrine roles of mesenchymal stem cells (MSCs) in tissue repair have potential in therapeutic strategies against various diseases. However, the key therapeutic factors secreted from MSCs and their exact molecular mechanisms of action remain unclear. In this study, the cell-free secretome of umbilical cord-derived MSCs showed significant anti-fibrotic activity in the mouse models of liver fibrosis. The involved action mechanism was the regulation of hepatic stellate cell activation by direct inhibition of the $TGF{\beta}$/Smad-signaling. Antagonizing the milk fat globule-EGF factor 8 (MFGE8) activity blocked the anti-fibrotic effects of the MSC secretome in vitro and in vivo. Moreover, MFGE8 was secreted by MSCs from the umbilical cord as well as other tissues, including teeth and bone marrow. Administration of recombinant MFGE8 protein alone had a significant anti-fibrotic effect in two different models of liver fibrosis. Additionally, MFGE8 downregulated $TGF{\beta}$ type I receptor expression by binding to ${\alpha}v{\beta}3$ integrin on HSCs. These findings revealed the potential role of MFGE8 in modulating $TGF{\beta}$-signaling. Thus, MFGE8 could serve as a novel therapeutic agent for liver fibrosis.

• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.237-243
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• 2020

A novel psychrotolerant Psychrobacillus strain PB01, isolated from an Antarctic iceberg, was comparatively analyzed with five related strains. The complete genome of strain PB01 consists of a single circular chromosome (4.3 Mb) and a plasmid (19 Kb). As potential low-temperature adaptation strategies, strain PB01 has four genes encoding cold-shock proteins, two genes encoding DEAD-box RNA helicases, and eight genes encoding transporters for glycine betaine, which can serve as a cryoprotectant, on the genome. The pan-genome structure of the six Psychrobacillus strains suggests that strain PB01 might have evolved to adapt to extreme environments by changing its genome content to gain higher capacity for DNA repair, translation, and membrane transport. Notably, strain PB01 possesses a complete TCA cycle consisting of eight enzymes as well as three additional Helicobacter pylori-type enzymes: ferredoxin-dependent 2-oxoglutarate synthase, succinyl-CoA/acetoacetyl-CoA transferase, and malate/quinone oxidoreductase. The co-existence of the genes for TCA cycle enzymes has also been identified in the other five Psychrobacillus strains.

• International Journal of Concrete Structures and Materials
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• v.10 no.3
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• pp.383-391
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• 2016

This paper reports the results of an experimental program involving several small-scale columns which were constructed to simulate corrosion damage in the field using two accelerated corrosion techniques namely, constant voltage and constant current. A total of six columns were cast for this experiment. For one pair of regular RC columns, corrosion was accelerated using constant voltage and for another pair, corrosion was accelerated using constant current. The remaining pair of regular RC columns was used as control. In the experiment, all the columns were subjected to cyclic wetting and drying using sodium chloride (NaCl) solution. The currents were monitored on an hourly interval and cracks were visually checked throughout the test program. After the specimens had suffered sufficient percentage steel loss, all the columns including the control were tested to failure in compression. The test results generated show that accelerated corrosion using impressed constant current produces more corrosion damage than that using constant voltage. The results suggest that the constant current approach can be better used to simulate corrosion damage of reinforced concrete structures and to assess the effectiveness of various materials, repair strategies and admixtures to resist corrosion damage.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05b
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• pp.1-19
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• 2002

It is well established that the initiating event in chemical carcinogenesis is the binding of reactive carcinogens to DNA. Thus, a number of analytic methods have been developed for determining levels of carcinogen-DNA adducts in humans as a marker of individual exposure and, potentially, of risk for cancer development. In addition, reactive carcinogens also bind to protein suggesting protein adducts can be used as a surrogate for DNA adducts in some situations. We have developed monoclonal and polyclonal antibodies to carcinogen-DNA and protein adductis and highly sensitive ELISA and immunohistochemical assays for determining levels of adducts in human tissues. These studies have demonstrated higher levels of adducts in those with higher exposure as a result of workplace, dietary, chemotherapy, environmental of lifestyle (smoking) exposures. Elevated levels of adducts have been found in lung and liver cancer cases compared to controls. We have also used DNA adducts to determine efficacy of an antiosidant vitamin intervention. DNA adduct studies have demonstrated very different levels of damage in those with similar exposure levels. These interindividual differences are likely the result genetic differences in capacity to activate carcinogens, detoxify reactive intermediates and repair DNA adducts once formed. We are currently investigating the relationship between polymorphisms in a number of these genes to determine their relationship to adduct levels as well as their ability to confer increased risk for cancer development. The ability to identify high risk individuals will allow the targeting of screening and preventive strategies to those most likely to benfit.

• Journal of environmental and Sanitary engineering
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• v.21 no.2 s.60
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• pp.69-83
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• 2006

This research aims to improve the environmental education for elementary student's education program. That let environmental education be connected to other curriculum with a compunction enhancement plan to the internal volume side of environmental education, and grope for activation of compunction environmental education with curriculum necessary paradigm conversion of education for continuance possibility in green education. In case of legal and system, improving of legal and system by establishment of the environmental education act for system repair and source of revenue preparation of environmental education is needed. Based on importance of teaching-education and evaluation, it must be developed various teaching-education ways of environmental education in case of curriculum and an improvement of teaching-education ways and evaluation must be performed. After teaching-education about environmental education has been executed, a teaching-education improvement must be performed by evaluation.

• International Journal of Oral Biology
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• v.33 no.4
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• pp.187-195
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• 2008

Reparative dentine formation requires newly differentiated odontoblast-like cells. Therefore, identification of the molecule that stimulates the odontogenic differentiation of precursor cells in the tooth pulp will be helpful for the development of strategies to repair damaged pulp. In this study, we examined the effect of N-acetylcysteine (NAC) on the odontogenic differentiation of MDPC-23 cells, a mouse odontoblast-like cell line derived from dental papilla, and primary cultured rat dental papilla cells (RDPCs). NAC (1-30 mM) suppressed production of reactive oxygen species in MDPC-23 cells in a dose-dependent manner. Although 5 to 20 mM NAC did not alter MDPC-23 cell proliferation, 1 or 30 mM NAC significantly inhibited it. NAC enhanced mineralized nodule formation and the expression of several odontoblast differentiation-associated genes in both RDPCs and MDPC-23. This NAC stimulatory effect was significant, even at concentrations lower than 1 mM. However, NAC did not stimulate expression of bone morphogenetic protein-2, -4, or -7, which are known to enhance odontogenic differentiation. Since reactive oxygen species are also involved in the pulp toxicity of resin-based restorative materials, these results suggest that NAC may be a promising candidate for supplementation of dental restorative materials in order to enhance reparative dentine formation.

• Journal of Korean Society of Rural Planning
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• v.17 no.2
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• pp.13-21
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• 2011

The federal government has been implemented several housing policies attempting to improve living quality at Eup-Myun area(rural area), but those were mostly fund supports to reconstruct or repair houses. Existing minimum housing standard is focused on urban apartments and indoor space, but the houses of Eup-Myun area are scattered and are different from urban's house space. Therefore, this study focused on these area, and intended to propose suitable minimum housing standard for Eup-Myun area. Based on literature reviews about housing standard of England, U.S., Japan and South Korea, questionnaire survey was given to 50 experts divided into 2 groups, professors of architecture and researchers on rural environment. This study proposed the direction of new minimum housing standard of Eup-Myun area, it could be added to 2 household composition, be divided into 2 groups, agricultural and non-agricultural residents into facility guideline, be added to outdoor facilities, for example warehouse and open yard, and finally be inserted water quality into environment standard. The results of this study provide insightful strategies for rural housing standard.

• Journal of the Korean Society of Clothing and Textiles
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• v.17 no.1
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• pp.3-10
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• 1993

This study intends to provide a beneficial foundation which can aid our understanding of how a clothing consumer group can be classified according to the clothing buying motives, and what differences are there about the importances store image attribute among them and how consumer's preferences to the store image are shown differently among them and ultimately, some concrete data which can be useful in establishing efficient store image strategies for clothing stores. 484 subjects were gathered through convenience sampling method and, for data analysis, cronbach' ${\alpha}$, frequency, percentage, mean, ${\chi}^2$-text, t-test, ANOVA, Duncan Multiple Range Test, Factor Analysis, Cluster Analysis were conducted. the results are as follows; 1. three kind of factors in the clothing buying motives were determined for analysis of consumers group and by which it was revealed as to be significant for us to classify them three subdivisions; those of fashion pursuit group, self display group, financial utilitarian group. 2. Importance on store image attribute was revealed that Ewha students regarded quality, price, more important factors than others. 3. Store image preferences show significantly when concerned with quality, price, fashion, impression and age of store personnel, convenience for exchanging and returning goods, credit, delivery and repair, mailing of catalogue and discount coupon, bightness of store among consumer groups.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.133-143
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• 2012

Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are re-sponsible for degradation and remodeling of extracellular matrix proteins. The activity of MMPs is tightly regulated at several levels including cleavage of prodomain, allosteric activation, com-partmentalization and complex formation with tissue inhibitor of metalloproteinases (TIMPs). In the central nervous system (CNS), MMPs play a wide variety of roles ranging from brain devel-opment, synaptic plasticity and repair after injury to the pathogenesis of various brain disorders. Following general discussion on the domain structure and the regulation of activity of MMPs, we emphasize their implication in various brain disorder conditions such as Alzheimer's disease, multiple sclerosis, ischemia/reperfusion and Parkinson's disease. We further highlight accumu-lating evidence that MMPs might be the culprit in Parkinson's disease (PD). Among them, MMP-3 appears to be involved in a range of pathogenesis processes in PD including neuroinflamma-tion, apoptosis and degradation of ${\alpha}$-synuclein and DJ-1. MMP inhibitors could represent poten-tial novel therapeutic strategies for treatments of neurodegenerative diseases.